News
FDA Approves 3-Month Leuprolide Mesylate 21 mg Formulation for Advanced Prostate Cancer
The FDA has approved a ready-to-use long-acting injectable formulation that is administered every 3 months as a treatment for advanced prostate cancer.
Published: 8/29/2025
Many Patients With Statin Intolerance Self-Medicate, Despite No Link to Lowering LDL-C
Self-medication, including the use of dietary supplements and pain relief drugs, were reported by many patients with statin-associated muscle symptoms to lower their low-density lipoprotein cholesterol (LDL-C).
Published: 8/29/2025
FluMist Home Delivery Expands Access to Seasonal Influenza Vaccination
FluMist Home, the first at-home nasal spray flu vaccine, is now available for direct delivery to patients in 34 US states.
Published: 8/29/2025
Iza-Bren Receives FDA Breakthrough Therapy Designation for EGFR-Mutated NSCLC
The action is supported by 3 ongoing clinical trials, which are evaluating izalontamab brengitecan (iza-bren) in non–small cell lung cancer (NSCLC) and other diseases.
Published: 8/29/2025
Study: Apitegromab Meaningfully Improves Motor Function in Spinal Muscular Atrophy
Results from the phase 3 SAPPHIRE trial show significant improvements in motor function in children and adults with spinal muscular atrophy.
Published: 8/29/2025
Abemaciclib Plus Endocrine Therapy Improves Survival in Patients With HR+/HER2– Breast Cancer
Abemaciclib enhances overall survival in high-risk HR+, HER2– early breast cancer, establishing its role as a standard adjuvant therapy.
Published: 8/28/2025
Expert: With New COVID-19 Vaccine Approvals, Pharmacists Should Remain Vigilant
Allison Hill, PharmD, RPh, emphasized that pharmacists must stay updated on ACIP and state-level guidance following HHS’s changes to COVID-19 vaccine authorizations.
Published: 8/28/2025
New Nanoparticle Treatment Shows Promise for Preventing Rheumatoid Arthritis Flares
An immunomodulatory nanoparticle called Agg-CLNP has been shown to effectively prevent disease onset for rheumatoid arthritis (RA).
Published: 8/28/2025
Pneumococcal Positivity Associated With More Severe COVID-19 Outcomes
Patients with severe COVID-19 who tested positive for Streptococcus pneumoniae had higher mortality rates.
Published: 8/28/2025
FDA Approves REMS Modification for Sparsentan in IgA Nephropathy
The FDA updated sparsentan's REMS, easing monitoring requirements, enhancing treatment access for IgA nephropathy patients, and supporting kidney function preservation.
Published: 8/28/2025
FDA Approves Generic Version of Liraglutide Injection, a GLP-1 for Weight Loss
Generic liraglutide injection is the first GLP-1 indicated for weight loss.
Published: 8/28/2025
Long-Lasting Drug Shortages Highlight Fragile Supply Chains and Systemic Market Pressures
Drug shortages challenge U.S. healthcare, driven by systemic issues like low pricing and manufacturing concentration, impacting patient care and safety.
Published: 8/28/2025
Emerging Evidence Shows Hesperidin's Benefits in Cardiometabolic Health
Hesperidin, a citrus-derived flavonoid, shows promise in improving cholesterol, blood pressure, and metabolic health, particularly at higher doses and longer durations.
Published: 8/28/2025
COVID-19 Vaccination Could Lower Risk of Developing Asthma
COVID-19 vaccination significantly reduces the risk of asthma and other airway inflammatory diseases, offering vital protection against respiratory complications.
Published: 8/28/2025
Switching From Reference Adalimumab to Biosimilar Shows No Major Differences in Patients With RA, PsA
Biosimilars can be a more affordable and accessible treatment option for patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA).
Published: 8/28/2025
Oral SERDs in Breast Cancer: Imulnestrant and Elacestrant
Oral selective estrogen receptor degraders (SERDs) are a promising line of treatments for patients with breast cancer.
Published: 8/27/2025
FDA Approves Updated COVID-19 Vaccines Targeting LP.8.1 For Older Adults, Those At Risk
The FDA's approvals follow new COVID-19 guidance announced by the commissioner of the agency in May 2025, focusing future approvals on older adults.
Published: 8/27/2025
Orforglipron's Success in Phase 3 Trial Triggers Regulatory Submissions for Obesity Treatment
Orforglipron is an effective treatment, leading to significant body weight reduction and improved glycemic control.
Published: 8/27/2025
Neighborhood Marginalization Worsens Outcomes in Young Myocardial Infarction Survivors
Young adults who had experienced an acute myocardial infarction and lived in marginalized communities had increased risks of adverse events and reduced visits to their physician or cardiologist.
Published: 8/27/2025
FDA Grants I-DXd Breakthrough Therapy Designation in Treatment of ES-SCLC
The action is significant for patients with extensive-stage small cell lung cancer (SCLC), a population with limited treatment options.
Published: 8/27/2025
Metformin, Potential Treatment for ADPKD, Currently Undergoing Investigation in Long-Term Efficacy Trial
If long-term efficacy results are positive, metformin can become an accessible, affordable treatment option for autosomal dominant polycystic kidney disease (ADPKD).
Published: 8/27/2025
FDA Suspends Licensing of Ixchiq Chikungunya Vaccine Amid Safety Concerns
The FDA suspended the biologics license for Ixchiq, the first approved chikungunya vaccine, after reports of serious adverse events and fatalities.
Published: 8/27/2025
More Potassium, Less Pressure: The Diet-Hypertension Link
Increasing dietary potassium, such as from bananas, may lower blood pressure more effectively than reducing sodium alone.
Published: 8/27/2025
A High-Performance Room-Temperature Acetone Gas Sensor Could Aid Diabetes Detection
The sensor detects acetone levels in the breath to indicate diabetes.
Published: 8/26/2025
Common Cold Linked to Reduced Risk of COVID-19 Infection
Rhinovirus infection, which causes the common cold, could offer infected children more respiratory pathway protection from SARS-CoV-2 infection.
Published: 8/26/2025
Study Finds GLP-1 Receptor Agonists May Reduce Cancer Risk in Adults With Obesity
GLP-1 receptor agonists like semaglutide show promise in reducing obesity-related cancer risks, while highlighting the need for ongoing safety monitoring.
Published: 8/26/2025
Dynavax’s Z-1018 Shingles Vaccine Candidate Shows Promising Immune Response and Safety in Early Trial
A novel shingles vaccine candidate demonstrated positive top-line results of antibody and CD4⁺ T-cell vaccine responses.
Published: 8/26/2025
Suppression of JNK Pathway Drives Resistance to Endocrine and CDK4/6 Therapy in ER-Positive Breast Cancer
Researchers have identified suppression of the JNK pathway, particularly loss of MAP2K7, as a key driver of resistance to endocrine therapy plus CDK4/6 inhibitors in ER+ breast cancer.
Published: 8/26/2025
LY01011, Biosimilar of Denosumab, Meets Primary End Point in Study
When treating patients with bone metastases, the biosimilar demonstrated equivalent safety and efficacy to its reference product.
Published: 8/26/2025
Condition Watch: Opioid Use Disorder
Pharmacists play crucial roles in opioid use disorder treatment.
Published: 8/26/2025
Understanding Appetite-Controlling Amylin Receptors Could Aid Development of Future Weight Loss Drugs
A better understanding of the activation of amylin receptors is a step forward for developing new drugs.
Published: 8/25/2025
Mediterranean Diet Cuts Dementia-Linked Metabolites by 35% in APOE4 Carriers
The new data highlight how dietary changes could fuel Alzheimer- and dementia-related mechanisms.
Published: 8/25/2025
RSV-Associated Acute Respiratory Infections Show Comparable Outcomes to Influenza in Older Adults
RSV causes a significant burden of acute respiratory infections in older adults.
Published: 8/25/2025
Targeted Therapy Brings Remission in Patient With CAR-Positive T-Cell Lymphoma
A patient, who formerly had previously been treated with CAR therapy for multiple myeloma, achieved remission for both multiple myeloma and lymphoma.
Published: 8/25/2025
Rusfertide Gains Breakthrough Therapy Designation for Polycythemia Vera
The action follows phase 3 trial data that demonstrated reduced phlebotomy dependence, improved hematocrit control, and eased symptoms.
Published: 8/25/2025
FDA Expands Evolocumab to Treat Adults at Increased Risk for Major Adverse Cardiovascular Events
Evolocumab is now indicated for adults at increased risk for major adverse cardiovascular events (MACE).
Published: 8/25/2025
Patients With Systemic Sclerosis Face Decreased HDL-C, Increased Lipoprotein(a)
A systematic review and meta-analysis revealed key insights into lipid parameters in patients with systemic sclerosis.
Published: 8/25/2025
Professionalism and Communication Are Crucial Skills
Effective communication between pharmacy technicians and others is necessary to meet patient needs.
Published: 8/25/2025
Metformin Shows Survival Benefit in Patients With HER2-Positive Breast Cancer
The study results could help bolster metformin as a potentially attractive option for patients with HER2-positive breast cancer.
Published: 8/24/2025
Patients Express Confidence in Pneumococcal Vaccines Given by Pharmacists in Oncology Units
Patients in an outpatient oncology unit expressed willingness to receive a pneumococcal or influenza vaccine from a pharmacist if offered.
Published: 8/23/2025
Shingles Vaccine Linked to Reduced Risks of Stroke, Myocardial Infarction, and Herpes Zoster Ophthalmicus
The recombinant shingles vaccine not only reduces herpes zoster and herpes zoster ophthalmicus but is also associated with lower risks of hospitalization for stroke and myocardial infarction in adults aged 50 and older.
Published: 8/22/2025
Study Reveals Subtle Heart Muscle Dysfunction in Bipolar Disorder Patients
Individuals with bipolar disorder are at nearly a 2-fold higher risk of heart failure, which is marked as the main cause of premature cardiovascular mortality.
Published: 8/22/2025
The Farm Effect: What Amish Communities Can Teach Us About Allergy Prevention
The "farm effect" is a term researchers use to describe the protective impact of growing up on traditional farms—especially around livestock, barns, and raw farm environments—on the development of allergies and asthma.
Published: 8/22/2025
RSVpreF Vaccine Is Well-Tolerated in Adults, Demonstrating Favorable Safety Profile
RSVpreF was well tolerated in nonpregnant and pregnant individuals aged 18 years and older.
Published: 8/22/2025
Natural Alkaloids From Mitragyna speciosa, 7-OH Show Potential as Novel HER2 Inhibitors in Breast Cancer
A new study found that the natural alkaloids mitragynine and 7-hydroxymitragynine from Mitragyna speciosa showed stable binding and favorable drug-likeness as potential HER2 inhibitors in breast cancer.
Published: 8/22/2025
Limited Benefit of Adjuvant Chemotherapy in Older Women With HR-Positive, HER2-Negative Breast Cancer
The ASTER 70s trial found that adjuvant chemotherapy provided no significant survival benefit, but caused substantial toxicity in older women with high-risk HR-positive, HER2-negative breast cancer.
Published: 8/22/2025
Dulaglutide Biosimilar Achieves Equivalent Efficacy in HbA1c Reduction in Patients With T2DM
A new biosimilar, LY05008, shows comparable efficacy and safety to dulaglutide in managing type 2 diabetes mellitus (T2DM) in Chinese adults.
Published: 8/22/2025
Elevated High-Density Lipoprotein Cholesterol May Reduce Risk of Stress Urinary Incontinence
High-density lipoprotein cholesterol, known for protective cardiovascular effects, could play a role in reducing the risk of stress urinary incontinence.
Published: 8/21/2025
Orforglipron Shows Positive Efficacy, Tolerability in Weight Management
The oral glucagon-like peptide agonist-1 met its primary end point and all secondary end points in a randomized, double-blind, placebo-controlled clinical trial for weight management.
Published: 8/21/2025
Ibrutinib–Venetoclax Outperforms Ibrutinib Alone and FCR in Long-Term CLL
Ibrutinib combined with venetoclax significantly improved measurable residual disease and progression-free survival in patients with chronic lymphocytic leukemia.
Published: 8/21/2025
FDA Approves Donidalorsen as First RNA-Targeted Prophylactic Treatment for Hereditary Angioedema
The FDA approves donidalorsen, the first RNA-targeted therapy for hereditary angioedema, offering significant attack reduction and convenient administration.
Published: 8/21/2025
Study Reveals Why Some Children Still Have Asthma Attacks Even With Treatment
New research uncovers complex inflammatory pathways driving asthma flare-ups in children, highlighting the need for personalized treatment strategies.
Published: 8/21/2025
Study: High Similarity, Efficacy Between Tocilizumab Biosimilar and Reference Product in RA
New research confirms that switching from tocilizumab to its biosimilar, Avtozma, maintains efficacy and safety in patients with rheumatoid arthritis (RA).
Published: 8/21/2025
Nonpharmaceutical Interventions Can Disrupt Dynamics of Pneumococcal Disease
The implementation of nonpharmaceutical measures during the COVID-19 pandemic reduced transmission of Streptococcus pneumoniae, a key bacterium that causes pneumococcal disease.
Published: 8/21/2025
American Academy of Pediatrics Releases 2025 Child, Adolescent Immunization Recommendations
The AAP unveiled its 2025 immunization schedule, challenging CDC guidelines and emphasizing evidence-based vaccine recommendations for children's health.
Published: 8/21/2025
Advancing Breast Cancer Care: The Role of Palbociclib in HR+/HER2- Disease
Palbociclib revolutionizes HR+/HER2- breast cancer treatment, enhancing outcomes with endocrine therapies and promising new combinations for better patient care.
Published: 8/21/2025
Probiotic Supplementation in Very-Low-Birth-Weight Preterm Infants Lowers Gut Antibiotic Resistance
Probiotic supplementation in VLBW preterm infants reduces antibiotic resistance and promotes beneficial gut bacteria, enhancing neonatal health outcomes.
Published: 8/21/2025
Study Reveals New Pathway Linked to Overactive Platelets in Type 2 Diabetes
New research uncovers a pathway linking diabetes and heightened blood clot risks, paving the way for innovative treatments to prevent cardiovascular complications.
Published: 8/20/2025
Neoadjuvant Chemotherapy Improves Survival in HER2-Positive Breast Cancer
Research reveals that clinical stage significantly influences survival rates in HER2-positive breast cancer patients undergoing neoadjuvant chemotherapy.
Published: 8/20/2025
Vaccine Injury Suit Dismissed Over Records
Case highlights the importance of careful cocumentation.
Published: 8/20/2025
CGM System for Weight Loss Receives FDA Clearance
Signos CGM empowers users to manage weight effectively through personalized insights and real-time glucose tracking.
Published: 8/20/2025
Severe Childhood COVID-19 Associated With Heightened Cardiovascular Risk in Adulthood
The development of multisystem inflammatory syndrome in children infected with SARS-CoV-2 was associated with more marked shifts in metabolic parameters, leading to increased cardiovascular disease risk.
Published: 8/20/2025
MET Inhibitor With Chemoimmunotherapy Overcomes Treatment Resistance in Some Patients With SCLC
Both preclinical and translational evidence support MET inhibition as a therapeutic approach in patients with small cell lung cancer (SCLC).
Published: 8/20/2025
Antibody-Drug Conjugates Poised to Revolutionize Treatment of Urothelial Carcinoma
Enfortumab vedotin is one of many effective antibody-drug conjugates on the market that can be utilized to improve the treatment of urothelial carcinoma.
Published: 8/20/2025
Comparative Real-World Effectiveness of Rituximab vs Cladribine in Relapsing-Remitting Multiple Sclerosis
Study reveals rituximab outperforms cladribine in managing RRMS, showing superior disease control and improved disability outcomes.
Published: 8/20/2025
Long-Term Obesity Linked to Elevated Aging Biomarkers
Long-term obesity triggers aging biomarkers in young adults, linking excess weight to accelerated biological aging and chronic health risks.
Published: 8/19/2025
Immunoglobulin Replacement Therapy Fails to Lower Hospitalizations in CLL, Study Finds
New research reveals that immunoglobulin replacement therapy fails to lower infection-related hospitalizations in those with chronic lymphocytic leukemia (CLL), raising treatment concerns.
Published: 8/19/2025
FDA Issues CRL to Vatiquinone NDA Indicated For Friedreich Ataxia
The complete response letter (CRL) stated that vatiquinone's new drug application (NDA) did not provide substantial evidence of efficacy and would need to be evaluated in a new trial.
Published: 8/19/2025
Cardiovascular Screening Rates Declined in Adults With Disabilities During COVID-19 Pandemic
Individuals with cognitive and physical disabilities faced difficulties in health care utilization and had reduced rates of preventive cardiovascular screenings during the pandemic.
Published: 8/19/2025
Q&A: New Report Reveals Potential Shift from Brick-and-Mortar to Mail-Order Pharmacy
Christopher Lis, senior director at JD Power, shared key insights about the report and what the pharmacy landscape currently looks like.
Published: 8/19/2025
UNI-494 Receives US Patent for Treatment of Chronic Kidney Disease
Unicycive Therapeutics secures a US patent for UNI-494, a promising treatment for chronic kidney disease, enhancing its development and partnership potential.
Published: 8/19/2025
Bone Marrow Microenvironments Vary Widely in Multiple Myeloma, Study Finds
New research uncovers the complex tumor microenvironment in multiple myeloma, revealing unique plasma cell ecosystems that challenge existing treatment approaches.
Published: 8/19/2025
FDA Reviews Plozasiran: A Potential First-in-Class Therapy for Familial Chylomicronemia Syndrome
Plozasiran significantly reduces triglyceride levels and pancreatitis risk in FCS patients, offering hope for effective treatment options.
Published: 8/18/2025
New Drug Combination Shows Promise Against Resistant Influenza Strains
Researchers unveil a promising drug combination, arainosine and theobromine, that effectively targets influenza A M2 channels, outperforming existing treatments.
Published: 8/18/2025
Semaglutide Receives FDA Approval for Treatment of MASH
FDA approves semaglutide for treating MASH, offering new hope for affected individuals.
Published: 8/18/2025
Expert Highlights Advances in HER2-Directed Therapies Beyond HER2-Positive Disease
Published: 8/18/2025
FDA Approves Tonmya, First Treatment for Fibromyalgia in Over 15 Years
FDA approves Tonmya, the first new fibromyalgia treatment in 15 years, offering hope for effective pain relief and improved quality of life.
Published: 8/18/2025
Selection Considerations for Abemaciclib Versus Ribociclib in Early HR+/HER2- Breast Cancer: Efficacy, Safety, and Long-Term Outcomes
New research highlights abemaciclib and ribociclib as promising treatments for early HR-positive, HER2-negative breast cancer, emphasizing survival benefits and adverse effects.
Published: 8/17/2025
Tremelimumab–Durvalumab Combo Extends Survival and Improves Cost-Effectiveness Over Sorafenib in Unresectable HCC
Combination therapy with tremelimumab and durvalumab significantly improves survival in patients with liver cancer compared with standard sorafenib treatment.
Published: 8/16/2025
Trastuzumab and HER2-Targeted Therapy: Breaking Down the Basics
Morgan Cantley, PharmD, BCOP, shares key insights about the HER2-targeting antibody-drug conjugate trastuzumab deruxtecan.
Published: 8/15/2025
Study Finds Widespread Gaps in Knowledge About HPV and Its Link to Cancer
Many adults remain unaware of HPV's cancer risks, highlighting the urgent need for increased awareness.
Published: 8/15/2025
A Pharmacist’s Guide to New IDSA Guidelines for Complicated UTIs
IDSA updated cUTI guidelines for men and women emphasize antibiotic selection, transition to oral therapy, and optimal treatment duration.
Published: 8/15/2025
New Clinical Data Highlight Revumenib’s Potential Beyond KMT2A-Rearranged Leukemia
Revumenib shows promise in treating NPM1-mutant AML, expanding its role in precision oncology and offering hope for targeted leukemia therapies.
Published: 8/15/2025
Novel Prescription Digital Therapeutic Improves Negative Symptoms of Schizophrenia
CT-155, an investigational prescription digital therapeutic, was found to improve motivation, sociality, and other negative symptoms in patients with schizophrenia as an adjunct to antipsychotic treatment.
Published: 8/15/2025
Tenapanor in Hyperphosphatemia Is Effective but Has Cost, Market Barriers
Tenapanor offers a new approach to managing hyperphosphatemia in dialysis patients, balancing effectiveness with pill burden and cost considerations.
Published: 8/15/2025
PFAS Exposure Tied to Greater Weight Regain After Adolescent Bariatric Surgery
New findings highlight environmental impacts on weight management.
Published: 8/15/2025
FDA Officials Near Decision on Aficamten for Obstructive Hypertrophic Cardiomyopathy
Aficamten offers new hope for HCM patients, showing significant clinical benefits and safety in recent trials, enhancing treatment options.
Published: 8/15/2025
After the Approval: Assessing RSV Vaccine Safety in Older Adults and Pregnant Patients
Published: 8/14/2025
Acalabrutinib Demonstrates Improved Safety, Survival to Chemoimmunotherapy in CLL
Acalabrutinib shows improved safety and survival rates in chronic lymphocytic leukemia (CLL), reducing risks of mortality and cardiovascular complications.
Published: 8/14/2025
BEAM-101 Receives RMAT for the Treatment of Sickle Cell Disease
The designation is supported by promising results from the ongoing phase 1/2 BEACON clinical trial.
Published: 8/14/2025
Pharmacists’ Knowledge Gaps on Kratom: Building Competence for Patient Counseling
Pharmacists explore kratom's potential benefits and risks, emphasizing the need for education on its effects, safety, and patient guidance.
Published: 8/14/2025
Mechanistic Rationale and Safety Considerations for the Combined Supplementation of Vitamins D and K
Vitamins D and K work together to enhance bone strength and cardiovascular health, ensuring optimal calcium regulation for overall wellness.
Published: 8/14/2025
Medicaid Payment Cuts: Ripple Effects on Rural Health Care Access and Pharmacy Viability
Scott A. Soefje, PharmD, MBA, BCOP, FCCP, FHOPA, discusses how Medicaid payment changes could impact rural hospitals and local pharmacies, noting the importance of pharmacists staying involved as the situation develops.
Published: 8/14/2025
KRAS-Targeted Vaccine Shows Durable Immune Responses, Survival Benefits in Pancreatic Colorectal Cancers
Elicio Therapeutics' ELI-002 2P cancer vaccine shows promising survival benefits in patients with pancreatic and colorectal cancer, enhancing immune responses.
Published: 8/13/2025
RSV Vaccine Uptake Remains Low Among US Adults 60 Years and Older
RSV vaccination rates among older adults remain low despite new vaccines, highlighting disparities in uptake and the need for targeted outreach.
Published: 8/13/2025
TAR-200 Clears Tumors in 82% of Patients With BCG-Unresponsive Non–Muscle-Invasive Bladder Cancer
TAR-200 shows promise in treating BCG-unresponsive bladder cancer, achieving 82% tumor elimination and offering new hope for patients.
Published: 8/13/2025
Weight Loss Could Aid IVF Fertility Outcomes in Women with Obesity
Weight loss before IVF enhances pregnancy chances for women with obesity, potentially improving reproductive outcomes and fertility success rates.
Published: 8/13/2025
From Shelf to System: Enhancing Digital Visibility in Medication Inventory
Health care automation enhances efficiency, yet medication inventory visibility remains a challenge.
Published: 8/13/2025
High Perilipin 2 Expression Associated With Disease Progression, Shorter Survival in Lung Adenocarcinoma
New research links high perilipin 2 expression in lung adenocarcinoma to aggressive disease progression and shorter survival, highlighting potential treatment targets.
Published: 8/13/2025
Exercise Improves Risk Factors for Cardiovascular Disease in Children, Adolescents
In children and adolescents with overweight and obesity, exercise was demonstrated to reduce risk factors associated with cardiovascular disease, such as lipid and triglyceride levels.
Published: 8/13/2025
Atorvastatin Improves Outcomes, LDL-C Following Pipeline Therapy for Intracranial Aneurysms
By improving low-density lipoprotein cholesterol (LDL-C) levels, statins reduced complications after pipeline embolization device implantation for intracranial aneurysms.
Published: 8/13/2025
Mail Order and Supermarkets Outpace Chain Pharmacies in Customer Satisfaction
The JD Power 2025 US Pharmacy Study reveals rising satisfaction with mail-order pharmacies and supermarkets, driving a shift in prescription fulfillment preferences.
Published: 8/12/2025
Exploring Natural Compounds: Prunus Armeniaca, Bee Venom, and Bioactives in Breast Cancer Therapy
Natural compounds like Prunus armeniaca and bee venom enhance breast cancer treatment, boosting efficacy and reducing adverse effects.
Published: 8/12/2025
Brensocatib Becomes First Approved Treatment for Non-Cystic Fibrosis Bronchiectasis in Adults, Adolescents
Brensocatib emerges as the first FDA-approved treatment for non-cystic fibrosis bronchiectasis, revolutionizing care and targeting chronic inflammation.
Published: 8/12/2025
Study Finds Biomarkers That May Help Predict, Manage Chronic Kidney Disease
New research reveals that novel biomarkers enhance risk prediction for kidney failure and mortality in chronic kidney disease (CKD), paving the way for personalized treatment.
Published: 8/12/2025
Taking Their Shot: Pharmacists Are Advancing Vaccination in Oncology Care
Pharmacists play a crucial role in improving vaccination rates among patients with cancer, addressing barriers, and enhancing patient education in oncology care.
Published: 8/12/2025
‘Pharmacists Are the Care Coordinator’ in Type 1 Diabetes, Expert Says
Pharmacists help connect patients with the correct resources and help remove barriers so patients can receive continuous care.
Published: 8/12/2025
V116 Well Tolerated With Broad Immune Responses in Pneumococcal Vaccine-Naive Older Adults
In a phase 3 trial, V116 demonstrated significant immunogenicity in older adults who had not before received a pneumococcal vaccination.
Published: 8/12/2025
New Evidence Challenges Long-Standing Label Warning for Tamiflu
New research confirms oseltamivir (Tamiflu; Roche) is safe for children, reducing flu-related neuropsychiatric risks and encouraging timely antiviral treatment.
Published: 8/11/2025
Lithium Shows Potential as a Treatment for Alzheimer Disease
Harvard researchers reveal lithium deficiency as a potential early driver of Alzheimer disease, suggesting new treatment avenues for patients.
Published: 8/11/2025
Ketamine-Based Drug Receives FDA Fast Track Designation for Suicidal Ideation
NRX-100 receives FDA fast track designation, offering hope for treating suicidal ideation in depression and bipolar disorder, addressing a critical health crisis.
Published: 8/11/2025
Sunvozertinib Brings Changes in Non-Small Cell Lung Cancer Treatment
Amy C. Nieto delves into the latest advancements in non-small cell lung cancer (NSCLC) treatment, including sunvozertinib, a newly-approved therapy for challenging EGFR exon 20 insertion mutations.
Published: 8/11/2025
Childhood Cancer Survivors Face Increased Risk of Severe COVID-19
Individuals who have survived childhood cancer had a higher risk of developing a severe COVID-19 infection, while exhibiting a lower risk of contracting the virus.
Published: 8/11/2025
From Pill to Plate: Adding Nutrition Counseling to the Pharmacist’s Role
Pharmacists enhance patient care by integrating nutrition counseling, addressing gaps in training, and promoting chronic disease prevention through accessible health support.
Published: 8/11/2025
Pharmacists Play Crucial Role in Screening and Educating Patients With Type 1 Diabetes
Pharmacists can educate patients and health care professionals in addition to coordinating lab orders, interpreting results, and guiding patients through the next steps.
Published: 8/11/2025
FDA Approves Ketamine for Surgical Pain Management
The action follows 2 FDA-issued complete response letters.
Published: 8/11/2025
Pharmacists Bridge the Gaps in Care Transitions
From admission to discharge and beyond, pharmacists reduce medication errors, improve adherence, and prevent costly readmissions.
Published: 8/11/2025
Lipid-Lowering Effects Discovered in FDA-Approved Drugs Using Machine Learning
Multiple FDA-approved drugs without lipid-lowering indications were identified to have potential lipid-lowering properties.
Published: 8/9/2025
Blood Test Could Replace Bone Marrow Biopsies in Multiple Myeloma
SWIFT-seq revolutionizes multiple myeloma diagnosis, offering a noninvasive blood test that enhances monitoring and risk assessment for patients.
Published: 8/8/2025
Zongertinib Approved by FDA for Patients With Nonsquamous NSCLC With HER2 TKD Mutations
The action is supported by positive safety and efficacy findings from the phase 1a/1b first-in-human Beamion LUNG-1 trial.
Published: 8/8/2025
Intranasal Insulin Shows Promising Brain Uptake Patterns in Alzheimer Disease
Intranasal insulin shows promise in targeting memory regions of the brain, offering new hope for Alzheimer disease treatment in older adults.
Published: 8/8/2025
Large Burden of Community-Acquired Pneumonia Hospitalizations Among Older US Adults
Older adults in the United States continue to be burdened with disproportionate rates of community-acquired pneumonia hospitalizations, including due to serotypes covered in the recently approved V116 vaccine.
Published: 8/8/2025
Debunking Misconceptions and Understanding the Stages of Type 1 Diabetes
Jennifer Goldman, PharmD, CDCES, BC-ADM, FCCP, explains the different stages of type 1 diabetes, teplizumab’s use, and emphasizes the pharmacist’s role in care.
Published: 8/8/2025
Strategies to Improve Cardiovascular Health, Manage Obesity Are Evolving Rapidly
Discover effective strategies for managing obesity to enhance cardiovascular health, including innovative treatments and the vital role of pharmacists.
Published: 8/8/2025
Antidiabetic Medication Combinations Have Varying Effects on Diabetic Kidney Disease Progression
Pharmacists should consider GLP-1 receptor agonists as second-line agents in older adults with DKD when additional glycemic control is needed.
Published: 8/8/2025
Targeting Tumors: New Weapons in Gastrointestinal Cancer Therapy
Recent advances in GI oncology offer new treatment options for colorectal and pancreatic cancers, enhancing patient care and pharmacist roles in management.
Published: 8/8/2025
Researchers Evaluate Infection Control Challenges During an RSV Outbreak in a Cognitively Impaired Population
RSV poses a serious risk to older adults in long-term care, highlighting the need for effective outbreak management and infection control strategies.
Published: 8/7/2025
Beyond Pain Control: Understanding and Managing Opioid-Induced Constipation
Discover effective strategies for managing opioid-induced constipation, including the role of PAMORAs and pharmacist involvement in pain management.
Published: 8/7/2025
Headache or Harm: A Pharmacist’s Role in Differentiating Complement Inhibitor Adverse Effects
Pharmacists play a crucial role in managing headaches in patients on complement inhibitors for PNH, ensuring proper education and risk mitigation strategies.
Published: 8/7/2025
FDA Mandates Major Opioid Label Revisions to Highlight Long-Term Risks
The FDA intends to update opioid labels to highlight risks of addiction, overdose, and interactions, enhancing safety in pain management practices.
Published: 8/7/2025
FDA Grants Birelentinib Fast Track Designation for Patients With Relapsed or Refractory CLL/SLL
Birelentinib gains FDA fast track designation, offering hope for relapsed CLL/SLL patients resistant to current BTK and BCL2 therapies.
Published: 8/7/2025
Caffeine Consumption Not Associated With Chronic Kidney Disease, Study Finds
The researchers speculate that this is because of the antioxidant and anti-inflammatory properties of coffee and tea.
Published: 8/7/2025
FDA Grants Accelerated Approval to Dordaviprone For Diffuse Midline Glioma
The FDA approves dordaviprone, the first systemic therapy for H3 K27M-mutant diffuse midline glioma, offering hope for patients with limited options.
Published: 8/7/2025
Larazotide Safe, Effective in Children With COVID-19-Related MIS-C
Designed for use in Celiac disease, larazotide was found to hasten resolution of multisystem inflammatory syndrome symptoms in children with the condition.
Published: 8/7/2025
FDA Moves to Restrict 7-OH Opioid Products
The FDA targets 7-hydroxymitragynine, a potent kratom derivative, as a controlled substance due to its opioid-like effects and rising health risks.
Published: 8/6/2025
Focusing on Cardiovascular Health in Childhood Shows Lifelong Benefits
Promoting heart health in children reduces obesity and chronic disease risks, ensuring better overall well-being into adulthood.
Published: 8/6/2025
LDL-C–Lowering Inclisiran May Carry Lower Risk of Diabetes Than Atorvastatin
Inclisiran was found to have a lower risk of new-onset diabetes compared with other low-density lipoprotein cholesterol (LDL-C)-lowering therapies.
Published: 8/6/2025
Study Finds Association Between Lung Cancers and Ultraprocessed Foods
Recent data link a higher consumption of ultraprocessed food to increased lung cancer risk, highlighting the need for dietary changes and further research.
Published: 8/6/2025
FDA Approves Expanded Indication to Tocilizumab-Anoh IV for CRS
The FDA expands tocilizumab-anoh's approval for treating cytokine release syndrome (CRS), enhancing treatment options for patients aged 2 and older.
Published: 8/6/2025
Fremanezumab-vfrm Approved by FDA for Preventive Treatment of Episodic Migraine in Children, Adolescents
The FDA approved fremanezumab for pediatric migraine prevention, offering a new treatment option for children and adolescents aged 6 to 17 years.
Published: 8/6/2025
HHS Terminates $500 Million in mRNA Vaccine Development, Claiming Ineffectiveness
Secretary Robert F. Kennedy Jr announced the cancellation of 22 mRNA vaccine technology investments, alleging the vaccines lacked effectiveness against respiratory diseases.
Published: 8/6/2025
Multiple Myeloma: A Modern Look at an Ancient Disease and 2025’s Therapeutic Breakthroughs
Discover the latest advancements in multiple myeloma treatment, including new therapies and FDA approvals that enhance patient outcomes and survival rates.
Published: 8/6/2025
PHESGO Implementation Cuts Chair Time and Boosts Efficiency in HER2-Positive Breast Cancer Care
PHESGO reduced patient infusion time from 90 minutes to as few as 5, enhancing patient experience while maintaining efficacy and safety.
Published: 8/5/2025
Donanemab-azbt Demonstrated Long-Term Efficacy in Slowing Cognitive Decline
Donanemab-azbt shows sustained benefits in slowing cognitive decline in Alzheimer disease, emphasizing the value of early intervention and treatment.
Published: 8/5/2025
Trastuzumab Biosimilar Demonstrates Sufficient Efficacy in HER2+ Advanced Gastric Cancer
Herzuma shows promising efficacy and safety as a cost-effective biosimilar for treating HER2+ advanced gastric cancer, offering new hope for patients.
Published: 8/5/2025
Rising Incidence of Severe, Complicated Pneumococcal Pneumonia in Children Post Pandemic
New research highlights a surge in pediatric pneumococcal pneumonia cases post COVID-19, urging a shift toward supportive treatment strategies.
Published: 8/5/2025
Pharmacist-Led Education Associated With Increased Benzodiazepine Discontinuation
Explore effective strategies for safely discontinuing benzodiazepines and sedative-hypnotics, addressing risks and enhancing patient care in older adults.
Published: 8/5/2025
Body Fat Percentage Outranks BMI as a Predictor of Long-Term Mortality
Research reveals body fat percentage and waist circumference are more accurate predictors of mortality risk than BMI, highlighting flaws in traditional weight assessments.
Published: 8/4/2025
Discontinuing Lenalidomide After ASCT May Be Safe for Select MRD-Negative Patients With Multiple Myeloma
Discontinuing lenalidomide after 3 years of MRD negativity shows low relapse rates in multiple myeloma, offering hope for treatment-free remission.
Published: 8/4/2025
Hepatitis D Reclassified as Carcinogenic, According to WHO
WHO reclassifies hepatitis D as carcinogenic, urging global action to combat viral hepatitis and reduce liver cancer risk.
Published: 8/4/2025
Vaccine Coverage Among Kindergartners Continues Decline in 2024-2025 School Year
Continuing a trend observed since the end of the COVID-19 pandemic, vaccine coverage among kindergartners declined in the 2024-2025 school year, according to CDC data.
Published: 8/4/2025
Tirzepatide Provides Robust Cardiovascular Protection Versus Dulaglutide in T2D, ASCVD
In the SURPASS-CVOT clinical trial, tirzepatide was non-inferior to dulaglutide in a composite score of cardiovascular outcomes in patients with type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD).
Published: 8/4/2025
Harnessing AI to Advance Clinical Trials and Oncology Pharmacy
AI is transforming oncology by enhancing clinical trials, personalizing treatments, and improving pharmacy practices, promising faster, more precise cancer care.
Published: 8/4/2025
Bisphenol A as a Promoter of Hormone-Sensitive Breast Cancer Through Inflammatory Pathways
BPA exposure accelerates ER+ breast cancer growth, impacting treatment efficacy and altering the pharmacist's role in therapy administration.
Published: 8/4/2025
Noninvasive Saliva Tests Could Offer Early Clues for Diabetes and Obesity Risk
Researchers reveal that saliva tests for insulin levels offer a noninvasive method to predict type 2 diabetes and obesity risks effectively.
Published: 8/4/2025
Changing the Course of SCD: One Dose of Hydroxyurea at a Time
Mona El-Mouwfi explores how pharmacists enhance hydroxyurea therapy for sickle cell disease, improving patient outcomes and addressing treatment barriers effectively.
Published: 8/4/2025
Unlocking the Full Potential of Pharmacists in Medication Safety
Maximizing pharmacists’ impact on medication safety requires removing barriers to intervention and empowering proactive clinical roles.
Published: 8/1/2025
Vizz Becomes First, Only FDA-Approved Aceclidine-Based Eye Drop for Presbyopia
The FDA approves aceclidine ophthalmic solution 1.44%, the first aceclidine eye drop for presbyopia, offering a new solution for millions struggling with near vision loss.
Published: 8/1/2025
Inclisiran Receives FDA Approval for New Indication to Treat Hypercholesterolemia
FDA approves inclisiran as a monotherapy to effectively lower low-density lipoprotein cholesterol in adults with hypercholesterolemia, enhancing heart disease prevention strategies.
Published: 8/1/2025
FDA Expands Approval of Concizumab-mtci to Include Hemophilia A, B Without Inhibitor Use
The approval builds upon concizumab’s previous December 2024 clearance and allows for treatment in patients with hemophilia A or B, both with or without inhibitors.
Published: 8/1/2025
Study: Exposure to Trihalomethane Concentrations Increases CKD Risk
The authors note that the findings can have significant public health implications given the widespread water chlorination and increased chronic kidney disease burden.
Published: 8/1/2025
New Evidence Shows Ivermectin's Efficacy in Malaria Control
Ivermectin shows promise in reducing malaria cases, enhancing vector control, and highlighting pharmacists' vital roles in public health strategies.
Published: 8/1/2025
SAR446523 Granted Orphan Drug Designation for Patients With Relapsed, Refractory Multiple Myeloma
Sanofi's SAR446523 receives orphan drug designation for relapsed/refractory multiple myeloma, enhancing treatment options and patient outcomes.
Published: 7/31/2025
Weight Loss Drugs Show Promise in Preventing Stroke and Reducing Brain Injury Complications
New research reveals that GLP-1 receptor agonists like semaglutide may significantly reduce stroke impacts and improve recovery outcomes.
Published: 7/31/2025
Researchers Assess Cardiovascular Outcomes in Older Adults Hospitalized With Respiratory Syncytial Virus
RSV hospitalization in older adults links to increased cardiovascular events, highlighting the need for vigilant monitoring and vaccination strategies.
Published: 7/31/2025
Baxdrostat Reduces Systolic Blood Pressure in Uncontrolled, Treatment-Resistant Hypertension
By targeting aldosterone in a 2-dose regimen, baxdrostat effectively lowers mean seated systolic blood pressure in patients with difficult-to-treat hypertension.
Published: 7/31/2025
Pirtobrutinib Outperforms Ibrutinib in Head-to-Head Phase 3 Trial for CLL/SLL
Pirtobrutinib shows promising results in a head-to-head trial against ibrutinib for chronic lymphocytic leukemia (CLL)/small lymphocytic leukemia (SLL).
Published: 7/31/2025
Biosimilar Mvasi Demonstrates Similar Ophthalmic Safety Profile to Reference Product Avastin
A recent study reveals Mvasi's comparable safety profile to Avastin for retinal diseases, highlighting the need for on-label biosimilars in ophthalmology.
Published: 7/31/2025
How Decentralized Pharmacists Can Improve Medication Safety Through Team-Based Care
Decentralized pharmacists play a critical role in reducing medication errors by collaborating in real time with physicians and nurses to enhance patient safety across care settings.
Published: 7/31/2025
Study Finds Significant Antimicrobial, Multidrug Resistance Toward Key Pneumococcal Serotypes
Both vaccine and nonvaccine serotypes were identified as being resistant to critical antimicrobial treatments for pneumococcal disease.
Published: 7/31/2025
Balancing Cancer Risks and Benefits of Oral Contraceptives
Hormonal contraceptives present a nuanced risk-benefit profile, slightly increasing breast and cervical cancer risk while significantly reducing ovarian and endometrial cancer rates.
Published: 7/31/2025
Depression and Pregnancy: Clarifying the Role of SSRIs During Pregnancy
Pharmacists guide pregnant women in balancing depression treatment with SSRI safety, addressing risks of untreated depression and neonatal adaptation syndrome.
Published: 7/31/2025
Luspatercept-aamt Shows Clinically Meaningful Benefits in Reducing Transfusion Burden and Increasing Hemoglobin
Luspatercept shows promise in reducing transfusion dependence for myelofibrosis-associated anemia, despite not meeting primary trial end points.
Published: 7/30/2025
Taletrectinib Takes Aim: A New Chapter in ROS1-Positive NSCLC
Kevin Chen, PharmD, MS, BCOP, CPP; and Amanda Cass, PharmD, BCPS, BCOP, share key insights about ROS1, non-small cell lung cancer, and the newly approved drug taletrectinib.
Published: 7/30/2025
Astegolimab Reduces COPD Exacerbations in Clinical Trials
Astegolimab shows promise in reducing chronic obstructive pulmonary disease (COPD) exacerbations, offering hope for improved management of this debilitating lung disease.
Published: 7/30/2025
Hospitalized Older Adults With COVID-19 Face Accelerated Cognitive Decline
Hospitalized older adults infected with SARS-CoV-2 had faster declines in executive function and memory compared with both uninfected and nonhospitalized infected patients.
Published: 7/30/2025
How Pharmacist-Led Initiatives Reduce Adverse Drug Events
Pharmacists share their institution's individual, unique approaches to medication safety.
Published: 7/30/2025
Gedatolisib Doublet, Triplet Regimens Improve PFS in Patients With PIK3CA Wild-Type HR+/HER2– Breast Cancer
Emerging trial results reveal gedatolisib significantly enhances progression-free survival (PFS) in advanced HR+/HER2- breast cancer.
Published: 7/30/2025
Leveraging the EMR: How Pharmacists Improve Medication Safety in Practice
Pharmacist share actionable insights for EMR utilization and facilitation of medication safety practices.
Published: 7/30/2025
Study Evaluates Financial Implications, Socioeconomic Profile of Patients With Diabetes
A new study reveals that individuals with type 2 diabetes (T2D) face significant financial hardships, impacting their health and medication adherence.
Published: 7/29/2025
FDA Approves Pegcetacoplan to Reduce Proteinuria in 2 Kidney-Related Diseases
The treatment proved efficacy across all 3 key markers of C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN).
Published: 7/29/2025
FDA Restricts Elevidys Use Amidst New Safety Concerns
FDA places clinical hold on Sarepta's Elevidys gene therapy after safety concerns, but ambulatory patients regain access amid ongoing investigations.
Published: 7/29/2025
Tildrakizumab Improves Signs, Symptoms of Active Psoriatic Arthritis in Phase 3 Studies
Tildrakizumab 100 mg shows significant efficacy in treating psoriatic arthritis, achieving key clinical trial end points and offering hope for patients.
Published: 7/29/2025
High Burden of Pneumococcal Disease Found in Older Adults With Underlying Medical Conditions
Data from a retrospective study of adults in France found the highest incidence of pneumococcal disease in patients with the highest risk underlying medical conditions.
Published: 7/29/2025
OLC Demonstrates Safety and Tolerability in Patients With CKD and Hyperphosphatemia
A phase 2 trial shows oxylanthanum carbonate (OLC) effectively manages hyperphosphatemia in patients with chronic kidney disease (CKD), offering a promising treatment option.
Published: 7/29/2025
IAS 2025: Pharmacists Steer Modern HIV Care Through Coinfection Management
Experts discuss HIV management challenges, including HBV coinfections, anal cancer risks, and weight gain, highlighting innovative treatment strategies.
Published: 7/29/2025
Omega-3 Fatty Acids and Vitamin D Improves Inflammatory Biomarkers in Rheumatoid Arthritis
The supplements were also linked to improvements in pain and disease activity markers.
Published: 7/29/2025
FDA Approves Sepiapterin for Adults, Children Living With Phenylketonuria
Sepiapterin treatment allowed patients to liberalize their diet while reaching or exceeding recommended daily protein allowances in patients living with phenylketonuria.
Published: 7/28/2025
FDA Expedites Durvalumab Review for Resectable Early-Stage Gastric, Gastroesophageal Cancers
Durvalumab continues to demonstrate efficacy in a variety of cancers, with new data from the phase 3 MATTERHORN trial solidifying its use with chemotherapy in gastric cancer.
Published: 7/28/2025
Inconsistencies in Low-Density Lipoprotein Cholesterol Testing and Treatment After Revascularization
Patients with ASCVD face increased cardiovascular risks post revascularization, yet many miss timely LDL-C testing and treatment, highlighting critical care gaps.
Published: 7/28/2025
Lonapegsomatropin-tcgd Receives FDA Approval for Growth Hormone Deficiency
FDA approves lonapegsomatropin for once-weekly treatment of growth hormone deficiency, offering a promising alternative for improved patient adherence and outcomes.
Published: 7/28/2025
Osimertinib With Chemotherapy Improves OS in Patients With EGFRm NSCLC
The combination regimen had stronger benefits in patients with locally advanced or metastatic epidermal growth receptor-mutated (EGFRm) non–small cell lung cancer (NSCLC) than osimertinib alone.
Published: 7/28/2025
Study Explores the Survival Advantage of GLP-1s in Cancer Patients With Diabetes
GLP-1 receptor agonists show promise in improving survival rates for older patients with cancer who have type 2 diabetes (T2D), highlighting their potential in oncology.
Published: 7/27/2025
BET Inhibition Reverses Immune Suppression in CLL by Targeting MDSCs
Targeting BRD4 with BET inhibitors shows promise in reversing immune suppression by myeloid-derived suppressor cells in chronic lymphocytic leukemia.
Published: 7/25/2025
Global Landscape of RSV Outbreaks: Prevalence, Characteristics, and Trends
RSV outbreaks pose significant risks globally, highlighting the urgent need for targeted vaccination and treatment strategies to protect vulnerable populations.
Published: 7/25/2025
COVID-19 Pandemic Reduced Gaps in Pneumococcal Vaccination in Medicare Enrollees, but Lowered Overall Uptake
Conversely, Medicaid enrollees experienced widening gaps of pneumococcal vaccination uptake, likely driven by socioeconomic obstacles.
Published: 7/25/2025
Avatrombopag Receives FDA Approval for Treamtent of Pediatric Patients With Chronic Immune Thrompcytopenia
Avatrombopag gains FDA approval for pediatric ITP treatment, offering a new oral option for managing chronic thrombocytopenia in children.
Published: 7/25/2025
GLP-1 Receptor Agonists May Alleviate Symptoms in Patients With PCOS
GLP-1 receptor agonists show promise in alleviating PCOS symptoms, including weight loss and menstrual regulation, despite needing further research.
Published: 7/25/2025
Trastuzumab Deruxtecan Yields Promising Intracranial Activity in Patients With HER2+/HER2-Low Breast Cancer and Brain Metastases
Trastuzumab deruxtecan shows promising efficacy in treating HER2-positive metastatic breast cancer with brain metastases, offering hope for challenging cases.
Published: 7/24/2025
Department of Health and Human Services Announces Removal of Thimerosal From All US Flu Vaccines
CDC's ACIP recommends removing thimerosal from flu vaccines, igniting debate on vaccine safety and fueling antivaccine sentiments amid public health concerns.
Published: 7/24/2025
Oveporexton Demonstrates Statistically Significant, Clinically Meaningful Improvements in Patients With NT1
In 2 clinical trials, oveporexton shows promise in treating narcolepsy type 1 (NT1), paving the way for potential FDA approval.
Published: 7/24/2025
IBI303, Humira Biosimilar, Shows Comparable Efficacy and Cost Benefit to Reference Product
There were also no observed differences in retention rates or safety among patients with ankylosing spondylitis.
Published: 7/24/2025
Remnant Cholesterol, Independent of LDL-C, Serves as Predictor of MASLD
High levels of remnant cholesterol were associated with increased risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD) independent of low-density lipoprotein cholesterol (LDL-C).
Published: 7/24/2025
Drafts, Laughs, and Lasting Lessons: Inside a Unique Medical Writing Experience
The University of Connecticut's Medical Writing Certificate program transforms aspiring writers into confident communicators through hands-on training and real-world experience.
Published: 7/24/2025
Delgocitinib Cream Becomes First, Only Approved Treatment for Moderate-to-Severe Chronic Hand Eczema
The approval represents a major advancement for patients with moderate-to-severe chronic hand eczema, as delgocitinib becomes the first treatment available for this population in the US.
Published: 7/24/2025
COVID-19 Disrupts Cancer Care and Increases Hospitalizations
Immense burden is laid upon patients with cancer who are infected with COVID-19, as they are at higher risk of experiencing cancer treatment disruptions and severe illness that necessitates hospitalization.
Published: 7/23/2025
Danish Study Affirms Safety of Aluminum in Childhood Vaccines
A Danish study confirms no link between aluminum in childhood vaccines and chronic diseases, reinforcing vaccine safety amid rising skepticism.
Published: 7/23/2025
From Med Rec to AI: Pharmacists Expanding Their Role in Oncology Innovation
Eugene Przespolewski, PharmD, BCOP, DPLA, shares insights from his presentation at the 2025 OPC meeting in Austin, Texas.
Published: 7/23/2025
Study: Biomarker May Aid in Identification and Prevention of Uranium Toxicity–Related CKD
New research reveals uranium isotopes in urine as potential biomarkers for kidney damage, highlighting risks from contaminated drinking water in the US.
Published: 7/23/2025
FDA Grants Priority Review to Update Label for Sotatercept-csrk
Results from the ZENITH trial show sotatercept's promise for pulmonary arterial hypertension treatment.
Published: 7/22/2025
FDA Issues CRL to Replimune for Vusolimogene Oderparepvec With Nivolumab for Advanced Melanoma
The complete response letter (CRL) did not raise safety concerns, but stated the IGNYTE trial was inadequate and did not provide substantial evidence of effectiveness.
Published: 7/22/2025
Once-Daily Alixorexton Improves Wakefulness at All Doses in Patients With Narcolepsy Type 1
In the double-blind portion of Vibrance-1, alixorexton improved wakefulness while eliciting broad benefits in patient-reported outcomes.
Published: 7/22/2025
IAS 2025: Patients With HIV Grapple With Healthy Aging, Reducing CVD Risk
Challenges faced by individuals living with HIV include weight gain, cardiovascular risks, and healthy aging strategies.
Published: 7/21/2025
Study Reveals Comparative Effectiveness of Dietary Interventions for Type 2 Diabetes and Obesity Management
Different dietary strategies, including intermittent energy restriction, enhance weight loss and blood sugar control in those with type 2 diabetes (T2D) and obesity.
Published: 7/21/2025
GLP-1 Medications Can Increase Testosterone Levels in Men With Obesity
GLP-1 anti-obesity medications enhance testosterone levels, aiding weight management and improving health outcomes for those with obesity and type 2 diabetes (T2D).
Published: 7/21/2025
Nuvalent Initiates Phase 3 ALKAZAR Trial of Neladalkib in NSCLC
Neladalkib enters phase 3 trials, targeting advanced ALK-positive NSCLC, promising improved outcomes for TKI-naive patients with brain metastases.
Published: 7/21/2025
Influenza Vaccination: Direct and Indirect Impact
Influenza vaccination significantly reduces cases and enhances community immunity, highlighting pharmacists' vital role in promoting public health.
Published: 7/20/2025
Pharmacist-Led Interventions Significantly Increase Pneumococcal Vaccine Uptake in Older Adults
Education initiatives, facilitation, and immunization on the part of pharmacists were found to significantly increase uptake of pneumococcal vaccines among older adults.
Published: 7/19/2025
FDA Panel Rejects Belantamab Mafodotin Combinations for Multiple Myeloma, Citing Safety Concerns
The advisory committee cited concerns around ocular toxicity and overall tolerability, raising serious questions about the drug's benefit-risk profile ahead of its scheduled Prescription Drug User Fee Act action date on July 23, 2025.
Published: 7/18/2025
FDA Issues Complete Response Letter for Glofit-GemOx in R/R DLBCL
The CRL states that the STARGLO data do not provide sufficient evidence to support the second-line indication in the US patient population.
Published: 7/18/2025
Study Investigates Long-Term Cardiometabolic Impact of Early-Onset Obesity
Long-term obesity accelerates aging in young adults, increasing risks for cardiovascular diseases and metabolic dysfunction.
Published: 7/18/2025
ImCheck’s ICT01 Earns FDA Orphan Drug Designation for AML
ImCheck's ICT01 gains an orphan drug designation from the FDA, offering hope for acute myeloid leukemia (AML) treatment in older patients with limited options.
Published: 7/18/2025
Polypurine Hairpin Technology Is Safe, Effective at Inhibiting PCSK9 to Regulate Cholesterol
Researchers unveil a groundbreaking method using polypurine hairpins to inhibit PCSK9, offering a promising alternative for lowering cholesterol and reducing cardiovascular risk.
Published: 7/18/2025
Study Suggests Transplant Recipients Are at Greater Risk of Developing RSV
Immunocompromised patients, especially transplant recipients, face heightened RSV risks, leading to severe infections and complications.
Published: 7/18/2025
NCCN Guideline Update: Updated CML Recommendations Emphasize Distress Screening, Drug Interactions, and Cost
The updated version 1.2026 NCCN Guidelines for chronic myeloid leukemia (CML) emphasize individualized treatment strategies, TKI-specific considerations, drug interaction management, and pregnancy safety, highlighting the critical role of oncology pharmacists in optimizing therapy selection, patient counseling, and cost-effective care.
Published: 7/18/2025
Enzalutamide Plus Leuprolide Extends Survival in High-Risk Non-Metastatic Prostate Cancer
Enzalutamide combined with leuprolide significantly enhances survival in high-risk non-metastatic prostate cancer, marking a breakthrough in treatment strategies.
Published: 7/18/2025
HIV Reporting Meets the Front Line: How Pharmacists Translate Global Health Into Local Care
Pharmacists play a vital role in translating global health news into actionable knowledge for their communities.
Published: 7/17/2025
Insulin Efsitora Alfa Demonstrates A1C Reduction in Various Clinical Trials
Once-weekly efsitora alfa shows promising hemoglobin A1C reduction in type 2 diabetes (T2D), simplifying insulin therapy and reducing injection frequency significantly.
Published: 7/17/2025
Study Finds HER2-Negative Outperforms HER2-Low in Neoadjuvant Chemotherapy Response in Breast Cancer
Research reveals HER2-negative breast cancer shows higher pCR rates than HER2-low, influencing neoadjuvant chemotherapy strategies for early-stage patients.
Published: 7/17/2025
CDC-Led Study Affirms Robust Effectiveness of 2023-2024 COVID-19 Vaccines in Reducing Illness Severity, Mortality
A large retrospective study funded by the CDC indicates broad additional protection against COVID-19, especially for older adults and immunocompromised patients.
Published: 7/17/2025
Study Finds Higher BMI Increases Breast Cancer Risk in Women With Heart Conditions
Research reveals that higher BMI in women with cardiovascular disease significantly increases breast cancer risk, highlighting the need for targeted prevention strategies.
Published: 7/17/2025
FDA Approves Zoster Vaccine Recombinant Prefilled Syringe Presentation for Shingles Prevention
The FDA approves a prefilled syringe for the zoster vaccine recombinant, enhancing shingles vaccination convenience and effectiveness for adults 50 years and older.
Published: 7/17/2025
Gabapentin Use Linked to Increased Dementia Risk in Patients With Chronic Back Pain
New research links gabapentin use for back pain to increased dementia risk, especially in middle-aged adults.
Published: 7/17/2025
Micronutrient Deficiencies: A Modifiable Contributor to Chronic Pain
Micronutrient deficiencies, particularly in vitamins D, B12, and folate, significantly impact chronic pain intensity, suggesting dietary interventions may alleviate symptoms.
Published: 7/17/2025
GLP-1 and GIP Combination Shows Promise for Weight Loss, Cardiometabolic Improvement in Obesity
Maridebart cafraglutide showed promising results for weight management in obesity and type 2 diabetes (T2D), achieving significant weight loss without plateau.
Published: 7/16/2025
Secondary Analysis Investigates Spillover Effects of Antibiotic Audit and Feedback
New research shows effective interventions can reduce prescriptions across all ages.
Published: 7/16/2025
Zanubrutinib Outperforms Acalabrutinib in Adjusted Head-to-Head Analysis
An adjusted analysis of the ALPINE and ASCEND trials revealed a statistically significant progression-free survival advantage for zanubrutinib.
Published: 7/16/2025
Data Show Simvastatin Does Not Enhance Escitalopram Response in Comorbid Depression and Obesity
Statins such as simvastatin do not have additional antidepressive effects in combination with standard escitalopram treatment in patients with comorbid major depressive disorder (MDD) and obesity.
Published: 7/16/2025
Follow-Up Study Confirms Omlyclo Biosimilarity to Xolair in Treatment of CSU
The biosimilar showed similar efficacy, pharmacokinetics, pharmacodynamics, safety, quality of life, and immunogenicity in patients with chronic spontaneous urticaria (CSU).
Published: 7/16/2025
Insights From ASCO 2025 Guide Pharmacy Practice in Solid Tumors and Hematologic Cancers
The data highlight novel therapies and biomarkers shaping personalized cancer care.
Published: 7/16/2025
Oseltamivir Significantly Reduces Mortality in Hospitalized Patients With Influenza
New research highlights the benefits of early oseltamivir treatment for hospitalized patients with influenza, reducing mortality and readmission rates while optimizing care.
Published: 7/16/2025
Type 2 Diabetes and Obesity in Teens Could Increase Risk of Osteoporosis
Obesity and type 2 diabetes in youth significantly increase the risk of osteoporosis and fractures, highlighting the need for early intervention and healthy habits.
Published: 7/15/2025
Vaccination Can Reduce Long-Term Kidney Function Decline, Mortality Risk in Hospitalized Patients With COVID-19
Receiving a COVID-19 vaccination vastly reduced the risk of long-term hospitalization, necessitating dialysis, and morbidity in patients hospitalized with acute kidney injury related to SARS-CoV-2 infection.
Published: 7/15/2025
Insulin Aspart-xjhz Becomes First Interchangeable Biosimilar Rapid-Acting Insulin
The agent, Kirsty, represents a more affordable alternative to Novolog.
Published: 7/15/2025
Large Real-World Study Validates Idecabtagene Vicleucel Outcomes Seen in KarMMa Trial
The data showed patients with relapsed or refractory multiple myeloma achieved a 73% overall response rate.
Published: 7/15/2025
Study: Recommendations From Health Care Professionals Improve Immunization Rates Among Patients With CKD
Patients with chronic kidney disease (CKD) were more likely to get vaccinated for influenza and pneumococcal following a health care provider’s recommendation.
Published: 7/15/2025
Targeting the Integrated Stress Response Through a Platform for Antiviral Drug Discovery Against Zika, Herpes, and RSV
Researchers unveil compounds that enhance cell death and boost antiviral responses, offering hope against RSV and other viral infections.
Published: 7/15/2025
Bemarituzumab Elicits Positive Overall Survival in FGFR2b-Positive First-Line Gastric Cancer
The fibroblast growth factor receptor 2b (FGFR2b)-inhibiting bemarituzumab demonstrated improvements in overall survival and other key secondary end points compared with placebo in first-line gastric cancer.
Published: 7/15/2025
Independent Pharmacy Innovation Spotlighted at McKesson ideaShare 2025
Dave’s Pharmacy in Alliance, Nebraska, was named the Pharmacy of the Year for cutting-edge patient care.
Published: 7/14/2025
Independent Pharmacies Embrace AI to Solve Staffing Challenges and Boost Efficiency
Independent pharmacy owners Raj Chhadua and Marc Ost are turning to AI-powered tools to streamline operations, improve efficiency, and enhance patient engagement—without sacrificing the personal touch.
Published: 7/14/2025
Adjuvant Trastuzumab Emtansine Plus Trastuzumab Improved Disease-Free, Overall Survival in HER2+ Early Breast Cancer
Combination therapy with trastuzumab emtansine and trastuzumab significantly enhances survival rates in HER2-positive early breast cancer, outperforming trastuzumab alone.
Published: 7/14/2025
Independent Pharmacy Owners Harness Grassroots Strategies and Technology to Build Stronger Communities
From vaccine drives and prescriber dinners to YouTube education and automated workflows, these pharmacy owners are finding innovative, hands-on ways to expand services, boost revenue, and stay connected to the communities they serve.
Published: 7/14/2025
FDA Approves Expanded Labeling of Farapulse PFA System for Persistent Atrial Fibrillation
The expanded instructions for use labeling expand on the Farawave and Farawave Nav Pulsed Field Ablation (PFA) catheters.
Published: 7/14/2025
Riliprubart Receives FDA Orphan Drug Designation for AMR in Solid Organ Transplantation
This designation is significant because there are no FDA-approved treatments for transplant recipients with or preventing antibody-mediated rejection (AMR).
Published: 7/14/2025
Pneumococcal Vaccination Linked With Reduced COVID-19 Hospitalization, Death in Inflammatory Rheumatic Diseases
Patients with inflammatory rheumatic diseases may have a protective effect against serious COVID-19 outcomes once they receive a pneumococcal vaccination.
Published: 7/14/2025
TRE-5151 Receives FDA Fast Track Designation in Combination With Radiation Therapy for Prostate Cancer
FDA fast-tracks TRE-515 for advanced prostate cancer, combining it with radiation therapy to enhance treatment outcomes and patient care.
Published: 7/14/2025
Finerenone Approved by FDA for Treatment of Adults With Heart Failure
Previously indicated to reduce the risk of end-stage kidney disease, cardiovascular death, and hospitalization for heart failure (HF) in chronic kidney disease, finerenone is now approved for patients with HF directly, offering a new treatment option.
Published: 7/14/2025
Pharmacists Push Forward: Innovative Clinical Solutions Highlighted at McKesson ideaShare 2025
Pharmacy-based clinical services demonstrate both public health impact and financial sustainability.
Published: 7/12/2025
APhA Foundation Drives Innovative Clinical Models at McKesson ideaShare 2025
Innovative pharmacist-led care models—from tech-enabled Afib screenings and HPV immunizations to Medicare-supported diabetes prevention—demonstrate how pharmacies are redefining their role in team-based clinical care.
Published: 7/12/2025
Daily CBD Use at Consumer-Level Doses May Elevate Liver Enzymes, FDA-Led Trial Shows
CBD use can elevate liver enzymes in 5% to 6% of adults, highlighting the need for monitoring and safe usage practices.
Published: 7/12/2025
Dalpiciclib Plus Endocrine Therapy Prolonged Invasive Disease-Free Survival in HR+/HER2– Breast Cancer
Dalpiciclib combined with endocrine therapy significantly enhances progression-free survival in HR+/HER2– breast cancer, as shown in the DAWNA-A trial.
Published: 7/11/2025
Four States Pass Laws Allowing OTC Ivermectin, More States Pending Legislation
States have expanded access to over-the-counter ivermectin, raising concerns among health experts about safety, misinformation, and self-medication risks.
Published: 7/11/2025
FDA Publishes Hundreds of Complete Response Letters From First Half of the Decade
Complete response letters, which indicate reasons why a drug could not be approved in its current form, offer insightful information to drug developers on the inner mechanisms of the FDA’s approval process.
Published: 7/11/2025
Maternal Inflammatory Diet During Pregnancy Linked to Increased Type 1 Diabetes Risk in Offspring
A maternal inflammatory diet during pregnancy raises the risk of offspring developing type 1 diabetes, highlighting the impact of nutrition on early health.
Published: 7/10/2025
Lumateperone Submits Application for Schizophrenia Indication to FDA for Supplemental New Drug
Lumatperone showed a 63% reduction in relapse risk for patients with schizophrenia, promising improved patient stability and care.
Published: 7/10/2025
With Proper Adherence to Cholesterol-Lowering Drugs, Thousands of Cardiovascular Events Could Be Avoided
By closing the gap on patients who are recommended lipid-lowering therapies but do not receive them, researchers say that thousands of cardiovascular events could be prevented and billions of dollars would be saved.
Published: 7/10/2025
FDA Grants Full Approval to mRNA-1273 COVID-19 Vaccine in Children at Increased Risk
mRNA-1273, marketed as Spikevax by Moderna, is now fully approved for individuals aged 6 months through 64 years with high-risk features for severe COVID-19.
Published: 7/10/2025
Obesity-Linked Exosomes May Drive Tumor Aggressiveness in Triple-Negative Breast Cancer
Obesity and high-fat diets enhance the aggressiveness of triple-negative breast cancer through exosome-mediated mechanisms, revealing new therapeutic targets.
Published: 7/9/2025
Zanubrutinib Linked to Lower Infection Risk Than Venetoclax Plus Obinutuzumab in Real-World CLL/SLL Study
New research highlights the lower infection risk with zanubrutinib compared with venetoclax in CLL/SLL treatment, offering safer options for patients.
Published: 7/9/2025
Research Suggests Vitamin D Deficiency Is a Risk Factor for Autism
Discover how vitamin D supplementation may reduce Autism Spectrum Disorder symptoms and improve overall functioning in children with ASD.
Published: 7/9/2025
Reassessing the Safety and Efficacy of Very Low LDL Cholesterol
Although cholesterol-lowering guidance often touts the achievement of very low levels of low-density lipoprotein (LDL) cholesterol, emerging research demonstrates possible safety risks.
Published: 7/9/2025
Steroid Use During ICI Treatment Lessens Effectiveness in Patients With NSCLC
Steroids hindered the shrinkage of tumors in patients with non-small cell lung cancer (NSCLC) receiving immune checkpoint inhibitor (ICI) therapy.
Published: 7/9/2025
Donanemab-Azbt Receives FDA Label Update With New Dosing for Alzheimer Disease
FDA approves a new dosing schedule for donanemab, enhancing safety and efficacy in treating early symptomatic Alzheimer disease.
Published: 7/9/2025
McKesson ideaShare 2025 Set to Empower Pharmacy Professionals in Nashville
Packed with CE sessions, interactive learning, expert insights, and a vibrant expo floor, McKesson ideaShare 2025 aims to equip independent pharmacists with the tools and strategies to elevate patient care and drive pharmacy innovation.
Published: 7/9/2025
Community Pneumococcal Vaccination Support Program for Older Adults Reduces Pneumonia-Related Mortality
In a community of older adults, initiating a pneumococcal vaccination support program reduced annual pneumonia-related mortality by 25%, demonstrating broad public and individual health benefits.
Published: 7/9/2025
McKesson ideaShare 2025 Unveils Robust Education Tracks to Empower Independent Pharmacies
The conference offers immersive, peer-driven education tracks designed to help independent pharmacies innovate, adapt, and thrive in a changing health care landscape.
Published: 7/9/2025
Isa-KRd Induction Achieves 95% Response Rate in Multiple Myeloma
New data reveal isatuximab-based therapy achieves high MRD-negativity rates in newly diagnosed multiple myeloma.
Published: 7/8/2025
Radiation or Immune-Modulating Drugs Could Mitigate Resistance to CDK4/6 Inhibitors in Breast Cancer
Research reveals that combining radiotherapy or immune-modulating drugs with CDK4/6 inhibitors enhances treatment efficacy in HR+/HER2– breast cancer.
Published: 7/8/2025
Study Assesses Weight Reduction and Glycemic Status With GLP-1 Medications
Real-world studies reveal GLP-1 medications like semaglutide and tirzepatide yield less weight loss than clinical trials, highlighting treatment discontinuation challenges.
Published: 7/8/2025
Mucosal EV Adjuvants May Revolutionize Intranasal Flu Vaccines
New research reveals that extracellular vesicles enhance intranasal flu vaccines, boosting mucosal immunity and offering broader protection against diverse strains.
Published: 7/8/2025
Guiding Patients Through Allergy Medication Safety: Pharmacists’ Role Following FDA Warning on Cetirizine and Levocetirizine
The FDA is warning of rare severe itching after stopping long-term use of popular allergy medications cetirizine and levocetirizine, urging patient education.
Published: 7/8/2025
Infliximab Biosimilar Initiation Has Increased in Pediatric IBD, Study Finds
The study found biosimilar initiation rose to nearly 42% from 2016 to 2023.
Published: 7/8/2025
Medical Societies Sue HHS, Secretary Kennedy Over Changes in COVID-19 Vaccine Guidance
The lawsuit alleges that Health and Human Services (HHS) Secretary Robert F. Kennedy Jr. violated the law when issuing new guidance for COVID-19 vaccination.
Published: 7/8/2025
mRNA Flu Vaccine Meets Primary End Point Among Older Adults
Moderna's mRNA-1010 flu vaccine shows promising efficacy, especially for older adults, addressing the urgent need for better influenza prevention.
Published: 7/8/2025
FDA Approves Immunoglobulin Formulation With Low IgA Content for Primary Immunodeficiency
The new formulation contains little IgA, reducing possible risks associated with infusion in patients with primary immunodeficiency.
Published: 7/7/2025
FDA Approves Y-90 Resin Microspheres for Unresectable Hepatocellular Carcinoma
Y-90 resin microspheres offer a new option for patients with liver cancer for the treatment of unresectable hepatocellular carcinoma.
Published: 7/7/2025
Sebetralstat Becomes First and Only FDA-Approved Oral, On-Demand Treatment for HAE
Sebetralstat becomes the first FDA-approved oral treatment for hereditary angioedema (HAE), offering rapid relief for patients experiencing acute attacks.
Published: 7/7/2025
Efepoetin Alfa Noninferior to Mircera When Correcting Anemia, Maintaining Hemoglobin in CKD
Patients with chronic kidney disease (CKD) receiving efepoetin alfa demonstrated a response rate of about 75.6%.
Published: 7/7/2025
Study: High Long-Term Exposure to Fine Particulate Air Pollution Is Associated With Diffuse Myocardial Fibrosis
The data emphasize the idea that there are no safe exposure limits as well as the need for guidelines.
Published: 7/7/2025
Sunvozertinib Approved by FDA as Oral Treatment of NSCLC With EGFR Exon 20 Insertion Mutations
Sunvozertinib becomes the first and only targeted approval treatment for patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) exon 20 insertion mutations.
Published: 7/7/2025
Integrity Concerns in Ticagrelor Trials Challenge Clinical Confidence
New findings question the integrity of ticagrelor's clinical trials, raising safety concerns and impacting its use in cardiovascular care.
Published: 7/7/2025
Novo Nordisk Drops Hims & Hers: Inside the Compounded GLP-1 Crisis
GLP-1 medications like semaglutide face scrutiny over compounded versions, raising concerns about patient safety and counterfeit products in diabetes treatment.
Published: 7/6/2025
Elevated Remnant Cholesterol, Lp-PLA2 Linked to Heightened Risk of Composite Adverse Events
Stroke, myocardial infarction, and all-cause death were included in the composite of adverse cardiovascular events.
Published: 7/4/2025
Hospitalized Adults With Community-Acquired Pneumonia Suffer Significant Morbidity Post Discharge
Six months following discharge from the hospital, adults who battled community-acquired pneumonia were at heightened risk of losing the ability to perform activities and experiencing poor quality of life.
Published: 7/4/2025
Real-World Data Show Similar Clinical Outcomes in Patients Receiving Biosimilars Following Switch From Reference Product
Real-world data show that patients switching from Humira to biosimilars Hadlima and Hyrimoz achieve similar outcomes without hospitalization.
Published: 7/4/2025
Shingles and RSV Vaccines Show Promise Against Dementia
Recent research reveals that RSV and shingles vaccines significantly lower dementia risk, highlighting the potential benefits of AS01 adjuvants in vaccination.
Published: 7/4/2025
Adjusting Asthma Management After Achieving Control on Long-Term Biologic Therapy
Published: 7/3/2025
Reinventing Transplant Care: From Inpatient Tradition to Outpatient Innovation
LeAnne Kennedy, PharmD, BCOP, CPP, FHOPA, discusses the new outpatient transplant program at Atrium Health Wake Forest Baptist in North Carolina.
Published: 7/3/2025
FDA Issues Complete Response Letter to Manufacturer of OLC, Treatment for CKD-Related Hyperphosphatemia
The letter cited deficiencies previously identified at a third-party manufacturing vendor unrelated to oxylanthanum carbonate (OLC).
Published: 7/2/2025
Study Links Specific Hormone Therapies to Breast Cancer Risk in Younger Women
Research reveals a link between estrogen plus progestin hormone therapy and increased breast cancer risk in young women, urging personalized treatment approaches.
Published: 7/2/2025
Study Examines How Vitamin C Shapes Skin Health Through TET-Mediated Demethylation
Vitamin C enhances skin health by promoting epidermal cell growth and regeneration, offering a potential solution for aging and thinning skin.
Published: 7/2/2025
Breaking New Ground in Migraine Prevention: Eptinezumab-jjmr
Discover how Vyepti revolutionizes migraine prevention with rapid efficacy and strong safety, empowering pharmacists to enhance patient care.
Published: 7/2/2025
Lung Transplant Recipients at High Risk of Secondary Lung Infections Post Infection With SARS-CoV-2 Omicron Variant
Lung transplant recipients were found to be at heightened risk of developing secondary lung infections, including bacterial and fungal infections, due to unique risk factors.
Published: 7/2/2025
FDA Approves Linvoseltamab-gcpt for Treatment of Relapsed or Refractory Multiple Myeloma
The treatment becomes the first approved BCMAxCD3 bispecific antibody with the potential to achieve biweekly or monthly dosing in patients with relapsed/refractory multiple myeloma.
Published: 7/2/2025
Atrium Health: Pioneering Outpatient Transplant Models Driven by Pharmacist-Led Care
LeAnne Kennedy, PharmD, BCOP, CPP, FHOPA, discusses the new outpatient transplant program at Atrium Health Wake Forest Baptist in North Carolina.
Published: 7/2/2025
FDA Approves Vancomycin Injection For Ready-to-Infuse Sepsis Therapy
The injection is indicated for the treatment of sepsis and other serious infections, enhancing treatment efficiency and patient care.
Published: 7/2/2025
Cilta-Cel Spurs Remission Milestone—But Is It a Cure?
CARTITUDE-1 trial reveals cilta-cel's potential in achieving long-term remission for relapsed/refractory multiple myeloma, sparking discussions on curative possibilities.
Published: 7/1/2025
Study Evaluates Impact of Dietary Acid Load on Weight Loss in Vegan and Mediterranean Diets
A low-fat vegan diet reduces dietary acid load and promotes weight loss more effectively than a Mediterranean diet.
Published: 7/1/2025
Pharmacists Have a Crucial Role Helping Patients With ATTR-CM Navigate Treatment With Tafamidis
Pharmacists can help oversee the treatment process to ensure patients with transthyretin amyloid cardiomyopathy (ATTR-CM) are adhering to tafamidis.
Published: 7/1/2025
ASCO 2025: Age-Related Differences in Relapsed/Refractory ALL Treatment Outcomes
Obecabtagene autoleucel shows promising efficacy and safety in treating relapsed/refractory B-ALL, benefiting patients of all ages, including older adults.
Published: 7/1/2025
Study Reveals Alarming Gaps in HER2 Therapy Access for Patients With Breast Cancer
The data revealed that only 75% of patients receive HER2-targeting therapies.
Published: 7/1/2025
FDA Removes REMS for Currently Approved BCMA-, CD19-Directed CAR T-Cell Immunotherapies
FDA removes REMS for CAR T-cell therapies, enhancing patient access while ensuring safety in cancer treatment.
Published: 6/30/2025
Pulmonary Hypertension Associated With Increased Risk of Progression in Patients With Myeloproliferative Neoplasms
Pulmonary hypertension significantly increases the risk of disease progression and cardiovascular events in patients with myelofibrosis, emphasizing a need for routine screening.
Published: 6/30/2025
Ropeginterferon Alfa 2b Is Well Tolerated, Efficacious in Treatment of Prefibrotic Myelofibrosis
Ropeginterferon alfa-2b shows promising results in treating preprimary myelofibrosis, enhancing clinical responses and safety in patients.
Published: 6/30/2025
21-Valent Pneumococcal Conjugate Vaccine Exhibits Consistent Safety and Immunogenicity Across Manufacturing Lots
Across 3 different manufacturing lots, V116 (21-valent pneumococcal conjugate vaccine) demonstrated consistent immunogenicity and efficacy against S pneumoniae, which causes pneumococcal diseases.
Published: 6/30/2025
Study Sheds Light on Impact of Vaccination, Infection on Anti-RSV IgG Levels
A recent study reveals high RSV antibody levels in older adults, highlighting the importance of vaccination and natural infection for enhanced immunity.
Published: 6/30/2025
FDA Approves Emapalumab-Lzsg as First-Ever Treatment for Macrophage Activation Syndrome in Still Disease
The FDA approves emapalumab-lzsg as the first treatment for macrophage activation syndrome in Still disease, offering a new treatment approach for patients with the rare condition.
Published: 6/30/2025
INCB057643 in Combination with Ruxolitinib Improves Symptoms in Patients With Myelofibrosis
INCB057643 shows promise in treating myelofibrosis, enhancing anemia and symptom relief.
Published: 6/30/2025
Is Belantamab Mafodotin Making a Comeback?
The agent continues to show promising clinical benefit despite being pulled from the market in 2023.
Published: 6/27/2025
Chronic IVIG Therapy May Reduce Incidence of Cancer, Especially in Patients With CIDP
Intravenous immunoglobulin (IVIG) use over an extended period in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was potentially associated with a reduced incidence of cancer over time, although more research is necessary.
Published: 6/27/2025
Zimislecel Could Pave the Way for a Type 1 Diabetes Cure
A groundbreaking trial shows zimislecel significantly reduces insulin dependence in patients with type 1 diabetes, offering hope for a functional cure.
Published: 6/27/2025
Dual-Antigen Targeting in Myeloma: Improved Responses in Extramedullary Disease
Shaji Kumar, MD, shares data and insights from the phase 2 RedirecTT-1 study.
Published: 6/26/2025
Perceptions of Pharmacy Care Vary Among Diverse Populations, Including Patients With Disabilities
Explore how community pharmacies enhance care for diverse patients with disabilities, addressing barriers and improving accessibility in pharmacy services.
Published: 6/26/2025
ACIP Recommends Adults Receive Seasonal, Single-Dose Influenza Vaccines Free of Thimerosal
The Advisory Committee on Immunization Practices (ACIP) voted 5-1, with 1 voter abstaining, to recommend that adults receive seasonal influenza vaccines that do not contain the preservative thimerosal.
Published: 6/26/2025
Mid-Year Roundup: FDA’s Novel Retail and Specialty Drug Approvals in 2025
Explore the latest FDA-approved novel drugs transforming treatment options for various conditions, enhancing patient care and outcomes in community and specialty pharmacy.
Published: 6/26/2025
FDA Approves Amyvid Injection Updated Label to Support Diagnosis of Alzheimer Disease
Amyvid is used for brain imaging to estimate amyloid plaque density in patients with cognitive impairment undergoing evaluation for Alzheimer disease.
Published: 6/26/2025
Understanding the Link Between SGLT2 Inhibitors, Red Blood Cell Counts, and Blood Clots in Adults With Type 2 Diabetes
SGLT2 inhibitors improve diabetes management but may cause erythrocytosis without increasing blood clot risks, highlighting the need for careful monitoring.
Published: 6/26/2025
Sticking With It: A Meta-Review of Anti-Dementia Medication Use and Adherence
A recent meta-analysis reveals low persistence rates with anti-dementia drugs, highlighting factors influencing adherence and the need for standardized reporting.
Published: 6/26/2025
Pharmacist-Led Delabeling Protocol Aims to Determine Penicillin Allergies
A pharmacist-led program effectively reduces incorrect penicillin allergy labels, promoting better antibiotic use and enhancing patient care in intensive care units.
Published: 6/25/2025
OPC 2025: What Pharmacists Love Most About Oncology Pharmacists Connect
Pharmacy experts share the benefits of the annual Oncology Pharmacists Connect meeting.
Published: 6/25/2025
Real-World Data Suggest Cannabis Use is Associated With Major Adverse Cardiovascular Events
Health care professionals are encouraged to educate patients on potential cannabis-related risks to cardiovascular health.
Published: 6/25/2025
Anlotinib Following Benmelstobart Plus Chemotherapy Improves Progression-Free Survival in S-NSCLC
Combining benmelstobart and anlotinib shows promise for patients with squamous non-small cell lung cancer.
Published: 6/25/2025
Pharmacists at the Front Lines of Innovation in Lung Cancer Care
Kevin Chen, PharmD, MS, BCOP, CPP, highlighted key thoracic cancer advances from the 2025 ASCO Annual Meeting.
Published: 6/25/2025
Efficiency, Education, and Evolution: What’s Next for Pharmacy Practice?
Scott Soefje, PharmD, MBA, BCOP, shares insights about the evolving role of pharmacists at the 2025 OPC meeting.
Published: 6/24/2025
Timing of Antihypertensive Medication Yields No Benefit in Older Adults With Frailty
New research reveals that bedtime antihypertensive dosing does not improve cardiovascular outcomes in frail older adults, emphasizing safety over timing.
Published: 6/24/2025
ADA 2025: Combination of Bimagrumab and Semaglutide Shows Enhanced Fat Loss and Muscle Preservation
New research reveals that combining bimagrumab and semaglutide enhances fat loss while preserving muscle mass, revolutionizing obesity treatment strategies.
Published: 6/24/2025
Cholesterol-Lowering Drugs May Significantly Increase Risk of Diabetic Microvascular Complications
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HMGCR inhibitors were found to significantly increase the risk of experiencing microvascular complications in patients with diabetes, whereas NPC1L1 inhibitors were found to reduce the risk.
Published: 6/24/2025
Pharmacists Reimagine Myeloma Care With Insights from ASCO
Gabe Hinojosa, PharmD, BCOP, shares key data for pharmacists from the 2025 American Society of Clinical Oncology Annual Meeting.
Published: 6/24/2025
Belimumab Autoinjector Receives FDA Approval for Children With Active Lupus Nephritis
Compared with prior intravenous formulations, the autoinjector is a more accessible administration method for children and their caregivers.
Published: 6/24/2025
23-Valent Pneumococcal Polysaccharide Vaccine Provides Protection Up To 6 Years Following Vaccination
Six years following vaccination with 23-valent pneumococcal polysaccharide vaccine in a Chinese population, antibody levels remained high, although not as high as 28 days following vaccination.
Published: 6/24/2025
Study Confirms Interchangeability of Hulio, Biosimilar of Humira, in Severe Chronic Plaque Psoriasis
Hulio shows comparable efficacy and safety to Humira in treating chronic plaque psoriasis, supporting its FDA interchangeability status.
Published: 6/24/2025
Research Finds Low-Energy Total Diet Replacement Does Not Increase Eating Disorder Symptoms in Individuals With Overweight or Obesity
Low-energy total diet replacement programs show promise for individuals with obesity and type 2 diabetes, without increasing eating disorder risks.
Published: 6/24/2025
ADA 2025: Advances in Type 2 Diabetes Management With Tirzepatide
The session highlighted tirzepatide’s unique mechanism of action, based on comprehensive clinical data and real-world evidence.
Published: 6/23/2025
FDA Approves Datopotamab for Treatment of EGFR-Mutated Non-Small Cell Lung Cancer
Datopotamab deruxtecan gains FDA approval, offering new hope for adults with advanced EGFR-mutated non-small cell lung cancer after prior therapies.
Published: 6/23/2025
IVIG-Glucocorticoid Combination Therapy Reduces Need for Adjunctive Immunotherapy in Pediatric MIS-C
Glucocorticoids alone were found to reduce treatment failure and fever duration, but the combination with intravenous immunoglobulin (IVIG) significantly reduced the need for adjunctive immunotherapy following treatment.
Published: 6/23/2025
Lorundrostat Shows Clinically Meaningful Outcomes in Patients With CKD and Hypertension
Lorundrostat reduces blood pressure and urine albumin-to-creatinine ratio in patients with chronic kidney disease (CKD) and hypertension.
Published: 6/23/2025
ADA 2025: Oral Semaglutide Demonstrates Cardiovascular Benefits in SOUL Trial
Oral semaglutide shows promising cardiovascular benefits for type 2 diabetes patients, reducing major adverse events by 14% in the SOUL trial.
Published: 6/23/2025
ADA 2025: CagriSema Demonstrates Significant Weight Loss in REDEFINE Clinical Trials
CagriSema shows promising weight loss and metabolic benefits in recent trials, offering new hope for obesity and type 2 diabetes management.
Published: 6/22/2025
ADA 2025: Semaglutide Shows Promise in Improving Mobility for Patients With Diabetes and Peripheral Arterial Disease
Semaglutide shows promise in enhancing walking ability and reducing disease progression in patients with type 2 diabetes and peripheral artery disease.
Published: 6/22/2025
Immunotherapy Takes the Lead in Advanced Cutaneous Malignancies
Heidi Finnes, PharmD, BCOP, FHOPA, discusses the evolving landscape of treatment of cutaneous malignancies.
Published: 6/20/2025
Expanding Pneumococcal Vaccinations to Healthy Adults Aged 50 to 64 Years Offers Significant Health, Economic Benefits
The expansion of pneumococcal vaccine recommendations would ultimately lead to economic and health benefits, especially for underserved populations.
Published: 6/20/2025
FDA Approves Dupilumab for Treatment of Bullous Pemphigoid
The FDA approves dupilumab as the first targeted treatment for bullous pemphigoid, offering hope for patients with this debilitating skin condition.
Published: 6/20/2025
Inside the Synergy Between HOPA and OPC’s Evolving Educational Impact
Jolynn Sessions, PharmD, BCOP, FHOPA, shares her experience as a clinical pharmacist and the value of the Oncology Pharmacists Connect meeting.
Published: 6/20/2025
New Drugs, New Decisions: How Pharmacists Are Guiding the Future of Hematologic Care
Victoria Nacher, PharmD, BCOP, offers key insights about the evolving treatment landscape for hematologic malignancies.
Published: 6/19/2025
Nitisinone Becomes First and Only FDA-Approved Treatment for HGA in Adults With AKU
Its approval was based on data from a 3-year trial that enrolled patients with alkaptonuria.
Published: 6/19/2025
Remnant Cholesterol Directly Associated With Higher Risk of Chronic Kidney Disease Development
Remnant cholesterol, a novel lipoprotein marker linked to elevated triglycerides, is associated with increased risk of progression and development of chronic kidney disease.
Published: 6/19/2025
Tafasitamab-Cxix With Rituximab, Lenalidomide Approved by FDA for Relapsed/Refractory Follicular Lymphoma
Following robust progression-free survival indications in the phase 3 inMIND trial, the FDA granted approval to tafasitamab-cxix in combination with standard-of-care lenalidomide and rituximab for patients with relapsed or refractory follicular lymphoma.
Published: 6/19/2025
Navigating EGFR Mutations and ALK Fusions in Early-Stage Non-Small Cell Lung Cancer
The emergence of biomarkers plays a critical role in the growing success of treatment.
Published: 6/19/2025
From Trial to Practice in the Evolving Landscape of Hematologic Malignancies
Tim Mok, PharmD, BCOP, BCPS, discusses emerging advancements in treatment of leukemia and lymphoma.
Published: 6/19/2025
Study Estimates the Hidden Burden of Adult RSV Hospitalizations
New research highlights the significant health risks of respiratory syncytial virus (RSV) in older adults, emphasizing the need for effective vaccines and public health strategies.
Published: 6/18/2025
Midyear Roundup: FDA’s Novel Oncology Drug Approvals in 2025
In the first half of 2025, the FDA approved 7 novel drugs for oncologic conditions, including for non-small cell lung cancer; ovarian cancer; and metastatic, hormone receptor-positive, human epidermal growth factor 2-negative breast cancer.
Published: 6/18/2025
Proinflammatory SARS-CoV-2 Cytokines Higher in Men Than Women, Causing Heightened Rates of Severe Disease
When infected with SARS-CoV-2, the virus that causes COVID-19, higher levels of proinflammatory cytokines are released in men compared with women, leading to more severe disease.
Published: 6/18/2025
FDA Approves Twice-Yearly Lenacapavir for HIV Preexposure Prophylaxis
Lenacapavir becomes the first and only twice-yearly option for HIV prevention.
Published: 6/18/2025
Omega-3 Supplementation in Combination With Exercise Could Aid Tooth Root Infections
Combining omega-3 supplements with exercise enhances immune response and alleviates tooth infections, offering new insights into managing apical periodontitis.
Published: 6/18/2025
Sequencing of Liposomal Daunorubicin/Cytarabine Versus Hypomethylating Agents Plus Venetoclax for Secondary Acute Myeloid Leukemia
This abstract will be presented at the Oncology Pharmacists Connect (OPC) meeting in Austin, Texas, from June 19 to 20, 2025.
Published: 6/18/2025
Review Demonstrates Impaired Quality of Life in Children With Pneumococcal Disease Despite Variations in Study Methodologies
Accurate utility estimates are critical to providing a comprehensive view of quality of life for children impacted by pneumococcal disease.
Published: 6/18/2025
Clinical Manifestations of Acute, Chronic Graft-vs-Host Disease With PTCy in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation
This abstract will be presented at the Oncology Pharmacists Connect (OPC) meeting in Austin, Texas, from June 19 to 20, 2025.
Published: 6/18/2025
Study: Prevalence and Clinical Implications of MASLD in Type 2 Diabetes
New research reveals a significant link between type 2 diabetes, obesity, and fatty liver disease.
Published: 6/17/2025
Garadacimab-gxii Receives FDA Approval for Hereditary Angioedema Treatment
The FDA approves garadacimab-gxii, a treatment for hereditary angioedema (HAE), offering convenient monthly self-injections for patients 12 years and older.
Published: 6/17/2025
Prevalence of Dosage Modifications and Impact on Response Milestone Among Patients With CML Treated With Imatinib Using RWD
This abstract will be presented at the Oncology Pharmacists Connect (OPC) meeting in Austin, Texas, from June 19 to 20, 2025.
Published: 6/17/2025
Multi-Phenotype Approach Highlights Increased Power of cPCA When Identifying CKD-Related Loci
The authors note that the combinatorial principal component analysis (cPCA) may be effective in other complex diseases outside of chronic kidney disease (CKD).
Published: 6/17/2025
Heightened Awareness, Effective Treatment Options Critical to C difficile Management
Clostridioides difficile (C difficile) represents a serious public health threat, with pharmacists and advocacy organizations playing critical roles in prevention, education, and management.
Published: 6/17/2025
New Tirzepatide Access and Pricing Through Self-Pay Options
Eli Lilly is expanding access to tirzepatide, a groundbreaking GLP-1 medication for weight management, offering more affordable options for obesity treatment.
Published: 6/17/2025
High Response Rates With Talquetamab Plus Teclistamab in Triple-Class Refractory Multiple Myeloma
Talquetamab and teclistamab showed significant promise in a phase 1b/2 dose escalation and expansion trial.
Published: 6/16/2025
Nemolizumab Shows Rapid, Sustained Efficacy in Atopic Dermatitis
Nemolizumab shows promising long-term efficacy in reducing itch and skin lesions for atopic dermatitis, enhancing quality of life for patients.
Published: 6/16/2025
FDA Approves Ustekinumab-Stba, Biosimilar to Stelara, for Pediatric Patients With PsO or PsA
The subcutaneous infusion is indicated for pediatric patients aged 6 to 17 years who weigh less than 60 kg.
Published: 6/16/2025
FDA Approves mRNA-1345 Vaccine for Adults Aged 18 to 59 Years
Moderna's mRNA-1345 vaccine gains FDA approval, enhancing protection against RSV for high-risk adults aged 18 to 59 years, following earlier approvals for older populations.
Published: 6/16/2025
ASCO 2025: Cost-Effectiveness of Ribociclib in Early Breast Cancer
Ribociclib plus endocrine therapy shows improved survival in HR+, HER2- breast cancer, but its cost-effectiveness raises concerns in the US market.
Published: 6/15/2025
Study Shows High-Dose Vitamin D Boosts Treatment Response in Breast Cancer
Vitamin D could offer an alternative option over hard-to-access and burdensome cancer drugs to heighten the response of chemotherapy.
Published: 6/13/2025
Enlicitide Decanoate Demonstrates Meaningful Reductions in LDL-C
In 3 phase 3 clinical trials, enlicitide decanoate demonstrated clinically significant reductions in low-density lipoprotein cholesterol (LDL-C) in patients with hyperlipidemia and familial hypercholesterolemia.
Published: 6/13/2025
Real-World Data on Expanding Step-Up Dosing Administration of Bispecific T-Cell Engagers in the Outpatient Setting
This abstract will be presented at the Oncology Pharmacists Connect (OPC) meeting in Austin, Texas, from June 19 to 20, 2025.
Published: 6/13/2025
Beyond Dispensing: How Pharmacists and Technicians Can Expand Services to Meet Patient Needs
Pharmacists and pharmacy technicians are key to offering more accessible and efficient care.
Published: 6/13/2025
ASCO 2025: Ribociclib With NSAI in HR+/HER– Breast Cancer Improves iDFS, Yields Substantial Work Productivity Gains
Ribociclib in combination with a nonsteroidal aromatase inhibitor (NSAI) improved invasive disease-free survival (iDFS) while allowing for better quality of life in hormone receptor-positive (HR+)/human epidermal growth receptor 2-negative (HER2−) early breast cancer.
Published: 6/13/2025
Overweight, Obesity Associated With Neurologic and Neuropsychiatric Symptoms in Post-COVID-19 Condition
Results from a systematic review shed light on the role that obesity and overweight play in increasing the severity of symptoms in long COVID.
Published: 6/13/2025
Blood Test Outperforms Tissue Biopsy in Detecting HPV+ Head and Neck Cancers
The investigational blood test achieved 99% sensitivity and specificity.
Published: 6/13/2025
Five-Year Data Show Sustained Efficacy of Zanubrutinib in CLL With High Response Rates
The data from the 5-year analysis of arm C validate and support the efficacy and safety of zanubrutinib for treatment-naive patients with CLL/SLL harboring del(17p).
Published: 6/13/2025
Pembrolizumab Receives FDA Approval for Treatment of Head and Neck Squamous Cell Carcinoma
Pembrolizumab gains FDA approval as a groundbreaking neoadjuvant treatment for resectable locally advanced head and neck squamous cell carcinoma, enhancing patient outcomes.
Published: 6/12/2025
Study: How Individual Carbohydrate Responses Reveal Metabolic Health and Potential Biomarkers
New research reveals how individual blood glucose responses to carbohydrates vary, highlighting the importance of personalized dietary approaches for diabetes management.
Published: 6/12/2025
Finerenone and Empagliflozin Outperform Either Treatment Alone in Patients With CKD
Patients with chronic kidney disease (CKD) and type 2 diabetes receiving both treatments had greater reductions in urinary albumin-to-creatinine ratio.
Published: 6/12/2025
Mitomycin Intravesical Solution Receives FDA Approval for Non–Muscle-Invasive Bladder Cancer
Mitomycin intravesical solution is the first FDA-approved treatment for low-grade intermediate-risk non–muscle-invasive bladder cancer.
Published: 6/12/2025
Understanding Biologics and Biosimilars Amid an Evolving Treatment Landscape
Biologics and biosimilars have a major role in modern medicine because of their clinical benefits and economic impact on patient care.
Published: 6/12/2025
The Path to Cervical Cancer Eradication: Overcoming Barriers to HPV Vaccination
Significant challenges persist, particularly in low- and middle-income countries.
Published: 6/12/2025
Addressing Pharmacy Deserts and Expanding the Pharmaceutical Workforce
Innovative strategies are essential to recruit pharmacy students and transform practices, ensuring equitable access to pharmacy services in underserved areas.
Published: 6/12/2025
FDA Approves Tablet Formulation of Zanubrutinib for All Indications
The approval of the tablet formulation of zanubrutinib covers all 5 approved indications of the Bruton tyrosine kinase inhibitor.
Published: 6/11/2025
Glecaprevir/Pibrentasvir Combination Receives FDA Approval Expanded Indication for Acute HCV
The expansion marks glecaprevir/pibrentasvir as the first and only indicated direct-acting antiviral approved for acute hepatitis C virus (HCV) infection.
Published: 6/11/2025
Taletrectinib Gains FDA Approval for Locally Advanced or Metastatic ROS1+ NSCLC
Taletrectinib demonstrated high response rates and was well tolerated among patients with ROS1+ non-small cell lung cancer (NSCLC).
Published: 6/11/2025
Study Finds Depression May Increase Risk of Developing Dementia
The authors wrote that a life course approach to the treatment and prevention of depression may help reduce individual burdens of dementia.
Published: 6/11/2025
Perioperative Nivolumab Shows Long-Term EFS, Favorable OS in Resectable NSCLC
Building on positive event-free survival (EFS) and overall survival (OS) rates in the original analysis of CheckMate 77T, new results indicate sustained survival over 3 years following treatment with nivolumab compared with placebo in non-small cell lung cancer (NSCLC).
Published: 6/11/2025
The Role of Pharmacists in Cardiovascular Health: A Collaborative Approach to Treatment, Counseling, and Nutrition
Pharmacists have a unique opportunity to improve cardiovascular outcomes by integrating medication management with food-as-medicine approaches.
Published: 6/11/2025
ASCO 2025: Asciminib Demonstrates Superiority Compared With Nilotinib in Ph+ CML-CP
Asciminib shows superior tolerability over nilotinib in newly diagnosed patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase, enhancing treatment options and patient outcomes.
Published: 6/11/2025
Semaglutide Combinations Show Promise in Phase 2 COURAGE Obesity Trial
Combining GLP-1 therapy with specific antibodies can reduce muscle loss during weight management, enhancing overall health outcomes.
Published: 6/10/2025
Uptake of Pneumococcal Vaccine Low Both Before and After Hospitalization for IPD Among Hong Kong Cohort
Low uptake of vaccination to protect against invasive pneumococcal disease (IPD) was observed both before and after a pneumococcal-related hospitalization, with countless missed vaccination opportunities documented.
Published: 6/10/2025
Department of Health and Human Services Reconstitutes ACIP, Removing 17 Sitting Members
The restructuring of the Advisory Committee for Immunization Practices (ACIP) could impact recommendations for routine childhood and adult vaccinations.
Published: 6/10/2025
Inpatient Biosimilar Use Grows, Offering Cost-Saving Opportunities for Health Systems
Published: 6/10/2025
FDA Approves Meloxicam Injection For Moderate-to-Severe Pain in Adults
Meloxicam injection gains FDA approval for effective management of moderate-to-severe pain, offering a nonopioid alternative in pain control strategies.
Published: 6/10/2025
Pharmacist-Led HCV Program Uncovers Syndemic Risks, Supports Expanded Screening
Published: 6/10/2025
Clesrovimab Receives FDA Approval for RSV Lower Respiratory Tract Prevention in Infants
The FDA approves clesrovimab-cfor, a new RSV vaccine, offering infants effective protection against severe respiratory illness during their first RSV season.
Published: 6/9/2025
ASCO 2025: Evaluating Nivolumab Plus Relatlimab in Resected Stage 3 or 4 Melanoma
Nivolumab plus relatlimab does not significantly improve recurrence-free survival in patients with stage 3, 4 melanoma.
Published: 6/9/2025
Neoadjuvant Nivolumab With Chemotherapy Yields Significant Overall Survival Benefit in Resectable NSCLC
Nivolumab (Opdivo) and chemotherapy demonstrated an overall survival benefit at 5 years, affirming its role as a standard of care option.
Published: 6/9/2025
ASCO 2025: Promising Safety and Efficacy of Encorafenib and Binimetinib in Resected Stage II Melanoma
A new study reveals the combination therapy enhances safety and efficacy for high-risk BRAF-mutated stage II melanoma.
Published: 6/9/2025
Single Infusion of Cilta-Cel Yields 5-Year Progression-Free Survival in Multiple Myeloma
Cilta-cel shows promise as a CAR T-cell therapy, offering long-term remission for patients with relapsed/refractory multiple myeloma without maintenance treatment.
Published: 6/9/2025
Community Pharmacist Collaboration Expands Access to Long-Acting Injectable Antipsychotics
A multidisciplinary team enhances psychiatric care by empowering community pharmacists to administer long-acting injectable antipsychotics, improving patient adherence and outcomes.
Published: 6/9/2025
Study Reveals Gaps in GINA Guideline Adherence for Asthma Treatment
The findings highlight the need for improved prescribing practices and patient outcomes.
Published: 6/9/2025
New Online Competency Modules Standardize CPA Pharmacist Training at Academic Medical Center
Standardized online modules ensure consistent, high-quality care in collaborative practice agreements.
Published: 6/9/2025
FDA Approves First, Only Single-Pill Triple Combination for Treatment of Hypertension
The FDA has approved a groundbreaking single-pill combination therapy for hypertension, enhancing cardiovascular health with triple-agent efficacy.
Published: 6/9/2025
Pharmacists Take the Lead on Advanced Therapeutics
Pharmacists lead the charge in implementing advanced therapeutics, navigating complex challenges and shaping the future of health care innovation.
Published: 6/9/2025
ASCO 2025: THP Without Carboplatin Shows Noninferior pCR Rates, Improved Tolerability in HER2+ Early Breast Cancer
About 64.1% of patients receiving taxane, trastuzumab, and pertuzumab (THP) without carboplatin had pathological complete response rates (pCRs).
Published: 6/9/2025
ASCO 2025: Vepdegestrant Shows Superiority to Fulvestrant in ER+/HER2- Advanced Breast Cancer
Vepdegestrant was the first PROTAC to be evaluated in a phase 3 clinical trial.
Published: 6/9/2025
Ambulatory Pharmacy in Action: House Calls and Harm Reduction Clinics Expand the Reach of Care
Ambulatory pharmacists innovate care delivery, enhancing patient access and outcomes through home visits and harm reduction clinics for complex health needs.
Published: 6/8/2025
Specialty Pharmacist Integration in Neurology Clinics: A Model for Enhanced Patient Care
Integrating specialty pharmacists into neurology teams enhances patient care, medication management, and clinical outcomes for chronic conditions.
Published: 6/8/2025
Reimagining Pain Management: Pharmacists Urged to “Deconstruct the Cupcake”
Innovative pain management strategies emerge as experts advocate for personalized, multifaceted approaches to chronic pain, likening treatment to a tailored cupcake.
Published: 6/8/2025
Meta-Analysis Evaluates RSV Viral Load and Symptom Kinetics
New research analyzes human challenge infection studies to reveal insights on respiratory syncytial virus viral load and symptom dynamics, aiding treatment development.
Published: 6/6/2025
GLP-1 Receptor Agonists Demonstrate Increased Risk of Neovascular Age-Related Macular Degeneration in Diabetes
Patients with diabetes using glucagon-like peptide-1 (GLP-1) drugs face double the risk of developing neovascular age-related macular degeneration, highlighting crucial ocular health concerns.
Published: 6/6/2025
SCIg More Effective Immunoglobulin Option for Immunocompromised Patients With Inborn Errors of Immunity
Subcutaneous immunoglobulin was found to elicit fewer viral infections compared with other routes of immunoglobulin replacement therapy, including intravenous immunoglobulin.
Published: 6/6/2025
Study Finds VPS72 Is Overactive in Patients With Hepatocellular Carcinoma
The investigators suggested that blocking VPS72’s interactions can be a foundation for future therapeutic interventions.
Published: 6/6/2025
Tarlatamab Significantly Improves Survival in Patients With Small Cell Lung Cancer Post-Progression
Granted accelerated approval by the FDA in 2024, tarlatamab continues to demonstrate efficacy and safety in patients with small cell lung cancer, with results showing improved overall survival and progression-free survival in patients who had progressed or previously received chemotherapy.
Published: 6/6/2025
Breaking Financial Barriers: Pharmacists as Value-Driven Health Care Providers
Pharmacists navigate reimbursement challenges while advocating for legislative support and innovative models to enhance patient care and financial sustainability.
Published: 6/5/2025
ASCO 2025: Camizestrant With CDK4/6 Inhibitor Improves PFS in Patients With HR+/HER2- Advanced Breast Cancer
Compared with standard of care, camizestrant in combination with a CDK4/6 inhibitor shows promise in enhancing progression-free survival (PFS) for patients with advanced breast cancer.
Published: 6/5/2025
To Combat Medication Errors, Proper Pharmacy Inventory Counts Are Essential
New products are poised to aid pharmacists in proper counting of inventory to prevent medication errors.
Published: 6/5/2025
Vadadustat and Darbepoetin Alfa Show Similar Safety, Efficacy in Patients With NDD-CKD and DD-CKD
Vadadustat and darbepoetin alfa show similar safety and efficacy in treating CKD-related anemia, with regional differences impacting cardiovascular risks.
Published: 6/5/2025
Study Finds Vitamin D3 Supplementation Reduces Telomere Attrition
New research highlights vitamin D's potential to slow telomere shortening, suggesting it may combat aging and promote cellular health.
Published: 6/5/2025
Targeted Screening Tools Can Increase Pneumococcal Vaccine Uptake in Health System Retail Pharmacies
Implementation of the Plan-Do-Study-Act cycle in health system retail pharmacies significantly increased uptake of 20-valent pneumococcal conjugate vaccine among eligible adults.
Published: 6/5/2025
Amid Measles Outbreak, CDC Advises International Travelers to Receive MMR Immunization
CDC urges all US travelers to get vaccinated for measles, mumps, and rubella (MMR) amid rising measles cases, emphasizing prevention as key to combating outbreaks.
Published: 6/5/2025
Researchers Identify Sex-Based Differences in Diet and Metabolism
Although women might benefit from fattier breakfasts, men could respond best to carbohydrates.
Published: 6/4/2025
Recombinant Human Hyaluronidase-Facilitated SCIg Sustains Clinical Remission in Idiopathic Inflammatory Myositis
Subcutaneous immunoglobulin (SCIg) is a hopeful alternative to intravenous immunoglobulin in patients with inflammatory myositis due to a lack of adverse effects and fewer financial constraints.
Published: 6/4/2025
Study: LYR-210 Shows Promise in Chronic Rhinosinusitis With Nasal Polyps
New findings show LYR-210's potential to significantly alleviate chronic rhinosinusitis symptoms, offering hope for patients with nasal inflammation and polyps.
Published: 6/4/2025
Neoadjuvant Osimertinib With or Without Chemotherapy Improves Response in Resectable EGFRm NSCLC
Results from the NeoADAURA trial demonstrate the sustained efficacy of osimertinib in patients with epidermal growth factor receptor-mutated (EGFRm) non-small-cell lung cancer (NSCLC).
Published: 6/4/2025
GLP-1 Receptor Agonists and FGF21 Analogues May Be Key Treatments for MASH-Related Cirrhosis
New treatments for metabolic dysfunction-associated steatohepatitis (MASH)–related cirrhosis address unique challenges in drug development.
Published: 6/4/2025
Fixed-Duration Ibrutinib Plus Venetoclax Shows Long-Term Efficacy in First-Line CLL/SLL Treatment
Ibrutinib plus venetoclax shows promising long-term survival rates, including those who are considered high risk.
Published: 6/4/2025
ASCO 2025: Adding Carboplatin Did Not Result in Statistically Significant Improvements in Patients With TNBC
New research finds that adding carboplatin to paclitaxel and adjuvant chemotherapy shows no significant survival benefits in triple-negative breast cancer (TNBC).
Published: 6/4/2025
S2. Ep 56: Insights From a Pharmacy Times Peer Exchange: How to Talk the Talk
Experts share insights on patient discussions and adverse effect management strategies in HER2 breast cancer.
Published: 6/3/2025
ASCO 2025 Delivers Insights into Future of Myelofibrosis Care
Explore the latest advancements in myelofibrosis treatment, focusing on JAK inhibitors and pegylated interferons for improved patient outcomes.
Published: 6/3/2025
Darolutamide Approved by FDA for Metastatic Castration-Sensitive Prostate Cancer
The FDA has approved darolutamide for patients with metastatic castration-sensitive prostate cancer after positive results in the ARANOTE clinical trial.
Published: 6/3/2025
From MGUS to Myeloma: Understanding and Interrupting Disease Progression
The 2025 ASCO Annual Meeting discusses the latest advancements in understanding and treating precursor diseases.
Published: 6/3/2025
FDA Grants De Novo Authorization to 5-Year Breast Cancer Risk Prediction Device
Clairity Breast's FDA-approved AI platform revolutionizes breast cancer risk prediction, enhancing early detection and personalized prevention strategies.
Published: 6/3/2025
ASCO 2025: Zongertinib Shows Strong Potential in HER2-Mutant NSCLC Treatment Landscape
Zongertinib shows promising efficacy and safety for HER2-mutant NSCLC, with a 71% response rate and low toxicity, paving the way for future treatments.
Published: 6/3/2025
CDC Clarifies That Kids May Receive COVID-19 Vaccine Through Shared Clinical Decision-Making
The CDC has updated its COVID-19 vaccine guidance for children and pregnant individuals, sparking a debate among health experts and concerns over insurance coverage.
Published: 6/2/2025
New Jersey Society of Health-System Pharmacy Hosts 2nd Annual Pharmacy Leader and Pharmacy Technician Symposium
The NJSHP's 2nd Annual Symposium fosters networking and education for pharmacy professionals, featuring expert insights on compliance and regulation in pharmacy compounding.
Published: 6/2/2025
Phase 3 PIVOT-PO Trial Evaluating Tebipenem HBr in cUTIs Ends Early After Meeting Primary End Point
A clinical trial shows tebipenem pivoxil hydrobromide (Tebipenem HBr; Spero Therapeutics and GSK) effectively treats complicated urinary tract infections (cUTIs), potentially transforming patient care and reducing hospital costs.
Published: 6/2/2025
FDA Approves mRNA-1283 COVID-19 Vaccine for Adults 65 Years and Older, Those With Underlying Conditions
Amid intensified scrutiny of COVID-19 vaccines at HHS, Moderna’s mRNA-1283 COVID-19 vaccine was granted FDA approval for patients 65 years and older and patients aged 12 to 64 years with at least 1 or more underlying risk factors for severe COVID-19.
Published: 6/2/2025
ASCO 2025: Informing Treatment Decisions Using a 14-Gene Assay in Early-Stage NSCLC
A study reveals a 14-gene assay guides chemotherapy decisions effectively in patients with early-stage non-small cell lung cancer (NSCLC).
Published: 6/2/2025
FDA Grants Interchangeability Designation to Hadlima, a Biosimilar for Humira
The FDA designated Hadlima as an interchangeable biosimilar to Humira, enhancing patient access and potential savings for various conditions.
Published: 6/2/2025
ASCO 2025: Expert Insights on Endocrine, Cardiac, Ocular, and Dermatologic Toxicities in Breast Cancer Care
Explore the complexities of managing toxicities in breast cancer treatments, including endocrine therapies, antibody drug conjugates, and immune checkpoint inhibitors.
Published: 6/2/2025
ASCO 2025: Vepdegestrant's Efficacy and Safety in ER+/HER2- Advanced Breast Cancer
Compared with fulvestrant, vepdegestrant significantly extended progression-free survival and improved response rates.
Published: 6/2/2025
Reducing the Risks: Managing CRS, ICANS, and Skin Reactions in Emerging Lung Cancer Therapies
Experts discuss BiTE therapy in treating lung cancers, focusing on innovative agents like tarlatamab and amivantimab, and their toxicity management.
Published: 6/2/2025
MRD Monitoring May Help Redefine Long-Term Goals in Myeloma Therapy
MRD testing transforms multiple myeloma treatment, guiding personalized strategies and improving patient outcomes through innovative testing methods.
Published: 6/1/2025
From Resistance to Response: The Microbiome’s Role in Optimizing Cancer Therapy
Explore how the gut microbiome influences cancer therapy responses, resistance mechanisms, and the potential of microbiota-focused strategies for improved outcomes.
Published: 5/31/2025
NLA 2025: GLP-1 Therapies May Impact Cardiovascular and Renal Health Independent of Weight Loss
GLP-1 receptor agonists, including semaglutide and tirzepatide, significantly reduce cardiometabolic risk factors such as dyslipidemia, type 2 diabetes, metabolic dysfunction-associated steatohepatitis, obstructive sleep apnea, chronic kidney disease, and cardiovascular events, with evidence suggesting that some of these benefits may occur independently of weight loss.
Published: 5/31/2025
Updated ASCO-NCODA MIP Standards Emphasize Health Equity, Patient-Centered Care, and Integrated Workflows in Oral Oncolytic Management
Gurjyot K. Doshi, MD, discusses key updates to medically integrated pharmacy standards, which reflect the evolving landscape of oral oncolytic therapy.
Published: 5/31/2025
IVIG Increases Platelet Counts in Pregnant Patients With Severe Thrombocytopenia, With Identifiable Aspects of Response
IVIG treatment significantly boosts platelet counts in pregnant people with thrombocytopenia, revealing key predictors for effective response and optimizing clinical decisions.
Published: 5/31/2025
NLA 2025: ApoC3 Inhibitors Show Promise Across a Spectrum of Hypertriglyceridemic Disorders
Emerging therapies targeting apolipoprotein C-III (ApoC3) are demonstrating significant promise in lowering triglycerides and reducing cardiovascular risk for patients with severe hypertriglyceridemia and rare disorders, such as familial chylomicronemia syndrome.
Published: 5/31/2025
Novel Agents, Promising Data: The Evolving Landscape of Oncology Care
Groundbreaking oncology drugs transform treatment for glioblastoma, HR+ breast cancer, and small cell lung cancer.
Published: 5/30/2025
NLA 2025: Inclisiran With Standard Care Provides Rapid, Sustained Lowering of LDL-C in Patients With Recent Acute Coronary Syndrome
Building on positive low-density lipoprotein cholesterol (LDL-C)-lowering seen in patients with atherosclerotic cardiovascular disease, inclisiran was found to induce meaningful and sustained LDL-C reductions following recent acute coronary syndrome.
Published: 5/30/2025
Proactive Dermatologic Care Reduces Symptom Severity and Boosts Quality of Life in NSCLC
Enhanced dermatologic management reduces skin rash and improves quality of life for patients with EGFR-mutant non-small cell lung cancer.
Published: 5/30/2025
FDA Grants Fast Track Designation to Drug Candidate for Celiac Disease
The FDA grants fast track designation to TEV-53408, a promising treatment for celiac disease designed to address gluten intolerance and improve patient outcomes.
Published: 5/30/2025
HHS Cancels Millions in Pandemic Influenza mRNA Vaccine Development Grants
The announcement is set to affect multiple grants awarded to Moderna, which is developing mRNA-1018, a candidate vaccine against avian influenza.
Published: 5/30/2025
Patient Reported Outcomes Show Improved Symptoms With Zongertinib for HER2-Mutated Non-Small Cell Lung Cancer
Zongertinib shows significant benefits in managing symptoms and improving quality of life for patients with HER2-mutated non-small cell lung cancer.
Published: 5/30/2025
Cellular Senescence Is a Central Driver of Chronic Kidney Disease–Related Kidney Fibrosis
Researchers explore cellular senescence's role in kidney fibrosis, highlighting potential therapies to combat chronic kidney disease progression.
Published: 5/30/2025
Elecsys PRO-C3 Test Aims to Improve Precision Evaluation of Liver Fibrosis Severity
The test offers health care professionals a simple and efficient method of identifying patients with liver fibrosis of varying severity.
Published: 5/30/2025
Going with the Flow: Updates in Diabetes and Chronic Kidney Disease
CKD is a complication of diabetes. Emerging treatments aim to optimize management and reduce risks. Pharmacists are key in applying new evidence to clinical practice.
Published: 5/29/2025
Pneumococcal 15-Valent Conjugate Vaccine Provides Heightened Protection Against Certain Serotypes Compared With PCV13
V114, a 15-valent pneumococcal conjugate vaccine (PCV), provided better protection against serotypes 22F and 33F compared with 13-valent PCV (PCV13).
Published: 5/29/2025
ASCO 2025: Adding Elranatamab to Daratumumab, Lenalidomide Induces Durable Responses in Newly Diagnosed Multiple Myeloma
Elranatamab shows promising efficacy and manageable safety in transplant-ineligible newly diagnosed multiple myeloma patients, highlighting its potential as a treatment option.
Published: 5/29/2025
Childhood Cancer Survivors at an Increased Risk of Developing CKD, Study Finds
The investigators suggest that early detection and treatment of chronic kidney disease (CKD) in childhood cancer survivors may decrease late complications and mortality.
Published: 5/29/2025
FDA Approves Khindivi, First Oral Solution of Hydrocortisone, for Pediatric Patients
The formulation allows for individualized treatment in children with adrenocortical insufficiency.
Published: 5/29/2025
Study Reveals Impact of RSV on the Heart
New research highlights the significant cardiovascular risks associated with RSV, emphasizing the need for vaccination to protect vulnerable populations.
Published: 5/29/2025
Daratumumab Plus VRd Yields Sustained MRD-Negativity Regardless of Cytogenetic Risk Status in NDMM
Daratumumab combined with VRd significantly improved outcomes in transplant-ineligible/transplant deferred patients with newly diagnosed multiple myeloma.
Published: 5/29/2025
Epcoritamab-bysp Yields Long-Term Disease Remission in Patients with Relapsed, Refractory Large B-Cell Lymphoma
Epcoritamab shows impressive long-term remission rates in relapsed large B-cell lymphoma, highlighting its potential as a key treatment option.
Published: 5/29/2025
FDA Approves Acoltremon Ophthalmic Solution 0.003% for Signs, Symptoms of Dry Eye Disease
FDA approves acoltremon ophthalmic solution, a groundbreaking treatment for dry eye disease, enhancing natural tear production and patient quality of life.
Published: 5/28/2025
Insights from a Pharmacy Times Peer Exchange: Toxicity Monitoring and Management in Real-World Settings
This segment takes a deeper dive into toxicity management—focusing not just on what to monitor, but how institutions are putting these protocols into action in real-world clinical settings.
Published: 5/28/2025
Quadrivalent Meningococcal Vaccine Receives FDA Approval for Infants and Children With Meningococcal Disease
The FDA approved the MenQuadfi vaccine for young children, enhancing protection against invasive meningococcal disease and its severe complications.
Published: 5/28/2025
FDA Approves Ustekinumab-hmny Injection, a Biosimilar Referencing Stelara
A new biosimilar to ustekinumab (Stelara) has been approved by the FDA, further expanding treatment options for patients with immune conditions such as plaque psoriasis and psoriatic arthritis.
Published: 5/28/2025
Five-Year Follow-Up Data Show Zanubrutinib Improves Progression-Free Survival, Overall Survival in CLL/SLL
The data from the phase 3 SEQUOIA study are to be presented at the 2025 ASCO Annual Meeting.
Published: 5/27/2025
Phase 3 Trial Explores Imetelstat for Advanced Myelofibrosis After Promising Phase 2 Data
Imetelstat shows promise in treating myelofibrosis, enhancing survival, and modifying disease biology in patients resistant to JAK inhibitors.
Published: 5/27/2025
WEHI-3773 May Be Leveraged to Develop Therapeutic Strategies for Neurodegenerative Conditions
The small molecule effectively blocks cell death effector proteins, potentially rescuing cells from degeneration.
Published: 5/27/2025
CDC to End COVID-19 Vaccine Recommendation for Healthy Children, Pregnant Women
The change is poised to impact countless individuals who may have sought a COVID-19 vaccine this upcoming respiratory season.
Published: 5/27/2025
FDA Recommends 2025-2026 COVID-19 Vaccines Be Monovalent, Target LP.8.1 Strain
Following a meeting of the Vaccines and Related Biological Products Advisory Committee, the FDA announced its recommendation of COVID-19 vaccines targeting LP.8.1, a strain of the JN.1 variant that has become dominant in the US.
Published: 5/27/2025
FDA Approves Treprostinil Inhalation Powder for PAH and PH-ILD
The approval is based on findings from the INSPIRE trial, where treprostinil demonstrated efficacy in pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease (PH-ILD).
Published: 5/27/2025
GADD45A May Prevent Inflammation, Fibrosis, and Preserve Cardiac Function
The authors are optimistic that GADD45A serves as a foundation for therapeutic approaches to slow the progression of heart failure.
Published: 5/26/2025
Physical Activity Can Improve Quality of Life in Patients With Newly Diagnosed Multiple Myeloma
Physical activity significantly enhanced quality of life and reduced fatigue and depression in patients with newly diagnosed multiple myeloma.
Published: 5/23/2025
Oral GLP-1 Agonist Orforglipron Shows Promise for Type 2 Diabetes and Weight Management
Orforglipron showed promising results in managing type 2 diabetes, offering a potential oral alternative to injectable treatments.
Published: 5/23/2025
APOBEC3 Mutagenesis May Drive Therapy Resistance in Patients With Breast Cancer
APOBEC3 mutagenesis emerges as a key factor in breast cancer treatment resistance, offering new avenues for targeted therapies and predictive biomarkers.
Published: 5/23/2025
Diverse Interventions Found to Increase Pneumococcal Vaccine Uptake Among Older Adults in Primary Care Settings
Interventions such as educational brochures, provider-delivered educational programs, and computerized reminders were found to help improve pneumococcal vaccine uptake in older adults.
Published: 5/23/2025
Study: Predictive Mortality Tools Limited in Older Adults With Advanced CKD
After 3 predictive mortality tools demonstrate inefficiency within older adults with advanced chronic kidney disease (CKD), the authors call for the development of tools tailored for this population.
Published: 5/23/2025
FDA Approves Roflumilast Topical Foam 0.3% for Plaque Psoriasis in Adults and Children
This indication is for adult and pediatric patients aged 12 and older with plaque psoriasis of the scalp and body.
Published: 5/22/2025
FDA Approves Mepolizumab for Treatment of Patients With COPD and an Eosinophilic Phenotype
Mepolizumab gains FDA approval as a promising add-on therapy for COPD patients with eosinophilic phenotype, reducing exacerbation rates significantly.
Published: 5/22/2025
FDA Approves Ranibizumab Injection for Treatment of Diabetic Retinopathy
Ranibizumab injection (Susvimo; Genentech) could offer long-lasting vision preservation and reduce the need for frequent injections in patients with diabetic retinopathy.
Published: 5/22/2025
The Mentorship Model: Cultivating Resilience and Leadership in Palliative Care Pharmacy
At the 2025 SPPCP Virtual Conference, Carolyn Hall, PharmD, BCPS, and Maria Felton Lowry, PharmD, BCPS, BCGP, presented a comprehensive and practical framework for pharmacy professionals to build effective, adaptable mentorship relationships.
Published: 5/22/2025
FDA Grants Interchangeability Designation to Yuflyma, Biosimilar for Humira Across All Approved Doses
Yuflyma gains FDA interchangeability with Humira, enhancing patient access to effective biosimilar treatments for various inflammatory conditions.
Published: 5/22/2025
Distinct NK Cell Subset Predicts Ibrutinib Response and Immune Pathway Activation in CLL
Published: 5/22/2025
Risk of Cardiovascular Event Increases With Rising Lipoprotein(a) Levels in Patients With ASCVD
With each increase in lipoprotein(a) level in patients with atherosclerotic cardiovascular disease (ASCVD), there was a corresponding increase in risk of experiencing an ASCVD event.
Published: 5/22/2025
T-DXd Demonstrates Safety, Efficacy After Pyrotinib Therapy Failure in Patients With HER2+ Breast Cancer
Trastuzumab deruxtecan (T-DXd) yielded favorable outcomes and improved survival rates.
Published: 5/22/2025
Sogroya Observed as Efficacious and Well-Tolerated in Children With Growth Disorders
The phase 3 REAL8 trial shows once-weekly Sogroya effectively improves growth in children with growth disorders, offering a promising alternative to daily injections.
Published: 5/22/2025
Additional Dose of IVIG Provides Positive Therapeutic Effect in Patients With Infliximab-Refractory Kawasaki Disease
Additional intravenous immunoglobulin (IVIG) treatment shows promise for patients with Kawasaki disease who are resistant to infliximab, potentially matching the efficacy of second IVIG doses in patients resistant to IVIG.
Published: 5/22/2025
An Over-the-Counter Evidence-Based Approach to Reducing the Risk of Antibiotic-Associated Diarrhea
Published: 5/22/2025
Managing Opioid Complexity: The Role of Pharmacists in OUD and C-POD Care
In a session at the 2025 Virtual Conference on Pain and Palliative Care, Isabella Zerfas, PharmD, and Abbey Galligan, PharmD, BCPS, explore effective pain management strategies for opioid use disorder (OUD) and complex persistent opioid dependence.
Published: 5/21/2025
FDA to Restrict Future COVID-19 Vaccine Recommendations to Older Adults, High-Risk Groups
In a major policy shift, officials from the FDA announced a new regulatory framework for COVID-19 vaccinations, prioritizing adults 65 years and older and individuals with serious comorbidities putting them at high risk for severe COVID-19.
Published: 5/21/2025
Zanidatamab Plus Chemotherapy Shows Promising Anti-Tumor Activity in Treatment of HER2-Mutated Breast Cancer
The data were presented at the ESMO Breast Cancer 2025 Annual Meeting.
Published: 5/21/2025
Study Links MUC1-C to Estrogen Receptor Expression and Endocrine Resistance in HR+/HER2– Breast Cancer
Studies suggest that prolonged activation of MUC1-C encourages disease progression.
Published: 5/21/2025
Study Finds Increased Risk of CVD Among Women With History of Infertilty
The risk of cardiovascular disease (CVD) was higher among those who were exposed to assisted reproductive technology.
Published: 5/21/2025
Ruxolitinib Plus Siremadlin Yielded Superior Spleen Volume Reduction in Patients With Myelofibrosis
The combination demonstrated improved efficacy compared with ruxolitinib as a monotherapy.
Published: 5/20/2025
Anti-Diabetic Drug Could Offer New Treatment for Prostate Cancer
Research reveals pioglitazone, a diabetes drug, may slow prostate cancer progression, offering new hope for patients with both conditions.
Published: 5/20/2025
Glofit-GemOx in R/R DLBCL: FDA Advisory Committee Reviews STARGLO Phase 3 Results for Transplant-Ineligible Patients
Glofitamab combined with GemOx shows promising survival benefits for patients with relapsed DLBCL, offering a new treatment option for those ineligible for transplants.
Published: 5/20/2025
Triple-Combination Therapy Met Primary End Point in Phase 3 Trials, Providing Treatment for Individuals With Asthma
A new triple-combination therapy shows promise in improving asthma management, offering hope for millions with uncontrolled symptoms.
Published: 5/20/2025
Mentorship, Leadership, and Professional Growth in Oncology Pharmacy
Don Moore, PharmD, BCPS, BCOP, DPLA, FCCP, FASHP, received a leadership award at the 2025 HOPA Annual Meeting.
Published: 5/20/2025
Declines in Pediatric Pneumococcal Complicated Pneumonia Evident Following Introduction of Higher Valent Vaccines
A systematic review reveals declining pediatric pneumococcal complicated pneumonia rates following the introduction of pneumococcal conjugate vaccine 13.
Published: 5/20/2025
Linerixibat Significantly Improves PBC-Related Cholestatic Pruritus in Adult Patients
Compared with placebo, patients with cholestatic pruritus and primary biliary cholangitis (PBC) receiving linerixibat experienced improved itch and sleep interference.
Published: 5/20/2025
Motivational Interviewing to Conquer Barriers for Diabetes Management
Motivational interviewing serves as a beneficial strategy to enhance medication adherence and improve patient outcomes in diabetes management.
Published: 5/20/2025
Study Reveals Safety and Effectiveness of RSV Vaccine for Older Adults
New research highlights the effectiveness and safety of RSV vaccines for older adults, revealing critical insights into vaccination benefits and risks.
Published: 5/19/2025
Insights from a Pharmacy Times Peer Exchange: Real-World Outcomes and Supportive Care
Pharmacists compare real-world practice data with clinical trial results and discuss supportive care options for patients.
Published: 5/19/2025
First Nationwide Seroprevalence Study of HDV in the US Offers Prevalence of HDV Among HBsAg-Positive Specimens
The authors believe the results may serve as a foundation for hepatitis D virus (HDV) testing among hepatitis B virus surface antigen (HBsAg)-positive specimens.
Published: 5/19/2025
FDA Approved Antihemophilic Factor, PEGylated-Aucl For Pediatric Patients With Hemophilia A
The approval expands the therapy’s indication to children as young as 7 years.
Published: 5/19/2025
Anti-PD-1 Monoclonal Antibody With Standard of Care Improves Outcomes for BCG-Naïve Bladder Cancer
A study reveals sasanlimab enhances event-free survival in high-risk bladder cancer patients, offering new hope against disease recurrence.
Published: 5/19/2025
FDA Grants Market Clearance to Diagnostic Blood Test for Alzheimer Disease
The Lumipulse G pTau217/ß-Amyloid 1-42 Plasma Ratio is the first in vitro diagnostic device that tests blood to aid in diagnosing Alzheimer disease.
Published: 5/19/2025
FDA Approves Novavax COVID-19 Vaccine for Patients 65 Years and Older, Those With Underlying Conditions
The vaccine, indicated with a restriction on use for those younger than 65 years and without comorbidities, was proven safe and effective in a series of large clinical trials, and marks the first protein-based vaccine to be approved in the United States.
Published: 5/19/2025
FDA Approved NDA for Aficamten to Treat Patients With Obstructive Hypertrophic Cardiomyopathy
Aficamten, a cardiac myosin inhibitor, gains FDA approval, offering hope for improved cardiovascular health in patients with obstructive hypertrophic cardiomyopathy.
Published: 5/16/2025
Adding Pertuzumab to Trastuzumab and Chemotherapy Reduced Risk of Death by 17% in HER2+ Breast Cancer
New data reveals that combining pertuzumab with trastuzumab significantly improves survival rates in HER2+ breast cancer patients, reducing death risk by 17%.
Published: 5/16/2025
ACOG Releases New Pain Management Recommendations for IUD Insertions
The new guidelines urge health care professionals to offer local anesthetics and other medications for intrauterine device (IUD) insertions and other gynecologic procedures.
Published: 5/16/2025
Durvalumab Regimen Improves Disease-Free Survival in High-Risk Non-Muscle-Invasive Bladder Cancer
The regimen, which consists of durvalumab and Bacillus Calmette-Guerin, offers new hope to patients with high-risk non-muscle-invasive bladder cancer.
Published: 5/16/2025
Several Comorbidities Found to Reduce Likelihood of Pneumococcal Vaccination, While Use of Implantable Devices Heightens Odds
A new study reveals that heart failure patients with implantable devices are more likely to receive the pneumococcal conjugate vaccine 13, impacting vaccination rates and mortality.
Published: 5/16/2025
The Role of Specialty Pharmacists in Managing Chronic Kidney Disease
Specialty pharmacists enhance CKD management through personalized care, medication adherence strategies, and collaboration with health care providers.
Published: 5/16/2025
Retifanlimab-Dlwr Becomes First and Only FDA-Approved First-Line Treatment for Advanced Anal Cancer
The FDA approves retifanlimab for advanced anal cancer, offering new hope with improved survival rates and treatment options for patients.
Published: 5/15/2025
Interferon Lowers Myelofibrosis Risk in Young Patients With Polycythemia Vera, Essential Thrombocytopenia
Published: 5/15/2025
Gap-Scheduled Olaparib Plus Neoadjuvant Chemotherapy Improved Survival in Patients With gBRCAm TNBC
Combining olaparib with neoadjuvant chemotherapy enhances survival rates for early-stage gBRCAm triple-negative breast cancer, offering new hope for patients.
Published: 5/15/2025
Real-World Study Shows Comparable Survival Outcomes With First-Line Ibrutinib in High-Risk and Non-High-Risk CLL/SLL
Ibrutinib offers comparable survival outcomes for high-risk chronic lymphocytic leukemia patients, challenging traditional prognostic markers in real-world settings.
Published: 5/15/2025
Medication Meltdown: Unpacking Drug Shortages
Pharmacy staff can be instrumental members of shortage management teams.
Published: 5/15/2025
High LDL Cholesterol Associated With Earlier Progression in Synchronous Metastatic Colorectal Cancer
In patients with synchronous metastatic colorectal cancer treated without curative intent, high low-density lipoprotein (LDL) cholesterol was associated with poor survival.
Published: 5/15/2025
FDA Grants Orphan Drug Designation to Oligonucleotide Therapeutic for Spinocerebellar Ataxia
Cure Rare Disease's CRD-002 receives FDA orphan drug designation, advancing hope for SCA3 treatment with innovative oligonucleotide therapy.
Published: 5/15/2025
FDA Approves Brekiya, First and Only DHE Autoinjector, for Acute Treatment of Migraine, Cluster Headaches
The approved injection contains dihydroergotamine (DHE), which is the same medication used in hospitals, in a ready-to-use device.
Published: 5/15/2025
Considerations for RSV Vaccination During Pregnancy
Explore the latest advancements in RSV vaccination strategies for newborns, focusing on maternal immunization and post-birth protection options.
Published: 5/15/2025
CVS Health Announces It Will Drop Zepbound and Prioritize Coverage of Wegovy
The announcement came shortly before updated results from the SURMOUNT-5 clinical trial, which found Zepbound had superior weight-loss effects over Wegovy.
Published: 5/14/2025
New OTC Option Offers Patients Itch Relief During Summer Activities
The seasonal surge in skin irritations underscores the ongoing need for effective and convenient remedies.
Published: 5/14/2025
Zepbound Shows Superior Weight Loss Compared to Wegovy in SURMOUNT-5 Trial
Tirzepatide outperforms semaglutide in weight loss, achieving an average reduction of 20.2% in a pivotal trial for obesity management.
Published: 5/14/2025
Anitocabtagene Autoleucel Yields Overall Response Rate of 97% in Patients With Multiple Myeloma
The data are from the phase 2 iMMagine-1 study.
Published: 5/14/2025
FDA Grants Accelerated Approval to Telisotuzumab vedotin-tllv for NSCLC
Emrelis is a groundbreaking treatment for advanced non-small cell lung cancer, targeting high c-Met protein overexpression.
Published: 5/14/2025
FDA Approves Belzutifan for Treatment of Locally Advanced, Unresectable, or Metastatic Pheochromocytoma and Paraganglioma
The FDA approved belzutifan, the first oral treatment for pheochromocytoma and paraganglioma, offering a new treatment pathway for patients with these rare tumors.
Published: 5/14/2025
Icotrokinra Demonstrates Significant Skin Clearance in Difficult-to-Treat Scalp, Genital Psoriasis
New trial results reveal icotrokinra's effectiveness in achieving significant skin clearance for challenging scalp and genital psoriasis.
Published: 5/14/2025
Engaging in Research and Disseminating Information Are Essential For All Stakeholders, Experts Say
Effectively communicating research findings to patients, health care professionals, and policy payers is necessary for engagement.
Published: 5/14/2025
Children With Sickle Cell Disease Have Higher Rates of Invasive Pneumococcal Disease Despite Vaccination
Like other high-risk groups, children with sickle cell disease have a heightened risk of invasive pneumococcal disease, even if they receive proper pneumococcal conjugate vaccine coverage.
Published: 5/14/2025
Launch of Generic Eltrombopag Expands Access for Patients With Thrombocytopenia, Aplastic Anemia
This new generic will impact both oncology and community pharmacists.
Published: 5/14/2025
Carefully Consider Optimal Timing of RSV Vaccination in Older Adults
Administration during peak vaccine effectiveness provides maximal protective benefit
Published: 5/13/2025
Ixchiq Vaccine Linked to Fatal Adverse Events in Seniors, FDA and CDC Urge Caution
FDA and CDC halt Ixchiq chikungunya vaccine for adults 60 years and older due to severe adverse events, including fatalities, urging caution in vaccination practices.
Published: 5/13/2025
President Trump Signs Executive Order Aiming to Lower Prescription Drug Costs by Up to 90%
The executive order gives pharmaceutical companies 30 days to voluntarily lower prices.
Published: 5/13/2025
Community Behavioral Health Clinics Can Be Instrumental in Switching Patients to Long-Acting Injectable Antipsychotics
Published: 5/13/2025
Mild to Moderate Adverse Events Possible in Pediatric Patients With Primary Immunodeficiency Receiving IVIG
Despite being an effective treatment option, intravenous immunoglobulin (IVIG) can cause transient adverse events in pediatrics with primary immunodeficiency, including headache and fever.
Published: 5/13/2025
Research Suggests Natural Supplementation Could Decrease Biological Age
A natural aging supplement enhances muscle strength and reduces biological age, promoting healthier aging.
Published: 5/13/2025
Leveraging AI Within Rare Disease Care While Maintaining Humanity
Artificial intelligence (AI) can transform rare disease research by leveraging patient data, enhancing evidence generation, and improving communication between patients and health care professionals.
Published: 5/13/2025
Multicomponent COVID-19/Influenza Vaccine Induces Higher Immune Responses Than Standard Care Immunizations
A new multicomponent vaccine, mRNA-1083, shows promise in enhancing immune responses against influenza and COVID-19, addressing vaccine hesitancy effectively.
Published: 5/12/2025
Insights from a Pharmacy Times Peer Exchange: Emerging ADCs and Real-World Management
Explore the latest insights on emerging antibody drug conjugates for HER2 breast cancer and real-world management strategies.
Published: 5/12/2025
Children Born to Mothers With Cardiometabolic Issues Before or During Pregnancy Face Increased Risk of Childhood, Adolescent Hypertension
Maternal cardiometabolic issues during pregnancy significantly elevate children's blood pressure, highlighting the need for preventive health measures.
Published: 5/12/2025
Patient-Centered Value is Essential Within Health Care Research
During a panel discussion, 3 experts highlighted ways health care professionals and researchers can help provide patient-centered care.
Published: 5/12/2025
Pharmacist Champion Role Improves Access to Resmetirom for MASH
A pharmacist champion enhances access to resmetirom for treating MASH, demonstrating the importance of coordinated specialty care in medication approval.
Published: 5/12/2025
New Walgreens Program Aims to Enable Pharmacy Technicians to Pursue PharmD Degrees
PharmStart empowers pharmacy technicians to pursue their education with tuition-free prerequisites, addressing barriers to entering pharmacy school.
Published: 5/12/2025
Study: Specialized Face Mask Accurately Detects Presence of CKD Using Chemicals in Patient’s Breath
In approximately 84% of cases, the mask was able to detect if patients had chronic kidney disease (CKD).
Published: 5/11/2025
Global Review Finds Gaps in Pneumococcal Vaccine Policies for High-Risk Children
The study found that only 38% of nations have risk-based pneumococcal vaccine policies.
Published: 5/10/2025
Specialty Pharmacy at a Crossroads, Say Attendees at Asembia’s AXS25 Summit
Specialty pharmacy experts and key opinion leaders gathered at Asembia’s AXS25 Summit and discussed critical insights in interviews with Pharmacy Times®.
Published: 5/9/2025
Tyk2 Inhibition Prevents Islet Inflammation and Delays Type 1 Diabetes Development in Mice
New research reveals a promising strategy to slow type 1 diabetes progression by targeting inflammation with an existing psoriasis drug.
Published: 5/9/2025
AUC 5 vs AUC 6: MUSC Study Highlights the Trade-offs in Neoadjuvant Breast Cancer Treatment
Lacy La Fever, PharmD, MS, discussed outcomes associated with different carboplatin AUC dosing strategies.
Published: 5/9/2025
FDA Approves Teal Wand, First At-Home Self-Collection Cervical Cancer Screening Device
The new at-home test aims to increase comfort and screening timeliness through a more accessible method.
Published: 5/9/2025
Live Zoster Vaccine May Reduce Risk of Cardiovascular Events by 23%, Study Finds
The most substantial reduction was achieved 2 to 3 years after vaccination with a sustained protective effect lasting up to 8 years.
Published: 5/9/2025
Considerations for the Use of Abemaciclib vs Ribociclib in Breast Cancer
Abemaciclib and ribociclib have various risks and benefits in treating early breast cancer, highlighting the importance of patient-provider communication.
Published: 5/9/2025
Study: RSV Vaccine Response in Lung Transplant Recipients
A recent study highlights the promising immune response and safety of the Arexvy vaccine in lung transplant recipients, crucial for preventing RSV infections.
Published: 5/9/2025
Study Finds Endometriosis May Be Linked to Traumatic Experiences
These findings demonstrate an association that is independent of the disease’s genetic predisposition.
Published: 5/9/2025
Plozasiran Shows Promise as Cholesterol-Lowering Treatment for Mixed Hyperlipidemia
Plozasiran shows promise in reducing cholesterol and triglyceride levels in patients with mixed hyperlipidemia and other harmful conditions, addressing significant cardiovascular risks.
Published: 5/9/2025
Obicetrapib Plus Ezetimibe Reduced LDL-C in Patients With or at Risk of Atherosclerotic Cardiovascular Disease
The fixed-dose combination yielded a 49% greater reduction in low density lipoprotein cholesterol (LDL-C) compared with placebo.
Published: 5/8/2025
FDA Approves Avutometinib/Defactinib for Adults With KRAS-Mutated Recurrent LGSOC
With the FDA approval, avutometinib/defactinib is now the first and only FDA-approved treatment for patients with recurrent low-grade serous ovarian cancer (LGSOC).
Published: 5/8/2025
Vitamin B Supplements Could Aid Glaucoma, Slowing Disease Progression
New research reveals that B vitamins and choline may slow glaucoma progression, offering hope for innovative treatments beyond traditional methods.
Published: 5/8/2025
Coalition of Pharmacy Organizations Urges Congress to Pass ECAPS Legislation
The Ensuring Community Access to Pharmacist Services (ECAPS) Act would enhance Medicare coverage for pharmacist services and ensure seniors can access essential care in underserved areas.
Published: 5/8/2025
B4DT Cognitive Behavioral Therapy Has Sustained Treatment Effects in Patients With Panic Disorders
These results build off prior studies which demonstrated effectiveness of Bergen 4-day treatment (B4DT) in patients with panic disorders.
Published: 5/8/2025
The Role of Physical Activity in Breast Cancer Risk Reduction and Survival
Pharmacists can educate patients on nonpharmacologic strategies that help improve survival outcomes.
Published: 5/8/2025
FDA Grants Fast Track Designation to IBS 2001, An Investigational Trispecific Antibody for Multiple Myeloma
The agent demonstrated promising tolerability and manageable safety.
Published: 5/8/2025
Neoadjuvant Trastuzumab Deruxtecan Improves Pathologic Complete Response in Patients With HER2+ Early Breast Cancer
Trastuzumab deruxtecan was safe and efficacious prior to treatment with paclitaxel, trastuzumab, and pertuzumab.
Published: 5/8/2025
INF108 Granted Orphan Drug Designation, Rare Pediatric Drug Designation for Preterm Infants With NEC
Necrotizing enterocolitis (NEC) is a life-threatening illness that is characterized by the inflammation of the intestinal lining, which can lead to intestinal perforation.
Published: 5/8/2025
GLP-1 Drugs Show Promise in Lowering Health Care Costs, Report Says
Adherence to GLP-1 receptor agonists showed a 59% drop in inpatient hospital costs.
Published: 5/7/2025
Low-Dose Chlorthalidone Granted FDA Approval for Treatment of Adults With Hypertension
The 12.5-mg dose tablet enhances hypertension treatment options and reduces adverse effects for patients.
Published: 5/7/2025
Ruxolitinib Discontinuation at Conditioning Does Not Increase GVHD Risk in Myelofibrosis
Patients with myelofibrosis who stopped ruxolitinib on the first day of conditioning did not show higher rates of acute graft-vs-host disease (GVHD).
Published: 5/7/2025
Study: Predictive CAD Model Outperforms Standard Practice in Estimating Individual Risk
The coronary artery disease (CAD) predictive model help health care professionals tailor personalized treatment methods for patients.
Published: 5/7/2025
IVIG Can Cause Kidney Function Decline, Thromboembolism in Patients With Dermatological Conditions
Intravenous immunoglobulin (IVIG) treatment for dermatologic conditions shows effectiveness but poses risks of kidney decline and thromboembolism, necessitating careful monitoring.
Published: 5/7/2025
Investigational CAR T-Cell Therapy BCB-276 Receives FDA Breakthrough Designation for Pediatric Patients With DIPG
The agent targets B7-H3, a commonly overexpressed protein in diffuse intrinsic pontine glioma (DIPG).
Published: 5/6/2025
Statins May Improve Survival in Patients With Chronic Lymphocytic Leukemia Receiving Ibrutinib
There was no significant increase in severe adverse events associated with statin use.
Published: 5/6/2025
Constraint-Induced Cognitive Therapy Found to Improve Multiple Long COVID Symptoms
A rehabilitation method commonly used in patients who experience a traumatic brain injury was found to improve symptoms of long COVID, including brain fog and measures of daily living.
Published: 5/6/2025
One Dose of the HPV Vaccine Is More Than 97% Effective at Preventing HPV Infection
One dose of the vaccine compared with 2 may help increase global HPV vaccine uptake.
Published: 5/6/2025
Transforming What Community Pharmacy Offers: Giant Food’s Cancer Screening Initiative
This screening method can help empower patients to better manage their health and seek additional care.
Published: 5/6/2025
Study Demonstrates Semaglutide Improves Liver Histologic Results in Patients With MASH
About 62.9% of patients with metabolic dysfunction–associated steatohepatitis (MASH) receiving semaglutide experienced resolution of steatohepatitis without worsening of fibrosis.
Published: 5/6/2025
Rite Aid Intends to File Second Bankruptcy, Raising Questions About Its Future
An insider expressed skepticism about the company’s future, indicating that Rite Aid may be looking to close up shop entirely.
Published: 5/5/2025
Novel HER2-low Therapies and Pharmacist-Led ADC Sequencing
This installment of our series on ADCs and HER2 breast cancer offers key insights about novel agents in clinical trials and management of ADC therapies.
Published: 5/5/2025
GPRC5D-Targeted CAR T-Cell Therapy Shows Promise After BCMA Treatment Failure
The salvage therapy led to an 80% overall response rate in patients with relapsed/refractory multiple myeloma.
Published: 5/5/2025
Preliminary Data Show Over One-Third of Patients With Psychiatric Diagnoses Visit ED After GLP-1 Initiation
A recent study reveals a significant number of patients with psychiatric histories experience emergency visits after starting glucagon-like peptide-1 (GLP-1) medications, raising safety concerns.
Published: 5/5/2025
Emerging Efforts to Expand Access to Psilocybin Therapy: A Critical Opportunity for Underserved Communities Facing Mental Health and Addiction Crises
As evidence grows for psilocybin-assisted therapy’s effectiveness in treating mental health and addiction, efforts are increasingly focused on ensuring equitable access—particularly for underserved communities disproportionately affected by systemic barriers and public health crises.
Published: 5/5/2025
INX-315 Granted FDA Fast Track Designation for Platinum-Resistant/Refractory Ovarian Cancer
Currently, the treatment is undergoing evaluation in a 3-part clinical trial to determine its safety, efficacy, and pharmacokinetics in patients with recurrent advanced/metastatic cancers.
Published: 5/5/2025
Trial Data Show Long-Term Safety, Efficacy of Xanomeline/Trospium for Schizophrenia
New trials reveal xanomeline and trospium effectively alleviate schizophrenia symptoms, offering a novel treatment option with minimal adverse effects.
Published: 5/4/2025
Research Identifies Need for Increased Evidence-Based Use of Buspirone
New research highlights the need for evidence-based buspirone use in psychiatric settings, revealing high off-label prescriptions and suboptimal dosing practices.
Published: 5/3/2025
Ferritin-NP-preS1 Therapeutic Vaccine With siRNA Shows Durable Effects in CHB
In chronic hepatitis B (CHB) mouse models, the ferritin nanoparticle-preS1 (ferritin-NP-preS1) with small interfering RNA (siRNA) showed 100% and sustained serum HBsAg over an approximate 11-month period.
Published: 5/3/2025
Single Dose of Xofluza Reduces Odds of Untreated Household Members Contracting Influenza
Reductions of approximately 32% were observed during the study.
Published: 5/3/2025
Community Oncology Faces Crossroads Under the Inflation Reduction Act
Despite benefits for reducing drug costs, community oncology practices face the unintended consequences of the IRA.
Published: 5/2/2025
Measles Update: The Public’s View and How Pharmacists Can Combat Misinformation
Pharmacists are on the front lines of the outbreak, making them well-positioned to educate and counsel patients with vaccine hesitancy.
Published: 5/2/2025
Alzheimer Disease Prevalence Reaches Record High, Surpassing 7.2 Million Cases
A survey showed that 92% of Americans are open to treatments that would slow disease progression.
Published: 5/2/2025
MTM Pharmacists Improve Patient Outcomes in Type 2 Diabetes
Research shows comprehensive medication reviews enhance medication adherence in those with type 2 diabetes, highlighting pharmacists' vital role in improving health outcomes.
Published: 5/2/2025
Study Findings Suggest Addressing Maternal Anemia Could Reduce Risk of Congenital Heart Disease in Infants
Research reveals a significant link between maternal anemia and increased risk of congenital heart defects in infants, highlighting the need for effective prevention strategies.
Published: 5/2/2025
Results From ADVANCE-CIDP Trial Show IVIG 10% Effectively Treats CIDP Relapse
New trial results highlight intravenous immunoglobulin (IVIG) 10% as an effective rescue treatment for relapsing chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), enhancing patient care and pharmacist involvement in management.
Published: 5/2/2025
Expert: Dual Interaction is Present Between Epilepsy and Menopause
Paula E. Voinescu, PhD, MD, emphasized the need for additional research in this area, noting it is both “surprising and upsetting.”
Published: 5/2/2025
Blocking IL-6 Pathway May Prevent Progression of Skin Ulcers in Calciphylaxis CKD-Related Disease
The condition, which is common in patients with chronic kidney disease (CKD), is characterized by skin lesions and currently has no curative treatment.
Published: 5/2/2025
Engineered Extracellular Vesicles May Be a New Approach to Treating MASH
In the treatment of metabolic dysfunction-associated steatohepatitis (MASH), engineered extracellular vesicles helped mitigate disease progression and did not compromise bone density.
Published: 5/2/2025
The Problem With PBMs: Challenges for Community Oncology Pharmacies
Pharmacy Benefit Manager (PBMs) practices disrupt care, cut reimbursements, and steer patients from provider-managed treatment.
Published: 5/1/2025
AACR 2025: Liposomal Annamycin May Enhance Chemotherapy Efficacy Across Hematologic and Solid Tumors
Liposomal annamycin demonstrates broad synergistic activity with multiple FDA-approved chemotherapies across hematologic and solid tumors in preclinical models, offering a promising and safer combination strategy for resistant and high-risk cancers.
Published: 5/1/2025
FDA Approves Atzumi, Nasal Powder Formulation of DHE, for Acute Treatment of Migraine
In clinical trials, the dihydroergotamine (DHE) nasal powder had favorable safety profiles and rapid pain relief in patients with migraine with or without aura.
Published: 5/1/2025
Campaign Aims to Raise Awareness About Updated CDC Recommendations for Pneumococcal Pneumonia
The American Lung Association is raising awareness about updated pneumococcal vaccine guidelines, emphasizing prevention and patient education for at-risk populations.
Published: 5/1/2025
Adult RSV-ARI Linked to Higher Death Risk and Health Care Costs
New research shows adults with RSV-ARI may face significantly higher mortality and health complications, emphasizing the need for targeted vaccination strategies.
Published: 5/1/2025
Neoadjuvant Pembrolizumab May Redefine Standard of Care in Locally Advanced Head and Neck Cancer
Douglas Adkins, MD shares key data and findings from the phase 3 KEYNOTE-689 study.
Published: 5/1/2025
Updates in the Management of Transplant-Ineligible Patients With Multiple Myeloma
Explore the latest advancements in treating transplant-ineligible multiple myeloma, highlighting new therapies and clinical trial outcomes for improved patient care.
Published: 5/1/2025
Researchers Call for Better Risk Stratification Methods in Older Individuals With Hypercholesterolemia
Experts provide guidance on managing high cholesterol in adults older than 75 years, emphasizing personalized care and shared decision-making for optimal outcomes.
Published: 5/1/2025
Asembia AXS25: Patients Desire Education and Thorough Resources to Better Navigate Health Plans
A panel of health care experts at Asembia’s AXS25 Summit discussed the critical need for improved patient education and resources to help navigate complex financial assistance programs and health care plans.
Published: 5/1/2025
Asembia AXS25: Transformative Challenges for Pharmacists, Providers Ahead as IRA Drug Negotiations Go Into Effect
The Inflation Reduction Act of 2022 (IRA) drug negotiation provisions will fundamentally reshape Medicare drug pricing, provider reimbursement, and health care delivery dynamics across Part B and commercial markets, according to panelists at Asembia’s AXS25 Summit.
Published: 5/1/2025
NCCN Flash Update: Changes to NCCN Guidelines for Breast Cancer Version 4.2025
Updates on April 30, 2025, introduce changes to treatment regimens, sequencing flexibility, febrile neutropenia risk assessments, and drug-specific safety and supportive care guidance.
Published: 4/30/2025
From Mutation to Management: Risk Stratification, the Power of JAK Inhibition, and the Pharmacist’s Role
Explore the role of JAK inhibitors in myelofibrosis treatment, focusing on optimizing dosages and managing adverse effects for better patient outcomes.
Published: 4/30/2025
AACR 2025: Continuous Subcutaneous Lenalidomide Shows Promise in Reducing Toxicity in R/R Multiple Myeloma
A phase 1b study demonstrated that continuous subcutaneous infusion of low-dose lenalidomide in patients with relapsed or refractory (R/R) multiple myeloma achieved promising efficacy with significantly reduced hematologic toxicity compared to conventional oral dosing.
Published: 4/30/2025
Analysis Finds Children Have Elevated Kidney, Heart Risks Years After COVID-19 Infection
Research reveals that children face significant long-term health risks, including kidney, gastrointestinal, and cardiovascular issues, after COVID-19 infection.
Published: 4/30/2025
Biomarker Testing Transforms NSCLC Care, But Gaps Persist in Community Settings
Biomarker testing transforms non-small cell lung cancer treatment, enhancing outcomes through targeted therapies and next-generation sequencing for better patient care.
Published: 4/30/2025
FDA Approves Nipocalimab-Aahu to Treat Patients With Generalized Myasthenia Gravis
Nipocalimab the first and only FcRn blocker approved in anti-acetylcholine receptor– or anti-muscle-specific kinase adults and children with generalized myasthenia gravis.
Published: 4/30/2025
AACR 2025: AI-Driven Biomarker Model Can Accurately Detect Cancer Cachexia
Artificial intelligence (AI) models enhance cancer cachexia detection, improving accuracy in predicting muscle atrophy and patient outcomes through advanced biomarker analysis.
Published: 4/30/2025
Asembia AXS25: Cell and Gene Therapies Enter New Phase of Growth in Specialty Pharmacy
As the cell and gene therapy pipeline expands, experts at Asembia’s AXS25 Summit emphasized the need for error-proof logistics, value-based access strategies, and coordinated reimbursement models.
Published: 4/30/2025
Asembia AXS25: Pharmacists Continue to Expand Clinical, Collaborative Role in Health Care
At Asembia’s AXS25 Summit, Shea Hudson spotlighted how pharmacists are transforming into essential clinical partners through advanced technology, patient advocacy, and value-based collaboration.
Published: 4/29/2025
Targeted Therapies Transform CLL Care: Inside the Era of BTK and BCL2 Inhibitors
Explore the latest advancements in chronic lymphocytic leukemia treatment, focusing on BTK and BCL2 inhibitors, monoclonal antibodies, and patient management strategies.
Published: 4/29/2025
AACR 2025: Orally Bioavailable RIPTAC Therapeutic Targets p53-Y220C Mutant Tumors for Selective Cancer Cell Death
A novel orally bioavailable RIPTAC therapeutic targeting the p53-Y220C mutation demonstrates selective cancer cell killing by inducing proximity between mutant p53 and an essential protein, offering a promising new strategy for treating historically untreatable tumors.
Published: 4/29/2025
Insights from a Pharmacy Times Peer Exchange: ADC Drug Design and HER2 Ultra-Low Breast Cancer Indiciations
Pharmacists discuss how drug design impacts drug efficacy and indications for HER2-low and -ultra-low breast cancer.
Published: 4/29/2025
Hyperglycemia in HR+ Breast Cancer: Prevention and Management Strategies for Oncology Pharmacists
Hyperglycemia is a common and significant adverse effect of PI3K and AKT inhibitors in hormone receptor-positive (HR+) breast cancer.
Published: 4/29/2025
FDA Approves Prademagene Zamikeracel, First and Only Cell-Based Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa
FDA approves Zevaskyn, the first gene therapy for RDEB, offering hope for effective wound healing and pain relief in patients.
Published: 4/29/2025
FDA Approves Upadacitinib for Adult Patients With Giant Cell Arteritis
A 15-mg dose with a corticosteroid taper regimen was superior to placebo in sustained remission from week 12 to 52.
Published: 4/29/2025
AACR 2025: Tailored Treatment Guided by Combined Tissue and Liquid Biopsies May Improve Outcomes in Advanced Solid Tumors
The phase 2 ROME trial demonstrated that combining tissue and liquid biopsies to guide tailored therapy in advanced solid tumors significantly improves survival outcomes compared to standard of care or single-biopsy approaches, highlighting the value of dual profiling in precision oncology.
Published: 4/29/2025
AACR 2025: Breast Cancer Mortality Declines in Younger Women, But Survival Gaps Remain
Study shows a significant decline in breast cancer mortality across multiple subtypes.
Published: 4/29/2025
Asembia AXS25: Balancing Innovation With Affordability Crucial for Sustainable Rare Disease Economic Models
Experts at Asembia’s AXS25 Summit discussed the economics of specialty pharmacy for rare diseases, addressing high treatment costs and strategies for balancing innovation.
Published: 4/29/2025
Asembia AXS25: Community Pharmacists Can Optimize Specialty Pharmacy Care
Integrating community pharmacists into specialty pharmacy care can enhance patient access, address physician shortages, and expand pharmacists' roles in delivering high-quality clinical services, according to experts at Asembia’s AXS25 Summit.
Published: 4/29/2025
AACR 2025: Investigational LUT014 Gel Improves Acneiform Rash in Patients With Metastatic Colorectal Cancer
Acneiform rash is a common adverse effect of EGFR-targeting therapies.
Published: 4/28/2025
AACR 2025: High Response Rates With Dostarlimab Suggest New Standard for dMMR Treatment
Dostarlimab in the neoadjuvant setting yielded a 100% clinical complete response in patients with rectal cancer.
Published: 4/28/2025
AACR 2025: ctDNA-Guided Adjuvant PD-1 Blockade Shows Promise for Patients With Resected dMMR Solid Tumors
A phase 2 trial showed that using ctDNA to guide adjuvant pembrolizumab therapy after surgery effectively cleared minimal residual disease and reduced recurrence in patients with resected mismatch repair-deficient (dMMR) solid tumors.
Published: 4/28/2025
AACR 2025: ctDNA Testing Identifies Recurrence Risk Within Weeks of Surgery in Colorectal Cancer
The study found that 4 weeks was the ideal time point to test for cTDNA.
Published: 4/28/2025
Moderate Alcohol Consumption Could Help Prevent Rheumatoid Arthritis
Patients Should Also Have a Diet Rich in Fruits, Oily Fish, and Cereals
Published: 4/28/2025
AACR 2025: Bridging the Diagnostic Gap in Pediatric Sarcomas With AI
AI may help to accurately classify pediatric sarcoma subtypes using digitized pathology images, potentially improving diagnosis and treatment accessibility across diverse health care settings.
Published: 4/28/2025
AACR 2025: Off-the-Shelf CAR NK Therapy SENTI-202 Shows Potential for Complete Remission in R/R AML
Interim results from the phase 1 SENTI-202-101 trial show that SENTI-202, a logic-gated, off-the-shelf chimeric antigen receptor natural killer (CAR NK) cell therapy, achieved complete remission in 4 patients with relapsed or refractory (R/R) acute myeloid leukemia (AML).
Published: 4/27/2025
AACR 2025: Off-the-Shelf Machine Learning Models May Bridge Diagnostic Gaps in Global Skin Cancer Care
Pretrained foundation machine learning models significantly improved the accuracy of diagnosing non-melanoma skin cancer from digital pathology images and may offer a practical, resource-efficient solution for cancer diagnosis in underserved settings.
Published: 4/27/2025
AACR 2025: Perioperative Pembrolizumab Enhances Survival and Response in Locally Advanced Head and Neck Cancer
The phase 3 KEYNOTE-689 trial demonstrated that adding perioperative pembrolizumab to standard care significantly improves event-free survival and major pathological response in patients with resectable, locally advanced head and neck squamous cell carcinoma.
Published: 4/27/2025
Hydroxyurea Produces Long-Term Clinical Benefits in Pediatrics With Sickle Cell Anemia
New research confirms hydroxyurea's long-term effectiveness in reducing hospital visits for children with sickle cell anemia, supporting its use as standard treatment.
Published: 4/26/2025
NCCN Flash Update: Changes to Colon Cancer Guidelines, Version 3.2025
NCCN updates colon cancer guidelines, emphasizing testing for DPYD gene variants before initiating fluoropyrimidine-based chemotherapy.
Published: 4/25/2025
Asembia's AXS25 Summit: Must-See Sessions, Expert Interviews as Specialty Pharmacy Gathers
The Asembia AXS25 Summit will include the latest news and expert insights in the specialty pharmacy field.
Published: 4/25/2025
Research Shows Diabetes Rewires the Brain, Mimicking Early Alzheimer Disease
New research reveals how high blood sugar from type 2 diabetes alters brain function, mimicking early Alzheimer symptoms and impacting memory.
Published: 4/25/2025
Survey Respondents Report Dietary Modifications Help Relieve Endometriosis-Related Pain
Although participants noted symptom relief, there was not a dietary modification uniquely perceived as beneficial.
Published: 4/25/2025
Many Patients With Elevated LDL Cholesterol Are Not Prescribed Lipid-Lowering Medication
A significant number of patients with high low-density lipoprotein (LDL) cholesterol lack prescribed lipid-lowering medications, highlighting gaps in treatment and care practices.
Published: 4/25/2025
JAK1 Inhibitor NS-229 Granted FDA Orphan Drug Designation to Treat Allergic Autoimmune Condition
NS-229 is a Janus kinase 1 (JAK1) inhibitor being investigated in eosinophilic granulomatosis with polyangiitis, a rare autoimmune condition that can cause severe allergic and asthmatic symptoms through inflammation of nerve cells.
Published: 4/25/2025
Pyrotinib-Based Therapy May Improve Survival in Patients With HER2+ Breast Cancer and Liver Metastases
Pyrotinib is a tyrosine kinase inhibitor that is independently developed in China.
Published: 4/25/2025
FDA Approves Penpulimab-Kcqx for Indications in Nonkeratinizing Nasopharyngeal Carcinoma
The treatment received indications as a monotherapy and in combination regimen with carboplatin or cisplatin and gemcitabine.
Published: 4/24/2025
RSV and Aging: Understanding Increased Vulnerability
New research reveals how aging weakens immune responses to RSV in older adults, increasing severity and hospitalization risks.
Published: 4/24/2025
Intravenous Immunoglobulin Does Not Improve Clinical Outcomes Compared With Tocilizumab in Severe COVID-19
A study reveals IVIG treatment shows no significant benefits over tocilizumab for severe COVID-19, highlighting higher adverse events and costs.
Published: 4/24/2025
Hormonal Contraceptive Initiation Associated With Increased Risk of Depression Postpartum in First-Time Mothers
Because mothers are already at risk of depression postpartum, health care professionals must properly counsel mothers on hormonal contraceptives.
Published: 4/24/2025
Sacituzumab Govitecan-hziy Plus Pembrolizumab Improves PFS in Patients With Metastatic Triple-Negative Breast Cancer
The combination yielded superior progression-free (PFS) survival compared with standard of care.
Published: 4/24/2025
Investigators Anticipate Hydronidone Will Be Beneficial for Liver Fibrosis in CHB
The investigators’ hypothesis is supported by phase 2 trial data in which hydronidone resulted in significant reversal of liver fibrosis in patients with chronic hepatitis B (CHB).
Published: 4/24/2025
Type 5 Collagen Linked to Kidney Scarring, Offers New Treatment Hope for Patients With CKD
This component of scar tissue may have a role in kidney fibrosis for slowing disease progression and improving outcomes for patients with chronic kidney disease (CKD).
Published: 4/24/2025
Ribociclib With Nonsteroidal Aromatase Inhibitor Does Not Reduce Quality of Life in HR+/HER2- Early Breast Cancer
Patients in both arms achieved statistically significant rates of compliance up to 97%.
Published: 4/24/2025
Study: Mineral and Vitamin Levels in Pregnancy Linked to Midlife Blood Pressure
Research reveals that higher levels of vitamin B12, copper, and manganese during pregnancy lower midlife blood pressure and hypertension risk.
Published: 4/23/2025
Study Links PAK5 to Poor Outcomes and Drug Resistance in HER2-Positive Breast Cancer
PAK5 is a protein that drives resistance to trastuzumab emtansine in patients with HER2+ breast cancer.
Published: 4/23/2025
Full COVID-19 mRNA Vaccination Course Induces Long-Term Antibody, Memory B-Cell Response
New research highlights the long-lasting effectiveness of mRNA COVID-19 vaccines, showing sustained B-cell and antibody responses in health care workers over 3 years.
Published: 4/23/2025
NCCN Flash Update: Guideline Update for Esophageal and Esophagogastric Junction Cancers in Version 3.2025
The Version 3.2025 update adds tislelizumab-based regimens as preferred first-line treatments and introduces new dosing schedules for PD-L1–positive esophageal squamous cell carcinoma.
Published: 4/23/2025
Study: Antibiotic Allergy Delabeling Is Feasible and Safe With Few Adverse Events
The smartphone application-led delabeling also did not delay surgeries or procedures in the evaluated clinics.
Published: 4/23/2025
Optum Rx Reduces Over 10% of Overall Pharmacy Prior Authorizations, Impacting Dozens of Drugs
The announcement could ease the burden of prior authorizations on patients, which can cause unnecessary delays for patients receiving prescriptions and serious complications.
Published: 4/22/2025
Thrombosis May Increase Risk of Cardiovascular Disease, Secondary Cancers in Myeloproliferative Neoplasms
Thrombosis occurs in approximately 20% of myeloproliferative neoplasms.
Published: 4/22/2025
PBGENE-HBV Granted FDA Fast Track Designation for Chronic Hepatitis B
The in vivo gene editing program is designed to eliminate cccDNA and inactive integrated hepatitis B DNA.
Published: 4/22/2025
Amid the Ongoing Measles Outbreak, Cases of Whooping Cough Are on the Rise
Experts attribute the increase of pertussis cases to declining DTaP vaccination rates.
Published: 4/22/2025
Surveillance, Targeted Interventions Critical to Combat Variable Nature of Invasive Pneumococcal Disease
Invasive pneumococcal disease trends have fluctuated greatly over the past 2 decades, with older adults remaining at the center of disease burden.
Published: 4/22/2025
Oral Colchicine Receives FDA Orphan Drug Designation for Pericarditis
An oral dose of 0.6 mg per 5 mL of colchicine could aid individuals who have trouble with swallowing pills.
Published: 4/21/2025
Trastuzumab Deruxtecan Plus Pertuzumab Improves Progression-Free Survival in Patients With HER2+ Metastatic Breast Cancer
The meaningful results were reported in the DESTINY-Breast09 trial.
Published: 4/21/2025
Analysis Reveals Polypharmacy Challenges in Patients With Cancer
Although most health care professionals agree that patients do not need prescriptions for chronic diseases during end-of-life care, patients often receive them anyway.
Published: 4/21/2025
FDA Grants Breakthrough Therapy Designation to AMT-130 to Treat Huntington Disease
The breakthrough designation is supported by clinical data from ongoing phase 1/2 trials.
Published: 4/21/2025
FAERS Analysis Provides New Insights on Cefiderocol Adverse Effects
In contrast to the study findings, the prescribing information for cefiderocol lists different common adverse effects.
Published: 4/21/2025
Antibiotic Use in Infants and Young Children May Increase Risk of Allergic Conditions
Children who received antibiotics between birth and 2 years of age were more likely to develop food allergies, allergic rhinitis, and asthma, but not neurodevelopmental conditions.
Published: 4/21/2025
Migraine With Aura Plays Most Prominent Role in Women With Young-Onset CIS
Traditional risk factors were more contributable to cryptogenic ischemic stroke (CIS) without patent foramen ovale (PFO), whereas nontraditional ones were more critical for CIS with PFO.
Published: 4/21/2025
AAN 2025: Pharmacists Play Critical Role in Monitoring, Managing Lecanemab Therapy
Philip Kuball, MD, neurology resident at NYU Langone Health, highlights the integral role of pharmacists in monitoring patient eligibility, managing dosing schedules, and ensuring safe medication interactions for lecanemab treatment in Alzheimer disease.
Published: 4/20/2025
PCV10 Elicits Durable Immune Response in T2D, Though Response Remains Inferior to Nondiabetics
These results suggest that individuals who are immunocompromised with type 2 diabetes (T2D) may need multiple doses of a pneumococcal conjugate vaccine (PCV) to sustain their protection.
Published: 4/19/2025
AAN 2025: Insights on Pediatric Multiple Sclerosis Treatment and Management
Lauren B. Krupp, MD, FAAN, provides comprehensive guidance on treating pediatric multiple sclerosis, emphasizing early intervention, high-efficacy therapies, and holistic family support.
Published: 4/19/2025
Measles Cases Climb to 800 in United States as Outbreak Spreads Across Borders
Cases have been confirmed in Mexico and Canada.
Published: 4/18/2025
Momelotinib Shows Strong Efficacy in JAK-Exposed Myelofibrosis Patients
Real-world data support momelotinib as an effective and well-tolerated treatment for myelofibrosis-related anemia.
Published: 4/18/2025
Study: Vision Impairment Signals Linked to Semaglutide Use
The findings suggest a potentially elevated risk of vision impairment with semaglutide (Ozempic, Wegovy; Novo Nordisk) use compared with other weight loss and diabetes medications.
Published: 4/18/2025
FDA Approves Dupilumab, Marking First Targeted Therapy in a Decade for Chronic Spontaneous Urticaria
Multiple phase 3 clinical trials demonstrated dupilumab’s (Dupixent; Regeneron, Sanofi) effectiveness in reducing hives and itch in patients with chronic spontaneous urticaria compared with placebo.
Published: 4/18/2025
Real-World Data Show Improved Survival With Sacituzumab Govitecan as First-Line ADC in HER2-Low Breast Cancer
Sequencing of antibody-drug conjugates (ADCs) in HER2-mutated breast cancer is crucial for optimizing treatment outcomes.
Published: 4/18/2025
Alternative Methods in Identifying Allergic, Nonallergic Type 2 Asthma Endotypes Are Necessary
Authors of a review published in The Journal of Allergy and Clinical Immunology emphasized that blood eosinophil count and fractional exhaled nitric oxide cannot be relied on.
Published: 4/18/2025
Lepodisiran Reduces Lipoprotein(a) by Nearly 94% in Adults With Elevated Levels of Lp(a)
Lepodisiran, a small interfering RNA, demonstrated cholesterol-lowering effects at 16-mg, 96-mg, and 400-mg doses, with the highest dose being the most effective.
Published: 4/18/2025
ACIP Votes to Expand Lowering RSV Vaccine Recommendation Age to 50 for High-Risk Adults
The recommendations are not considered to be final until they are published in the Morbidity and Mortality Weekly Report.
Published: 4/17/2025
Zanubrutinib Plus Venetoclax and Obinutuzumab Yields Deep Remissions in Patients With Chronic Lymphocytic Leukemia
Undetectable minimal residual disease rates improved with ongoing therapy.
Published: 4/17/2025
Research Finds Discharge Pharmacy Programs Can Reduce Hospital Readmission Rates
The implementation of hospital-based discharge pharmacy services presents a savvy strategy to improve clinical outcomes for patients while cutting excess spending.
Published: 4/17/2025
High-Dose Aspirin With IVIG Does Not Meaningfully Reduce Coronary Artery Lesions in Children With Kawasaki Disease
Although the rate of coronary artery lesions decreased across both cohorts of this trial of children with Kawasaki disease, there were no differences in lesion reduction between those receiving intravenous immunoglobulin (IVIG) alone and those receiving IVIG with aspirin.
Published: 4/17/2025
Tucatinib and Trastuzumab Demonstrates Safety, Efficacy in HER2-Mutated Breast Cancer
The data showed improvements in overall response rates, progression-free survival, and duration of response.
Published: 4/17/2025
Inhaled siRNA-Based MIR 19 Reduces Progression to Severe Disease in Outpatients With Mild COVID-19
With a more direct mechanism of action against viral replication compared with standard treatments, the small interfering RNA (siRNA)-based MIR 19 treatment could revolutionize outpatient COVID-19 treatment.
Published: 4/16/2025
COVID-19 Associated With Higher Risk of Postacute Kidney Outcomes in Pediatric Patients With Preexisting CKD
At 28 to 179 days, COVID-19 infection in patients with preexisting chronic kidney disease (CKD) was associated with an increased risk of composite kidney events.
Published: 4/16/2025
Five Domains, One Outcome: How Social Factors Shape Cancer Survival
Iman Ahmed, PharmD, BCOP, shared key insights about how social determinants of health impact treatment access and outcomes for patients with leukemia.
Published: 4/16/2025
Essential Immune Cells in Intestine Cause Gut Inflammation, Allergic Responses to Foods When Absent
In mouse models, researchers identified that immune cells within the intestine may prevent unwarranted attacks against harmless food allergens.
Published: 4/16/2025
Allogeneic T Regulatory Cell Product CK0801 Granted FDA Orphan Drug Designation for Aplastic Anemia Treatment
Some patients with aplastic anemia treated with CK0801 achieved durable transfusion independence lasting over 3 years.
Published: 4/16/2025
Innovations in Hematology and Oncology Explored at HOPA Annual Conference
Zahra Mahmoudjafari, PharmD, BCOP, FHOPA, shared insight from the HOPA Annual Meeting 2025.
Published: 4/16/2025
Diazepam Nasal Spray Receives FDA Approval for Seizure Clusters in Individuals 2 Years and Older
The safety profile of diazepam nasal spray among pediatric patients was consistent with older patients, supporting its use in this age group.
Published: 4/16/2025
Reduced POMP Dosing Shows Comparable Efficacy in ALL Maintenance
Arefa Bacchus, PharmD, shared key insights about the use of POMP therapy in patients with acute lymphoblastic leukemia (ALL).
Published: 4/16/2025
Pharmacists Help Guide Regimen Choice Between Flu/Cy/TBI and Flu/Bu2
Monica Sawiris, PharmD, said there were noticeable differences in toxicities between each regimen.
Published: 4/15/2025
FDA Grants Interchangeable Designation to Yuflyma for Humira
The designation was supported based on data from the randomized, double-blind, active-controlled phase 3 interchangeability study.
Published: 4/15/2025
Little Association Found Between Pneumococcal Vaccination and Severe COVID-19 Outcomes in Older Adults
Patients who received a pneumococcal 13-valent conjugate vaccination had slightly lower incidence of severe COVID-19 outcomes, but the directions of these associations were mixed.
Published: 4/15/2025
From Inpatient to Outpatient: A Pharmacy-Led Evolution in Transplant Care
Erin Lexner, PharmD, BCPS, discussed her team’s experience transitioning to outpatient BEAM from inpatient CBV.
Published: 4/15/2025
More Options, More Questions: How Pharmacists Are Managing EGFR-Positive Non-Small Cell Lung Cancer
Shelby Quinn, PharmD, BCOP shares insights about treatment using osimertinib in early lines.
Published: 4/15/2025
Study: Hepatic PTPRD Expression Impaired in Etiologies of Chronic Liver Disease Associated With Metabolic Disease
Strategies for rescuing PTPRD function in diseased livers could provide potential therapeutic options, according to the study authors.
Published: 4/15/2025
Imlunestrant Plus Abemaciclib Improves Progression-Free Survival in Patients With ER+, HER2- Advanced Breast Cancer
Imlunestrant is an investigational, brain-penetrating, oral selective degrader of estrogen receptor.
Published: 4/14/2025
FDA Approves Vyvgart Hytrulo Prefilled Syringe With Self-Injection for Generalized Myasthenia Gravis, CIDP
The new indication expands administration methods for the combination of efgartigimod alfa and hyaluronidase-qvfc, which are already approved for the treatment of some immune-related conditions.
Published: 4/14/2025
Study Finds Adverse Pregnancy Outcomes Mediate Association With CVD Risk, Prepregnancy Obesity in Midlife
Promoting weight management prior to pregnancy and in early life may yield stronger cardiovascular and maternal health.
Published: 4/14/2025
Antibody Drug Conjugates and Breast Cancer: Insights from a Pharmacy Times Peer Exchange
Pharmacists share key insights about the use of ADCs for treatment of breast cancer.
Published: 4/14/2025
Understand the Use of Panzyga for Immune-Related Disorders
Pharmacists should educate patients about their treatment regimen and potential adverse effects.
Published: 4/12/2025
Pharmacists Play Key Role in Managing Toxicity During Neoadjuvant Therapy for Melanoma
Christine Barrett, PharmD, BCOP, shares insights, challenges, and advice for oncology pharmacists navigating neoadjuvant therapy.
Published: 4/12/2025
Expanding Roles for Pharmacy Technicians in Ambulatory Oncology
Jessica Davis, PharmD, BCOP highlights the role of pharmacy technicians in ambulatory oncology clinic settings.
Published: 4/12/2025
Lower Vitamin K Levels Associated With Impaired Learning and Memory in Mice
Rather than turning to vitamin K supplements, individuals should incorporate more vegetables into their diets.
Published: 4/11/2025
Study Finds Reduction in RSV Hospitalizations Among Vaccinated Older Adults in England
The findings suggest a positive impact of RSV vaccination on RSV-associated hospital admission, emphasizing the importance of protection in this population.
Published: 4/11/2025
FDA Approves Nivolumab With Ipilimumab for First-Line Treatment of Adult Patients With HCC
Patients with unresectable or metastatic hepatocellular carcinoma (HCC) receiving this regimen had favorable median overall survival (23.7 months) compared with standard of care (20.6 months).
Published: 4/11/2025
Nipocalimab Sustains Disease Control Over 84 Weeks in Patients With gMG
Nipocalimab with standard of care helped patients with generalized myasthenia gravis (gMG) maintain improvements in daily living and quantitative scores compared with placebo.
Published: 4/11/2025
PBM Reform Takes Off in 2025
Meaningful reform was challenging in 2024, but this year could turn the tide.
Published: 4/11/2025
Study Finds 4-Factor Prothrombin Complex Concentrate Offers Superior Hemostatic Efficacy to Frozen Plasma During Cardiac Surgery
These data provide compelling evidence to revise existing transfusion protocols, recommending 4F-PCC as the preferred treatment for hemostatic management in cardiac surgery.
Published: 4/11/2025
FDA Approves Bevacizumab Biosimilar for Various Cancer Types
This approval marks bevacizumab-nwgd as the sixth reference product to bevacizumab (Avastin).
Published: 4/11/2025
AZD0780, Novel Oral PCSK9 Inhibitor, Demonstrates Major LDL Cholesterol Reductions
When used in combination with background statin therapy, AZD0780 resulted in major reductions in low-density lipoprotein cholesterol (LDL-C) and achievements of guideline-recommended LDL-C goals.
Published: 4/11/2025
HOPA 2025: Insights Into Post-Transplant Cyclophosphamide Use for Graft-Versus-Host Disease Prevention
Lauren Dietz, PharmD, highlighted the role of oncology pharmacists in guiding prophylaxis decisions to optimize transplant outcomes.
Published: 4/11/2025
The Evolving Pharmacist Role in HER2-Negative Adjuvant Breast Cancer Therapy
Julia Ziegengeist, PharmD, BCOP offers insights for pharmacists navigating adjuvant and neoadjuvant treatment of breast cancer.
Published: 4/11/2025
Insights From HOPA 2025: Pharmacists Discuss CAR-T Safety at a Comprehensive Cancer Center
Amir Ali, PharmD, BCOP, and Allison Hsieh, PharmD share insights from their presentation about cytokine release syndrome, ICANS, and CAR T-cell therapy.
Published: 4/10/2025
FDA Approves Larotrectinib for Adult and Pediatric Patients With NTRK Gene Fusion-Positive Solid Tumors
The approval is for those with metastatic disease or in whom surgical resection is likely to result in severe morbidity, have no satisfactory alternative treatments, or have progressed following treatment.
Published: 4/10/2025
For Optimal Bioavailability, Administer Dronedarone With a Complete Meal
Bioavailability of dronedarone is markedly increased when administered with food. To maximize absorption, patients should take dronedarone with a complete meal (ideally >500 calories).
Published: 4/10/2025
Study Reveals Impact on Utilization and Cost of Point-of-Sale Diagnosis Verification of GLP-1s
Automated diagnosis verification offers a promising alternative for managing the use of GLP-1 medications.
Published: 4/10/2025
HOPA Fellow Reflects on Mentorship, Leadership, and the Future of Oncology Pharmacy
Alexandra Wolff, PharmD, BCOP, FHOPA, was awarded a fellow of HOPA at the 2025 annual meeting.
Published: 4/10/2025
FDA Clears Dexcom G7 15 Day, Marking the Longest-Lasting CGM System
Data show that the system is also the most accurate continuous glucose monitor (CGM).
Published: 4/10/2025
Study Finds Negative Correlation Between NCC, pNCC in Urinary Extracellular Vesicles of Patients With CKD
In patients with CKD, there were negative associations between the sodium cotransporter (NCC) and its phosphorylation (pNCC) in urinary extracellular vesicles (uEVs), but further research is needed to confirm these findings in a larger cohort.
Published: 4/10/2025
Study Finds Low Prevalence of HDV Antibody Positivity in Patients With Chronic HBV Infection
The prevalence of hepatitis D virus (HDV) antibody positivity was about 0.24% in patients with chronic hepatitis B virus (HBV).
Published: 4/10/2025
Pharmacists Face Key Knowledge Barriers to Ensuring Effective Pneumococcal Vaccination
In a survey among community pharmacists in South Carolina, many pharmacists were unable to correctly identify proper pneumococcal vaccination guideline, raising concerns.
Published: 4/10/2025
Combination Therapies and Resistance-Based Approaches Reshape EGFR Care
Mya Tran, PharmD, BCOP, offers insights for navigating the complex treatment landscape for non-small cell lung cancer.
Published: 4/10/2025
From Diagnosis to Therapy: Pharmacists Can Help Close the Gap in Colorectal Cancer Treatment
Michael Arnold, PharmD, discussed the role of oncology pharmacists in enhancing biomarker testing for patients with metastatic colorectal cancer.
Published: 4/9/2025
AAN 2025: Precision Medicine and Pharmacogenomics in Neurological Care
The future holds the promise of earlier diagnosis, more targeted therapies, and personalized neurological care, said speaker William D. Freeman, MD, FAAN.
Published: 4/9/2025
AAN 2025: Pridopidine Shows Sustained Benefits on Progression, Cognition, and Motor Function in Patients With HD
Huntington disease (HD) has no curative treatments, therefore, there is a great need for therapies that can reduce or slow the progression of symptoms.
Published: 4/9/2025
Financial Incentives for COVID-19 Vaccination May Have Adverse Spillover Effects on Booster Uptake
Monetary incentives to receive a COVID-19 vaccine at a public vaccination event may have inadvertently turned away others from receiving a booster, emphasizing the importance of recognizing spillover in trials addressing vaccine hesitancy.
Published: 4/9/2025
Bortezomib Off-Week Regimen Shows Promise for Reducing Toxicity in Multiple Myeloma
Erin Harrell, PharmD, offers insights about managing peripheral neuropathy in patients receiving bortezomib.
Published: 4/9/2025
AAN 2025: Fremanezumab Superior to Placebo in Reducing Monthly Migraine Days in Children and Adolescents
Numerical differences were observed as early as Month 1.
Published: 4/8/2025
Expert Insights: At APhA 2025, Pharmacists Reaffirmed Their Essential Role in Patient Care
Pharmacy professionals gathered at the American Pharmacists Association 2025 Annual Meeting and Exposition and discussed critical insights in interviews with Pharmacy Times®.
Published: 4/8/2025
Nivolumab Plus Ipilimumab Receives FDA Approval for MSI-H/dMMR mCRC
The approval was based on efficacy and safety data from a randomized, 3-arm, open-label phase 3 CHECKMATE-8HW trial.
Published: 4/8/2025
Study Finds ADHD Stimulants Have Minimal Effect on Cardiovascular System
Small changes in blood pressure and pulse were shown in patients of all ages, and the authors suggested that these are monitored carefully in patients being treated for ADHD.
Published: 4/8/2025
AAN 2025: APP Care Models Can Be a Solution to Promoting Patient Access and Equity Within the Neurology Space
Advanced practice provider (APP) care models allow for health systems to better individualize care for patients, effectively meeting their needs.
Published: 4/8/2025
Subcutaneous Pembrolizumab Matches IV in Lung Cancer Trial
Enriqueta Felip, MD, PhD, discussed the benefits of subcutaneous pembrolizumab for patients with metastatic non–small cell lung cancer.
Published: 4/7/2025
Breaking Down Lipid Storage in Triple Negative Breast Cancer Cells May Help Overcome Treatment Resistance
Fatty acid metabolism plays a critical role in treatment responses.
Published: 4/7/2025
Emerging Bispecific T-Cell Engagers in Myeloma: Promises and Hurdles
The multiple myeloma landscape is evolving, with bispecific T-cell engagers offering hope.
Published: 4/7/2025
Pharmacists Can Bridge Gaps in the Evolving Esophageal Cancer Treatment Landscape
Scott Soefje, PharmD, MBA, BCOP, FCCP, FHOPA, offers insights for oncology pharmacists treating patients with metastatic esophageal squamous cell carcinoma.
Published: 4/7/2025
A Case-Based Approach to Second-Line Immunotherapy in Esophageal Cancer
Scott Soefje, PharmD, MBA, BCOP, FCCP, FHOPA, discusses a case study of a patient with metastatic esophageal squamous cell carcinoma.
Published: 4/7/2025
Long-Term Tirzepatide Demonstrates Benefits in Patients With CKD, Obesity, and HFpEF
Tirzepatide-treated patients with chronic kidney disease (CKD), obesity, and heart failure with preserved ejection fraction (HFpEF) had improved renal function both by cystatin C and creatinine.
Published: 4/7/2025
Community Engagement Is Crucial When Taking Action Against Climate Change
Beth A. Malow, MD, MS, FAAN, said that pharmacists and health care professionals are at the frontlines of collaborating and raising awareness of climate change’s impacts.
Published: 4/5/2025
Beth A. Malow, MD, MS, FAAN: ‘As Health Care Professionals, Climate Change Is In Our Lane’
Malow also emphasized the importance of staying educated on the potential neurological risks that may occur as a result of climate change.
Published: 4/5/2025
Study Reveals Low RSV Knowledge and Vaccine Uptake Among Hospitalized Older Adults
A significant portion of unvaccinated individuals were open to future vaccination.
Published: 4/4/2025
MANIFEST-2 Study: Pelabresib Plus Ruxolitinib Is Superior to JAK Inhibitors Alone
The trial showed that adding pelabresib to ruxolitinib improved outcomes in myelofibrosis with manageable adverse effects.
Published: 4/4/2025
New Poll Shows COVID-19 Pandemic Changed Survey Takers’ Perspectives on Vaccinations
The poll also showed that social media and general media coverage influenced about 33% of participants to not get vaccinated.
Published: 4/4/2025
Rilzabrutinib Granted Orphan Drug Designation For Multiple Rare, Immune-Mediated Conditions
The new designations span both warm autoimmune hemolytic anemia and IgG4-related disease, 2 rare, immune-mediated conditions that burden patients due to a lack of available treatment options.
Published: 4/4/2025
Fitusiran Maintains Long-Term Bleeding Control in Hemophilia A or B, With or Without Inhibitors
Compared with the original dose regimen, an antithrombin-based dose regimen of fitusiran was associated with an improved safety profile.
Published: 4/4/2025
FDA Grants Fast Track Designation to Investigational Tau-Targeting Therapy for Alzheimer Disease
BIIB080 is designed to target microtubule-associated protein tau mRNA, aimed to reduce the production of tau protein.
Published: 4/4/2025
Caveolin-1 May Be A Promising Therapeutic Target For Multiple Myeloma, Study Finds
CAV-1 is a key protein in lipid rafts that helps control cellular processes such as growth, survival, and migration.
Published: 4/4/2025
Aldehyde-Based Surface Disinfectants May Reduce Hepatitis A Virus Transmission, Study Finds
Among the 9 surface disinfectants studied, only 2 demonstrated a reduction in viral titer below the limit of detection.
Published: 4/4/2025
FDA Approves Inebilizumab to Treat Adult Patients With IgG4-RD
This action makes inebilizumab the first and only FDA-approved treatment for adults with immunoglobulin G4-related disease (IgG4-RD).
Published: 4/3/2025
Low HDL-C, Triglyceride Levels in Late Life Independently Associated With Alzheimer Disease and Related Dementias
Notably, high levels of high-density lipoprotein cholesterol (HDL-C) were not associated with the risk of dementia following adjustments for triglyceride levels.
Published: 4/3/2025
Study: Prevalence of Micronutrient Deficiencies in Patients With Type 2 Diabetes
Pharmacists can address micronutrient deficiencies, aiding those with type 2 diabetes as they face a higher risk.
Published: 4/3/2025
Siremadlin Demonstrates Efficacy, Safety in Treatment of Patients With TP53 Wild-Type Chronic Lymphocytic Leukemia
Siremadlin is a novel, investigational, second-generation antagonist that binds to MDM2.
Published: 4/3/2025
Organon Expands Portfolio With Biosimilar Tocilizumab-bavi for Arthritis and COVID-19
Tocilizumab-bavi received FDA approval in September 2023 as the first biosimilar to tocilizumab for the treatment of various adult and pediatric arthritis conditions.
Published: 4/3/2025
FDA Issues Complete Response Letter to Manufacturer of Reproxalap, Treatment for Dry Eye Disease, Allergic Conjunctivitis
No manufacturing or safety issues were identified, but the FDA stated the new drug application did not demonstrate efficacy in adequate and well-controlled studies.
Published: 4/3/2025
Researchers Use CRISPR Screens to Identify Factors Influencing Trastuzumab Emtansine Sensitivity, Resistance
The predictive tool may reveal the mechanisms underlying treatment resistance in patients with HER+ breast cancer.
Published: 4/3/2025
FDA Grants Accelerated Approval to Atrasentan for Proteinuria Reduction in Primary IgA Nephropathy
Positive results from an interim analysis of the phase 3 ALIGN study bolstered atrasentan towards receiving accelerated approval for patients with immunoglobulin A nephropathy, a rare condition that can cause kidney failure.
Published: 4/3/2025
Nivolumab May Restore T-Cell Fitness Following CAR T-Cell Therapy in Patients With Multiple Myeloma
Real-time profiling of T-cell activation states in non-CAR T-cells may help guide treatment decisions.
Published: 4/3/2025
The GLP-1 Conundrum: Insights From the 2025 Pharmacy in Focus Report
Pharmacists play a crucial role in educating patients on proper administration and adherence to GLP-1 treatments.
Published: 4/2/2025
Single Dose of PCV20 for Toddlers Following Previous PCV13 Doses Protects Against Additional Pneumococcal Serotypes
These new phase 3 results indicate the effectiveness of the 2-dose 13-valent pneumococcal conjugate vaccine (PCV13) and 1-dose PCV20 regimens.
Published: 4/2/2025
Understand the 2025-2026 Flu Vaccine Composition Recommendations
The only major change is in the included strain of influenza A/H2N2 virus, which has been updated for both the egg-based and the cell- and recombinant-based vaccines.
Published: 4/2/2025
The Use of CMR in Patients With Recurrent Pericarditis Initiating Rilonacept
The registry data showed that cardiac magnetic resonance (CMR) was obtained in more clinically complex patients with recurrent pericarditis.
Published: 4/2/2025
FDA Approves Auto-Pure 2400 for Faster, More Accurate Tuberculosis Diagnosis
The Auto-Pure 2400 system combines liquid handling and magnetic cell isolation for efficient latent tuberculosis testing.
Published: 4/2/2025
Pharmacist-Driven Management of Venetoclax Ramp-Up Safe, Feasible in Patients With Chronic Lymphocytic Leukemia
Pharmacists performed weekly toxicity and tumor lysis syndrome monitoring.
Published: 4/2/2025
How Pharmacies Can Better Support Employees Living With Serious Mental Illness
Reducing stigma, improving mental health benefits, and addressing workload concerns all need to happen simultaneously.
Published: 4/2/2025
NCCN 2025: Advancing Breast Cancer Risk Assessment and Prevention Strategies
Evolving breast cancer risk models and prevention methods are necessary to improve patient outcomes, according to Sagar Sardesai, MD.
Published: 4/1/2025
Study: Vitamin B12 Levels Within "Normal" Range Linked to Cognitive Decline in Older Adults
Current recommended levels of vitamin B12 might not be sufficient to protect against neurological decline.
Published: 4/1/2025
Finerenone Shows Promise in Heart Failure and Kidney Disease Management
John Ostrominski, MD shares insights into the safety and efficacy of finerenone, based on data from the FINEARTS-HF trial.
Published: 4/1/2025
As the Measles Outbreak Continues to Spread, Texas Hospitals Report Cases of Vitamin A Toxicity
The CDC reports 483 total cases across 20 states as of March 28, 2025.
Published: 4/1/2025
Cardiovascular Risks of BTK Inhibitors: What Pharmacists Need to Know
Sarah Spinler, PharmD, FCCP, FAHA, FASHP, AACC, discussed management of atrial fibrillation in patients with cancer.
Published: 4/1/2025
Intravenous Immunoglobulin Plus Rituximab Effective Alternative Option for Refractory Autoimmune Disease Treatment
Given rituximab’s tendency to cause infections in patients being treated for autoimmune diseases, the addition of intravenous immunoglobulin works to reduce that risk and induce clinical improvements.
Published: 4/1/2025
Personalized Prevention: Identifying At-Risk Patients With Image-Based Screening
Anna Sophie Mueller, MD discusses how imaging could advance risk identification in cardiovascular care.
Published: 4/1/2025
mRNA Vaccine Candidate for Chlamydia Receives FDA Grants Fast Track Designation
A phase 1/2 clinical trial will provide crucial data on the vaccine's tolerability and pave the way for future development and potential widespread use.
Published: 3/31/2025
NCCN 2025: Managing Immune Checkpoint Inhibitor-Related Toxicities in Cancer Care
Effective management of immune checkpoint inhibitor-related toxicities requires early intervention, evolving guideline adherence, and multidisciplinary collaboration, with steroids remaining a key treatment.
Published: 3/31/2025
FDA Grants BA1302 Orphan Drug Designation for Squamous NSCLC and Pancreatic Cancer
The antibody-drug conjugate is currently undergoing evaluation in a phase 1 trial that enrolled patients with pancreatic cancer and squamous non-small cell lung cancer (NSCLC).
Published: 3/31/2025
BEAM-302 Receives FDA IND Clearance for AATD, a Genetic Disorder Affecting the Liver and Lungs
Currently, BEAM-302 is undergoing a phase 1/2 clinical trial to evaluate its efficacy in patients with alpha-1 antitrypsin deficiency (AATD) who have lung disease and liver disease.
Published: 3/31/2025
Sotatercept Demonstrates Its Potential in the Phase 3 ZENITH Trial
Marc Humbert, MD, PhD, shared data that were presented at the ACC 2025 Scientific Sessions.
Published: 3/31/2025
FINEARTS-HF Analysis: How Liver Biomarkers Influence Heart Failure Risk
Jawad Butt, MD, offers insight into his analysis of the FINEARTS-HF trial.
Published: 3/31/2025
Semaglutide and Cardiovascular Risk Reduction: What the Latest Data Tell Us
John Buse, MD, PhD discusses the expanding role of GLP-1 receptor agonists in treatment of cardiovascular conditions.
Published: 3/30/2025
ACC 2025: Intravenous Iron Safe, but Results in Mixed Findings for Patients With Heart Failure
Patients in the treatment group had a 21% lower risk of cardiovascular death or first heart failure hospitalization overall, but the between-group difference did not meet the threshold for statistical significance for this primary end point.
Published: 3/30/2025
ACC 2025: Oral Semaglutide Reduces Cardiovascular Events by 14% at 4 Years
The trial is the first to test the cardiovascular benefits of an oral glucagon-like peptide-1 (GLP-1) agonist.
Published: 3/30/2025
New Data Highlights Abelacimab’s Safety Advantage in Atrial Fibrillation
Christian Ruff, MD, highlights abelacimab’s potential to significantly reduce bleeding in patients with high-risk atrial fibrillation.
Published: 3/30/2025
ACC 2025: Dapagliflozin Found Safe, Effective in Older Adults With Heart Failure Undergoing Valve Replacement
The DapaTAVI study is the first trial of a sodium-glucose cotransporter-2 (SGLT2) inhibitor for valvular disease.
Published: 3/29/2025
ACC 2025: Ticagrelor Antidote Restores Platelet Function, Treats Bleeding
The availability of this option could make physicians more comfortable when prescribing ticagrelor, which could help solve the challenge of undertreatment with antiplatelet therapy.
Published: 3/29/2025
ACC 2025: Rivaroxaban Comparable to Warfarin in Left Ventricular Blood Clots
Rivaroxaban offers more predictable dosing, eliminates frequent blood tests, and is less likely to interact with foods.
Published: 3/29/2025
ACC 2025: Lower-Dose Apixaban Is Effective, Safer Than Full Dose for Preventing VTE Recurrence in Patients With Cancer
The results should lead to a guideline update recommending extended treatment with a reduced-dose anticoagulant in this patient population.
Published: 3/29/2025
ACC 2025: Semaglutide Significantly Improves Walking Distance, Symptoms, QOL for Individuals with PAD and Diabetes
The STRIDE trial was first of its kind to evaluate the use of a GLP-1 agonist in PAD management.
Published: 3/29/2025
NCCN 2025: Immune Checkpoint Inhibitors Expand Treatment Options for Early-Stage NSCLC
PD-L1 immune checkpoint inhibitors are now standard for early-stage non-metastatic non-small cell lung cancer (NSCLC), with neoadjuvant, adjuvant, and perioperative strategies improving survival and outcomes.
Published: 3/29/2025
Exploring the Vascular Benefits of Semaglutide in Peripheral Artery Disease
Marc Bonaca, MD, PHH, FACC discussed semaglutide’s potential benefits for non-diabetic patients with peripheral artery disease.
Published: 3/29/2025
Prenatal Vitamin E May Reduce Peanut Allergy Risk in Infants
Vitamin E intake, specifically α-tocopherol, may reduce the development of peanut allergies and anaphylaxis in newborns.
Published: 3/28/2025
Durvalumab Receives FDA Approval for Muscle Invasive Bladder Cancer
Approval of durvalumab is in combination with gemcitabine and cisplatin as neoadjuvant treatment for adults with muscle invasive bladder cancer.
Published: 3/28/2025
From Screening to Survival: The Pharmacist’s Role in Colorectal Cancer
Colorectal cancer cases are on the rise—here is everything you need to know as an oncology pharmacist.
Published: 3/28/2025
FDA Approves Fitusiran For Prophylactic Hemophilia A, B Treatment Regardless of Inhibitor Status
Approval of fitusiran, a small interfering RNA drug, was found effective in patients with hemophilia regardless of inhibitor status.
Published: 3/28/2025
Novo Nordisk Expands Semaglutide Access With Discounted Pricing
The expanded discount program offers semaglutide for $499 per month for all eligible cash-paying customers.
Published: 3/28/2025
Peritoneal Dialysis May Be Feasible, Safe Long-Term Treatment for Patients With CKD
In certain patients with chronic kidney disease (CKD), peritoneal dialysis maintained hemodynamic stability, optimal nutritional status, reduced hospitalization, and lowered diuretics reliance.
Published: 3/28/2025
The Impact of Postherpetic Neuralgia on Frailty in Older Adults with Herpes Zoster
Results support a 2020 meta-analysis showing that older adults with chronic pain are nearly twice as likely to develop frailty compared to those without chronic pain.
Published: 3/28/2025
Very Low LDL-C Achieved With Evolocumab Not Associated With Long-Term Cognitive Impairment
These results align with those from shorter-term analyses of low-density lipoprotein cholesterol (LDL-C) reductions with evolocumab and cognitive impairment risk.
Published: 3/28/2025
Denosumab-bnht Biosimilar Receives FDA Approval
The biosimilar is approved for all indications of the reference products, Prolia and Xgeva.
Published: 3/27/2025
Aromatase Inhibitors Show Greater Benefit in Preventing Contralateral Breast Cancer
Aromatase inhibitors were superior to tamoxifen in reducing risk of contralateral breast cancer.
Published: 3/27/2025
High Low-Density Lipoprotein Cholesterol Associated With Improved Survival in Acutely Decompensated Heart Failure
Low-density lipoprotein cholesterol value below 88 mg/dL was associated with heightened mortality, highlighting the need for more liberal cholesterol targets in this population.
Published: 3/27/2025
Drug Shortages and Alternative Sourcing Opportunities
All stakeholders across the drug supply chain must work together to develop and support proactive strategies, creating resilience across the health care ecosystem to avoid and mitigate shortages.
Published: 3/27/2025
Dupilumab Associated With Reduction of Food-Specific IgEs at 12, 24 Months
At 12 and 24 months, there were 56.9% and 73.5% reductions in food-specific immunoglobulin E (IgE).
Published: 3/27/2025
FDA Approves Diazoxide Choline Extended-Release Tablets in Prader-Willi Syndrome
The approval fills a treatment gap for patients with this rare disease, which can severely diminish quality of life.
Published: 3/27/2025
Optimal Ruxolitinib Dosing in Myelofibrosis Critical for Improved Effectiveness, Survival in Real-World Setting
Interim results from an observational trial of patients with myelofibrosis indicate upward trends in health-related quality of life when started on the highest tolerable dose of ruxolitinib.
Published: 3/27/2025
AIM Test Could Help Predict COVID-19 Vaccine Response in Patients With CLL
Patients with chronic lymphocytic leukemia (CLL) show weakened T-cell memory responses to COVID-19 vaccination.
Published: 3/26/2025
Thrombosis, Major Bleeding Events More Frequent in Myelofibrosis Compared With Other Myeloproliferative Neoplasms
Using Janus kinase inhibitors, having experienced a previous thrombosis episode, and higher age were associated with a heightened risk of a new thromboembolic event.
Published: 3/26/2025
Researchers Identify Key Signaling Pathway Disruptions Driving Breast Cancer Treatment Resistance
The findings provide a deeper understanding of the mechanisms underlying breast cancer progression and treatment resistance.
Published: 3/26/2025
Long-Term Follow-Up Data from the CASSIOPEIA Trial Show Continued MRD, PFS Benefit in Multiple Myeloma
Adding daratumumab improved minimal residual disease (MRD) negativity rates, leading to superior progression-free survival (PFS).
Published: 3/26/2025
Moderate Aerobic Exercise Improves Hematological Parameters in Sedentary Young Adults
In previously sedentary young males and females, 14 days of moderate aerobic exercise increased red and white blood cell counts and hemoglobin concentrations without altering key cardiometabolic enzymes.
Published: 3/26/2025
48-Week Data Show Efficacy of Valbenazine in Patients With Tardive Dyskinesia and Schizophrenic, Mood Disorders
About 59.2% of patients with tardive dyskinesia (TD) who completed the 48-week trial achieved remission.
Published: 3/26/2025
Cabozantinib Gains FDA Approval for Patients With Pancreatic Neuroendocrine Tumors
Patients achieved statistically significant benefits in progression-free survival and overall response rates.
Published: 3/26/2025
HBcrAg Rapid Diagnostic Test Shows Potential in Timely Detection of HBV DNA Concentrations
The hepatitis B core-related antigen (HBcrAg) rapid diagnostic test was more timely and showed a stronger sensitivity and specificity compared with other testing methods.
Published: 3/26/2025
Interplay of Community, Treatment, and Patient Factors Critical for Improving Joint Outcomes in Severe Hemophilia
Older age and being insured with Medicare or Medicaid were associated with heightened annual joint bleeding rates, whereas treatment in the Northeast United States improved outcomes in both hemophilia A and hemophilia B.
Published: 3/26/2025
Gepotidacin Receives FDA Approval for uUTIs in Adult, Pediatric Female Patients
Gepotidacin is indicated for female patients who are at least 12 years of age and weigh at least 40 kg with uncomplicated urinary tract infections (uUTIs) caused by certain microorganisms.
Published: 3/25/2025
First Antibody Therapy for Acute Myocardial Infarction Granted FDA Fast Track Designation
If approved, this novel monoclonal antibody therapy could become a standard of care emergency option for patients with acute myocardial infarction, which affects millions in the United States and across the world.
Published: 3/25/2025
COVID-19 5 Years Later: The Impact on Drug Discovery
As the COVID-19 pandemic moves into an endemic phase, the major impacts on drug research, collaboration, and use of new technologies due to the spread of the virus warrant recognition.
Published: 3/25/2025
Pharmacists Are Key Players in C difficile Infection Prevention
Pharmacists can promote prevention through the implementation of antimicrobial stewardship initiatives and advocate for fecal microbiota transplant.
Published: 3/25/2025
Marcella Kinaya, PharmD, on Flu Season: ‘We’re Here to Protect People and Make Sure They’re Healthy’
A district leader at CVS Health emphasizes that patients should get tested, be up to date with immunizations, and staying home and reach out to health care professionals when experiencing symptoms.
Published: 3/25/2025
Medication Compliance When Treating CKD is Crucial, UPMC Health Plan Expert Says
Helping patients adhere to their medications to manage their chronic kidney disease (CKD) and comorbidities is one of the key areas pharmacists should prioritize.
Published: 3/25/2025
Lurbinectedin and Tarlatamab: Emerging Second-Line Therapies in the SCLC Space
Megan May, PharmD, BCOP, FHOPA, FAPO, discusses lurbinectedin and tarlatamab and what ongoing research in the small cell lung cancer (SCLC) space entails.
Published: 3/25/2025
Best Practices and Guidelines in Immunoglobulin Therapy
Evidence-based guidelines support the safe and effective administration of Ig therapy in clinical practice.
Published: 3/24/2025
Preventing Adverse Drug Events: A Call to Action for Pharmacists
National Adverse Drug Event Awareness Day was established to promote awareness, drive policy changes, and encourage health care professionals and patients to prioritize medication safety.
Published: 3/24/2025
FDA Grants Fast Track Designation to STM-01, Neonatal Cardiac Cell Therapy for Treatment of HFpEF
The innovative neonatal cardiac progenitor cell therapy is designed to repair heart tissue in patients with heart failure with preserved ejection fraction (HFpEF).
Published: 3/24/2025
BCMA-Targeting CAR T-Cell Therapy Is Feasible in Patients With Multiple Myeloma and CNS Involvement
Patients with central nervous system (CNS) involvement achieved favorable outcomes with chimeric antigen receptor (CAR) T-cell therapy.
Published: 3/21/2025
Elevated Non-HDL Cholesterol a Stronger Indicator of Major Cardiovascular Events Compared With LDL-C
Non-high-density lipoprotein cholesterol was found to be more effective at predicting cardiovascular events such as stroke, myocardial outcomes, heart failure, and others compared with low-density lipoprotein cholesterol.
Published: 3/21/2025
Nipocalimab Is Granted Fast Track Designation for Treatment of Patients With Sjögren’s Disease
Sjögren's disease is one of the most common chronic autoimmune diseases that affects 4 million individuals around the world.
Published: 3/21/2025
Experts: Vast Disparities in Opioid Prescribing Observed for Minority Communities in Past Decade
Allison Ju-Chen Hu, PhD and Yuhua Bao, PhD describe results of their landmark study that found significant differences in opioid prescriptions in racially and ethnically minoritized communities.
Published: 3/21/2025
Despite New Agents in SCLC, Prolonged Survival Remains an Unmet Need
After decades without improvements, an expert with Baptist Health described the small cell lung cancer (SCLC) space as “exciting” following multiple innovations in the past few years.
Published: 3/21/2025
Guselkumab Receives FDA Approval for Adults With Moderately to Severely Active Crohn Disease
The new indication for guselkumab in Crohn disease builds off a previous approval in ulcerative colitis, providing patients a treatment option for the major forms of inflammatory bowel disease.
Published: 3/21/2025
FDA Approves Vutrisiran to Reduce Cardiovascular Death, Hospitalizations in Patients With ATTR-CM
Vutrisiran becomes the first and only therapeutic FDA-approved to treat cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM) in adults.
Published: 3/21/2025
The Importance of Measles Vaccination Amidst Vitamin A Discussions
As cases rise, experts warn that vitamin A supplementation should not be used as a replacement for vaccination.
Published: 3/21/2025
Iptacopan Receives Third FDA Approval for Adult Patients With C3 Glomerulopathy
The agent is the only approved therapy designed to address the underlying mechanisms of the disease.
Published: 3/21/2025
Bringing Better Health to the Navajo Nation
For two years in a row, McKesson has partnered with customers and industry partners to bring health education and awareness of resources to members of the Navajo community.
Published: 3/21/2025
Ustekinumab Biosimilar Launches in the US
The launch of ustekinumab-stba following its FDA approval expands patient access to this therapy with a variety of indications.
Published: 3/20/2025
Study Reports Challenges Screening Disordered Eating in Adults With Type 1 Diabetes
Health care professionals in the study found it challenging to manage the complexities of disordered eating in patients with type 1 diabetes alongside their other responsibilities.
Published: 3/20/2025
Concerns Surrounding Compounded GLP-1s Mount As Shortages of Tirzepatide, Semaglutide End
An expert roundtable discussed what consumers and pharmacists should be aware of as compounded versions of glucagon-like peptide-1 receptor agonists continue to proliferate.
Published: 3/20/2025
Allo-SCT, Myeloablative Conditioning With Busulfan/Fludarabine Improves Survival in Myelofibrosis
Allogeneic stem cell transplant (allo-SCT) conditioning with busulfan/fludarabine with thiotepa and posttransplant cyclophosphamide induced improved 2-year progression-free survival and overall survival in patients with myelofibrosis, especially older adults.
Published: 3/20/2025
Researchers Identify BeeR, a Novel Protein That May Enhance Drug Delivery in Cancer Care
BeeR is a bacterial protein from the family Verrucomicrobiota that influences cell shape and division.
Published: 3/20/2025
Study Reveals Virtual Reality Effectively Educates Pharmacists on Continuous Glucose Monitors
Community pharmacists are uniquely positioned to assist with diabetes management using CGM devices.
Published: 3/20/2025
PBMs, Pricing, and Policy: The Fight for Fair Access to GLP-1s
As demand for GLP-1 therapies grows, patients face rising costs and restrictive insurance policies.
Published: 3/19/2025
Age and Comorbidities Drive RSV Hospitalization Rates in Older Adults
Prioritizing preventive measures for high-risk individuals would effectively address half of RSV hospitalizations.
Published: 3/19/2025
Pembrolizumab in Combination With Platinum-, Fluoropyrimidine-Based Chemotherapy Receives FDA Approval for GEJ
The combination was approved for treatment of patients with gastroesophageal junction (GEJ) adenocarcinoma.
Published: 3/19/2025
FDA Grants Orphan Drug Designation to Exidavnemab for Multiple System Atrophy
Exidavnemab is a novel monoclonal antibody with disease-modifying potential.
Published: 3/19/2025
New Data on HIV-1 Treatments, Including Biktarvy and Novel Lenacapavir Combination Regimen, Presented at CROI 2025
Results highlight promising advancements in novel treatments for patients with HIV-1, including a combination regimen with broadly neutralizing antibodies and long-term data on bictegravir, emtricitabine, and tenofovir alafenamide (Biktarvy).
Published: 3/19/2025
FDA Grants Orphan Drug Designation to Radiprodil for GRIN-Related Neurodevelopmental Disorder
Patients with a disorder from this family of neurodevelopmental conditions face a lack of approved treatment options, making radiprodil poised to transform the treatment paradigm.
Published: 3/19/2025
Depemokimab Suppresses Blood Eosinophil Counts in Adults With CRSWNP
Approximately 74% of patients with chronic rhinosinusitis with nasal polyps receiving depemokimab across 2 trials did not need additional intervention.
Published: 3/19/2025
Study Explores Effectiveness of HTD1801 in Type 2 Diabetes
Treatment with HTD1801 resulted in significant reductions in the hemoglobin A1c level and improved key cardiometabolic and liver parameters.
Published: 3/18/2025
Real-World Study Supports Ibrutinib Dose Reduction for Managing Adverse Events in CLL
Reducing the dose of ibrutinib following adverse events improved tolerability without compromising clinical efficacy in chronic lymphocytic leukemia (CLL).
Published: 3/18/2025
Meta-Analysis of Phase 3 Trials Support Use of Sacituzumab Govitecan Over Physician’s Choice Treatment
The findings extend prior data underscoring the clinical benefit of the agent and its place in global clinical practice guidelines.
Published: 3/18/2025
Second Dose of IVIG in Guillain-Barré Syndrome Increases Adverse Events Without Major Clinical Benefit
As indicated by prior literature, a second dose of intravenous immunoglobulin (IVIG) in patients with Guillain-Barré syndrome increases serum immunoglobulin G levels without improving clinical outcomes.
Published: 3/18/2025
Hecolin HEV Vaccination Shows Safety and Immunogenicity in Patients With CHB
Patients with chronic hepatitis B (CHB) who received the Hecolin hepatitis E virus (HEV) 3-dose regimen had a somewhat low incidence of local and systemic adverse events.
Published: 3/18/2025
Artificial Intelligence Has Implications for Medication Safety
Data privacy and security breaches are a critical concern with AI in health care.
Published: 3/18/2025
FDA Approves SCN-102, Liquid Oral Suspension Formulation of Losartan
The treatment is indicated for patients aged 6 and older with hypertension, the reduction of stroke in hypertension and left ventricular hypertrophy, and diabetic nephropathy in certain patients with type 2 diabetes.
Published: 3/18/2025
Elotuzumab-Based Regimen Demonstrates Efficacy in Relapsed/Refractory Multiple Myeloma
A phase 2 study showed that elotuzumab combined with pomalidomide, bortezomib, and dexamethasone was safe and efficacious.
Published: 3/17/2025
Ensitrelvir Effective as Oral Antiviral for Postexposure Prophylaxis Against COVID-19
The 3CL protease inhibitor is designed to suppress the replication of SARS-CoV-2, preventing COVID-19 illness, even if a household member is infected.
Published: 3/17/2025
Patient Cured of Sickle Cell Anemia With Innovative Gene Therapy
The patient is the first to be cured using lovotibeglogene autotemcel, a novel cell-based gene therapy.
Published: 3/17/2025
FDA Accepts Priority Review for Finerenone New Indication to Include Patients With Heart Failure
The new indication would include adults with heart failure with a left ventricular ejection fraction (LVEF) of 40% or higher, such as mildly reduced or preserved LVEF.
Published: 3/17/2025
Self-Care Measures for the Prevention and Management of Constipation
Pharmacists can identify medications and conditions that may augment or exacerbate constipation.
Published: 3/17/2025
CROI 2025: Key Updates on ViiV Healthcare’s Cabenuva and Apretude
Data from conference abstracts and presentations indicate that both preexposure prophylaxis methods continue to demonstrate efficacy.
Published: 3/17/2025
Patients With Myelofibrosis and Anemia Treated With Ruxolitinib Have Higher Health Care Resource Utilization, Clinical Burdens
Treatment with ruxolitinib in patients with myelofibrosis and anemia was associated with more inpatient medical center and emergency department visits while increasing health care-related financial burdens compared with nonanemic patients.
Published: 3/16/2025
Patient-Reported Outcomes Reinforce Clinical Benefits of Tarlatamab in Small Cell Lung Cancer
Tarlatamab was approved by the FDA in May 2024 for patients who progressed after platinum-based chemotherapy.
Published: 3/14/2025
Executive Order Advances Price Transparency Efforts to Lower Health Care Costs
This marks steps toward improving health care pricing transparency, but further reforms are needed to reduce costs long-term.
Published: 3/14/2025
Alcohol Initiation, Cessation Associated With Dose-Dependent Changes in LDL, HDL Cholesterol
Alcohol consumption, though typically associated with adverse health outcomes, could be associated with reduced low-density lipoprotein cholesterol (LDL-C) and improved high-density lipoprotein cholesterol (HDL-C).
Published: 3/14/2025
Regulating Cholesterol May Enhance T-Cell Function in Patients With Chronic Lymphocytic Leukemia
Lipid metabolism plays a critical role in the function of T-cells.
Published: 3/14/2025
DC646 Shows Promise as a Therapeutic Approach for MASH
DC646 had a strong safety profile, targeted intestinal FXR, and disrupted FXR-co-activator interactions in metabolic dysfunction-associated steatohepatitis (MASH).
Published: 3/14/2025
Oral Immunotherapy Can Play Key Role in Food Allergy Management in Preschool-Aged Patients
The authors note that further research is needed to clarify cost-effectiveness, long-term adherence, and psychosocial impacts of oral immunotherapy.
Published: 3/14/2025
Patients With Type 1 Diabetes Have Reduced Cardiovascular Event Rates Compared With T2D
The new data emphasize the fundamental differences in management and associated complications with each form of diabetes.
Published: 3/14/2025
Poor Diet May Drive Lung Adenocarcinoma Progression Through Glycogen Accumulation
The Western diet was associated with increased risk of lung cancer.
Published: 3/13/2025
Updated CKD Guidelines Emphasize Implementation of Evidence-Based Approaches
Some of these approaches for chronic kidney disease (CKD) include cystatin C, SGLT2 inhibitors, point-of-care testing in remote areas, and acid-lowering medications.
Published: 3/13/2025
Genetic Study Sheds Light on Inherited Risk of Multiple Myeloma
Approximately 10% of patients with multiple myeloma have pathogenic germline variants, indicating a hereditary risk.
Published: 3/13/2025
National Institutes of Health Limits Grants for Vaccine Hesitancy Studies, Raising Questions About Future of Research
Reported terminations and limitations on research projects studying vaccine hesitancy and strategies to increase vaccine uptake are poised to greatly impact studies of the phenomenon.
Published: 3/13/2025
An Overview of Vitamins and Supplements in Multiple Sclerosis
By examining the evidence, pharmacists can gain insights into whether these supplements could be integrated into MS treatment regimens to improve patient outcomes.
Published: 3/13/2025
Promising Survival Rates Observed With 3D Spleen Size Analysis, Fludarabine/Melphalan-Based HSCT in Myelofibrosis
Measures including disease-free survival and overall survival were improved in patients with MF who underwent hematopoietic stem cell transplantation (HSCT) and a 3D volumetric splenomegaly analysis.
Published: 3/13/2025
Subcutaneous Cagrilintide, Semaglutide Shows Significant Weight Loss in Type 2 Diabetes Trial
Patients adhering to cagrilintide/semaglutide treatment experienced an average 15.7% weight loss.
Published: 3/13/2025
Automation and New Technologies Are Pushing Pharmacy Forward
By saving time on mundane tasks, these tools allow pharmacists to focus on direct patient care.
Published: 3/13/2025
Study Finds Elevated RSV Hospitalization Rates in Patients With Asthma, COPD
Adults with asthma or COPD face a heightened risk of RSV-related illness.
Published: 3/12/2025
FDA Approves Expanded Indication of Eculizumab for Pediatric Generalized Myasthenia Gravis
Eculizumab, a humanized monoclonal antibody, was first approved for adults with generalized myasthenia gravis in 2017.
Published: 3/12/2025
Lipid Biology Helps Distinguish Hepatitis From Cirrhosis and Identifies 90-Day Mortality
Untargeted lipidomics identified a glycerophospholipid and sphingolipid signature that differentiated severe alcohol-related hepatitis (sAH) from decompensated cirrhosis (DC).
Published: 3/12/2025
Empowering Pharmacies to Add New Sustainable Care Services
A new free resource provides clear insights on contracted rates, enabling pharmacies to fill the community care gap.
Published: 3/12/2025
Tezepelumab-Ekko Reduces CSU Activity in Patients Through 32 Weeks of Treatment
Although the 16-week end point was not met, tezepelumab demonstrated meaningful effects in patients with chronic spontaneous urticaria (CSU) after 32 weeks.
Published: 3/12/2025
Dexamethasone Shows Promise as Cost-Effective Alternative to Tocilizumab for Cytokine Release Syndrome in RRMM
Use of dexamethasone over tocilizumab was associated with significant cost-savings for patients with relapsed/refractory multiple myeloma (RRMM).
Published: 3/12/2025
Early Intervention With IV Iron Is Safe, Effective for Anemia During Pregnancy
Compared with daily oral iron, a single intravenous (IV) infusion of iron was shown to lower rates of low birth weight in infants and decrease reliance on further iron supplementation or transfusions in pregnant patients with anemia.
Published: 3/12/2025
MDMA Rejected: The Story of a Study Participant Entrenched in Ethical Violations
The health care community was left largely unaware of the controversy that occurred at one of the clinical trial sites.
Published: 3/12/2025
Vepdegestrant Demonstrates Progression-Free Survival in Patients With ER+/HER2- Metastatic Breast Cancer
Vepdegestrant is an experimental oral PROteolysis TArgeting Chimera that degrades estrogen receptor (ER) in patients with metastatic breast cancer.
Published: 3/11/2025
Ongoing Clinical Trial Compares Omega-3 Types for Dementia Risk Reduction
The study aims to assess how docosahexaenoic acid levels in cerebrospinal fluid relate to both neurodegeneration and cognitive function.
Published: 3/11/2025
Acalabrutinib Plus Venetoclax Superior to Chemoimmunotherapy in Patients With Chronic Lymphocytic Leukemia
The favorable outcomes were observed in the phase 3 AMPLIFY trial.
Published: 3/11/2025
Deucravacitinib Improves Quality of Life, Response Rates in Adults With Active Psoriatic Arthritis
Results of the POETYK PsA-2 trial indicate deucravacitinib’s effectiveness at reducing the severity and burden of symptoms in patients with psoriatic arthritis.
Published: 3/11/2025
Algorithmic Identification Intervention Increased Adherence to BP Medications in Patients With Hypertension
Although improvements were observed in blood pressure (BP) medication adherence, there were no improvements in stain or glucose-lowering medication use.
Published: 3/11/2025
Neutropenia Should Be Considered a Possible Complication of Treatment With IVIG
Though rare and typically presenting as transient, a case study demonstrates severe, chronic neutropenia in a patient with multifocal motor neuropathy treated with intravenous immunoglobulin (IVIG).
Published: 3/11/2025
Pharmacists Will Play an Essential Role in Optimizing Vutrisiran Therapy for ATTR-CM
If approved, vutrisiran would be the first FDA-approved therapy to treat both the polyneuropathy and cardiomyopathy aspects of transthyretin amyloidosis (ATTR).
Published: 3/10/2025
Icotrokinra Demonstrates Meaningful Skin Clearance in Moderate-to-Severe Plaque Psoriasis
Icotrokinra, an oral pill that blocks the IL-23 receptor, had a favorable safety profile in adults and adolescents 12 years and older with moderate-to-severe plaque psoriasis.
Published: 3/10/2025
New Research Sheds Light on Link Between Leukocyte Count and Long COVID Symptom Severity
In older postmenopausal women, leukocyte count was found to be an independent predictor of long COVID symptom severity, highlighting its potential for use as a novel symptom biomarker.
Published: 3/10/2025
FDA Grants Orphan Drug Designation to EN001 for Neuromuscular Disorder, CMT Disease
Currently, EN001 is undergoing evaluation in a phase 1b trial.
Published: 3/10/2025
FDA Approves Interchangeable Biosimilar to Xolair
Omalizumab-igec is designed to attach to immunoglobulin E (IgE), which is produced at high levels among individuals with allergies.
Published: 3/7/2025
Experts Raise Alarm Over Vaccine Hesitancy and Misinformation as the Measles Outbreak Spreads
The outbreak has grown to a total of 222 confirmed cases of measles, as well as 2 measles-associated deaths.
Published: 3/7/2025
Pharmacists Play an Essential Role in Bispecific Therapy for Multiple Myeloma
Pharmacists also navigate the REMS program and monitor and manage adverse effect profiles associated with bispecifics.
Published: 3/7/2025
Adults With High Ratio of Non-HDL Cholesterol to HDL Cholesterol Have Higher Sarcopenia Risk
Sarcopenia, a progressive skeletal order that involves the accelerated loss of muscle mass and function, is associated with adverse outcomes such as functional decline, frailty, and mortality.
Published: 3/7/2025
First-in-Kind Trametinib Antiviral Gel Can Fight HPV Precancers and Prevent Progression
The novel formulation of trametinib has the potential to change the treatment paradigm of human papillomavirus (HPV) and prevent infections before they progress to deadly cancers.
Published: 3/7/2025
Prenatal Exposure to PFAS Via Contaminated Drinking Water May Increase Risk of Childhood Cancer, Study Finds
The cancers linked with per- and polyfluoroalkyl substance (PFAS) exposure included nonastrocytoma gliomas, acute myeloid leukemia, and Wilms tumors.
Published: 3/7/2025
FDA Grants ODD and RPDD to NEU-001 for Patients With Hirschsprung Disease
The treatment is currently undergoing evaluation in an investigational preclinical program and is projected to be in human trials in 2026.
Published: 3/7/2025
Practical Advice for Perioperative Management of Patients With Harmful Alcohol Intake
A team of clinical and academic experts from the Association of Anaesthetists produced a consensus statement outlining the key components to minimizing the impact of harmful alcohol intake in the surgical population.
Published: 3/7/2025
Pharmacy-Led Prior Authorization Model Reduces Delays and Improves Patient Care
A pilot program integrated oncology pharmacists into prior authorization workflows to streamline and expedite medication approvals.
Published: 3/7/2025
The Benefits and Challenges of Subcutaneous Infusion in Cancer Care
Subcutaneous infusion reduces treatment times for patients and eases operational burdens for providers.
Published: 3/7/2025
PBM Reform: Tackling Transparency, Pricing, and Patient Access
Policymakers and health care providers call for reforms to improve transparency, pricing, and patient access.
Published: 3/7/2025
Beyond the Bed: Transitioning Cancer Care From Hospitals to Outpatient Infusion Centers
Specialty pharmacists are critical for enhanced management of clinical and logistical aspects of treatment.
Published: 3/6/2025
FDA Approves Expansion for Furosemide Injection to Treat Edema In Patients With CKD
The treatment's expanded indication for chronic kidney disease (CKD) is expected to be available by April 2025.
Published: 3/6/2025
Study Finds Rapid Dietary Effects On Brain Insulin and Obesity Risk
A brief period of overeating ultra-processed, high-calorie snacks could lead to liver fat accumulation and temporary disruption of brain insulin action.
Published: 3/6/2025
Tapinarof Cream 1% Once Daily Shows Consistent Efficacy Across All Body Regions
Efficacy and tolerability of topical treatments can vary by region, particularly sensitive areas such as the face and neck.
Published: 3/6/2025
Melatonin Supplementation Could Improve DNA Repair in Night Shift Workers
Melatonin supplementation could improve oxidative DNA damage repair capacity among night shift workers.
Published: 3/6/2025
OpCT-001, Stem Cell-Derived Therapy for Primary Photoreceptor Diseases, Receives FDA Fast Track Designation
With the new designation, OpCT-001 can receive expedited investigations into its potential to improve vision function in patients with primary photoreceptor diseases.
Published: 3/6/2025
Ruxolitinib in Patients with Myelofibrosis Reduces Incidence of Acute and Chronic GVHD
At 1- and 2-year follow-up points, ruxolitinib led to considerable improvements in survival in patients with myelofibrosis who develop graft-versus-host disease (GVHD).
Published: 3/6/2025
FDA Approves Revakinagene Taroretcel, Marking First Treatment for MacTel Type 2
The approval is based on results from 2 phase 3 clinical trials that showed revakinagene taroretcel’s efficacy in macular telangiectasia type 2 (MacTel).
Published: 3/6/2025
FDA Removes Clozapine REMS Requirement to Report Patients’ Absolute Neutrophil Count
The move is expected to expand clozapine access for patients with schizophrenia.
Published: 3/6/2025
FDA Approves neffy 1 mg for Type 1 Allergic Reactions, Including Anaphylaxis, in Children
According to a news release, this marks the first significant innovation in epinephrine delivery for this patient population is more than 35 years.
Published: 3/6/2025
Pharmacists Play a Crucial Role in Adalimumab Biosimilars for Patient Care
Adalimumab biosimilars differ from adalimumab in approved indications, concentration and dosage, and formulation.
Published: 3/5/2025
Camizestrant Plus CDK 4/6 Inhibitor Improved PFS in Patients With HR+, HER2– Breast Cancer
Camizestrant is an investigational oral selective estrogen receptor degrader.
Published: 3/5/2025
Survivors of Breast Cancer Treated With Chemotherapy Experience Long-Term Physical Health Decline, Study Finds
The authors’ findings show a greater decline in those treated with chemotherapy vs endocrine therapy.
Published: 3/5/2025
Luspatercept Is Effective Treatment for Anemia Post-Allo-HSCT in Patients With Hematologic Conditions
Following allogeneic hematopoietic stem cell transplantation (allo-HSCT), luspatercept effectively improved signs of anemia in patients with a variety of hematologic conditions.
Published: 3/5/2025
Tezepelumab-Ekko Reduces Nasal Polyp Severity and Need for Surgery in Patients With CRSWNP
Tezepelumab demonstrated efficacy compared with placebo when treating patients with chronic rhinosinusitis with nasal polyps.
Published: 3/5/2025
FDA Grants Fast Track Designation to AVB-114 for Crohn Disease Perianal Fistulas
The designation was granted after positive results from the phase 1 STOMP-I clinical trial (NCT01915927).
Published: 3/5/2025
Study Reveals Vaccine Hesitancy and Acceptance Patterns for RSV
RSV vaccine acceptance among older adults is significantly influenced by perceived benefits.
Published: 3/4/2025
FDA Issues New Labeling Changes Clarifying Safety of Testosterone Products Following Clinical Trials
The FDA is issuing new changes to labels on testosterone products, clarifying that there are no increases in major cardiac events among men with hypogonadism but noting an increase in blood pressure with the use of such products.
Published: 3/4/2025
Daratumumab Plus VRd Yields Deep, Durable Responses in Patients with NDMM
The data supports quadruplet therapy’s potential in the first line for patients with newly diagnosed multiple myeloma (NDMM).
Published: 3/4/2025
Automated Insulin Delivery Technology Receives FDA Clearance for Individuals With Type 2 Diabetes
The t:slim X2 insulin pump and Tandem Mobi system both use Control-IQ.
Published: 3/4/2025
Efgartigimod Monotherapy More Effective Than IVIG in Older Patients With Generalized Myasthenia Gravis
Given the increasing age of patients with generalized myasthenia gravis, knowing which therapies are most effective for different subgroups is essential.
Published: 3/4/2025
Emapalumab-Lzsg Receives FDA Priority Review for Treatment of Children and Adults With HLH/MAS
The action follows pooled data from 2 studies that enrolled patients with hemophagocytic lymphohistiocytosis (HLH)/macrophage activation syndrome (MAS) in Still disease.
Published: 3/4/2025
Patients With CKD at Elevated Risk of Kidney Failure and Acute Ischemic Stroke
Additional risk factors included older age and advanced chronic kidney disease (CKD) stage.
Published: 3/4/2025
FDA Approves Biosimilars Referencing Denosumab for Osteoporosis-, Cancer-Related Skeletal Events
The new approval expands the portfolio of denosumab biosimilars, increasing access and improving costs for patients.
Published: 3/4/2025
Tislelizumab-Jsgr Plus Chemotherapy Receives FDA Approval for Advanced Esophageal Squamous Cell Carcinoma
The decision is based on clinically meaningful results from a phase 3 trial.
Published: 3/4/2025
Nirmatrelvir-Ritonavir Has Little Impact on COVID-19 Hospitalization, Mortality in Vaccinated Older Adults
New results shed light on the ineffectiveness of the combination antiviral therapy in patients vaccinated against COVID-19.
Published: 3/3/2025
ADI-001 Receives FDA Fast Track Designation to Treat Systemic Sclerosis
ADI-101 targets CD20 for the treatment of autoimmune diseases and is advancing across 6 autoimmune indications.
Published: 3/3/2025
Tenecteplase Receives FDA Approval, Marking First New Stroke Medication in Nearly 30 Years
In a clinical trial, tenecteplase was shown to be a comparable alternative to alteplase.
Published: 3/3/2025
FDA Annual Flu Vaccine Meeting and CDC’s ‘Wild to Mild’ Campaign Canceled
The decisions were made amid the United States worst flu outbreak in over 2 decades.
Published: 3/3/2025
Google’s Pixel Watch 3 Loss of Pulse Detection Feature Receives FDA Clearance
The feature is expected to be available to US users in late March 2025.
Published: 3/3/2025
CDC Releases Reports of Encephalopathy in Children With Influenza-Associated Mortality
The data were released in the CDC’s Morbidity and Mortality Weekly Report.
Published: 3/3/2025
Trastuzumab Rezetecan Is Safe, Efficacious for Patients With HER2-Mutated Non-Small Cell Lung Cancer
Trastuzumab rezetecan is a novel antibody-drug conjugate.
Published: 3/2/2025
Novel Porosome Reconstitution Therapy Receives Orphan Drug Designation for Treatment of Cystic Fibrosis
The advanced therapy yielded superior enhanced mucus secretion compared with available therapies.
Published: 3/1/2025
HDL Cholesterol Linked to Higher Risk of Glaucoma in Adults Over 55 Years
The results act as a contradiction to conventional wisdom of high-density lipoprotein (HDL) cholesterol being healthy and lowering the risk of heart disease, but more research is warranted.
Published: 3/1/2025
Study Finds Increased Economic Impact of RSV Among Older Adults
RSV infection resulted in higher costs among specific age groups, especially patients aged 70 to 80 years.
Published: 2/28/2025
FDA Approves Odactra Label Expansion to Include Children With House Dust Mite Allergy
The updated indication now includes pediatric patients aged 5 through 11 years.
Published: 2/28/2025
Adding Bevacizumab to Vinorelbine, Platinum-Based Chemotherapy Improves Outcomes for Patients with HER2- Metastatic Breast Cancer
Patients achieved an overall survival of 12.4 months.
Published: 2/28/2025
Daily Vitamin E Achieves Liver Histology Improvements in Patients With MASH
Patients with metabolic dysfunction-associated steatohepatitis (MASH) receiving 300 mg of vitamin E daily presented improved steatosis, lobular inflammation, and fibrosis stages.
Published: 2/28/2025
Age-Specific Monitoring and Emergency Treatment Enhance Safety in Patients Receiving Allergen Immunotherapy
Health care professionals and patients must recognize that rapid administration of adrenaline is the only first-line treatment for anaphylaxis.
Published: 2/28/2025
Gepotidacin’s Potential FDA Approval and Novel Mechanism Treating UTIs
If approved, gepotidacin (GSK) will be a new oral agent added to the treatment paradigm for urinary tract infections (UTIs).
Published: 2/28/2025
Bird Flu, Tuberculosis, Measles, and More: Top News From February 2025
Pharmacists play a crucial role in understanding and responding to these developments, ensuring patients remain informed about the latest advancements and potential threats.
Published: 2/28/2025
Study Finds Radon Exposure Increases Odds of Gestational Diabetes
Radon exposure during pregnancy was significantly linked to increased odds of gestational diabetes.
Published: 2/27/2025
Glecirasib Improved Response Rates, Survival in Patients With Non-Small Cell Lung Cancer
Glecirasib is a potent oral inhibitor of KRASG12C.
Published: 2/27/2025
AAAAI: Twice-Daily Ruxolitinib Cream Improves Atopic Dermatitis Severity
At week 8, significantly more children, adolescents, and adults who applied 1.5% ruxolitinib cream versus vehicle achieved IGA treatment success.
Published: 2/27/2025
FDA Ends Semaglutide Shortage Listing, Contributing to Ongoing Legal Challenges
Pharmacies could still experience localized availability issues for semaglutide despite its removal from the drug shortage list.
Published: 2/27/2025
Navigating Triple-Negative Breast Cancer Treatment With Sacituzumab Govitecan
Sacituzumab govitecan improves outcomes but requires careful management of adverse effects.
Published: 2/27/2025
Phase 3 Data Offer Hope to Patients With Meniere Disease
SPI-1005, a novel anti-inflammatory compound, achieved coprimary end points for efficacy, including improvements in hearing loss and speech discrimination.
Published: 2/27/2025
Measles Outbreak in West Texas Marks Largest Surge in 30 Years
Officials urge vaccinations as mobile vaccine drives ramp up to contain the outbreak.
Published: 2/27/2025
High Ratio of Non-HDL Cholesterol to HDL Cholesterol Associated With Heightened Hypertension, Heart Disease Risk
Compared with other indicators of cardiovascular risk, the ratio of non-high-density lipoprotein cholesterol (HDL-C) to normal HDL-C had a stronger association with the risk of hypertension and heart disease.
Published: 2/27/2025
Pre-Transplant Ruxolitinib Potentially Linked With Improved Non-Relapse Mortality, Survival Benefits in Myelofibrosis
Even for patients with myelofibrosis who could otherwise proceed directly to hematopoietic cell transplantation, pre-transplant treatment with ruxolitinib led to improved survival benefits.
Published: 2/27/2025
Pharmacists Play Key Role When Individualizing Treatments for UTIs
Pharmacists must consider drug Interactions, allergies, and comorbidities when treating patients with urinary tract infections (UTIs).
Published: 2/27/2025
ASCO GU: ARANOTE and ARASENS Trials Reinforce Darolutamide in Metastatic Hormone-Sensitive Prostate Cancer
Fred Saad, MD, discussed findings from the phase 3 ARANOTE and ARASENS trials.
Published: 2/26/2025
Deep Responses in Smoldering Multiple Myeloma Linked to Improved Outcomes
Risk stratification remains a challenge when selecting patients for treatment of smoldering multiple myeloma.
Published: 2/26/2025
FDA Approves Miudella, First Hormone-Free, Copper IUD in Over 40 Years
The newly-approved intrauterine device (IUD) prevents pregnancy in people of reproductive potential for up to 3 years.
Published: 2/26/2025
Pharmacists Optimize Management of Nontuberculous Mycobacterial Infections
Clinical pharmacists can optimize treatment through effective medication management and therapeutic drug monitoring.
Published: 2/26/2025
New Pricing, Access to Tirzepatide Available Through Self-Pay Options
New options for tirzepatide provide a transparent, out-of-pocket choice for patients by streamlining the supply chain and bypassing insurance.
Published: 2/26/2025
Tenofovir Amibufenamide Comparable to TDF in the Treatment of Chronic Hepatitis B
Although tenofovir amibufenamide and tenofovir disoproxil fumarate (TDF) had similar effects, the former resulted in better renal safety and did not impact lipid levels.
Published: 2/26/2025
Pembrolizumab Plus Standard of Care Receives Priority Review for Resectable Locally Advanced Head and Neck Cancer
Pembrolizumab is a humanized monoclonal antibody that targets PD-1.
Published: 2/26/2025
FDA OKs Label Changes for Buprenorphine Injections, Reducing Time to Treatment in Opioid Use Disorder
The label changes to buprenorphine extended-release injections can increase convenience and adherence for patients with moderate to severe opioid use disorder.
Published: 2/25/2025
Study Finds Fewer Than 1% of US Clinical Trials Enroll Pregnant Participants
The authors note that this lack of inclusion can leave important safety and efficacy questions unanswered.
Published: 2/25/2025
FDA Accepts New Drug Application for Dordaviprone to Treat Recurrent H3 K27M-Mutant Diffuse Glioma
The designation is supported by pooled data from 4 clinical trials.
Published: 2/25/2025
Nadofaragene Firadenovec Shows CR and Tolerability in Patients With NMIBC
Nadofaragene firadenovec led to most patients with Bacillus Calmette-Guérin-unresponsive non-muscle invasive bladder cancer (NMIBC) experiencing a complete response (CR) at 3 months.
Published: 2/25/2025
Study: Certain Hormonal Contraceptives Increase Risks of Ischemic Stroke, Myocardial Infarction
Levonorgestrel-releasing intrauterine devices were not found to increase women’s risks of these conditions.
Published: 2/25/2025
Omalizumab Shows Superiority Over Immunotherapy in Stage 2 of OUtMATCH Study
The FDA-approved treatment did not cause as many adverse events as immunotherapy when treating patients with multi-food allergy.
Published: 2/24/2025
Updates on the Use of Biosimilars for Pediatric Patients With Rheumatic Disease
Although more research is needed in pediatric patients, biosimilars could improve treatment access and reduce costs.
Published: 2/24/2025
Tanshinlactone May Inhibit the Growth of ER+, HER2+, or EGFR-Mutated Cells in Breast Cancer
Tanshinlactone is an active ingredient that is commonly used in Chinese herbal medicine.
Published: 2/24/2025
FDA Grants EXG-34217 Orphan Drug Designation for Treatment of Telomere Biology Disorders
The treatment is currently under evaluation in an ongoing phase 1/2 trial.
Published: 2/24/2025
Molecular COVID-19/Flu Multiplex Test Is Granted FDA Emergency Use Authorization
The test results are available in as little as 20 minutes.
Published: 2/24/2025
B-Together Trial Demonstrates Efficacy of Bepirovirsen Followed By Peg-IFN for HBV
The long-term durability of response will be evaluated in the B-Sure trial (NCT04954859), which will enroll patients with hepatitis B virus (HBV) from B-Together (NCT04676724).
Published: 2/24/2025
Evaluating Options for Respiratory Syncytial Virus Prophylaxis
Curbing RSV and its complications can reduce health care costs associated with its treatment.
Published: 2/24/2025
FDA Grants Fast Track Designation to BRTX-100 to Treat Chronic Lumbar Disc Disease
Currently, the agent is undergoing evaluation in a phase 2 clinical trial to determine its safety and efficacy.
Published: 2/23/2025
A Common Blood Pressure Medication May Help Treat Symptoms of ADHD
In a study of 5 different drugs, amlodipine was the only one to reduce hyperactivity in patients with attention-deficit hyperactivity disorder (ADHD).
Published: 2/21/2025
Engineered Fat Cells Starve Cancer and Slow Tumor Growth
The approach targets cancer glucose and fatty acid metabolism, which is essential for cancer cell growth.
Published: 2/21/2025
FDA Grants Breakthrough Therapy Designation to SkinTE for Diabetic Foot Ulcers
SkinTE could aid Wagner grade 1 diabetic foot ulcers by regenerating and activating the tissues surrounding the wound to heal it completely.
Published: 2/21/2025
Chenodiol, First Treatment for Cerebrotendinous Xanthomatosis, Receives FDA Approval
This marks the first FDA-approved treatment for this rare lipid storage disease.
Published: 2/21/2025
Administering Plasma Therapy Requires Pharmacist Collaboration With Specialty Care Team
Plasma therapy can involve burdensome procedures and infusions for patients, but pharmacists can use their expertise to make the process easier and more convenient.
Published: 2/21/2025
VP250 Is Safe and Effective Treatment for Young Children With Peanut Allergy
In children aged 1 to 3 years, the VP250 peanut patch was superior to placebo in the desensitization to peanuts and increasing the peanut dose that triggers allergic symptoms.
Published: 2/21/2025
Chromosome Genomic Array Testing Improves Myelofibrosis Prognostication for Patients Undergoing Transplantation
Using chromosome genomic array testing in combination with existing risk stratification models can better determine patients with myelofibrosis who can benefit from transplant.
Published: 2/21/2025
Weekly Mim8 Effective in Pediatric Hemophilia A With and Without Inhibitors
The new data demonstrates the effectiveness of Mim8 in children with hemophilia A regardless of inhibitor status, expanding the populations in which the novel drug in development could have a treatment benefit.
Published: 2/21/2025
FDA Grants Fast Track Designation to 67Cu-SAR-bisPSMA for Prostate Cancer
67Cu-SAR-bisPSMA is indicated for adult patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC).
Published: 2/20/2025
Study Shows Semaglutide Holds Promise in Reducing Alcohol Cravings
Treatment with semaglutide yielded superior effects on drinking outcomes compared with existing therapies to reduce alcohol cravings.
Published: 2/20/2025
Study Finds Central Obesity Measures More Accurate for Assessing Colorectal Cancer Risk Than BMI
Using central obesity measures provides more accurate estimates of the proportion of CRC cases attributable to excess weight compared to using BMI alone.
Published: 2/20/2025
Fluctuating Cholesterol Over Time Associated With Dementia Risk in Older Adults
There was an association observed between fluctuating low-density lipoprotein cholesterol and the risk of developing dementia and cognitive impairment.
Published: 2/20/2025
ACTIVATE-Kids Study Demonstrates Efficacy of Oral Therapy for Children With PK Deficiency
Improvements in baseline for markers of hemolysis (indirect bilirubin, lactate dehydrogenase, and haptoglobin) were observed only in the mitapivat arm.
Published: 2/20/2025
FDA Grants Priority Review to Zongertinib for Treatment of HER2-Mutated, Advanced Non-Small Cell Lung Cancer
Priority review status will allow for expedited development of zongertinib, putting it on the path toward approval as the first in a new class of drugs for mutated NSCLC.
Published: 2/20/2025
Research Shows Infusing Isatuximab in Just 30 Minutes Provides Same Safety
The 75 minutes of infusion time typically required is costly and difficult for patients.
Published: 2/20/2025
New and Evolving: Pretreatment Risk Factors for Pneumonitis and Trastuzumab-Deruxtecan
T-DXd has a boxed warning for interstitial lung disease and pneumonitis.
Published: 2/20/2025
Single-Dose Malaria Vaccine Demonstrates 90% Efficacy in Early Trials
PfSPZ-LARC2 is a genetically engineered malaria vaccine that marks a significant step forward in combating malaria around the world.
Published: 2/20/2025
Focusing Treatment on Multiple Pathways to Reduce Resistance and Improve Outcomes in Triple-Positive Breast Cancer
Using new treatment advances, traditional medications, genetic profiles, immunotherapies, and individualized plans enables providers to improve outcomes for patients with TPBC.
Published: 2/19/2025
Novel Blood Test Detects Early-Stage Pancreatic Cancer With 85% Accuracy
The test offers an accurate, fast, low-cost, and noninvasive tool for early diagnosis of pancreatic ductal adenocarcinoma.
Published: 2/19/2025
Managing Endometriosis Treatment: Pharmacists as Key Partners in Patient Care
Pharmacists play a vital role in supporting patients with endometriosis through guidance on treatment options and managing side effects.
Published: 2/19/2025
Pharmacists Can Improve Specialty Medication Management in Dermatology
Embedding a pharmacist in the dermatology clinic improved clinical and financial outcomes.
Published: 2/19/2025
Later-Onset Menopause Associated With a Lower Risk of Heart Disease, Study Finds
These findings may lead to new therapies to help reduce the risk of heart disease in women who are at risk.
Published: 2/19/2025
Impact of RSV and hRV Coinfection on Respiratory Disease Severity
Coinfection with RSV and hRV is linked to a higher prevalence of lower respiratory tract infections, according to new data.
Published: 2/19/2025
CDC Study Raises Concerns Over Undetected H5N1 Infections in Humans
Research suggests H5N1 may be spreading undetected among humans, particularly in veterinarians with frequent animal exposure.
Published: 2/18/2025
Larsucosterol Did Not Show Statistical Significance Compared With Placebo in Phase 2b AHFIRM Trial
Although larsucosterol did not show statistical significance, it showed clinically meaningful trends in 90-day mortality in patients with severe alcohol-associated hepatitis.
Published: 2/18/2025
Sickle Cell Disease Management Requires Pharmacist Involvement in Multidisciplinary Care Team
Prescribing and dosing appropriate treatments for patients with sickle cell disease while managing episodes of acute pain are some of the integral roles of pharmacists.
Published: 2/18/2025
Children and Adolescents With Postacute COVID-19 Face Higher Risk of Poor Gastrointestinal Tract Outcomes
New data from the longest known trial of pediatrics and adolescents in the postacute phase of COVID-19 show they are at a heightened risk of gastrointestinal tract symptoms.
Published: 2/18/2025
New Study Puts Community Pharmacists at Forefront of Diabetic Kidney Disease Therapy
Clinical decision support systems based on algorithms have improved outcomes and reduced costs in other health care settings.
Published: 2/18/2025
Data Support Adjuvant Nivolumab for High-Risk MIUC, Regardless of Prior Chemotherapy
Nivolumab demonstrated a sustained disease-free survival benefit over placebo in high-risk muscle-invasive urothelial carcinoma (MIUC).
Published: 2/17/2025
Chikungunya Vaccine Receives FDA Approval for Individuals 12 Years and Older
The approval makes the vaccine the first of its kind for this indication in the United States.
Published: 2/17/2025
Cabozantinib in Combination With Nivolumab and Ipilimumab Met Primary End Point in the Phase 3 COSMIC-313 Trial
The data were presented at the 2025 ASCO Genitourinary Cancers Symposium.
Published: 2/17/2025
Pharmacists at the Forefront: Enhancing Care for Patients With Alzheimer Disease Receiving Disease-Modifying Treatment
Pharmacists can support patients with treatment education, monitoring, and adherence, helping to overcome challenges posed by cognitive decline.
Published: 2/17/2025
Study Finds Gut Microbiota Associated With Development of Food Allergy, Sensitivity in Infants
The authors are optimistic that these findings may help develop defenses to prevent food allergies in at-risk infants.
Published: 2/17/2025
Treating Recurrent Pericarditis With Rilonacept and What Future Research May Entail
Future research can explore the underlying cause of recurrent pericarditis with systemic Sjögren syndrome and the combination of rilonacept with immunosuppressive therapies.
Published: 2/17/2025
Gut-Brain Axis, Chronic Inflammation Important Targets for Treating CKD and Depression
The authors suggest future research should consider inflammation and the gut as potential therapeutic targets improve depression in patients with chronic kidney disease (CKD).
Published: 2/17/2025
Rising Demand for GLP-1 Receptor Agonists Means an Increase in Patient Questions
Pharmacists should emphasize the importance of medication adherence and lifestyle changes.
Published: 2/17/2025
FDA Approves Biosimilar Denosumab-dssb to Treat Osteoporosis-, Cancer-Related Bone Loss
The approval in multiple indications is designed to improve access to effective, proven treatments for skeletal fractures, which can greatly reduce patient quality of life.
Published: 2/17/2025
5-in-1 Meningococcal ABCWY Vaccine Candidate Receives FDA Approval for Meningococcal Disease
Invasive meningococcal disease is a severe bacterial infection caused by the bacterium Neisseria meningitidis, often leading to meningitis or sepsis.
Published: 2/17/2025
Video: Etranacogene Dezaparvovec Has Long-Term Efficacy, Can Expand Eligibility for Hemophilia B
Steven Pipe, MD, explains the long-term efficacy data surrounding etranacogene dezaparvovec in patients with hemophilia B.
Published: 2/17/2025
FDA Grants Fast Track Designation to Amlenetug for Possible Treatment of Multiple System Atrophy
Amlenetug could provide a treatment option for patients with multiple system atrophy, a progressive and rare condition that causes damage to the brain’s nerve cells.
Published: 2/16/2025
Cabozantinib Extends Survival in Patients With RCC and Untreated Brain Metastases
Data from the phase 2 CABRAMET trial suggests the potential of cabozantinib for treatment of brain metastases from renal cell carcinoma (RCC).
Published: 2/15/2025
Targeting Nectin-4 and HER2 in Urothelial Cancer: The Evolving Role of ADCs
Enfortumab vedotin, trastuzumab deruxtecan, and disitamab vedotin were highlighted at the 2025 ASCO Genitourinary Cancers Symposium.
Published: 2/15/2025
Etranacogene Dezaparvovec-drlb Delivers Sustained, Increased Bleed Protection Compared With Prophylaxis in Hemophilia B
A one-time infusion of etranacogene dezaparvovec-drlb led to sustained bleeding control and a reduction in factor IX prophylaxis in patients with hemophilia B.
Published: 2/15/2025
Enhancing Outcomes With Immunotherapy Agents for Patients With Non-Muscle Invasive Bladder Cancer
Panelists at the 2025 ASCO Genitourinary Cancers Symposium discussed challenges and new approaches to treatment.
Published: 2/14/2025
RSV in Older Adults: Risks, Prevention, and the Pharmacist's Role
RSV poses a significant threat to high-risk adults, but effective vaccines offer strong protection, highlighting the need for increased vaccination rates and education.
Published: 2/14/2025
Rapid-Acting Insulin Biosimilar Receives FDA Approval for Diabetes
Insulin-aspart-szjj (Merilog) is the first rapid-acting insulin biosimilar product approved by the FDA.
Published: 2/14/2025
FDA Approves Vimseltinib for the Treatment of Adults With Symptomatic TGCT
The indication is for symptomatic tenosynovial giant cell tumor (TGCT) for which surgical resection will potentially cause worsening functional limitation or severe morbidity.
Published: 2/14/2025
FDA Grants OPN-6602 Orphan Drug Destination for Treatment of Patients With Relapsed, Refractory Multiple Myeloma
OPN-6602 is an oral EP300/CBP bromodomain inhibitor that yielded 100% tumor regression as a combination therapy in mouse models.
Published: 2/14/2025
First-Line Enfortumab Vedotin, Pembrolizumab Superior to Chemotherapy in Patients With Urothelial Carcinoma
The combination of the antibody-drug conjugate and PD-1/L1 inhibitor yielded an improved progression-free survival in locally advanced or metastatic urothelial carcinoma.
Published: 2/14/2025
Potential Drug for Mitigation of Cannabis Withdrawal Symptoms Receives FDA Fast Track Designation
PP-01 could become a first-in-class treatment for patients with cannabis use disorder.
Published: 2/14/2025
Darolutamide Improved Survival in Phase 3 Trials for Patients With Metastatic Hormone-Sensitive Prostate Cancer
The data were presented at the 2025 ASCO Genitourinary Cancers Symposium in San Francisco, California.
Published: 2/14/2025
‘Off-Grid’ Electrical Activity Drives Tumor Growth in Small Cell Lung Cancer
The cancer cells developed their own electrical network similar to neural behavior seen in the brain.
Published: 2/14/2025
As Nonopioid Alternatives for Pain Management Emerge, Pharmacists Prove Essential
Therapies like the newly approved suzetrigine, a nonopioid NaV1.8 pain signal inhibitor, could revolutionize pain management and mitigate the risks associated with opioid use.
Published: 2/14/2025
Semaglutide Does Not Increase Depression or Suicidal Ideation Risk in Adults With Overweight, Obesity
Treatment with 2.4 mg of semaglutide did not increase the risk of developing suicidal ideation or behavior compared with placebo.
Published: 2/14/2025
The Role of Pharmacists in Optimizing Care for Seizures in Neonatal Patients
Pharmacists can help patients and their caregivers manage seizures, assess seizure control, and recommend appropriate treatments such as phenobarbital or rescue medications.
Published: 2/14/2025
Pharmacists Educate and Bridge Communication Gaps for Patients With Pericarditis
Pharmacists can help educate patients, identify adverse events, and help patients communicate with other health care professionals or drug companies.
Published: 2/14/2025
Study Finds Easy-to-Implement Treatment Strategy for Children With Peanut Allergy
After gradually consuming increased doses of peanut butter, children who could initially tolerate about half a peanut could consume 3 tablespoons without an allergic reaction.
Published: 2/14/2025
Pharmacists Play a Crucial Role Monitoring Patients With Psoriasis and Psoriatic Arthritis
Through frequent interactions, pharmacists can discuss patients' treatment satisfaction, adherence issues, or potential adverse events.
Published: 2/14/2025
Enfortumab Vedotin Plus Pembrolizumab Outperforms Chemotherapy in Advanced Urothelial Carcinoma
The combination greatly improved progression-free survival and overall survival.
Published: 2/13/2025
Talazoparib Plus Enzalutamide Meets Primary End Point in Phase 3 Trial of Patients With Metastatic Castration-Resistant Prostate Cancer
Talazoparib in combination with enzalutamide yielded significant improvements in radiographic progression-free survival and overall survival.
Published: 2/13/2025
Bariatric Surgery Improves Adverse Outcomes in Patients with MASH-Related Cirrhosis
This surgery can be significant in reducing the long-term risk of adverse outcomes and decompensation in cirrhosis related to metabolic dysfunction-associated steatohepatitis (MASH).
Published: 2/13/2025
High Blood Glucose in Diabetes Promotes Rapid Development of Antibiotic-Resistant Staphylococcus Aureus
Diabetes management through insulin could play a significant role in preventing antibiotic resistance.
Published: 2/13/2025
CUSP06 Granted FDA Fast Track Designation for Patients With Platinum-Resistant Ovarian Cancer
Currently, the Cadherin-6 targeting antibody-drug conjugate is undergoing evaluation in a phase 1a/1b clinical trial.
Published: 2/13/2025
FDA Accepts BLA for Lerodalcibep, a Novel Agent to Lower LDL Cholesterol in Atherosclerotic Cardiovascular Disease
The agency will now review the novel PCSK9 inhibitor for possible approval in patients with or at high risk of atherosclerotic cardiovascular disease.
Published: 2/13/2025
FDA Grants Fast Track Designation to Amezalpat for Treatment of Hepatocellular Carcinoma
Building on a previously granted orphan drug designation, the latest FDA action for amezalpat puts the drug in a position for regulatory approval.
Published: 2/13/2025
Real-World Study Shows Efficacy, Safety of First-Line Dacomitinib in Patients With EGFR-Mutated NSCLC
Up to 61% of all non-small cell lung cancer (NSCLC) cases harbor EGFR mutations.
Published: 2/13/2025
Expanded Label for Avacincaptad Pegol Intravitreal Solution Receives FDA Approval
Avacincaptad pegol intravitreal solution is a prescription eye injection used to treat geographic atrophy.
Published: 2/13/2025
Risdiplam Receives FDA Approval for Spinal Muscular Atrophy
Risdiplam is the only approved non-invasive disease-modifying SMA treatment.
Published: 2/12/2025
Pharmacist's Role in Duloxetine Therapy: Improving Medication Adherence in Older Adults With Depression, Pain
Duloxetine offers treatment for various neuro-psychiatric and pain disorders in patients who have difficulty swallowing.
Published: 2/12/2025
Brentuximab Vedotin Plus Lenalidomide and Rituximab Receives FDA Approval for Adults With LBCL
The approval follows the ECHELON-3 study, which enrolled adults with relapsed or refractory large B-cell lymphoma.
Published: 2/12/2025
Chronic Kidney Disease Associated With Abnormal Cerebellar Growth in Pediatric Patients
Reductions in cerebellar volume were associated with cognitive deficits and lower kidney function in those with CKD.
Published: 2/12/2025
Pharmacists Can Recommend Supplements and Lifestyle Modifications for Patients With Alzheimer Disease
Supplements, such as Prevagen, as well as lifestyle and diet modifications can provide additional support to patients with Alzheimer disease.
Published: 2/12/2025
Patients With Cytopenic Primary Myelofibrosis Face Unique Therapeutic Challenges, Poor Prognosis
Cytopenic myelofibrosis is characterized by poorer prognosis and more severe anemia and thrombocytopenia compared with proliferative myelofibrosis.
Published: 2/12/2025
FDA Approves Mirdametinib for Treatment of Adults, Children With NF1-PN
The approval is based on positive clinical trial results that indicated deep and durable reductions in plexiform neurofibroma.
Published: 2/11/2025
Amazon's RxPass Shown to Improve Days' Supply, Refills, and Out-of-Pocket Costs for Common Medications
Amazon Pharmacy’s subscription service could cause sale disruptions for traditional retail pharmacies.
Published: 2/11/2025
Trastuzumab Deruxtecan Meets Primary End Point in the DEBBRAH Trial for Patients with HER2+ Advanced Breast Cancer
Presence of leptomeningeal disease is associated with poorer treatment outcomes and quality of life for patients with breast cancer.
Published: 2/11/2025
FDA Grants Rezpegaldesleukin Fast Track Designation for Treatment of Children, Adults With Atopic Dermatitis
Rezpegaldesleukin is designed to balance the body’s immune system response through activation of regulatory T-cells.
Published: 2/11/2025
SARS-CoV-2 Infection Associated With Increased Plaque in Coronary Arteries, Higher Risk of Cardiac Events
Emerging data indicate that COVID-19 is also characterized by inflammation present in the heart and other organs
Published: 2/11/2025
FDA Grants Priority Review to Brensocatib for Treatment of Bronchiectasis
If approved, brensocatib will be the first and only approved treatment for bronchiectasis and the first within a new class of medicines, called dipeptidyl peptidase 1 inhibitors.
Published: 2/11/2025
Study: Vitamin D Status in Early Pregnancy and Infant Outcomes
Pharmacists can recommend vitamin D supplements and vitamin D-rich foods to support healthy pregnancy outcomes.
Published: 2/11/2025
Phase 3 HYPERION Trial Evaluating Sotatercept-Csrk Ends Prematurely, Moving to Final Analysis
The decision to end HYPERION (NCT04811092) comes after positive results from an interim analysis of the ZENITH trial (NCT04896008).
Published: 2/11/2025
For Pharmacists Treating Thalassemia, Monitoring Anemia and Proper Counseling on Therapies is Crucial
Thalassemia, a chronic blood condition that reduces hemoglobin levels, requires a hands-on approach from pharmacists in patient monitoring and diagnosis.
Published: 2/11/2025
Lactate Is a Key Regulator of Immune Escape, Bone Marrow Fibrosis in Myelofibrosis
Circulating lactate is increased in patients with myelofibrosis and corresponds with the remodeling of lactate export channel monocarboxylate transporter 4, suggesting a link with fibrosis establishment.
Published: 2/11/2025
Study Links PTSD to Higher Rates of Heart Disease in Vietnam Veterans
Vietnam war trauma continues to affect veterans’ health 50 years later.
Published: 2/10/2025
Investigators Use Sequencing Methods to Identify Triggering Allergen in Patient With EoE
The authors are optimistic that this method can be replicated to identify other allergens that manifest into eosinophilic esophagitis (EoE).
Published: 2/10/2025
FDA Accepts Biologics License Application for Pertuzumab Biosimilar to Treat Breast Cancer
If approved, HLX11 could offer a more cost-effective alternative to pertuzumab for the treatment of human epidermal growth factor receptor 2-positive breast cancer.
Published: 2/10/2025
Novel Molecular Imaging Agent for Detection of Bowel Inflammation in Crohn Disease Receives FDA FTD
BR55, an injection of perfluorobutane/nitrogen lipopeptide-coated microbubbles, could aid in the detection of angiogenesis and allow for earlier diagnosis in patients with Crohn disease.
Published: 2/10/2025
Iclepertin Fails to Show Statistically Significant Effects on Cognition and Functioning in Patients With Schizophrenia
In the phase 3 CONNEX clinical trial program, iclepertin did not meet its primary and secondary end points.
Published: 2/10/2025
ACR-368 OncoSignature Assay Receives FDA Breakthrough Device Designation for Endometrial Cancer
The indication is for patients with endometrial cancer who may benefit from treatment with ACR-368 (Acrivon Therapeutics).
Published: 2/10/2025
Investigational Vvax001 Vaccine Shows Significant Potential in Reducing Precancerous Cervical Lesions
The therapeutic vaccine could provide patients with a non-surgical alternative to traditional treatment approaches.
Published: 2/10/2025
Machine Learning Shows Promise Predicting Progression of CKD to Kidney Failure
These findings can lay the foundation for the development of machine learning models in chronic kidney disease (CKD) and kidney failure.
Published: 2/9/2025
Nipocalimab Demonstrates Sustained Disease Control, Reduction in Autoantibodies in Generalized Myasthenia Gravis
Compared with other treatments for myasthenia gravis, nipocalimab demonstrated more significant improvements in disability scores, with tolerable safety.
Published: 2/8/2025
Study Finds Fasting Plasma Glucose Level Is Associated With Development of Diabetes
Age, body mass index, and male sex are also associated with the development of diabetes.
Published: 2/7/2025
Aztreonam and Avibactam Receive FDA Approval for Treatment of Adults With Complicated Intra-Abdominal Infections
The decision offers patients with antimicrobial resistance, who have limited or no treatment options, a new alternative.
Published: 2/7/2025
Quadruple Therapy With Isatuximab Shows Promise for Older Adults With Multiple Myeloma
The quadruple treatment was active and safe as initial therapy for older patients with transplant-ineligible multiple myeloma.
Published: 2/7/2025
Pharmacists Can Stay Aware of the Evolving Landscape of Gout Treatment to Address Unmet Needs
New therapies are being developed for individuals with gout.
Published: 2/7/2025
The AQUILA Debate: Daratumumab and Smoldering Multiple Myeloma
Ming-Hei Tai, PharmD, BCOP, shares his concerns about the AQUILA trial and use of daratumumab for smoldering multiple myeloma.
Published: 2/7/2025
Highest SMM Rates in Pregnant People With Chronic Hypertension and Preeclampsia, Preeclampsia Alone
The prevention of preeclampsia may reduce severe maternal morbidity (SMM) risk in pregnant people.
Published: 2/7/2025
FDA Grants Fast Track Designation to ADI-001 for Treatment of Refractory Systemic Lupus Erythematosus
The designation builds on previous regulatory action for ADI-001 and allows for expedited development of the treatment for systemic lupus erythematosus.
Published: 2/7/2025
ABO-101 Receives FDA Orphan Drug and Rare Pediatric Designations for Primary Hyperoxaluria Type 1
ABO-101 is supported by preclinical data that demonstrated significant reductions in urinary oxalate in PH1 disease models.
Published: 2/7/2025
Risk Scores Using Molecular Data Can Better Identify Patients With Primary Myelofibrosis Who Benefit From HSCT
More accurate prognostic risk assessment could aid pharmacists in the management and counseling of patients with primary myelofibrosis.
Published: 2/7/2025
IVIG Does Not Reduce Late Gadolinium Enhancement Burden in Pediatrics With Myocarditis
Often an indicator of fibrosis or damage to the heart, late gadolinium enhancement was found to be unaffected by the administration of intravenous immunoglobulin (IVIG) in pediatric patients with myocarditis.
Published: 2/6/2025
Mindfulness Program Reduces Opioid Cravings During Buprenorphine Treatment
There were no substantial differences for the mindfulness with substance use or anxiety outcomes compared with the recovery control group.
Published: 2/6/2025
Pregnant Individuals With MS More Likely to Experience Mental Illness
Pregnant individuals with multiple sclerosis (MS) are more likely to experience mental illness both during their pregnancy and in the first years after giving birth.
Published: 2/6/2025
Sacituzumab Govitecan Shows Potential in Overcoming Barriers to Brain Tumor Treatment in Patients With Breast Cancer
The Trop-2-tagreting antibody drug conjugate facilitated improved intracranial penetration with favorable tolerability.
Published: 2/6/2025
Young Adults With Sickle Cell Disease Have Elevated p16 mRNA, Contributing to Premature Aging
Higher p16 expression in patients with sickle cell disease led to heightened risk of age-related complications.
Published: 2/6/2025
American Heart Association Launches Initiative to Increase Education on Heart Failure
The initiative will provide information about care models for specialists and clinical teams to improve patient outcomes in heart failure.
Published: 2/5/2025
Phase 3 Trial Shows Promising Results for Encorafenib Combination Regimen for Patients with Metastatic Colorectal Cancer
Encorafenib in combination with cetuximab and mFOLFOX6 met its dual primary end point of overall response rate of 61%.
Published: 2/5/2025
Ranibizumab Injection Delivered Through Port Delivery Platform Is FDA Approved as Continuous Delivery Treatment for DME
Diabetic macular edema (DME) is the leading cause of new blindness in the US.
Published: 2/5/2025
Efruxifermin Demonstrates Potential in Treating Patients With MASH-Related Scarring or Cirrhosis
Efruxifermin is undergoing 3 phase 3 clinical trials to evaluate its safety, efficacy, and tolerability in metabolic dysfunction-associated steatohepatitis (MASH).
Published: 2/5/2025
Obesity in Patients With Non-Small Cell Lung Cancer Is Linked to Longer Survival
The study results build on the “obesity paradox,” which suggests that patients with cancer and obesity have better outcomes.
Published: 2/5/2025
Dual Immunotherapy Shows Promise in MSI-H/dMMR Metastatic Colorectal Cancer
Nivolumab plus ipilimumab demonstrated a 38% reduction in the risk of disease progression or death.
Published: 2/5/2025
Study: Mechanisms Impacting LDL-C Are Inversely Associated With Type 2 Diabetes Risk
An inverse relationship was observed between genetic conditions associated with high levels of low-density lipoprotein cholesterol and the risk of developing T2D.
Published: 2/5/2025
Study Finds COVID-19 Infection Associated With More Severe Disease Compared With Flu, RSV
Investigators noted that the differences between the 3 respiratory infections were not as pronounced during the 2023-2024 season.
Published: 2/4/2025
Study Finds High Prevalence of Vitamin and Mineral Deficiency in Type 2 Diabetes
Investigators found that 60% of individuals with type 2 diabetes are vitamin D deficient.
Published: 2/4/2025
ADHD Stimulant Dispensing Decreased Over the Past Decade, Study Finds
Prescription stimulant dispensing was greatly impacted by the COVID-19 pandemic and drug shortages.
Published: 2/4/2025
Central Nervous System Disease Drives Mortality in HER2+ Metastatic Breast Cancer Despite Longer Survival
In the study, 50% of the deaths amongst patients were linked to central nervous system-related causes.
Published: 2/4/2025
Findings Suggest Hemoglobin A1c, HDL-C Associated With Increased Risk of Stroke
The results highlight hemoglobin A1c/high-density lipoprotein cholesterol as a potential clinical marker for long-term stroke risk.
Published: 2/4/2025
Prevalence of CKD in Patients With LN and SLE Ranges From 10% to Almost 50%, Review Finds
Some risk factors for chronic kidney disease (CKD) in patients with lupus nephritis (LN) and systemic lupus erythematosus (SLE) were renal impairment, delayed diagnosis, and hypertension.
Published: 2/4/2025
Updated Clinical Guidelines Outline Optimal Treatment of Helicobacter pylori Infection
For pharmacists wondering whether bismuth quadruple therapy still reigns as the gold standard, the wait is over—the latest recommendations are here.
Published: 2/4/2025
GLP-1 Medication Not Associated With Risk of Thyroid Cancer
Overall, there is no long-term increased risk of developing thyroid cancer after initiating treatment with a glucagon-like peptide-1 (GLP-1) receptor agonist, although there is a short-term increase.
Published: 2/4/2025
Sacubitril/Valsartan Shows Efficacy in Treatment of Resistant Hypertension
Angiotensin receptor neprilysin inhibitors show promise as an alternative to standard management of resistant hypertension.
Published: 2/4/2025
FDA Approves Apomorphine Hydrochloride to Treat Motor Fluctuations in Advanced Parkinson Disease
The approval marks the first subcutaneous infusion device approved for the treatment of Parkinson disease, providing a new option for patients with serious disease who are unresponsive to other therapies.
Published: 2/4/2025
Topical Drug Delivery May Offer Welcome Alternatives for Breast Cancer Treatment
Topical, targeted drug delivery increases drug concentrations at the desired site while also reducing toxicity and unwanted adverse effects.
Published: 2/3/2025
Flu, RSV, COVID-19, and More: Updates on the 2025 Respiratory Virus Landscape
Rising seasonal viruses and emerging concerns emphasize the need for public awareness and prevention.
Published: 2/3/2025
A Review of Treatment Options for Shingles
Antiviral treatments can accelerate healing and reduce complications.
Published: 2/3/2025
Prioritizing Whole-Person Care in Diabetes Management is Crucial, UPMC Experts Say
Three experts from UPMC Health Plan highlight the importance of treating patients’ physical, mental, and social health when managing diabetes, rather than the disease alone.
Published: 2/3/2025
Novo Nordisk Announces Top-Line Results for Amycretin as Potential Obesity, Overweight Treatment
The phase 1b/2a results show the potential of amycretin, a unimolecular glucagon-like peptide-1 and amylin receptor agonist.
Published: 2/3/2025
People Who Achieve REM Sleep Later Might Be Experiencing Early Symptom of Alzheimer Disease
Health care professionals, particularly pharmacists, can recommend that patients take over-the-counter supplements, such as melatonin, to facilitate REM sleep.
Published: 2/3/2025
Improve Asthma Management With Triple Inhaled Therapy
Many patients do not attain sufficient disease control with inhaled corticosteroids in combination with long-acting β-2 agonists and remain vulnerable to exacerbations.
Published: 2/3/2025
Oral Antiviral Candidate Shows Promise for Respiratory Syncytial Virus Treatment
S-337395 demonstrated an 88.4% reduction in viral load and had a statistically significant improvement in clinical symptoms scores.
Published: 2/3/2025
Fitusiran Is a Drug to Watch in the Hematology Space in 2025
Fitusiran is part of a generation of novel RNA interference therapies and is designed for subcutaneous administration for the prophylactic treatment of hemophilia A or B.
Published: 2/1/2025
FDA Approves Diagnostic Label Expansion for HR+, HER2–Ultra-Low Metastatic Breast Cancer
The diagnostic identifies patients who may be eligible for treatment with fam-trastuzumab-deruxtecan-nxki (Enhertu; Daiichi-Sankyo, AstraZeneca).
Published: 2/1/2025
Patients With Juvenile Dermatomyositis Treated With IVIG Had No Increased Risk of Thromboembolic Events
These results provide a pediatric lens into the potential risk of thromboembolic events in patients with dermatomyositis.
Published: 1/31/2025
The AQUILA Debate: Daratumumab for Treatment of Smoldering Multiple Myeloma
Expert weighs in on data from the AQUILA trial and Johnson & Johnson's approval request for daratumumab for smoldering multiple myeloma.
Published: 1/31/2025
Ribociclib Plus Adjuvant Endocrine Therapy Is Safe, Tolerable in Patients With HR+/HER2– Breast Cancer
Continuous dosing of ribociclib was associated with better tolerability and outcomes.
Published: 1/31/2025
Calreticulin Mutations Can Worsen Survival Outcomes in Ruxolitinib-Treated Patients With Myelofibrosis
Myelofibrosis patients with CALR mutations have lower responses to symptoms and higher rates of anemia after 6 months of therapy with ruxolitinib.
Published: 1/31/2025
Model Estimates Prevalence of MASLD Will Increase From 33.7% in 2020 to 41.4% in 2050
The model also predicted prevalent cases of decompensated cirrhosis would more than triple, incident liver cancer cases would nearly double, and transplant almost quadruple.
Published: 1/31/2025
Pain or Anxiety Medication Prescription With IUD Insertion Procedures Are Proportionately Low, Studies Find
Although there were increases in prescriptions during the studies’ durations, the proportion of anxiety or pain medications on the same day of intrauterine device (IUD) insertion procedures were low.
Published: 1/31/2025
FDA Grants Regenerative Medicine Advanced Therapy Designation to Laru-Zova for X-Linked Retinitis Pigmentosa
The regenerative medicine advanced therapy designation expedites the development and review of regenerative medications that have the potential to address unmet needs for serious or life-threatening diseases.
Published: 1/31/2025
Statin Therapy Did Not Affect Kidney Function in Older Adults With and Without CKD
Statin use is not associated with a change in incident chronic kidney disease (CKD) and estimated glomerular filtration rate in adult patients aged 65 and older.
Published: 1/31/2025
FDA Approves Tocilizumab-Anoh as a Biosimilar to Actemra
The approval includes indications for rheumatoid arthritis, giant cell arteritis, polyarticular juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis, and COVID-19.
Published: 1/31/2025
FDA Approves Suzetrigine, New Alternative to Opioids for Acute Pain
The drug is a selective NaV1.8 pain signal inhibitor and is the first new class of medication to treat acute pain in over 20 years.
Published: 1/30/2025
FDA Approves Symbravo for Acute Treatment of Migraine With or Without Aura
Meloxicam and rizatriptan reduces migraine pain and help patients return to normal functioning with efficacy through 24 to 48 hours after a single dose for some patients.
Published: 1/30/2025
Digoxin Effectively Reduces Circulating Tumor Cell Clusters in Metastatic Breast Cancer, Study Finds
Digoxen is the active ingredient found in the foxglove plant and is commonly used to treat heart failure.
Published: 1/30/2025
Scholar Rock Submits FDA Application for Apitegromab to Improve Motor Function in Spinal Muscular Atrophy
Apitegromab is a muscle-targeted therapy for improvement of motor function in individuals with spinal muscular atrophy.
Published: 1/30/2025
Study: Radiotherapeutic Agent for GEP-NETs Demonstrates Positive Results
Lu-edotreotide (ITM-11; ITM) met its primary endpoint of prolonging progression-free survival (PFS).
Published: 1/30/2025
Trametinib Reduces in Mortality, Morbidity for Children With Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy is caused by abnormal genes in the heart muscle, causing the left ventricle to become thicker and effecting blood flow.
Published: 1/30/2025
New Research Explains Why Immunotherapy Is Less Effective in Children With Cancer
Children and adults with cancer have differing immune system responses, mutational burdens, and tissue microenvironments.
Published: 1/30/2025
Inavolisib in Combination With Palbociclib and Fulvestrant Meets Secondary End Point in the INAVO120 Trial
The overall survival data were immature at the primary analysis of the study.
Published: 1/30/2025
Red Cell Distribution Width Could Predict Anemia in Ruxolitinib-Treated Patients With Myelofibrosis
Diagnosing anemia, a serious and common complication of patients with myelofibrosis, could be made easier with the use of red cell distribution width assessment.
Published: 1/30/2025
Childhood-Onset Epilepsy Is Associated With Amyloid Accumulation in Late Adulthood
Additionally, the authors observe that childhood-onset epilepsy is associated with an earlier age at the onset of amyloidosis.
Published: 1/30/2025
Belzutifan Receives FDA Priority Review for Advanced Pheochromocytoma and Paraganglioma
The supplemental new drug application is based on objective response rate and duration of response results from a phase 2 study that assessed the efficacy and safety of belzutifan.
Published: 1/30/2025
FDA Accepts Review of Biologics License Application for AVT05, a Biosimilar Candidate for Golimumab
This marks the first US biologic license application filing acceptance for a biosimilar candidate to golimumab.
Published: 1/29/2025
PD-1, PD-L1-Targeting Agent Shows Promise in Treatment of Patients with Non–Small Cell Lung Cancer
As lung cancer cases rise, there is a significant need for therapeutic options that meet the challenges and needs of individual patients.
Published: 1/29/2025
Fedratinib Shows Efficacy in Previously Treated Myelofibrosis, Some Patients With Ruxolitinib Failure
Data indicates fedratinib’s role as an effective second-line treatment in patients with myelofibrosis who have been previously treated with a JAK inhibitor, such as ruxolitinib, though more research is necessary.
Published: 1/29/2025
Generic Everolimus Receives FDA Approval for Treatment of Tuberous Sclerosis Complex
This follows the approval of everolimus tablets for patients aged 1 and older in January 2025.
Published: 1/29/2025
CD5 CAR-T Cell Therapy Receives FDA Orphan Drug Designation for T-Cell Lymphoma
MB-105 is a first-in-class CD5-targeted chimeric antigen receptor (CAR) T-cell therapy for the treatment of relapsed or refractory CD5-positive T-cell lymphoma.
Published: 1/29/2025
Common Osteoporosis Treatments May Offer Protection Against COVID-19
Through similar targeting of the RdRp enzyme, these treatments could offer groundbreaking new options for patients with COVID-19 if proven effective in real-world trials.
Published: 1/29/2025
A 30-Minute Infusion of Isatuximab Is Safe, Feasible in Patients with Newly Diagnosed Multiple Myeloma
Isatuximab is a CD38-targeting monoclonal antibody that has demonstrated significant clinical success in improving minimal residual disease rates and progression-free survival.
Published: 1/29/2025
Iron Deficiency Is Prevalent in Patients With Non-Anemia, Non-Dialysis-Dependent-CKD
The authors note that transferrin saturation levels may be a modifiable risk factor of chronic kidney disease (CKD) progression and all-cause mortality.
Published: 1/29/2025
Kansas Reports Historic Numbers of Active Tuberculosis Cases
Pharmacists can have informed discussions with patients about the importance of adherence to tuberculosis (TB) treatment regimens, especially for patients with active TB.
Published: 1/29/2025
Mitochondrial Dysfunction Present in Visceral Adipose Tissue in Patients With Obesity-Related MASH
The authors note that this may cause disruptions in the metabolic stability of lipid processing and storage, impacting the liver and accelerating damaging adaptative responses.
Published: 1/29/2025
FDA Grants Orphan Drug Designation to ZL-1310 for Treatment of Small Cell Lung Cancer
Preliminary phase 1 trial results demonstrate that patients with small cell lung cancer generated early clinical activity after being administered ZL-1310.
Published: 1/29/2025
FDA Approves Semaglutide to Reduce Kidney Disease, Cardiovascular Death Risk in Adults With Type 2 Diabetes, Chronic Kidney Disease
The new indication for semaglutide adds to the long list of conditions that the GLP-1 receptor agonist has been approved for, and provides a new option for high-risk patients with these chronic conditions.
Published: 1/28/2025
Hydroxychloroquine Enhances the Efficacy of Palbociclib, Letrozole Therapy in Patients With HR+, HER2– Metastatic Breast Cancer
Endocrine therapy in combination with CDK4/6 inhibitors improves patients’ outcomes, but many still become treatment resistant.
Published: 1/28/2025
Socioeconomic Inequities Have a Significant Impact on Treatment of Antimicrobial Resistant Infections
Pharmacist-led interventions significantly improve antibiotic prescribing practices, optimize therapy, and improve patient outcomes.
Published: 1/28/2025
Investigators Find Causal Link Between Apolipoprotein A-I and COPD
High-density lipoprotein cholesterol, total cholesterol, and apolipoprotein B did not have significant correlations with chronic obstructive pulmonary disease.
Published: 1/28/2025
Pembrolizumab Plus Lenvatinib Combination Shows Mixed Results in Gastroesophageal Cancer
The trial meets one of the study’s dual primary endpoints of progression-free survival, but did not meet its other primary endpoint of overall survival.
Published: 1/28/2025
Preliminary Results Show New Procedure Maintains Weight Loss After Discontinuing GLP-1 Medication
Fractyl Health also reports progress from the REMAIN-1 study evaluating weight management after discontinuing a GLP-1.
Published: 1/28/2025
FDA Grants Trastuzumab Deruxtecan Approval for Endocrine-Treated Patients With Metastatic HR+, HER2-Low Breast Cancer
The antibody-drug conjugate shows efficacy in reducing disease progression risk and increasing progression-free survival in patients with HR+, HER2-low, or HER2-ultralow metastatic breast cancer.
Published: 1/28/2025
A Single Sample Sexually Transmitted Infection System Receives FDA Clearance With CLIA Waiver
The cobas liat system is a closed system that aims to reduce contamination risks and enhances the reliability of results at the point of care.
Published: 1/28/2025
Study Links Racism With Increased Risk of High Postpartum Blood Pressure
Although the research focused on Black communities in the United States, there is also evidence linking racism and blood pressure for patients who are Asian or Hispanic.
Published: 1/27/2025
Poll Shows 11% of Patients Did Not Plan on Getting 2024-2025 Respiratory Vaccination
Approximately 66% of patients received a COVID-19 vaccine in the fall of 2024 and only 26% received a respiratory syncytial virus vaccine.
Published: 1/27/2025
Health Care Providers and Patients Have Differing Views on Asthma Remission
Remission is a new emphasis and treatment goal for the management of asthma.
Published: 1/27/2025
Cardiovascular Risk Factors Increase Thrombosis, Mortality in Patients With Myelofibrosis, Other MPNs
Patients with myelofibrosis have a higher likelihood of having a cardiovascular risk factor when compared with essential thrombocythemia or polycythemia vera.
Published: 1/27/2025
Study: Bile Acid Supplement Shows Promise for Liver Cancer
Boosting ursodeoxycholic acid (UDCA) levels through dietary supplementation was shown to control tumor growth in mice with liver cancer.
Published: 1/27/2025
FDA Approves Lecanemab-Irmb Maintenance Dosing for Early Alzheimer Disease Treatment
Administered every 4 weeks, the approval could serve as a breakthrough for easier and more effective care for patients with early Alzheimer disease.
Published: 1/27/2025
FDA Updates Viloxazine Label for ADHD
Based on the updated label, new pharmacodynamic data have been added for a better understanding of the drug for individuals with attention-deficit/hyperactivity disorder (ADHD).
Published: 1/27/2025
Investigators Test Novel Biosensor Linked to Bacterial Spores for Glucose Monitoring
Glucose monitoring can help providers and pharmacists optimize medication management for personalized diabetes care.
Published: 1/27/2025
Tucatinib in Combination With Trastuzumab Demonstrates Safety, Efficacy in Patients With HER2-Mutated Breast Cancer
Tucatinib is an oral HER2-targeting tyrosine kinase inhibitor that was approved by the FDA in 2020.
Published: 1/25/2025
Radiotherapy Benefits Overall Survival in Older Patients With Early-Stage Triple Negative Breast Cancer
Presence of comorbidities in older patients with breast cancer complicates treatment decisions.
Published: 1/25/2025
Adjuvant Trastuzumab Emtansine Improves Invasive Disease-Free Survival in Patients with HER2+ Early Breast Cancer
Rates of invasive breast cancer or death were 50% lower with adjuvant trastuzumab emtansine compared with trastuzumab alone.
Published: 1/24/2025
Findings Show Noncigarette Tobacco Use Associated With Cardiovascular Risks
Pharmacists can play an important role in tobacco cessation.
Published: 1/24/2025
Study: Biosimilar Efficacy and Safety in Pediatric Inflammatory Bowel Disease
Biosimilar use is not linked to an increased risk of treatment failure among pediatric patients with inflammatory bowel disease (IBD).
Published: 1/24/2025
Endocrine-Immune-Based Therapies Improved Responses in Chemo-Insensitive Patients With HR+/HER2– Breast Cancer
Endocrine-immune-based therapies yielded favorable objective response rates but had limited impact on pathological complete response.
Published: 1/24/2025
Neoadjuvant Atezolizumab Plus Epirubicin Shows Safety, Efficacy in Treatment of HER2+ Early Breast Cancer
These data suggest the potential efficacy of immune checkpoint inhibitors with anthracycline-based chemotherapy.
Published: 1/24/2025
US Supreme Court Undercuts Long-Standing Judicial Deference to Administrative Agencies
Ruling potentially affects federal ability to regulate pharmacy.
Published: 1/24/2025
Observational Study Aims to Assess RSV Incidence and Impact in Older Adults
Point-of-care testing implementation could provide valuable data on community respiratory syncytial virus incidence and enhance sentinel surveillance efforts.
Published: 1/24/2025
SDOH Can Both Support and Hinder Recovery From COVID-19
Patients recovering from COVID-19 and caregivers reported how some social determinants of health were helpful in their recovery, while others led to difficult social and mental challenges.
Published: 1/24/2025
PQA Releases Report to Define Quality Medication Use for Rare Diseases
The report highlights perspective from 4 key stakeholders of patients, specialty pharmacies and providers, biopharmaceutical industry, and public and private payers.
Published: 1/24/2025
Abelacimab Reduces Major, Clinically Relevant Non-Major Bleeding Compared WIth Rivaroxaban
Abelacimab (Anthos Therapeutics Inc) is a novel factor XI inhibitor being investigated for the reduction of bleeding for patients with atrial fibrillation.
Published: 1/24/2025
DYNE-101 Receives FDA Fast Track Designation to Treat Myotonic Dystrophy
The fast-track designation follows the FDA orphan drug designation that was granted for DYNE-101 in September 2023 for the same treatment population.
Published: 1/23/2025
New Report Aims to Further Define Diagnostic Criteria for Clinical Obesity
The Commission aims to provide information for clinical decision making, therapeutic interventions, and public health strategies.
Published: 1/23/2025
FDA Grants Fast Track Designation to [18F]Florbetaben for Diagnosis of Cardiac Amyloidosis
![FDA Grants Fast Track Designation to [18F]Florbetaben for Diagnosis of Cardiac Amyloidosis](https://cdn.sanity.io/images/0vv8moc6/pharmacytimes/bacb3ea221ee3b60cd141a3ce6c10cf0123791f7-6500x4000.jpg)
The drug is being investigated as a PET diagnostic of cardiac amyloid light-chain and amyloid transthyretin-related (ATTR) amyloidosis.
Published: 1/23/2025
Navacaprant Did Not Show Statistically Significant Improvements When Treating Patients With Major Depressive Disorder
Despite these findings, navacaprant was generally well-tolerated and safe in patients with major depressive disorder.
Published: 1/23/2025
FDA Grants Approval to Generic Extended-Release Memantine/Donepezil and Everolimus
Memantine/donepezil and everolimus are used to treat dementia of the Alzheimer type and tuberous sclerosis complex-associated subependymal giant cell astrocytoma, respectively.
Published: 1/23/2025
Study: Biotin Could Protect Against Manganese-Induced Parkinson Disease
Biotin supplementation could mitigate manganese-induced damage caused by manganese deficiency and excessive exposure.
Published: 1/23/2025
Investigational Dose of Semaglutide Shows 20.7% Weight Loss at 72 Weeks
Approximately 33.2% of patients who received semaglutide 7.2 mg achieved 25% or more weight loss after 72 weeks.
Published: 1/23/2025
FDA Adds Boxed Warning to Glatiramer Acetate Over Risk of Rare, Serious Allergic Reaction
Patients with multiple sclerosis being treated with glatiramer acetate have an increased risk of experiencing anaphylaxis.
Published: 1/23/2025
Patients With Myelofibrosis Face Long-Term Treatment and Hospitalization Despite Improvements in Therapy
Stem cell transplantation rates increased the longer patients remained on therapy for myelofibrosis.
Published: 1/23/2025
FDA Approves Treosulfan Regimen For Preparative Use in Stem Cell Transplantation Patients With AML, MDS
The FDA approved treosulfan, in combination with fludarabine, for patients 1 year of age and older with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
Published: 1/22/2025
FDA Gives Priority Review to Vusolimogene Oderparepvec for Melanoma
Vusolimogene oderparepvec in combination with nivolumab is being assessed to treat individuals with unresectable or metastatic stage IIIb-IV cutaneous melanoma.
Published: 1/22/2025
Reversal of Executive Order 14087 Raises Questions About Future Drug Pricing Reforms
The caps on insulin and yearly out-of-pocket drug costs remain unaffected by this decision.
Published: 1/22/2025
Trust-Building and Tailored Interventions Essential to Improving COVID-19 Vaccine Rates, Confidence Among Black Women
Engaging with the community, providing transparent information to patients, and using noncoercive methods of encouragement are strategies to reduce COVID-19 vaccine hesitancy.
Published: 1/22/2025
Advancing Precision Oncology: The Role of Targeted Therapies in HR+, HER2– Breast Cancer
A panel of experts discuss treatment of HR+, HER2– breast cancer with therapies such as ribociclib, alpelisib, everolimus, and elacestrant.
Published: 1/22/2025
High-Sensitivity C-Reactive Protein/High-Density Lipoprotein Cholesterol Ratio Predicts Long-Term Mortality
Regardless of confounding factors, the ratio of high-sensitivity C-reactive protein to high-density lipoprotein cholesterol predicts the all-cause long-term mortality.
Published: 1/22/2025
Two-Dose Hepatitis E Virus Vaccination Regimen Demonstrates Efficacy, Study Finds
The study shows benefits when Hecolin (HEV 239; Xiamen Innovax Biotech Co Ltd) is administered in 2 doses, rather than the typical 3-dose regimen.
Published: 1/22/2025
2025 American Cancer Society Report Estimates Younger Female, Black, and Native American Patients Frequently Affected With Cancer
Black and Native American patients were about 2 to 3 times more likely to die of cancer compared with White patients, and women younger than 50 years were affected more than male patients.
Published: 1/22/2025
SEL-212 Shows Promise in Treating Chronic Refractory Gout with High Response Rates
Pharmacists play a significant role in managing gout by educating patients about the disease and ensuring proper medication adherence to urate-lowering therapy.
Published: 1/22/2025
Ozempic, Biktarvy Among the Drugs Seeing List Price Increases at the Start of 2025
At the start of 2025, 590 drug prices changed, with only 7 drugs seeing decreases in wholesale acquisition costs (WAC).
Published: 1/21/2025
Transition From IVIG to Efgartigimod in Patients With CIDP Could Lead to Worsening of Disease
A series of patient cases demonstrates the potential harm that patients with chronic inflammatory demyelinating polyneuropathy (CIDP) may face when transitioning from intravenous immunoglobulin (IVIG) to FcRn therapy.
Published: 1/21/2025
Study Finds Structural Differences of Brain Associated With Eating Disorders, Harmful Eating Habits
The study found that internalizing and externalizing factors, brain maturation, and decreasing volumes of brain regions were linked to eating disorders.
Published: 1/21/2025
Ciltacabtagene Autoleucel Demonstrates Superior Progression-Free Survival in Patients With Relapsed, Refractory Multiple Myeloma
The international cohort study evaluated the safety, efficacy of BCMA-targeting agents ciltacabtagene autoleucel and idecabtagene vicleucel.
Published: 1/21/2025
Proper Dosing, Bleeding Awareness Are Essential Roles for Pharmacists in Hemophilia A and B, Thrombocytopenic Purpura Treatment
Multiple treatments have been approved by regulators for the treatment of hemophilia A and B, giving pharmacists options for their patients.
Published: 1/21/2025
Polypill Treatment for Cardiovascular Disease Shows Affordability for Majority Black Populations
Investigators found that the polypill treatment improved cardiovascular disease and lowered health care costs.
Published: 1/21/2025
KN026 and Docetaxel Show Promise as First-Line Treatment for HER2+ Metastatic Breast Cancer
KN026 is a humanized bispecific antibody that targets and binds to HER2 proteins on the surface of cancer cells.
Published: 1/21/2025
Esketamine Receives FDA Approval for Adults With Treatment-Resistant Depression
Esketamine targets glutamate, the most abundant neurotransmitters in the brain.
Published: 1/21/2025
US Department of Health and Human Services Grants $590 Million to Accelerate H5N1 mRNA Vaccine Development
As H5N1 bird flu outbreaks impact all 50 states, concerns grow over its spread to humans.
Published: 1/20/2025
Study Reports Dietary Recommendation for Managing GLP-1-Related Gastrointestinal Adverse Events
Recommendations help influence the rate of gastric emptying, improve compliance, and prevent interruption of weight loss for patients.
Published: 1/20/2025
Managing Cancer Treatment Amid a Nationwide IV Fluid Shortage
The closure of Baxter’s North Cove facility has significantly impacted existing IV fluid shortages into 2025.
Published: 1/20/2025
Air Pollution and Seasonal Variability Associated With Asthma- and COPD-Related Hospital Admissions
The authors found that humidity, cold and heat waves, and air pollution led to a higher likelihood of asthma- and chronic obstructive pulmonary disease (COPD)-related hospitalizations.
Published: 1/20/2025
US Court Files Civil Complaint Alleging Walgreens Dispensed Millions of Unlawful Prescriptions
The Justice Department alleges that Walgreens acted in violation of the Controlled Substances Act and sought reimbursement for unlawful prescriptions, violating the False Claims Act.
Published: 1/20/2025
Study Shows Potential Population-Level Benefits of Intensive BP Targets in Adults With CKD
The reduction in cardiovascular end points and the increase in adverse events observed in a clinical trial were largely transportable to trial-eligible chronic kidney disease (CKD) populations from clinical practice.
Published: 1/20/2025
Study Shows Real-World Outcomes of First-Line Palbociclib Plus Fulvestrant in HR+, HER2– Metastatic Breast Cancer
Palbociclib is an oral CDK4/6 inhibitor that was approved by the FDA in 2017.
Published: 1/18/2025
FDA’s Accelerated Approval Pathway Under Scrutiny for Key Drug Approvals
The report from the Office of Inspector General highlights inconsistencies, lack of transparency, and the need for stronger safeguards.
Published: 1/17/2025
IVIG Prophylaxis Significantly Reduces Hospital Admissions for Fever in Pediatrics With ALL
Admissions to the hospital for fever were reduced in pediatric patients with medium-risk ALL receiving intravenous immunoglobulin, a potentially useful finding to help prevent infections in vulnerable patients.
Published: 1/17/2025
FDA Approves Dato-DXd for Adults With Unresectable or Metastatic HR+, HER2- Breast Cancer
Compared with chemotherapy, Dato-DXd demonstrates favorable median progression-free survival and overall survival in a phase 3 clinical trial.
Published: 1/17/2025
FDA Targets Nicotine to Reduce Lung Cancer and Other Tobacco-Related Diseases
The FDA proposes to cap the nicotine level at 0.7 mg per gram of tobacco in cigarettes and certain other combusted tobacco products.
Published: 1/17/2025
FDA Proposes Front-of-Package Nutrition Label for Most Packaged Foods
If finalized, the requirement would include readily available nutrition information, including saturated fat, sodium, and added sugar content.
Published: 1/17/2025
Psilocybin May Improve Mental Health Symptoms in Patients With Cancer and Addiction
The authors note that future research will observe personality changes when psilocybin is used in patients with opioid-use disorder.
Published: 1/17/2025
Xalnesiran Plus Immunomodulator Results in HBsAg Loss Among Patients With Chronic Hepatitis B
Despite the reductions in hepatitis B surface antigen (HBsAg), grade 3 and 4 adverse events were not uncommon.
Published: 1/17/2025
Key Drugs to Watch in Oncology, Hematology, and Neurology for 2025
These drugs are set to revolutionize their respective disease states in 2025.
Published: 1/17/2025
The FDA Approves Sotorasib With Panitumumab for Treatment of Patients with KRAS G12C-Mutated Metastatic Colorectal Cancer
Data from the CodeBreaK 300 trial supported the FDA's approval.
Published: 1/17/2025
FDA Approves Acalabrutinib With Bendamustine, Rituximab For Patients With Previously Untreated Mantle Cell Lymphoma
Acalabrutinib with bendamustine and rituximab shows efficacy in patients with untreated mantel cell lymphoma by increasing progression-free survival in the ECHO trial.
Published: 1/17/2025
HHS Announces Next 15 Drugs for Medicare Part D Price Negotiations
As per the Inflation Reduction Act, the negotiations with the drug companies of the 15 drugs will occur in 2025, with the negotiated prices going into effect in 2027.
Published: 1/17/2025
Study Finds Link Between Hormonal Contraceptives and Higher Breast Cancer Risk in BRCA1 Carriers
Hormonal contraceptives did not increase breast cancer risk in patients with BRCA2 mutations.
Published: 1/16/2025
FDA Approves Axatilimab-csfr 9 mg and 22 mg Vial Sizes for cGVHD
The current approved dose of axatilimab-csfr is 0.3 mg/kg up to a maximum dose of 35 mg and will be administered as an intravenous infusion over 30 minutes every 2 weeks.
Published: 1/16/2025
FDA Approves Mirikizumab-Mrkz to Treat Adult Patients With Crohn Disease
This is mirikizumab’s second FDA-approved indication in inflammatory bowel disease.
Published: 1/16/2025
Survey Shows Gaps in Consumer Awareness of Pharmacist Services
Rite Aid survey highlights underutilized role of pharmacists in health care, with 62% of respondents viewing their pharmacists as a crucial part of their health and wellness care team.
Published: 1/16/2025
Talquetamab and Teclistamab Achieve Deep, Durable Responses in Patients With Relapsed, Refractory Multiple Myeloma
The combination yields promising results but was associated with high incidence of toxicity and infection.
Published: 1/16/2025
Tivozanib Monotherapy Shows Improved Median Progression Free Survival Following Immune Checkpoint Inhibitor in Renal Cell Carcinoma
However, investigators also find that the combination did not meet the primary end point of increasing progression free survival.
Published: 1/16/2025
COVID-19 Infection Associated With Higher Likelihood of Developing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
The finding could help better treat patients with long COVID, as pharmacists and treatment providers can look out for ME/CFS symptoms.
Published: 1/16/2025
FDA Grants Breakthrough Device Designation to pTau 217 Blood Test for Alzheimer Disease Detection
The test meets a critical unmet need for patients with Alzheimer disease who have not yet been undiagnosed.
Published: 1/16/2025
FDA Bans Red Dye No. 3 in Food and Drugs, Citing Cancer Risks
Studies shows that Red Dye No. 3 was associated with tumor growth in male rats.
Published: 1/15/2025
A Silent Killer: The Overlooked Risk of Radon in Lung Cancer
Radon is a tasteless, odorless radioactive gas associated with DNA damage and high genomic tumor instability.
Published: 1/15/2025
mRESVIA RSV Vaccine Is a Key Area to Watch for Community Pharmacy in 2025
mRNA-1345 (mRESVIA; Moderna) has the potential to significantly transform the RSV disease state in 2025, according to data analysts.
Published: 1/15/2025
IL-8+ Neutrophils Can Be Key in Therapeutic Developments for Alcohol-Associated Hepatitis
Severe alcohol-associated hepatitis has limited effective pharmacological therapies, emphasizing the need for treatment options.
Published: 1/15/2025
Data Show Significant Genetic Correlations Between PTSD and Various Cardiovascular Diseases
Posttraumatic stress disorder is found to be associated with coronary artery disease, hypertension, and heart failure.
Published: 1/15/2025
Comorbid Asthma Associated With Higher Risk for Early Onset, Severe, or Prolonged Alopecia Areata
The findings suggest that patients with alopecia areata (AA) who also have asthma may benefit from increased clinical monitoring and earlier intervention.
Published: 1/15/2025
Study Finds Glucarpidase Improves MTX-Induced Acute Kidney Injury
Patients with methotrexate (MTX)-induced acute kidney injury treated with glucarpidase were 2.70-times more likely to have kidney recovery and recover faster.
Published: 1/15/2025
Metronomic Capecitabine With an Aromatase Inhibitor Demonstrates Safety, Efficacy in Treatment of HR+, HER2– Metastatic Breast Cancer
The approach favors administration of frequent low-dose chemotherapy to reduce toxicities and optimize outcomes.
Published: 1/15/2025
New FTC Report Finds PBMs Increased Prices for Specialty Cancer, HIV Generic Drugs to Generate Billions in Revenue
Building on a previous report that revealed corrupt business practices among the big 3 PBMs, a second interim report finds that PBMs heightened prices for important specialty generic drugs to increase their profit margins.
Published: 1/15/2025
Cemiplimab Improves Disease-Free Survival as Adjuvant Therapy in High-Risk Cutaneous Squamous Cell Carcinoma
New data shows that, in high-risk patients with advanced cutaneous squamous cell carcinoma, cemiplimab reduces the risk of disease recurrence and death.
Published: 1/15/2025
Key Drugs to Watch for Community Pharmacy in 2025
These drugs are set to revolutionize their respective disease states in 2025.
Published: 1/15/2025
Wildfire Smoke Exposure Heightens Lung Cancer Risks and Complicates Patient Outcomes
Wildfire smoke carries toxic compounds that can trigger respiratory inflammation and cause cellular damage.
Published: 1/14/2025
Survey Finds Menopausal Women in Rural Areas Report More Symptoms and Barriers Attending Appointments
Women living in rural are more likely to report experiencing psychological and somatic menopause symptoms compared with those in urban and suburban areas.
Published: 1/14/2025
Brentuximab Vedotin Induces Cell Death, Protects Healthy Cells in Breast Cancer Treatment
Brentuximab vedotin is approved for treatment of adult and pediatric with classical Hodgkin lymphoma in combination with chemotherapy.
Published: 1/14/2025
Data Show Dyslipidemia as Independent Risk Factor for Primary Open-Angle Glaucoma
Dyslipidemia is a condition in which there are abnormal levels of lipids in the blood stream, including high levels of low-density lipoprotein cholesterol, low levels of high-density lipoprotein cholesterol, and/or high levels of triglycerides.
Published: 1/14/2025
BBO-850 Receives Fast Track Designation for NSCLC Treatment
According to the investigators, BBO-8520 represents a first-in-class approach to treating patients with previously treated KRASG12C-mutated metastatic non-small cell lung cancer (NSCLC).
Published: 1/14/2025
FDA Grants Additional Fast Track Designation to Emiltatug Ledadotin to Treat HER2 Low, HER2-Negative Breast Cancer
A new indication for the antibody-drug conjugate expands the future clinical potential of the treatment in patients with the rare breast cancer.
Published: 1/14/2025
FDA Grants Datopotamab Deruxtecan Priority Review for EGFR-Mutated NSCLC
Datopotamab deruxtecan was also granted breakthrough therapy designation in December 2024.
Published: 1/13/2025
Pharmacists Are Critical to Proper Management of IVIG for Chronic Inflammatory Demyelinating Polyneuropathy
Managing comorbidities, ensuring proper dosing, and treating IVIG-related adverse events are areas where pharmacists play a large role.
Published: 1/13/2025
Medicare Drug Pricing Reform Brings Financial Relief to Patients
The new Medicare cap limits out-of-pocket drug costs to $2000 annually.
Published: 1/13/2025
Could Scallops and Jellyfish Be Key for Brain Health?
Hokkaido scallop oil plasmalogen and Apoaequorin have both been posited to improve brain health.
Published: 1/13/2025
FDA Grants Priority Review to Nipocalimab as Potential Treatment of Generalized Myasthenia Gravis
If approved, nipocalimab can treat antibody positive individuals with generalized myasthenia gravis.
Published: 1/13/2025
Telehealth Follow-Up Appointments Effective Alternative to Maintaining Asthma Disease Control
Virtual appointments were also an accessible alternative to in-person visits for patients who face obstacles accessing asthma care.
Published: 1/13/2025
Extended Course of Paxlovid May Help Some Patients With Long COVID
Some patients treated with prolonged courses of oral nirmatrelvir/ritonavir experienced long COVID symptom improvements, while others reported little to no changes in their symptoms.
Published: 1/11/2025
AI Improves Breast Cancer Screening and Detection Rates in Real-World Study
Inclusion of AI improved detection and reduced instances of false-positive test results.
Published: 1/10/2025
How Redlining Continues to Affect Health and Life Expectancy in Marginalized Communities
Limited access to healthy food in redlined communities contributes to higher rates of chronic disease and reduced life expectancy.
Published: 1/10/2025
As Wildfires Spread Across California, Pharmacists' Role in the Crisis Proves Essential
As of January 10, there are 5 major fires across a combined 36,560 acres—Palisades, Eaton, Kenneth, Hurst, and Lidia—and the 2 largest fires are a combined 11% contained.
Published: 1/10/2025
Pharmacists Can Help Patients Navigate Current Treatment Landscape of Alzheimer Disease
The pharmacist’s role includes educating and making recommendations, collaborating with health care professionals, and observing early signs of cognitive impairment in patients during interactions.
Published: 1/10/2025
FDA Grants Fast Trask Designation to Invikafusp Alfa for Advanced Colorectal Cancer
Invikafusp alfa (STAR0602; Marengo Therapeutics Inc) is being investigated as a treatment for advanced colorectal cancer with high tumor mutational burden.
Published: 1/10/2025
Study Finds Discrepancies in Relationship Between CKD and Smoking
The observational study shows a positive correlation between smoking and chronic kidney disease (CKD) whereas the analyses imply smoking-related covariates may be a factor.
Published: 1/10/2025
FDA Grants Orphan Drug Designation to CNP-104 for Primary Biliary Cholangitis
The designation follows positive phase 2a trial results (NCT05104853) presented at the 2024 AASLD The Liver Meeting.
Published: 1/10/2025
FDA Grants ALG-801 Orphan Drug Designation for Treatment of Pulmonary Arterial Hypertension
ALG-801 could present new opportunities to improve treatment and management of patients with pulmonary arterial hypertension, a life-threatening condition.
Published: 1/10/2025
Abenacianine Injection Receives FDA Fast Track Designation, Helps Visualize Tumors During Surgery
In a phase 2 trial (NCT05400226), abenacianine helps surgeons visualize tumors in lung during surgery and is safe and well-tolerated in patients.
Published: 1/10/2025
Phase 2 Study Evaluates Serplulimab Plus HLX04 as First-Line Treatment for Advanced Hepatocellular Carcinoma
Serplulimab plus HLX04 demonstrates a favorable safety profile in patients with advanced hepatocellular carcinoma.
Published: 1/9/2025
How Jimmy Carter’s Melanoma Diagnosis Introduced Immunotherapy to Cancer Care
The late former president played a critical role in advancing cancer care, as well as efforts to eradicate preventable diseases.
Published: 1/9/2025
FDA Announces Priority Review for CUTX-101 to Treat Menkes Disease
These new regulatory developments put CUTX-101 on track to become the first FDA-approved treatment for patients with Menkes disease.
Published: 1/9/2025
IVIG Supplementation Reduces Infection Risk in Patients With Multiple Myeloma Receiving Teclistamab
For patients with multiple myeloma who may experience an infection while receiving teclistamab, supplementation with intravenous immunoglobulin (IVIG) can help resolve and prevent serious complications.
Published: 1/9/2025
Bleeding Disorder Management at a Health System Specialty Pharmacy Improves Quality of Life
High-cost medications necessary for treatment require close management to ensure patient safety and to adhere to payer-specific requirements.
Published: 1/9/2025
Deramiocel Shows Promise in Addressing Heart Failure in Duchenne Muscular Dystrophy
Duchenne muscular dystrophy is an incurable neuromuscular disorder that can lead to cardiomyopathy, resulting in heart failure.
Published: 1/9/2025
FDA Grants Amezalpat Orphan Drug Designation for Treatment of Hepatocellular Carcinoma
The new designation for the selective PPAR⍺ antagonist follows positive phase 1b/2 clinical trial results.
Published: 1/9/2025
FDA Grants Breakthrough Therapy Designation to Tividenofusp Alfa for Treatment of Hunter Syndrome
Regulatory action could help patients with Hunter syndrome who have cognitive and behavioral complications and often do not have an effective treatment crossing the blood-brain barrier.
Published: 1/9/2025
Palbociclib Combination Therapy Improves Outcomes for HR-positive, HER2-positive Metastatic Breast Cancer
Palbociclib demonstrates safety and efficacy in combination with anti-HER2 and endocrine therapies.
Published: 1/8/2025
Systemic Immune-Inflammation Index Associated With Increased Risk of Depressive Symptoms
Depression and cardiovascular disease are often linked, with research showing inflammation is common for the 2 disease states.
Published: 1/8/2025
Children With Autism Are More Likely to Be Diagnosed with Leukemia, Study Finds
This association was also observed in siblings of children with autism spectrum disorder.
Published: 1/8/2025
Posdinemab Receives FDA Fast Track Designation for Treatment of Alzheimer Disease
As an investigational monoclonal antibody, posdinemab targets the mid-domain of AD-specific phosphorylated tau.
Published: 1/8/2025
US Surgeon General Reports Alcohol Use Linked to Increased Cancer Risk
The advisory emphasizes the need for a comprehensive approach to reducing alcohol-related cancer by combining prevention, education, and treatment to improve public health outcomes.
Published: 1/8/2025
Transfusing More Blood to Heart Attack Patients With Anemia Reduces Risk of Death
Data from a follow-up at 6 months show a reduced risk of all-cause mortality in heart attack patients with anemia who receive a liberal transfusion strategy compared with a restrictive one.
Published: 1/8/2025
Report Links GLP-1 Medication to Decrease in Consumer-Packaged Goods, Food, and Beverages
The data from the report show how nutritional choices compliment the use of glucagon-like peptide-1 receptor agonists and how health care providers can educate patients further.
Published: 1/8/2025
Investigators Find Triglyceride/High Density Lipoprotein Cholesterol Ratio Is Significantly Associated With MACE
Patients with acute coronary syndrome who were in the high quartile were at significantly higher risk for major adverse cardiovascular events (MACE).
Published: 1/8/2025
Non-Invasive Nasal Swab Can Diagnose Specific Asthma Endotype in Young Patients
The investigators note that the test can allow health care professionals to more accurately prescribe medication or treatments.
Published: 1/8/2025
FDA Requires Warning for Guillain-Barré Syndrome in Prescribing Information for RSV Vaccines
Despite these concerns, experts have emphasized that the benefits of RSV vaccination outweigh potential risks for older adults, who are at heightened risk of severe RSV-related illness.
Published: 1/7/2025
Fear of COVID-19 Among Post-Infected Adults Can Impact Quality of Life
COVID-19 survivors deemed the most highly impacted and fearful also reported the lowest health-related quality of life scores, indicating an association.
Published: 1/7/2025
Rise in RSV Infections Is Associated With a Decrease in Vaccine Hesitancy
Approximately 61% of individuals said respiratory syncytial virus (RSV vaccination for adults 60 years and older is effective.
Published: 1/7/2025
FDA Grants Sunvozertinib Priority Review for Treatment of Non-Small Cell Lung Cancer With EGFR exon20ins Mutations
Sunvozertinib was originally approved in China, making it the world’s first and only oral treatment for these patients.
Published: 1/7/2025
Prucalopride Tablets for Chronic Idiopathic Constipation Launches, Approved for 180-Day CGT Designation
The tablets are indicated for treatment of adults with chronic idiopathic constipation, with further research needed to assess efficacy and safety in children.
Published: 1/7/2025
Structural Inequalities Contribute to Changes in Brain Structure and Connectivity
These inequalities, which can include socioeconomic disparities, show neurological changes associated with aging and dementia.
Published: 1/7/2025
Association Found Between Diabetes and Excessive Daytime Sleepiness
Age, frequent snoring, hypertension, and poor glycemic control are associated with excessive daytime sleepiness.
Published: 1/7/2025
Coffee and Tea Linked to Lower Risk of Head and Neck Cancers
A pooled analysis showed regular consumption of coffee and tea was associated with decreased risk of certain cancers.
Published: 1/7/2025
First US Death From H5N1 Bird Flu Reported in Louisiana
The patient was hospitalized after exposure to an infected backyard flock.
Published: 1/6/2025
Avutometinib Plus Defactinib Moves One Step Closer to Approval for Treatment of Ovarian Cancer
If approved, the combination of avutometinib with defactinib could be the first FDA-approved treatment option for low-grade serous ovarian cancer.
Published: 1/6/2025
As Human Cases of H5N1 Rise, Experts Voice Concerns About Mutations
Two cases of hospitalizations show mutations that may allow H5N1 to more easily target human cells.
Published: 1/6/2025
Relacorilant NDA Submitted to FDA for Treatment of Endogenous Hypercortisolism
Backed by positive results in multiple clinical trials, a new drug application (NDA) has been submitted for relacorilant for consideration by the FDA.
Published: 1/6/2025
Topical Immunotherapy Combination Reduces Premalignant Lesions and Prevents Skin Cancer
Calcipotriol in combination with 5-FU triggers Th2 immunity to prevent skin cancer.
Published: 1/6/2025
Real-World Outcomes Show Efficacy, Safety of Ciltacabtagene Autoleucel in Relapsed, Refractory Multiple Myeloma
The analysis shows patients achieved deep and durable responses despite being ineligible for the CARTITUDE-1 trial.
Published: 1/6/2025
Monitoring Kidney Function May Help Diagnose CKD in Patients Hospitalized for COVID-19
Early diagnosis of chronic kidney disease (CKD) can help optimize treatment and manage the disease to prevent further decline.
Published: 1/6/2025
Fiber-Rich Foods Improve Chronic Disease, Could Lead to Pharmaceutical Interventions
Fiber-rich foods show improvements in health and reductions in chronic diseases, including obesity, by promoting weight management and enhancing the metabolism.
Published: 1/5/2025
Intravenous Immunoglobulin Shows Efficacy as Adjunctive Therapy for Treatment of Pyoderma Gangrenosum
Treatment with IVIG leads to high responses 6 months following the initiation of therapy.
Published: 1/4/2025
Continuous Glucose Monitoring Shows Potential to Improving Clinical Outcomes in Type 2 Diabetes
However, the effects on patient-reported outcomes were inconclusive when compared with self-monitoring blood glucose or the usual care.
Published: 1/3/2025
Study Misinterprets Heavy Metal Levels in Prenatal Vitamins, Causing Unnecessary Concern
The inaccurate claim that these products pose a heavy metal risk is potentially detrimental, as it could discourage pregnant women from using vital prenatal supplements.
Published: 1/3/2025
Anemia in Patients With Cancer Causes Significant Fatigue, Impacting Quality of Life
Pharmacists should be aware of the impacts that anemia in patients being treated for cancer has on daily activities and overall quality of life.
Published: 1/3/2025
Study Suggests BMI Does Not Indicate Length of Hospital Stay for Patients With Hypertension
Certain laboratory tests indicate stronger predictions for hospital stay, suggesting pharmaceutical intervention could help reduce the length of cardiovascular-related hospital stay.
Published: 1/3/2025
Cardiovascular Disease May Accelerate Tumor Growth in Patients With Advanced Breast Cancer
Patients with hormone receptor–positive and human epidermal growth factor receptor 2 breast cancer are particularly at risk.
Published: 1/3/2025
Depemokimab Every 6 Months Reduces Rate of Severe Asthma Exacerbations
Investigators did not report serious adverse events or deaths related to depemokimab in either of the 2 phase 3a clinical trials.
Published: 1/3/2025
Study Suggests Weakened RSV Vaccine Response in Immunocompromised Individuals
Immunocompromised older adults developed fewer antibodies against RSV following vaccination compared with immunocompetent individuals.
Published: 1/2/2025
Equecabtagene Autoleucel Shows Efficacy, Safety in Treatment of Patients With Heavily Pretreated Multiple Myeloma
Patients with relapsed, refractory disease achieved deep, durable responses with equecabtagene autoleucel.
Published: 1/2/2025
Majority of Children, Young Patients With Long COVID Recover Within 2 Years
Over 70% of children and young people with long COVID reported improvements in their symptoms within 24 months of their initial positive SARS-CoV-2 test.
Published: 1/2/2025
Novel Deep-Learning Model May Predict Immune Checkpoint Inhibitor Responses in Patients With Non−Small Cell Lung Cancer
The model, Deep-IO, shows improved specificity and sensitivity compared with existing predictive biomarkers.
Published: 1/2/2025
MRX-5 Receives FDA Orphan Drug Designation for Treatment of Non-Tuberculous Mycobacteria Infections
The regulatory decision marks a significant step forward in the treatment of non-tuberculous mycobacteria infections.
Published: 1/2/2025
FDA Approves Tislelizumab in Combination With Chemotherapy for Gastric, Gastrosophageal Junction Adenocarcinoma
Tislelizumab is approved in combination with platinum and fluoropyrimidine-based chemotherapy as first-line treatment of unresectable or metastatic HER2-negative tumors.
Published: 1/2/2025
FDA Approves Nivolumab and Hyaluronidase-nvhy for Subcutaneous Use in Patients With Solid Tumors
The approval offers patients with solid tumors an alternative to intravenous PD-1 inhibitor administration.
Published: 1/2/2025
Study Finds Nearly 75% of Adolescents Experience Depression, Anxiety
Female adolescents were at an increased risk of experiencing depression and anxiety symptoms compared with males.
Published: 1/1/2025
Black Patients With Asthma More Likely to Miss Scheduled Appointments for Biologic Therapies
The disparity highlights opportunities for pharmacists to get involved and address health disparities.
Published: 12/30/2024
Updated BNT162b2 XBB COVID-19 Vaccine Protects Against Hospitalization in Children Aged 5 to 17
Study results show that the updated BNT162b2 XBB vaccine is effective in preventing hospitalizations or emergency department visits associated with COVID-19 complications.
Published: 12/28/2024
KRAKEN Trial Highlights Muvalaplin’s Efficacy, Safety in Reducing Lipoprotein(a)
Muvalaplin is an oral, small molecule inhibitor that can reduce lipoprotein(a).
Published: 12/27/2024
Collective Responsibility, Confidence in Immunizations Indicate Potential of Vaccine Refusal
Individuals who refused a pneumococcal vaccine were associated with low collective responsibility and confidence in vaccine efficacy and safety.
Published: 12/27/2024
Cholesterol-Metabolizing Bacteria May Potentially Benefit Lipid Homeostasis, Cardiovascular Health
High levels of the Oscillibacter genus of bacteria were associated with reduced cholesterol.
Published: 12/26/2024
Gecacitinib Demonstrates Safety, Efficacy Over Hydroxyurea in Patients With Myelofibrosis and Anemia
Gecacitinib is a novel inhibitor targeting both JAK and ACVR1.
Published: 12/25/2024
Study: Shingles Could Significantly Increase Risk of Dementia and Parkinson Disease
Researchers recommend early vaccination against herpes zoster to mitigate the risks.
Published: 12/24/2024
Dupilumab Lowers Incidence of Psychiatric and Sleep Disorders in Patients With Atopic Dermatitis
The monoclonal antibody demonstrates the ability to reduce the incidence and improve symptoms related to sleep disorders and psychiatric disorders such as anxiety.
Published: 12/24/2024
Mild IVIG-Related Adverse Events Are Frequent in Children, With Serious Reactions Possible
Factors associated with intravenous immunoglobulin (IVIG)-related adverse events include older age, dehydration, and administration of multiple IVIG infusions.
Published: 12/24/2024
Investigators Find Over 900 Chemicals Can Increase Risk of Breast Cancer
Of these chemicals, 414 were found to be commonly used in plastics and consumer goods, such as food packaging and personal care products.
Published: 12/24/2024
RECAP: 2024 Updates in the GLP-1 Space
Despite the explosion of public interest in these drugs, ongoing shortages and debates over compounding made access difficult.
Published: 12/24/2024
Pharmacy Focus: Oncology Edition – Key Insights and Interviews From the 2024 SABCS Meeting
Pharmacy Times attended the 2024 San Antonio Breast Cancer Symposium from December 10 to December 13.
Published: 12/23/2024
FDA Approves Vibegron for Men With Overactive Bladder Symptoms Receiving Therapy for Benign Prostatic Hyperplasia
Currently available for prescription in the United States, vibegron is now the first and only β3 agonist FDA approved to treat patients living with OAB and being treated for BPH.
Published: 12/23/2024
Researchers Evaluate Pain Management Therapy Intervention to Treat Chronic Postherpetic Neuralgia
Short-term spinal cord stimulation could provide long-term pain relief and improve the overall quality of life for individuals with herpes zoster-associated pain and postherpetic neuralgia.
Published: 12/23/2024
FDA Approves First Generic of Liraglutide Injection to Lower Blood Sugar in Patients With Type 2 Diabetes
The approval of the generic to liraglutide injection, currently in shortage, could help increase patient access to the type 2 diabetes treatment.
Published: 12/23/2024
FDA Approves Concizumab-mtci to Prevent, Reduce Bleeding in Patients With Hemophilia A or B
Concizumab-mtci is a subcutaneous, monoclonal antibody designed to achieve hemostasis in all hemophilia types.
Published: 12/23/2024
EPINEPHrine Nasal Solution, USP Recalled for Lack of Approval, Misbranding
The nasal spray label resembles that of the FDA-approved epinephrine injection, leading to potential dosing errors.
Published: 12/23/2024
Selective Antisense Oligonucleotide-based JAK2 Inhibitor Receives FDA Orphan Drug Designation for Polycythemia Vera
VGT-1849A could reduce JAK2 activity, lessening the disease burden faced by individuals with PV while providing a favorable safety profile.
Published: 12/22/2024
FDA Awards Fast Track Designation to Staphylococcus aureus Vaccine Candidate
Clinical trials will seek to evaluate the immunogenicity and safety of the LBT-SA7 vaccine.
Published: 12/22/2024
Research Shows Guillain-Barré Syndrome Remains Rare Among Older Adults After RSV Vaccination
Rates of GBS were similar between Arexvy and Abrysvo, at 0.12% and 0.11% of total reported events, respectively.
Published: 12/21/2024
FDA Issues Complete Response Letter for Much-Anticipated GLP-2 Analog
The medication, glepaglutide, is in development for the treatment of adults with short bowel syndrome with intestinal failure who are dependent on parenteral support.
Published: 12/21/2024
FDA Approves Alyftrek, Once-Daily CFTR Modulator for Cystic Fibrosis
The approval comes after clinical trial results in which vanzacaftor/tezacaftor/deutivacaftor (Alyftrek; Vertex Pharmaceuticals) demonstrated superiority compared with elexacaftor/tezacaftor/ivacaftor and ivacaftor (Trikafta; Vertex Pharmaceuticals).
Published: 12/21/2024
FDA Approves Premarket Approval Application for OraQuick HIV Self-Test, Expanding Access to Adolescents
OraQuick was the first at-home HIV test kit to be approved by the FDA in 2012.
Published: 12/21/2024
FDA Approves Tirzepatide as First Treatment for Moderate-to-Severe Obstructive Sleep Apnea in Adults With Obesity
The new approval continues to expand the therapeutic potential of GLP-1 medications such as tirzepatide, now being deemed effective in patients with obstructive sleep apnea.
Published: 12/20/2024
FDA Approves Expanded Use for Trikafta in Cystic Fibrosis
Vanzacaftor/tezacaftor/deutivacaftor (Alyftek) also received approval for the treatment of cystic fibrosis in people 6 years and older who have at least 1 F508del mutation.
Published: 12/20/2024
FDA Approves Expanded Indication for Setmelanotide to Include Patients 2 and Older
Setmelanotide is indicated to reduce excess body weight and maintain weight reduction long-term for patients with syndromic or monogenic obesity due to Bardet-Biedl syndrome.
Published: 12/20/2024
Study: Fatal Disseminated Herpes Zoster in Immunocompetent Individuals
Varicella-zoster vaccination could prevent fatal outcome among individuals with disseminated herpes zoster.
Published: 12/20/2024
Encorafenib With Cetuximab and mFOLFOX6 Receives Accelerated Approval for Patients With Metastatic Colorectal Cancer
The decision is based off favorable results from the BREAKWATER trial.
Published: 12/20/2024
Patients With Chronic Idiopathic Urticaria at Higher Risk of Developing Food Allergies
Knowing which patients are at higher risk for developing urticaria by analyzing their history of food allergies could lead to better outcomes in this population.
Published: 12/20/2024
FDA Affirms Decision on Tirzepatide Shortage Resolved, Sets Transition Period for Compounding
Compounding pharmacies have a 60- to 90-day grace period to complete production as it continues to monitor supply and demand.
Published: 12/20/2024
FDA Approves Symvess for Treatment of Extremity Vascular Trauma
The approval follows positive results from the V005 (NCT03005418) clinical trial.
Published: 12/20/2024
Women With History of Gestational Diabetes Found to Have Less Inflammatory Diets
This could be attributed to improved diet and health awareness.
Published: 12/20/2024
Study: Predictive Screening Models Less Likely to Widen Existing Health Disparities in PMAD Diagnosis
The findings show a need for researchers and health care professionals to consider model designs to minimize disparities when diagnosing perinatal mood and anxiety disorders (PMADs).
Published: 12/20/2024
FDA Approves Olezarsen as Adjunct to Diet for Familial Chylomicronemia Syndrome
The rare genetic disease is a severe hypertriglyceridemia that can lead to potentially life-threatening acute pancreatitis.
Published: 12/20/2024
Dupilumab Improves Moderate-to-Severe Atopic Dermatitis in Young Children With Inflammatory Comorbidities
Proven effective in the treatment of atopic dermatitis (AD) and other allergic conditions, these study results confirm the ability of dupilumab to improve symptoms in children with other concurrent conditions.
Published: 12/19/2024
FDA Recalls 233,000 Bottles of Duloxetine Over Risk of Cancerous Chemical
Duloxetine is a commonly prescribed medication used to treat anxiety, depression, and other mental health disorders.
Published: 12/19/2024
Lactate-to-Albumin Ratio Predicts Development of ARDS, Mortality Risk From Flu
Previously, the evidence to support the prediction with lactate-to-albumin ratio has been unclear.
Published: 12/19/2024
FDA Approves Ensartinib for Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer
The indication is for patients with locally advanced or metastatic disease who have not previously received treatment with an ALK-inhibitor.
Published: 12/19/2024
Remestemcel-L-rknd Receives FDA Approval for SR-aGvHD in Pediatric Patients
The approval makes remestemcel-L-rknd the first approved mesenchymal stromal cell in the United States.
Published: 12/19/2024
FDA Receive a Biologic License Application for Lerodalcibep, a Novel LDL-C-Lowering Drug
Lerodalcibep is a third-generation PCSK9 inhibitor that demonstrated success in reducing low density lipoprotein cholesterol (LDL-C).
Published: 12/19/2024
Study Finds Connections Between Nasal Mycobiota of Patients With Asthma and Allergic Rhinitis
These findings indicate that asthma and allergic rhinitis may be commonly linked, emphasizing the need to identify underlying causes.
Published: 12/19/2024
FDA Accepts Biologics License Application for Clesrovimab to Protect Infants from RSV Infection
Clesrovimab would be the first and only single dose immunization indicated for infants regardless of weight, aimed to protect against their first RSV season.
Published: 12/19/2024
Study: Varicella Zoster Virus Could Be a Major Cause of Aseptic Meningitis, Encephalitis, and Myelitis
The findings suggest that VZV is a common cause of CNS infections, even when there is no visible rash.
Published: 12/18/2024
Lawsuit Filed Against Major Food Companies Addresses Childhood Chronic Disease Epidemic
Ultra-processed food consumption fuels the rising rates of childhood obesity, diabetes, and liver disease, highlighting opportunities for pharmacist intervention.
Published: 12/18/2024
Study Shows Choline and Iodine Are Missing Links in Prenatal Supplements
Pharmacists and health care providers can recommend healthy foods that are rich in choline and iodine if individuals are not receiving enough in prenatal vitamin supplements.
Published: 12/18/2024
FDA Issues Boxed Warning for Fezolinetant Over Rare but Serious Liver Injury Risk
The updated prescribing information recommends laboratory tests prior to prescribing fezolinetant to determine baseline for hepatic function and injury.
Published: 12/18/2024
Ustekinumab-stba Receives FDA Approval for Autoimmune Disorder and Inflammatory Bowel Disease
Ustekinumab-stba (Steqeyma; Celltrion) is a subcutaneous treatment for adult and pediatric patients with plaque psoriasis arthritis, psoriatic arthritis, Crohn disease, and ulcerative colitis.
Published: 12/18/2024
Research Shows Efgartigimod Costs Are Far Higher Than Therapeutic Plasma Exchange for Myasthenia Gravis
Higher costs of efgartigimod alfa are primarily driven by its status as a newly approved, brand-name therapy without a generic alternative.
Published: 12/18/2024
Chronic Inflammation Driven by Diet May Contribute to Colorectal Cancer, Study Finds
The researchers suggest that an imbalance between pro-inflammatory and resolving lipid mediators may drive tumor growth.
Published: 12/18/2024
ASHP Midyear: Food Insecurity Impacted Hypertension for Patients, Especially in Rural Areas
Food insecurity in rural communities can affect hypertension, but pharmacists can mitigate the impact by educating themselves on nutrition options for low-income individuals.
Published: 12/18/2024
FDA Accepts New Drug Application for Cyclobenzaprine HCl in Management of Fibromyalgia
If approved, cyclobenzaprine hydrochloride (HCl) will be the first member of a new class of analgesic drugs for fibromyalgia.
Published: 12/18/2024
FDA Approves Crinecerfont for Adult, Pediatric Patients with Congenital Adrenal Hyperplasia
The decision is based on positive results from the CAHtalyst trials, which both met their primary and secondary end points.
Published: 12/17/2024
Men With History of Cannabis Use Have Less Cognitive Decline From Early Adulthood to Late Midlife
The investigators also find that age of initiation and frequent use were not associated with a greater age-related cognitive decline.
Published: 12/17/2024
Sacituzumab Govitecan-hziy Receives FDA Breakthrough Therapy Designation for Extensive-Stage Small Cell Lung Cancer Treatment
Abstract data presented in September demonstrate that the drug elicited strong antitumor activity in the second line in both platinum-sensitive and -resistant patients.
Published: 12/17/2024
Investigators Develop Training Tool to Improve Prescriber-Patient Communication About Biosimilars
The tool is designed to address the nocebo effect, which was a concern of prescribers and other health care professionals.
Published: 12/17/2024
Study Finds Asthma Is Common Among Children With Primary Ciliary Dyskinesia
The authors note that routine screening in patients with primary ciliary dyskinesia to help identify undiagnosed asthma.
Published: 12/17/2024
Pathways to Improve Overall Survival in Myelofibrosis: Finding Alternate Trial End Points
Measuring end points such as molecular response, cytokines, and histomorphometry may show a greater range of benefits.
Published: 12/17/2024
IVIG Identified as a Treatment Marker of High Medical Costs, Resource Utilization in Patients With Myasthenia Gravis
Often used as a treatment for severe exacerbations of myasthenia gravis, intravenous immunoglobulin can lead to high financial toxicity and resource utilization.
Published: 12/16/2024
Two Biomarkers Improve CRB-65 Predictability for Death Due to Community-Acquired Pneumonia
The study authors add that the validation improved the risk score in additional community-acquired pneumonia cohorts, and clinical studies would assess the broad clinical applicability.
Published: 12/16/2024
FDA Grants Breakthrough Therapy Designation to Tolebrutinib for Non-Relapsing Secondary Progressive Multiple Sclerosis
Based on positive results from the HERCULES trial, the new designation will allow for more thorough regulatory review and development of the multiple sclerosis treatment.
Published: 12/16/2024
Researchers Raise Questions About Low-Carb Diets and Effects on LDL Cholesterol
Results of the study showed an inverse relationship between BMI and LDL cholesterol changes for those who adopt a low-carbohydrate diet.
Published: 12/16/2024
Nemolizumab Granted FDA Approval For Moderate-to-Severe Atopic Dermatitis
Nemolizumab exclusively targets IL-31 receptor alpha, inhibiting the signaling of IL-31, which drives disease mechanism in atopic dermatitis.
Published: 12/16/2024
FDA Approves Cosibelimab-Ipdl for Adult Patients with mCSCC or laCSCC
The indication is for adults with metastatic cutaneous squamous cell carcinoma (mCSCC) or locally advanced CSCC (laCSCC) who are not candidates for curative surgery or radiation.
Published: 12/16/2024
FDA Approves Tapinarof Cream 1% for Treatment of Atopic Dermatitis in Adults, Children 2 and Older
The approval builds on previous indications for tapinarof, an aryl hydrocarbon receptor agonist, for the topical treatment of atopic dermatitis.
Published: 12/16/2024
Exploring the Role of Tumor Biology in Redefining Triple-Negative Breast Cancer Treatment
Emerging research in triple-negative breast cancer highlights the promise of molecular-based approaches to improve treatment outcomes.
Published: 12/14/2024
Reducing Risk: MUC1 Vaccines, Tamoxifen, and Denosumab in Breast Cancer Prevention
Advancements in prevention address cancer risk in high-risk patients and BRCA mutation carriers.
Published: 12/14/2024
Deciphering the Role of CDK4/6 and PDL-1 in Breast Cancer Immunotherapy Strategies
Combining CDK4/6 and PDL-1 inhibitors enhances treatment responses in patients with hormone receptor positive and triple-negative breast cancer.
Published: 12/14/2024
Approximately 1 in 6 US Adults With Asthma Report Non-Adherence to Medication Due to Cost
Despite the overall decline in medication non-adherence, adult patients with asthma are continuing to report taking less or skipping doses and refilling prescriptions later to save money.
Published: 12/13/2024
FDA Grants Breakthrough Therapy Designation to Tobevibart With Elebsiran for Treatment of Chronic Hepatitis Delta
The treatments are currently undergoing evaluation in the SOLSTICE trial (NCT05461170).
Published: 12/13/2024
Patients With PV Who Switched from Hydroxyurea to Ruxolitinib Had Improved Hematocrit, White Blood Cell Counts
Improvements were observed regardless of whether patients initiated ruxolitinib in the second or third line of treatment.
Published: 12/13/2024
FDA Expands Indication for Impella Heart Pumps to Include Pediatric Patients
The pumps can now be used to treat pediatric patients who have symptomatic acute decompensated heart failure and cardiogenic shock.
Published: 12/13/2024
Tafasitamab With Lenalidomide Plus Rituximab Improves PFS in Patients With R/R FL
Compared with placebo, patients with relapsed/refractory (R/R) follicular lymphoma (FL) who were treated with tafasitamab showed a median progression-free survival (PFS) of 22.4 months.
Published: 12/13/2024
Navigating the Evolving Landscape of ER-Positive Metastatic Breast Cancer Treatment
Novel therapies and personalized treatment plans are improving outcomes for patients with ER-positive breast cancer.
Published: 12/13/2024
FDA Grants Fast Track Designation to IMM-1-104 for Advanced Melanoma
Currently, the treatment is undergoing evaluation in a phase 2a trial.
Published: 12/12/2024
Paving the Way for Better Outcomes in HER2+ Early Breast Cancer Treatment
Trastuzumab deruxtecan and trastuzumab emtansine address key challenges such as recurrence and metastases in HER2+ early breast cancer treatment.
Published: 12/12/2024
FDA Reports Serious Liver Injury in Patients Without Cirrhosis Using Obeticholic Acid to Treat PBC
This update follows May 2021 guidelines which recommended patients with primary biliary cholangitis (PBC) with advanced cirrhosis discontinue obeticholic acid.
Published: 12/12/2024
Study: Dark Chocolate Consumption Lowers Risk of Type 2 Diabetes
Pharmacists play an essential role in educating patients about various health-related topics, including type 2 diabetes and nutrition.
Published: 12/12/2024
Tirzepatide Demonstrates Superiority for Weight Loss Compared With Semaglutide
The full results will be published in a peer-reviewed journal and presented at a medical meeting next year as the full results are evaluated.
Published: 12/12/2024
Benralizumab Achieves Positive Outcomes in Eosinophilic Exacerbations in Asthma, COPD
Compared prednisolone alone, benralizumab with and without prednisolone resulted in fewer treatment failures and stronger VAS scores.
Published: 12/12/2024
Belumosudil Commonly Used in Combination and After 3 or More Prior Lines of Therapy in Patients With cGVHD
Patients with chronic graft-versus-host disease (cGVHD) were most likely to receive belumosudil in the fourth line (33.7%) setting or the fifth through seventh line (33.1%).
Published: 12/12/2024
The Evolution of ADCs in Breast Cancer: Challenges and Innovations
At the 2024 San Antonio Breast Cancer Symposium, experts discussed the development, clinical impact, and challenges of antibody-drug conjugates (ADCs).
Published: 12/12/2024
FDA Grants Fast Track Designations to 2 Combination Influenza and COVID-19 Vaccine Candidates
The combination vaccine candidates will be evaluated in 2 separate phase 1/2 clinical trials.
Published: 12/11/2024
Improving Patient Outcomes With Innovative Dosing and Regimen Optimization Strategies
Experts highlight the importance of dosing and regimen optimization in breast cancer to improve treatment tolerability, reduce toxicities, and improve quality of life for patients.
Published: 12/11/2024
FDA Grants PLT012 Orphan Drug Designation for Liver, Intrahepatic Bile Duct Cancer
PLT012 demonstrates its potential against multiple tumors with unmet medical needs.
Published: 12/11/2024
ASHP Midyear: High Costs of Gene Therapies Present Major Challenges to Implementation
According to the report, 75% of survey participants expect pharmacists to oversee these therapies and 58% expect Medicare will require pharmacist involvement.
Published: 12/11/2024
Ribociclib and Inavolisib Approvals Highlight Advances in Breast Cancer Care
Experts discuss advancements in hormone receptor–positive/HER2-negative breast cancer treatment while addressing safety, diversity, and fertility challenges.
Published: 12/11/2024
Phase 3 POIESIS Trial Explores Safety, Efficacy of Navtemadlin and Ruxolitinib
Navtemadlin has demonstrated meaningful efficacy and safety as a monotherapy or combination treatment in various preclinical and clinical trials.
Published: 12/11/2024
Research Reveals Opportunities for Antimicrobial Stewardship When Treating Community-Acquired Pneumonia
Results suggest that patients commonly receive more than 5 days of treatment, which could be an opportunity for an antimicrobial stewardship initiative.
Published: 12/10/2024
Pharmacy Leaders Eye Opportunities, Challenges for Legislation in the Year Ahead
The progress made in areas like scope expansion and reimbursement is encouraging, suggesting a growing recognition of pharmacists’ value within the health care system.
Published: 12/10/2024
IV Form of NAC Receives FDA sNDA to Prevent, Lessen Liver Injury After Ingesting Toxic Quantities of Acetaminophen
Two studies found a 2-bag regimen of N-acetylcysteine (NAC) resulted in fewer and shorter delays in treatment as well as decreases in cutaneous non-allergic anaphylactoid reactions.
Published: 12/10/2024
PPSV23 Prevents Hospitalization Risk Due to Community-Acquired Pneumonia
The 23-valent pneumococcal polysaccharide vaccine (PPSV23, Pneumovax 23; Merck Sharp & Dohme Corp) demonstrates effective reductions in the risk of hospitalizations.
Published: 12/10/2024
CD19/CD22-Targeted CAR-T Cell Therapy Achieves Durable Remission in Children With B-ALL
This builds off prior data that showed safety and efficacy of CD19 and CD22 chimeric antigen receptor (CAR)-T cell therapy in children with relapsed or refractory B-lineage acute lymphoblastic leukemia (B-ALL).
Published: 12/10/2024
High-Dose Vitamin D Supplementation Shows Minimal Effect on Type 2 Diabetes Risk in Healthy Older Adults
Further research is needed to identify the influence of high-dose vitamin D supplementation among vitamin D–deficient populations.
Published: 12/10/2024
ASHP Midyear: Nearly Half of Adults With Epilepsy Use CBD Products
Adults with epilepsy are underrepresented in most CBD trials, including common etiologies.
Published: 12/9/2024
Phase 3 CEPHEUS Trial: DARA Plus VRd Is a Standard of Care for Frontline Treatment in Transplant-Ineligible Multiple Myeloma
The phase 3 CEPHEUS trial demonstrated that adding daratumumab (DARA) to the VRd regimen significantly improves minimal residual disease negativity, progression-free survival, and overall response in transplant-ineligible or transplant deferred patients with newly diagnosed multiple myeloma, establishing a new standard of care.
Published: 12/9/2024
Phase 3 GMMG-HD7 Trial: Assessing the Impact of Isatuximab on MRD Negativity and PFS in Multiple Myeloma
The GMMG-HD7 trial evaluated the addition of isatuximab to standard induction therapy in patients with newly diagnosed multiple myeloma who are eligible for autologous stem cell transplantation, demonstrating significantly higher rates of minimal residual disease negativity and improved progression-free survival (PFS).
Published: 12/9/2024
Researchers Identify Need for Standardized Cognition Measurements in Studies of Brain Supplements
Brain Health is an emerging research topic, but there is not a standard outcome measure.
Published: 12/9/2024
ASHP Midyear: Pharmacists Must Proactively Consider and Implement AI Tools
Although challenges and obstacles persist, artificial intelligence could help rural and smaller pharmacies close gaps in care.
Published: 12/9/2024
FDA Accepts NDA for Paltusotine to Treat Adult Patients With Acromegaly
If approved, the treatment will be the first and only once-daily, oral selective somatostatin receptor type 2 nonpeptide agonist available for acromegaly.
Published: 12/9/2024
Fixed-Duration Acalabrutinib and Venetoclax Regimens Redefine First-Line Treatment Options for Patients With CLL
The phase 3 AMPLIFY trial demonstrates that fixed-duration regimens of acalabrutinib and venetoclax, with or without obinutuzumab, significantly improve progression-free survival and deliver manageable safety profiles compared to chemoimmunotherapy in treatment-naive chronic lymphocytic leukemia (CLL).
Published: 12/8/2024
Daratumumab Demonstrates Significant Benefit in High-Risk Smoldering Myeloma: Results from the Phase 3 AQUILA Study
The AQUILA study demonstrates that early treatment with daratumumab significantly delays progression to symptomatic multiple myeloma, improves survival outcomes, and offers a well-tolerated alternative to traditional observation.
Published: 12/8/2024
ASHP Midyear: Opioid Use Disorder in Critically Ill Patients Has Unique Challenges
In hospital and critical care settings, pharmacists can play a significant role in educating other health care providers about treatment options, proper dosing, and more.
Published: 12/8/2024
ASHP Midyear: Identify and Counsel Patients at High Risk for Severe COVID-19
By identifying patients at high risk for progressing to severe disease and counseling them on their treatment options, pharmacists empower patients to make informed decisions about their treatment.
Published: 12/8/2024
Ketogenic Diet and β-Hydroxybutyrate May Enhance CAR T-Cell Therapy Efficacy
A ketogenic diet and its key metabolite, β-hydroxybutyrate, enhance the efficacy of CAR T-cell therapy by improving metabolic fitness, cytokine production, and cellular expansion, offering a promising, safe strategy for optimizing cancer immunotherapy.
Published: 12/7/2024
GLP1 Agonists and Dietary Fiber May Reduce VTE Risk and Improve GVHD Outcomes
Glucagon-like peptide 1 (GLP1) receptor agonists were shown to be associated with a reduced risk of venous thromboembolism (VTE), while high dietary fiber intake was shown to enhance microbiome health, lower graft-versus-host disease (GVHD) severity, and improve overall survival following allogeneic hematopoietic cell transplantation.
Published: 12/7/2024
Blinatumomab Plus Chemotherapy Improves DFS in Pediatric Patients With SR B-ALL
In newly diagnosed average and high standard risk B-cell acute lymphoblastic leukemia (B-ALL), blinatumomab improved disease-free survival (DFS) by approximately 97.5% and 94.1%, respectively.
Published: 12/7/2024
Experts Voice Concerns, Cautious Optimism With Kennedy Potentially Leading the HHS
As experts in medication management and health education, pharmacists can work with the administration to promote effective strategies that reduce misinformation and improve public health outcomes.
Published: 12/6/2024
USDA Announces Federal Order to Test Raw Milk Samples for H5N1 Bird Flu
The US Department of Agriculture’s (USDA) guidance will help expedite H5N1 bird flu surveillance within the nation’s milk supply and dairy herds.
Published: 12/6/2024
Long-Term Data On Olanzapine and Samidorphan Highlight Maintained Schizophrenia Symptom Control
The addition of samidorphan can support the antipsychotic efficacy of olanzapine while mitigating associated weight gain.
Published: 12/6/2024
Maternal Exposure to Certain Chemicals May Put Children at Risk for Asthma Development
The authors found high exposure to butylparaben and low exposure to 4-nonylphenol during pregnancy were risk factors for asthma development in children at 4 years of age.
Published: 12/6/2024
Muvalaplin Significantly Lowers Lipoprotein(a) in Adults With High Risk for Cardiovascular Events
Muvalaplin inhibits the formation of Lp(a) by blocking the initial interaction between apolipoprotein(a) and apo(b).
Published: 12/6/2024
FDA Grants Priory Review for Human Monoclonal Antibody Drug to Treat Muscle-Invasive Bladder Cancer
Durvalumab could offer further treatment for individuals with muscle-invasive bladder cancer.
Published: 12/6/2024
Preterm Children Show Poorer Cognitive Scores, Academic Performance at 9 Years
Children born moderate to late preterm also showed more behavior difficulties compared with those born early term or later.
Published: 12/6/2024
Surge in Hospital-Onset Respiratory Viral Infections Linked With Easing of Masking and Testing Policies
Reduced hospital masking and testing policies increased rates of hospital-onset respiratory infections, including RSV.
Published: 12/5/2024
Researchers Assess Shingles Vaccination Trends Among Older Adults With COPD
During a 15-year period, 1 in 5 older adults living with COPD received a shingles vaccine.
Published: 12/5/2024
Pelabresib and Ruxolitinib Achieve Primary End Point in Phase 3 MANIFEST-2 Trial
Pelabresib is an investigational, oral, small molecule that inhibits bromodomain and extraterminal (BET) proteins.
Published: 12/5/2024
FDA Grants Orphan Drug Designation to Novel Gene Therapy for Fabry Disease
Fabry disease is a rare lysosomal disorder that causes excessive deposition of lipids in tissues.
Published: 12/5/2024
Combining Ruxolitinib and Supportive Anemia Care Enhances Myelofibrosis Treatment
The data support the use of supportive anemia care agents in combination with ruxolitinib (Jakafi; Incyte Corp).
Published: 12/5/2024
Financial Difficulty Persists Through Early Breast Cancer Survivorship for Some Patients
The authors suggest that targeted interventions to mitigate financial toxicity should be implemented to better support patients.
Published: 12/5/2024
Zenocutuzumab-zbco Granted Accelerated Approval for Patients With NSCLC, Pancreatic Ductal Adenocarcinoma
Zenocutuzumab-zbco is a bispecific antibody that targets and binds to HER2 and HER3.
Published: 12/5/2024
FDA Grants Rare Pediatric Disease Designation to Small Molecule for Systemic Juvenile Idiopathic Arthritis
The treatment is a type IA prodrug of dexamethasone that targets CD206+ macrophages.
Published: 12/5/2024
FDA Approves Durvalumab for Treatment of Adults Patients With LS-SCLC
The indication is for adults with limited-stage small cell lung cancer (LS-SCLC) whose disease has not progressed after platinum-based chemotherapy and radiation therapy.
Published: 12/5/2024
Increases in Anaphylaxis Among Children, Adolescents Require Targeted Prevention Strategies
Prevalence increased across all subgroups among children and adolescents, with decreases observed in young adults and elderly populations.
Published: 12/5/2024
FDA Grants Breakthrough Therapy Designation to Sac-TMT for Previously Treated NSCLC
Sacituzumab tirumotecan (sac-TMT; Kelun Pharmaceutical, Merck) is currently being studied to treat non-small cell lung cancer (NSCLC) in the TroFuse-004 and TroFuse-009 trials.
Published: 12/5/2024
5 Key Interviews, Sessions at the 2024 ASH Annual Meeting and Exposition
The American Society of Hematology (ASH) Annual Meeting and Exposition will include the latest news and clinical trial updates in the hematology field.
Published: 12/5/2024
Hospital-Acquired Infections and Spread of Multi-Drug-Resistant Organisms Declined During COVID-19 Pandemic
The decline was attributed to continued adherence to infection prevention and control measures.
Published: 12/4/2024
Are GLP-1 Receptor Agonists Eliminating the Need for Bariatric Surgery?
Metabolic bariatric surgery rates has decreased in response to increased use of glucagon-like peptide-1 (GLP-1) receptor agonists.
Published: 12/4/2024
Real-World Insights Shed Light on the Impact of Anemia on Treatment Outcomes in Patients With Myelofibrosis Receiving Ruxolitinib
Anemia is a very common adverse effect associated with the use of ruxolitinib.
Published: 12/4/2024
Study Suggests Individuals Born Preterm Are at Increased Risk of Death Until Third, Fourth Decade of Life
These risks were observed to become higher as gestational age decreased.
Published: 12/4/2024
High-Dose Vitamin C Improves Outcomes for Late-Stage Pancreatic Cancer
High-dose vitamin C, when combined with chemotherapy, has shown the potential to double the survival rate of patients with late-stage metastatic pancreatic cancer.
Published: 12/3/2024
High-Dose IVIG, Rituximab Effective in Patients With Pemphigoid-Associated Conjunctivitis
A vast majority of patients achieved a positive clinical response with the combination, with improvements in their ocular condition.
Published: 12/3/2024
Pneumococcal Infection Reveals Underlying Immunosuppressive Conditions for Low-Risk Adults
Investigators say basic immunodeficiency screening should be completed in full for this patient population.
Published: 12/3/2024
Patients With Post-COVID POTS Experience Disruptions in Circadian Blood Pressure Rhythm Regulation
Postural orthostatic tachycardia syndrome (POTS) diagnoses have greatly increased following the COVID-19 pandemic.
Published: 12/3/2024
FDA Blocks Flavored E-Cigarettes, Sparking Legal Fight Over Risks to Minors
E-cigarette manufacturers claim the products aid in smoking cessation for adults without the risk of adolescent usage.
Published: 12/3/2024
Study Shows Comparable Safety, Efficacy of Idecabtagene Vicleucel in Older Patients
The therapy has similar benefits for both older and younger patients with multiple myeloma.
Published: 12/3/2024
Study Finds Nature-Based Interventions at School Does Not Reduce Children’s Poor Mental Health Symptoms
The authors recommend that longer assessments with lengthier interventions should be performed to assess potential benefits.
Published: 12/3/2024
FDA Receives 2 Supplemental Biologics License Applications for Guselkumab for Pediatric Indications
If approved, the new indications include children 6 years and older with moderate to severe plaque psoriasis and children 5 years and older with active juvenile psoriatic arthritis.
Published: 12/3/2024
Monitoring Serum Magnesium Levels Helps Manage Hypomagnesemia for Patients With Type 2 Diabetes
The pharmacist’s role includes determining if there are any medications that are contributing to magnesium deficiency for patients with diabetes who are at an increased risk.
Published: 12/2/2024
Data Further Confirm Proposed Denosumab Biosimilar Shows Similar Efficacy to Originator
Investigators presented additional data from a clinical trial at the American College of Rheumatology Convergence, demonstrating similar safety for postmenopausal women with osteoporosis.
Published: 12/2/2024
Looming PREP Act Expiration Could Impact Health Care Access for Rural Patients
The Act is set to end at the end of 2024, which will affect pharmacists’ abilities to administer COVID-19 tests, vaccines, and treatment that are distributed by the federal government.
Published: 12/2/2024
Photoacoustic Breast Imaging Can Reduce Skin Tone Biases While Detecting Cancer Early
When different skin tones are considered in imaging systems, women will receive more equitable screening and care.
Published: 12/2/2024
Zerlasiran Shows Significant Lipoprotein(a) Reduction in Phase 2 Trial
Lipoprotein(a) is a known risk factor for atherosclerotic cardiovascular disease.
Published: 12/2/2024
Study Finds Associations Between Memory Difficulties and History of Asthma in Children
Asthma onset earlier in childhood may be linked to more severe difficulties that could extend to executive function abilities.
Published: 12/2/2024
Real-World Analysis Highlights the Survival Impact of Anemia in Patients With Myelofibrosis Treated With Ruxolitinib
Anemia is a common adverse effect of ruxolitinib, calling for new approaches to mitigate risks.
Published: 12/2/2024
FDA Approves Ustekinumab-kfce as Sixth Biosimilar to Stelara
The biosimilar is approved for the treatment of Crohn disease, ulcerative colitis, plaque psoriasis, and psoriatic arthritis.
Published: 12/2/2024
Familiarize Yourself With Updated Clinical Guidelines Recommendations for Restless Legs Syndrome
Treatment for RLS includes lifestyle modifications, medication, and in some cases, non-drug therapies, aiming to reduce symptoms and improve sleep and daytime functioning.
Published: 12/1/2024
Analysis Finds Low-Income Countries Face More Cancer-Related Deaths and Inequities in Therapy Access
Potential solutions can include international funding, improved primary health care measures, and cost-effective screening methods.
Published: 11/30/2024
Navitoclax and Ruxolitinib Show Potential in Treating R/R Myelofibrosis
The addition of navitoclax was associated with durable response and potential disease modification.
Published: 11/29/2024
Childhood Pneumococcal Vaccination Programs Indirectly Protect Adults From Pneumococcal Disease
Pneumococcal disease incidence decreased in adults after pneumococcal vaccines began to be used in children due to indirect protection, with fewer adults found to carry the bacterium that causes disease.
Published: 11/29/2024
Recent Intravenous Immunoglobulin Administration Can Lead to Serum Protein Electrophoresis Misdiagnosis
Knowledge of recent intravenous immunoglobulin (IVIG) administration in patients receiving the common laboratory test can help inform misdiagnosis.
Published: 11/28/2024
COVID-19 Incidence Among Children Not Related to Elementary School Attendance
Evidence suggests that precautionary measures in elementary schools were able to effectively mitigate large increases in disease transmission.
Published: 11/27/2024
Study: Patients With Hypothyroidism Who Lost Weight on Semaglutide Saw Decreases in TSH Levels
These findings are significant in understanding interactions between glucagon-like peptide-1 medications and thyroid dysfunction because prior research has shown conflicting results.
Published: 11/27/2024
FDA Approves Methylene Blue Injection for Acquired Methemoglobinemia
Methemoglobinemia is a blood disorder that affects proper release of oxygen around the body.
Published: 11/27/2024
Policy Proposal Seeks to Include Weight-Loss Drugs in Medicare Coverage
The proposed rule would increase access to semaglutide for millions of Americans.
Published: 11/27/2024
Research Shows Healthy Women Have Cells in Breast Tissues Resembling Cancer
Because these cells are present throughout the body, there may also be implications for other cancer types.
Published: 11/27/2024
FDA Approves Landiolol For Treatment of Supraventricular Tachycardia
The approval is based on clinical studies that demonstrate the management of heart rate with minimal reductions to blood pressure.
Published: 11/27/2024
PPD Rates Increase Among All Racial Groups, but Asian/Pacific Islander and Black Patients See Highest Increases
Postpartum depression (PPD) rates also had notable increases in those with class I and class II/III obesity.
Published: 11/26/2024
Financial Incentives Increase Utilization of Biosimilars for Oncology Care
However, the monthly expenditure was not significantly associated with the financial incentives.
Published: 11/26/2024
Study Shows Adult HPV Vaccination Is Less Cost-Effective Than Adolescent Vaccination
Investigators also found that vaccination for those aged 27 to 45 produces a higher number needed to vaccinate.
Published: 11/26/2024
Childhood Air Pollution Exposure Associated With Higher Risk, Persistence of Peanut Allergy
Exposure to pollutants PM2.5 and NO2 was found to increase the likelihood of developing a peanut allergy and of the allergy persisting.
Published: 11/26/2024
FDA Approves Oral Liquid Solution of Imatinib for Certain Forms of Leukemia and Other Cancers
This is the first oral liquid form of imatinib (Imkeldi; Shorla Oncology) to be approved to treat cancers.
Published: 11/25/2024
Acoramidis Received FDA Approval for Treatment of Transthyretin Amyloid Cardiomyopathy
Acoramidis is a novel, highly potent transthyretin stabilizer.
Published: 11/25/2024
Study Results Show 1 in 20 Adults With RSV Are Hospitalized
Findings highlight the unmet medical need for outpatient interventions and preventive measures that can reduce hospitalizations.
Published: 11/25/2024
Disappearance of B/Yamagata Strain Influences Flu Vaccine, Public Health Decisions
The disappearance could impact updates for surveillance strategies and vaccine development.
Published: 11/25/2024
Community Health Care Workers Connect Children With Asthma to Care in Trigger Environments
Community health care workers help support both primary care and school settings by assisting with medication administration and communications with staff.
Published: 11/25/2024
IVIG Demonstrates Effectiveness in Several Neuroimmune Conditions, Indicating Potential for Long COVID Treatment
Intravenous immunoglobulin (IVIG) has proven efficacy in autoimmune neuropathies, with mixed but promising outcomes in severe COVID-19 cases and post-acute sequelae of SARS-CoV-2 infection trials.
Published: 11/23/2024
Belantamab Mafodotin Achieves Secondary End Point for Treatment of Relapsed, Refractory Multiple Myeloma
Belantamab mafodotin demonstrated benefits in overall survival in the phase 3 DREAMM-7 trial.
Published: 11/23/2024
Oseltamivir May Shorten Hospital Stays for Children With the Flu
Children with obesity, asthma, and gastrointestinal disease had longer durations of stays compared with children without comorbidities.
Published: 11/22/2024
Decision to Receive Pneumococcal Vaccine Among Older Adults Is Multi-Factorial, Influenced by Multidimensional Interventions
Commonly cited factors influencing uptake of pneumococcal vaccination included knowledge of pneumococcal disease and vaccine benefits, recommendations from health authorities, and perceived risk of infection.
Published: 11/22/2024
NCCN Announces Expanded Practice Guidelines for Breast Cancer With Hereditary Risks
The guidelines were expanded to include the growing use of genetic testing within cancer prevention, screening, and treatment.
Published: 11/22/2024
Arrowhead Pharmaceuticals Submits FDA Application for Plozasiran in Familial Chylomicronemia Syndrome
Familial chylomicronemia syndrome (FCS) currently has no FDA-approved treatment and is associated with an increased risk of acute pancreatitis.
Published: 11/22/2024
FDA Grants Orphan Drug Designation to RAG-21 for Treatment of ALS
If approved, RAG-21 can offer improved outcomes in patients with amyotrophic lateral sclerosis (ALS), particularly those with aggressive subtypes.
Published: 11/22/2024
Women With Natural Menopause at a Later Age May Have an Increased Risk of Asthma
Women aged 40 to 44 years at the time of natural menopause showed about a 30% decreased risk for asthma incidence.
Published: 11/22/2024
FDA Grants Rare Pediatric Disease, Fast Track Designations to Gildeuretinol for Stargardt Disease Treatment
As a rare and serious pediatric disorder, Stargardt disease can cause vision complications in patients.
Published: 11/22/2024
Rusfertide Reduces Phlebotomy Need, Improves Symptom Control in Polycythemia Vera
Rusfertide may sustain hematocrit levels in patients with polycythemia vera.
Published: 11/21/2024
Usage of AI With PET/CT Images Could Detect Impacts of Immunotherapy in Lung Cancer
The risk of developing interstitial lung disease after immunotherapy was 6.5 times higher in individuals with high inflammation.
Published: 11/21/2024
FDA Accepts sNDA for Darolutamide With ADT for Patients With mHSPC
The supplemental new drug application (sNDA) is based on results from a phase 3 trial that enrolled patients with metastatic hormone-sensitive prostate cancer (mHSPC).
Published: 11/21/2024
Clinical Safety Data Show Switching Between Rituximab Biosimilars Does Not Increase Adverse Events
There were 2 main types of switches, including switching to rituximab subcutaneous and switching among different intravenous rituximab treatments.
Published: 11/21/2024
Novel IVIG Formulation KIG10 Is Effective, Well Tolerated in Adults With Primary Immunodeficiency
No acute serious bacterial infections were observed in a trial of patients with the debilitating immune disorder, a strong mark of safety and tolerability.
Published: 11/21/2024
Antibody Drug Conjugate Targeting CLDN1 Receives FDA Fast Track Designation
ALE.P02 could provide further treatment options for advanced or metastatic anti–claudin-1+ squamous cancers.
Published: 11/21/2024
Intravenous Injections of Zanidatamab-Hrii Receives FDA Accelerated Approval for IHC+ BTC
The indication is for adults with previously treated unresectable or metastatic HER2+ (IHC+) biliary tract cancer (BTC) as detected by an FDA-approved test.
Published: 11/21/2024
Higher Composite Dietary Antioxidant Index Reduces Risk of Diabetes for Women
Investigators also established a negative association with higher vitamin C intake and diabetes prevalence.
Published: 11/21/2024
ACCC Hosts Online Expert Panel: Palliative Care in Oncology: Challenges and Opportunities
Published: 11/21/2024
Increase of Vitamin D Supplements Could Lower Blood Pressure Among Older Individuals With Obesity
Vitamin D and calcium decreased systolic and diastolic blood pressure among older individuals with obesity.
Published: 11/20/2024
Investigators Present New Data About HPV Vaccine, Supporting Its Use
Data from the BROADEN and PROGRESS studies were presented at the International Papillomavirus Conference 2024 in Edinburgh, UK, from November 12 to 15.
Published: 11/20/2024
Nasal Swab Test Can Predict COVID-19 Severity Through Autoantibody Analysis
Severity of a COVID-19 illness could be determined by examining autoantibodies in the nasal cavity, allowing more personalized treatment protocols.
Published: 11/20/2024
Early Asthma Onset Associated With Memory and Executive Function Difficulties in Children
Inflammation associated with asthma in children could perturb neurodevelopment.
Published: 11/20/2024
Study Finds Nearly 75% of Adults 25 and Older Have Overweight or Obesity
If patterns and trends were to continue, the authors predict that nationwide overweight and obesity prevalence in adults will surpass 80% by 2050.
Published: 11/20/2024
Alzheimer Disease Treatment Can Improve Population Health and Health Equity
Policies that focus on earlier diagnosis, treatment initiation, and expanded access to treatment can further improve treatment and health equity impacts.
Published: 11/20/2024
FDA Approves Bimekizumab-Bkzx as Treatment for Hidradenitis Suppurativa
Bimekizumab-bkzx is the first and only approved medication that targets both interleukin (IL) 17F and IL-17A.
Published: 11/20/2024
Study: In-Room Air Purifiers Could Impact RSV Incidence Among Older Adults
Use of in-room air purifiers with HEPA-14 filters did not result in a significant reduction of acute respiratory infections.
Published: 11/19/2024
Researchers Assess Incidence of Shingles Vaccination Among Individuals with Asthma
An increase of shingles vaccination was reported among individuals with asthma.
Published: 11/19/2024
FDA Grants Breakthrough Therapy Designation for Nipocalimab to Treat Sjögren Disease
This marks the first and only therapy to receive this designation for Sjögren disease, which currently has no approved treatment.
Published: 11/19/2024
FDA Grants Fast Track Designation to VAD044 for Treatment of Adults With HHT
Clinical trial analysis results studying VAD-44 in patients with hereditary hemorrhagic telangiectasia (HTT) will be presented at the 2024 American Society of Hematology Annual Meeting & Exposition.
Published: 11/19/2024
Spread of Seasonal Flu Returns to Pre-Pandemic Levels After End of COVID-19 Global Emergency
Increased global capacity for surveillance could help monitor seasonal influenza to reduce the risk of vaccine mismatch and inform effective interventions.
Published: 11/19/2024
FDA Grants Fast Track Designation to Potential Gene Therapy for Osteoarthritis of the Knee
GNSC-001 is a first-in-class gene therapy designed to offer long-term relief of musculoskeletal diseases such as osteoarthritis.
Published: 11/19/2024
Abelacimab Reduces Bleeding in AF Patients on Antiplatelet Therapy
Abelacimab is an investigational, selective, fully human monoclonal antibody.
Published: 11/19/2024
CHMP Recommends Lazertinib With Amivantamab to Treat EGFR-Mutated Advanced NSCLC
Lazertinib in combination with amivantamab displays positive outcomes for non–small cell lung cancer compared with standard first line treatment.
Published: 11/18/2024
Study Identifies Factors Influencing Quality of Life for Young Breast Cancer Survivors
Factors such as age, race, marital status, years since diagnosis, and out-of-pocket costs show significance as predictors of quality of life.
Published: 11/18/2024
Hoxb8 Mast Cell Activation Test Demonstrates Diagnostic Precision for Assessment of Peanut Allergy
When compared to established diagnostic assays such as the basophil activation test, the Hoxb8 mast cell activation test demonstrates similar precision.
Published: 11/18/2024
AHA 2024: Email Reminders Improve Flu Shot Rates, Particularly Among Heart Attack Survivors
The encouraging results suggest this low-cost, scalable strategy should be considered for population-level outreach globally to improve flu vaccination rates.
Published: 11/18/2024
FDA Grants Rare Pediatric Disease Designation for Treatment of Neonatal SP-B Deficiency
The disorder presents as severe lung disease, with lung transplantation as the only current therapeutic option for long-term survival.
Published: 11/18/2024
A Hospital’s Outpatient Pharmacies Attempt to Reduce DIR Fees Using Performance Reports
This quality improvement initiative demonstrates that pharmacies were unable to use performance reports provided by the payer to improve performance scores and decrease direct and indirect remuneration (DIR) fees.
Published: 11/18/2024
AHA 2024: Inclisiran Shows Efficacy, Improved Adherence for Reducing LDL-C
Twice-yearly dosing could significantly improve adherence rates.
Published: 11/17/2024
AHA 2024: Integrating Ambulatory Care Pharmacists in Value-Based Primary Care Improves Cardiometabolic Disease Management
Value-based payment models are becoming increasingly common, leading clinicians to find novel ways to engage patients and improve disease control with the goal of reducing morbidity, mortality, and cost.
Published: 11/17/2024
AHA 2024: Providing Feedback for Pharmacists Improved Care for Veterans With Heart Failure
Within the Veterans Health Administration System, primary care pharmacists are embedded in primary care panels and work alongside primary care physicians and nurses to optimize medication management for patients.
Published: 11/16/2024
AHA 2024: Tirzepatide Lowers Risk of Worsening Heart Failure, CVD Death in Adults With Obesity
This is the first trial that tested the effect of any medication on major heart failure outcomes in patients with HFpEF and obesity, according to investigators.
Published: 11/16/2024
AHA 2024: Unexplained Changes in Cholesterol Could Help Identify Adults At Risk of Dementia
High fluctuations (in the top 25%) in total cholesterol were associated with a 60% increase in dementia and a 23% increase in cognitive decline.
Published: 11/16/2024
FDA Approves Revumenib for the Treatment of Relapsed or Refractory Acute Leukemia
The indication is for adult and pediatric patients 1 year and older with a lysine methyltransferase 2A gene translocation.
Published: 11/15/2024
Shingles Vaccine Could Protect Cardiovascular Health
Pharmacists can continue to spread awareness of the importance of receiving a shingles vaccine.
Published: 11/15/2024
FDA Accepts sBLA Review for Dupilumab in Treatment of CSU in Adult and Pediatric Patients
The indication is for patients 12 and older with chronic spontaneous urticaria (CSU) whose disease is not adequately controlled with H1 antihistamine treatment.
Published: 11/15/2024
FDA Grants New Nilotinib Formulation Approval to Treat Adults With Chronic Myeloid Leukemia
The tablets become the first and only nilotinib with no mealtime restrictions indicated for this population.
Published: 11/15/2024
Intravenous Immunoglobulin Elicits Favorable Response in Pregnant Patient With Pemphigoid Gestationis
IVIG was found to cease development of new lesions and heal previously documented erosions without adverse events to the patient or fetus.
Published: 11/15/2024
AHA 2024: AI Tool Could Provide Fast, No-Contact Blood Pressure and Diabetes Screenings
The system, currently in early development in Japan, could minimize the need for blood tests, blood pressure cuffs, or expensive wearable devices.
Published: 11/15/2024
AHA 2024: High Temperatures Linked to Irregular Heartbeat in Individuals With Implanted Defibrillators
The global temperature has risen by an average of 0.11° Fahrenheit per decade since 1850, or about 2 degrees in total.
Published: 11/15/2024
Researchers Assess Burden of RSV Hospitalization Prior to Vaccine Introduction
Increasing vaccine coverage among adults at highest risk could lessen associated hospitalizations and severe outcomes caused by RSV.
Published: 11/14/2024
Allergic Diseases Potentially Increase Risk of Select Mental Health Conditions
The strongest association is found between asthma and the risk of attention deficit/hyperactivity disorder, though these links do not equate to causality.
Published: 11/14/2024
Study Shows Shingles Infection Could Be Associated With Dementia
Use of antitherapeutic medication prescribed for herpes zoster related to lower risk of subsequent dementia.
Published: 11/14/2024
AHA 2024: Patients With Cardiovascular Conditions Want More Guidance About Sexual Health
Community pharmacists are playing an increasing role in sexual and reproductive health services and can provide that trustworthy information to patients.
Published: 11/14/2024
FDA Adds Delayed Gastric Emptying as Adverse Event on Semaglutide Label
The label includes postmarking reports showing rare instances of pulmonary aspiration for patients undergoing procedures that require general anesthesia or deep sedation.
Published: 11/14/2024
AHA 2024: GLP-1, SGLT2 Treatments May Lower Risk of Future Heart Attack, Stroke for Stroke Survivors
The 2024 American Heart Association and American Stroke Association stroke prevention guidelines recommend glucagon-like peptide-1 receptor agonists to reduce the risk of stroke in individuals with diabetes and high cardiovascular risk.
Published: 11/14/2024
Study: Most Children Do Not Receive Interventions Reducing Asthma Exacerbations Despite Effectiveness
The intervention methods—annual asthma reviews, inhaler technique checks, and asthma management plans—were most effective when performed in the same visit.
Published: 11/14/2024
Risk of Psychiatric Disorders Increases for Children of Mothers With Eating Disorder History
The data also shows similar results for children with mothers who have pre-pregnancy body mass index outside of normal range.
Published: 11/14/2024
FDA Approves Eladocagene Exuparvovec-Tneq for Treatment of AADC Deficiency
Eladocagene exuparvovec-tneq is the first FDA-approved gene therapy for individuals with aromatic L-amino acid decarboxylase deficiency.
Published: 11/14/2024
RSV Vaccine Displays Effectiveness Against RSV-Associated Hospitalizations
RSV vaccination is approximately 77% to 81% effective against hospital and emergency department encounters among older adults.
Published: 11/13/2024
Study: Low Number of Patients With Chronic Respiratory Diseases Received Annual Flu Vaccination
In the analysis, 34.7% of commercially insured patients with chronic obstructive pulmonary disease or asthma received an influenza vaccination.
Published: 11/13/2024
Mushroom Supplement Displays Benefits in Slowing and Preventing Prostate Cancer
White button mushroom can rebuild anti-cancer immune defense while slowing cancer growth.
Published: 11/13/2024
5 Key Interviews, New Data at the American Heart Association 2024 Scientific Sessions
The sessions will include late-breaking science, clinical practice guidelines, early innovators spotlight sessions, and more.
Published: 11/13/2024
FDA Grants Rare Pediatric Disease Designation to Elraglusib for Ewing Sarcoma
The designation follows 2 previous orphan drug designations for pancreatic cancer and soft tissue sarcoma.
Published: 11/13/2024
New Model Can Assess Blast Phase Progression Risk in Myeloproliferative Neoplasms
According to the study, 20% of patients with myeloproliferative neoplasms progress to blast phase.
Published: 11/12/2024
Customized Antisense Oligonucleotides Could Further Lung Cancer Treatment
Researchers applied extracellular vesicles retrieved from human red blood cells to serve as natural carrier to deliver the anti-cancer antisense oligonucleotides to the tumor site.
Published: 11/12/2024
Proposed Biosimilar to Ocrelizumab Shows Comparability With Reference Product
Ocrelizumab (Ocrevus; Genentech) is used for the management and treatment of multiple sclerosis.
Published: 11/12/2024
Bispecific Antibody Receives FDA Orphan Drug Designation for the Treatment of Multiple Myeloma
LBL-034 could be best in class in treating individuals with multiple myeloma.
Published: 11/12/2024
COVID-19 Hospital Burden Associated With Increased Inpatient Adverse Events Among Patients With, Without COVID-19
High COVID-19 hospital caseload strain led to increases in inpatient adverse events among patients both with and without SARS-CoV-2 infection.
Published: 11/12/2024
Varying Messaging Strategies Increases Likelihood of Vaccination Against HPV
There were differences in the variables that influenced vaccination decision making for adults aged 18 to 26 years and for parents making the decision to vaccinate their child
Published: 11/12/2024
Johnson & Johnson Seeks FDA Approval of Daratumumab for Smoldering Multiple Myeloma
If accepted, daratumumab would be the first approved treatment for smoldering multiple myeloma.
Published: 11/11/2024
Lumateperone Demonstrates Positive Efficacy for Schizophrenia Relapse Prevention
In the trial, lumateperone had a significantly longer time to relapse in patients treated compared to placebo.
Published: 11/11/2024
An Overlook of Cagrilintinide and Semaglutide as it Progresses Through Phase 3 Trials
CagriSema is a subcutaneous injectable combination of cagrilintide and semaglutide that is currently in phase 3 trials.
Published: 11/11/2024
FDA Approves Obecabtagene Autoleucel for Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia
The regulatory approval corresponds with positive safety and efficacy data from the FELIX trial.
Published: 11/11/2024
CHEST Curriculum Pathway for Asthma Shows Ability to Improve Health Care Professionals’ Knowledge
Participants who completed the curriculum had answered 82% of the post-test correctly.
Published: 11/11/2024
Semaglutide Improves Liver Fibrosis in Patients with Metabolic Dysfunction-Associated Steatohepatitis
Glucagon-like peptide-1 agonists have increasingly showed potential for treating liver fibrosis in patients, which disproportionately affects those who are overweight or have obesity.
Published: 11/11/2024
Technology in the Classroom Helps Shape Tomorrow’s Pharmacy Leaders
Automation can enhance safety and efficiency and allow staff to concentrate on higher-value tasks as direct patient care roles expand.
Published: 11/11/2024
Researchers Assess the Role of Vitamin K2 in Managing Nocturnal Leg Cramps
Vitamin K2 displayed a marked reduction in cramp frequency compared to a placebo.
Published: 11/10/2024
Providers Prefer Increased Pneumonia, IPD Coverage and Lower Age Recommendation For Pneumococcal Vaccines
Reasons for supporting the lowering of the age-based pneumococcal vaccine recommendation included the likelihood it would increase vaccination rates in multiple age groups and demographics.
Published: 11/9/2024
Off-Label Semaglutide Linked to Deaths, Hospitalizations Calling for Compounding Regulation
Off-label semaglutide has been linked to serious adverse effects, calling for increased regulation around compounding.
Published: 11/8/2024
Researchers Evaluate the Safety and Efficacy of Brivudine as Oral Shingles Treatment
Brivudine is more effective in treating herpes zoster and does not increase the risk of adverse reactions.
Published: 11/8/2024
Moderna Bivalent COVID-19 Vaccine More Effective at Preventing Hospitalization in High-Risk Patients Compared With Pfizer-BioNTech Vaccine
Though both vaccines remain effective at preventing severe illness, Moderna’s mRNA-1273.222 vaccine was found to be significantly more effective among adults with underlying medical conditions.
Published: 11/8/2024
FDA Grants Orphan Drug Designation to Ifetroban for Treatment of Duchenne Muscular Dystrophy-Associated Cardiomyopathy
The drug is being investigated for its potential to reduce fibrosis associated with muscular dystrophy that can cause scarring of the heart tissue.
Published: 11/8/2024
History of Concussion Associated With Higher Risk of Adverse Psychiatric Outcomes Postpartum
The study found that this patient population was about 25% more likely to have serious mental health issues after childbirth.
Published: 11/8/2024
Researchers Develop Predictive Model for Patients with Prefibrotic Primary Myelofibrosis
The nomogram model demonstrated good predictive capabilities to assess progression risk to overt primary myelofibrosis.
Published: 11/8/2024
Web-Based Interventions Effective in Improving Quality of Life for Patients With Breast Cancer
The analysis also found that the intervention methods could improve patients’ physical, cognitive, and emotional functioning.
Published: 11/8/2024
FDA Proposes Removal of OTC Oral Phenylephrine From Cough/Cold Products
Evidence shows that the agent is not an effective nasal decongestant.
Published: 11/7/2024
Researchers Highlight Need for Increased RSV Vaccination
RSV vaccines were 80% effective in preventing hospitalization, ICU admission, and death among adults aged 60 years and older.
Published: 11/7/2024
Risk of Developing Eosinophilic Esophagitis Is Higher in Pediatric Patients With Atopic Conditions
Children with certain atopic conditions, including asthma and common food allergies, were observed to have a higher risk of developing the chronic disorder.
Published: 11/7/2024
Implementation of Supply-Related Restrictive Measures Reduces IVIG Use
Efforts include a mandatory intravenous immunoglobulin ordering form, blood bank gatekeeping, and a stewardship committee to ensure optimized use.
Published: 11/7/2024
Lerodalcibep Delivers Significant LDL-C Reduction for High-Risk Cardiovascular Patients
Lerodalcibep is a novel, third-generation, anti-PCSK9 therapy small binding protein.
Published: 11/7/2024
Peggy Lillis Foundation Announces “See C. Diff Diagnosed” Campaign, Events During National C. Diff Awareness Month
The organization will kick off the month of national recognition with the 15th annual Changing the Odds Gala.
Published: 11/7/2024
Severe Asthma Symptoms Reported by Two-Thirds of Sub-Saharan African Adolescents
Among this population, about 80% had not previously been diagnosed with asthma and over 30% were not using any asthma medications.
Published: 11/7/2024
'Treat These Patients With Compassion': Expert Discusses Pharmacists' Role in Counseling Benzodiazepine Use
Brian Anderson, PharmD, RPh provides important considerations for pharmacists regarding patient use of benzodiazepines.
Published: 11/6/2024
RSV Preventative Monoclonal Antibody Could Reduce Disease Incidence in Preterm, Full-term Infants
Clesrovimab reduced RSV-associated hospitalizations and RSV-associated lower respiratory infection hospitalizations by more than 84% and 90% in preterm and full-term infants, respectively.
Published: 11/6/2024
Bone Marrow Adipocytes May Offer Early Detection of MGUS Progression to Multiple Myeloma
Increased bone marrow adiposity is associated with progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma.
Published: 11/6/2024
Cigarette Smoke Hinders Innate Immune Response to Pneumococcal Infection
Known to be a leading cause of mortality worldwide, cigarette smoke exposure can make the respiratory tract more susceptible to pneumococcal infection.
Published: 11/6/2024
Fecal microbiota, live – jslm Demonstrates Safety, Efficacy in Prevention of Recurrent C difficile Infections
RBL is the first FDA-approved microbiota-based live biotherapeutic product for adults.
Published: 11/6/2024
Cognitive Remediation, Transcranial Direct Current Stimulation Slow Cognitive Decline in At-Risk Older Adults
For up to 6 years, cognitive remediation and transcranial direct current stimulation slowed cognitive decline associated with major depressive disorder in remission and mild cognitive impairment.
Published: 11/6/2024
Women Within Health Care Face Financial Disparities and Are More Likely to Experience Burnout
The authors believe that improvements can be made to overlook the motherhood penalty and its associated pay gaps as well as changes to address workforce burnout.
Published: 11/6/2024
ENVISION Trial Results Show UGN-102 Has Long-Term Durability in Patients With Bladder Cancer
Patients with low-grade intermediate-risk non-muscle-invasive bladder cancer who achieved a complete response rate after 3 months of UGN-102 treatment had an 82.3% duration of response at 12 months.
Published: 11/6/2024
Researchers Identify Significant Relationship Between Insomnia and Long-term Atrial Fibrillation Recurrence Following Radiofrequency Ablation
Insomnia exhibits a dose-response relationship with AF recurrence, indicating that an increased number of insomnia symptoms is associated with heightened probability of AF recurrence.
Published: 11/6/2024
Depression Is Core Symptom Shown in All CRF Networks Among Patients With Breast Cancer
The findings show robust connections between symptoms, with variations in depression scores directly or indirectly influence fatigue and other symptoms.
Published: 11/5/2024
Researchers Find Lack of Communication for Lung Cancer Screenings Among High-Risk Individuals
Less than 16% of high-risk lung cancer individuals have heard or discussed lung cancer screenings with a health care provider.
Published: 11/5/2024
Study Identifies Which Students at Risk for Pandemic-Related Psychological Distress
The results found that women, non-binary, and sexual minority students are at the highest risk.
Published: 11/5/2024
Study Finds Behaviors of Breast Cancer Cells Help Predict Risk of Bone Metastasis
Using in vitro models, study investigators predict the risk of bone metastasis in breast cancer based on correlations with their in vivo behaviors and potential.
Published: 11/5/2024
PP-007 Receives FDA Fast Track Designation for Treatment of Acute Ischemic Stroke
The novel therapy demonstrated safety and efficacy in a clinical trial.
Published: 11/5/2024
Dupilumab Shows Significant Reductions in Itch and Hive Activity in Patients With CSU
About 41% and 30% of patients with chronic spontaneous urticaria (CSU), respectively, achieved well-controlled disease status and complete response when treated with dupilumab.
Published: 11/5/2024
FDA Approves DFD-29 for Treatment of Adults With Rosacea-Related Inflammatory Lesions
The approval comes after the phase 3 clinical trials MVOR-1 (NCT05296629) and MVOR-2 (NCT05343455).
Published: 11/5/2024
Pegfilgrastim-Fpgk Shows Structural, Functional Biosimilarity to Reference Product
Pegfilgrastim (Neulasta; Amgen) treats neutropenia that is caused by cancer medications and helps the bone marrow to create new white blood cells.
Published: 11/5/2024
ELA026 Receives Orphan Drug Designation to Treat Hemophagocytic Lymphohistiocytosis
ELA026 is a first in class antibody therapy targeting signal regulatory proteins.
Published: 11/4/2024
Results of ELEVATUM Show Improvement in Diabetic Macular Edema With Vabysmo for Racial, Ethnic Minority Patients
The study investigated faricimab-svoa (Vabysmo) as treatment of diabetic macular edema for patients in racial and ethnic groups that are often underrepresented in trials.
Published: 11/4/2024
Report: 82.3% of Reported Vaccine Errors Reached the Patient
The most commonly reported errors included administering the wrong vaccine or administering an expired vaccine.
Published: 11/4/2024
Clofutriben Receives FDA Orphan Drug Designation to Treat Endogenous Cushing Syndrome
The randomized, placebo-controlled RESCUE phase 3 trial assessed clofutriben among individuals with ACTH-dependent endogenous Cushing syndrome.
Published: 11/4/2024
New Guselkumab Data Indicate Robust Effectiveness in Crohn Disease, Plaque Psoriasis
Recently announced trial results demonstrate the efficacy of the biologic in multiple disease indications.
Published: 11/4/2024
Lebrikizumab Demonstrates Improvements in Skin Clearance, Itch Relief in Patients With Atopic Dermatitis
At weeks 16 and 24, approximately 57% and 60% of patients with moderate to severe atopic dermatitis, respectively, achieved at least 75% improvement in Eczema Area and Severity Index score.
Published: 11/4/2024
Meta-Analysis Finds ICS-Formoteral and ICS-SABA Reduces Asthma Exacerbations, Improved Asthma Control
Compared with a short-acting β agonist (SABA) alone, inhaled corticosteroids (ICS) with formoteral and ICS with a SABA were associated with better asthma control.
Published: 11/4/2024
Pharmacist Involvement Within ASCO: Standards Development, Certification Programs, and the Potential for Pharmacy CE at Future ASCO Meetings
ASCO is prioritizing the expansion of pharmacist involvement in its organization by recognizing pharmacists' contributions to safety standards, quality improvement initiatives, and certification programs.
Published: 11/3/2024
Avutometinib With Defactinib for Recurrent KRAS Mutant LGSOC Completes Rolling New Drug Application
If approved, the combination regimen would be the first FDA-approved treatment for adults with recurrent KRAS mutant low-grade serous ovarian cancer (LGSOC).
Published: 11/2/2024
In Utero Exposure to Maternal COVID-19 Has No Association With Abnormal Neurodevelopment
In children aged 12, 18, and 24 months, there was no association between maternal COVID-19 exposure and abnormal scores on a neurodevelopment screening.
Published: 11/2/2024
Ruxolitinib Plus Pegylated Interferon Alfa-2a Show Promise in Newly Diagnosed Polycythemia Vera
Approximately 15% of patients with polycythemia vera will progress to myelofibrosis.
Published: 11/1/2024
Vitamin D Supplementation Could Aid Pediatric Obstructive Sleep Apnea
Low levels of vitamin D was linked with increased obstructive Apnea-Hypopnea Index scores.
Published: 11/1/2024
FDA Grants Orphan Drug Designation to CAP-002 to Treat Patients With Developmental and Epileptic Encephalopathy
If approved, the investigational intravenous gene therapy will be the first disease-modifying therapy for developmental and epileptic encephalopathy (DEE).
Published: 11/1/2024
Carfilzomib, Lenalidomide, and Dexamethasone: A Curative Approach for Smoldering Multiple Myeloma
In the results, 31% of patients maintained undetectable measurable residual disease 4 years after treatment.
Published: 11/1/2024
IVIG Prescriptions Guideline-Appropriate in Majority of French Adults With Severe Immune Thrombocytopenia
Intravenous immunoglobulin prescriptions deemed non-compliant according to French national guidelines were more common in younger patients.
Published: 11/1/2024
Smoking Cessation Within 6 Months of Cancer Diagnosis Boosts Survival Rates for Patients With Lung Cancer
Following lung cancer diagnosis, adjusting lifestyle habits can improve treatment responses.
Published: 10/31/2024
Simultaneous Zoster, Inactive Quadrivalent Influenza Vaccination Shows Acceptable Safety for Older Adults
The simultaneous doses of both vaccines compared with individual RZV and quadrivalent high-dose inactivated influenza vaccine (HD-IIV4, Fluzone; Sanofi) had similar overall safety findings.
Published: 10/31/2024
Early Treatment With Sebetralstat Correlates With Shorter Duration of Hereditary Angioedema Attacks
Patients with hereditary angioedema who received sebetralstat earlier had faster complete resolution of their attacks.
Published: 10/31/2024
Advanced Therapies Redefine Survival for Patients With Breast Cancer
Targeted therapies, CDK4/6 inhibitors, and precision medicine are improving outcomes for patients with high-risk and metastatic disease.
Published: 10/31/2024
Global Oncology Trends Highlight Rising Cancer Costs, Access Disparities, and Treatment Innovations
Rising cancer rates and costs pose challenges in global oncology markets amid AI and targeted therapy breakthroughs.
Published: 10/31/2024
From Diagnosis to Delivery: How Multidisciplinary Teams Tackle Stage 3A Lung Cancer
Experts from Moffitt Cancer Center discuss the benefit of multidisciplinary teams in lung cancer care.
Published: 10/31/2024
NCODA Fall Summit Recap: Key Sessions and Expert Interviews From the 2024 Meeting
The 2024 NCODA International Fall Summit took place in Orlando, Florida, from October 23 to October 25.
Published: 10/31/2024
FDA Accepts Biologic License Application for Biosimilar Denosumab
HLX14 (Organon) is an investigational biosimilar to denosumab (Prolia/Xgeva; Amgen).
Published: 10/30/2024
BPA Exposure May Increase Risk of Mortality in Adults With Hyperlipidemia
Bisphenol A (BPA) is a chemical compound that is linked to various adverse health effects.
Published: 10/30/2024
Patients With Inflammatory Bowel Disease Face Modest Increase in Risk of Lymphoma
The risk of developing lymphoma remained nearly the same between patients with Crohn disease and ulcerative colitis.
Published: 10/30/2024
Researchers Find “Digital Twin” Model Accurately Predicts Treatment Responses for Different Chemotherapy Drugs
This model, which uses technology that discovers black holes, pulls from real data to evaluate cancer treatments, optimizing treatment choices for patients with different cancers.
Published: 10/30/2024
Sublingual Epinephrine Film Promptly Resolves Symptoms in Patients With Oral Allergy Syndrome
Results indicate that sublingual epinephrine can resolve symptoms, including swelling of the face and throat, associated with oral allergy syndrome in minutes.
Published: 10/30/2024
Protecting Pharmacy Technicians: Key Practices in Hazardous Drug Compounding
Liz Vogel, CPhT-Adv, CSPT, discusses the procedures and best practices for safe compounding of hazardous and non-hazardous drugs.
Published: 10/30/2024
FDA Grants Accelerated Approval to Asciminib for Adult Patients With Newly Diagnosed Ph+ CML-CP
The accelerated approval comes after 48-week major molecular response rate data.
Published: 10/29/2024
Researchers Begin Phase 3 Trial Assessing Adjuvant V940 With Pembrolizumab to Treat Non–Small Cell Lung Cancer
The INTerpath-009 trial assessed a combination of V940 with pembrolizumab among individuals with stage II, IIIA, IIIB (N2) non–small cell lung cancer.
Published: 10/29/2024
STRIPE Names Recipients of the Inaugural Double Helix Awards
The STRIPE Double Helix Awards celebrate individuals and organizations that have made exceptional contributions to the field of pharmacogenomics.
Published: 10/29/2024
Oral Semaglutide Reduces Risk of MACE for Patients With Type 2 Diabetes
Oral semaglutide had a safe and well-tolerated profile for individuals with type 2 diabetes, which is in line with those previously reported for the drug in other trials.
Published: 10/29/2024
Human-Specific Genes Can Modify Expressions of Mutations That Lead to Neurodevelopmental Disorders
The investigators found that the SRGAP2 and SYNGAP1 genes act together to control the speed of human synapse development, which has impacts on neurodevelopmental disease pathways.
Published: 10/29/2024
Epinephrine Auto-Injectors May Not Be Reliably Effective in Preventing Fatal Anaphylaxis
Though auto-injectors are still considered an appropriate first-line treatment for anaphylaxis, limited evidence exists surrounding their effectiveness in preventing fatal anaphylaxis.
Published: 10/29/2024
Study Finds Similar Rates of Pregnancy in Women Who Were and Were Not Prescribed GLP-1 Medications
Pregnancy rtes show similarity across the different glucagon-like peptide-1 (GLP-1) medications that were prescribed.
Published: 10/29/2024
Tucatinib With Trastuzumab Shows Positive Effects in Patients With Bile Duct Cancer
The investigators note that these findings are significant because bile duct cancer is a rare disease with limited treatments and low survival rates.
Published: 10/29/2024
FDA Expands Methotrexate Indication to Included Children With Acute Lymphoblastic Leukemia
The new indications include pediatric individuals with acute lymphoblastic leukemia and polyarticular juvenile idiopathic arthritis.
Published: 10/29/2024
FDA Grants Approval to Oxycodone Hydrochloride Immediate-Release Tablets For Management of Severe Pain
The approval marks the first and only abuse-deterrent immediate release oxycodone formulation.
Published: 10/29/2024
Apalutamide Demonstrates Efficacy After Prostate-Directed Local Therapy for nmCRPC
Apalutamide is a hormone therapy indicated for men with nonmetastatic castration-resistant prostate cancer (nmCRPC).
Published: 10/29/2024
Study: Novel Investigational Combination Regimen Could Maintain Viral Suppression of HIV
Islatravir in combination with lenacapavir could become the first weekly oral HIV treatment.
Published: 10/28/2024
Survey: 8 in 10 Patients Believe Immunization Protects Them From Public Health Threats
Champions for Vaccine Education, Equity, and Progress reported that the majority of pharmacists believe that it is important to prioritize vaccine development and distribution.
Published: 10/28/2024
Vaccination Rates Increase With Electronic Letter Reminder for Influenza Immunization
Investigators found that electronic letter reminders were most effective for older individuals, those who were unvaccinated in the preceding season, those with cardiovascular disease, and those with diabetes.
Published: 10/28/2024
Some Disease Burden of Obesity Requires Pharmacotherapy, Not Just Lifestyle Interventions
Glucagon-like peptide-1 (GLP-1) receptor agonists are widely known as treatments for type 2 diabetes, though some have been approved for indications beyond diabetes.
Published: 10/28/2024
Study: Exercise 3 Times Per Week During Pregnancy Associated With Reduced Risk of Asthma in Children
The authors note that exercise beyond 3 times per week was not associated with a lower risk of asthma, and more research is needed to confirm this finding.
Published: 10/28/2024
FDA Grants Orphan Drug Designation to AND017 for the Treatment of Sickle Cell Disease
Results demonstrating safety and efficacy in those with anemia in non-dialysis dependent chronic kidney disease and anemia in dialysis-dependent chronic kidney disease were presented at the 2024 American Society of Nephrology Kidney Week.
Published: 10/28/2024
NCPA 2024: In Spite of Challenges, Independent Pharmacies Are Continuing to Serve Patients
Nearly 19,000 independent pharmacies continue to work across the country, with more than 200,000 employees and millions of patients.
Published: 10/27/2024
NCPA 2024: Incorporating Hormonal Contraceptive Prescribing Benefits Patients, Pharmacies
Nationally, 7 million women live in maternal health deserts, defined as counties with limited or no available obstetric care.
Published: 10/26/2024
NCPA 2024: Enabling Clinical Program Growth Requires a Change in Mindset
Changing the way pharmacists and pharmacy staff think about themselves is key, although providers, payers, and patients must also change how they view the value of pharmacy services.
Published: 10/26/2024
NCPA 2024: Latest Updates on Respiratory Vaccines
With COVID-19, influenza, respiratory syncytial virus (RSV), and other viruses now circulating, the time for pharmacists to get up to date on the latest vaccine recommendations is now.
Published: 10/26/2024
FDA Approves Estradiol Gel, 0.06% for Women Post-Menopause
In postmenopausal women, the gel can reduce moderate to severe hot flashes as well as menopausal changes and symptoms.
Published: 10/25/2024
Zaltenibart Receives FDA Rare Pediatric Disease Designation for C3 Glomerulopathy
Zaltenibart could be an effective treatment option for C3 glomerulopathy as the most proximal inhibitor of the alternative pathway.
Published: 10/25/2024
Ribociclib Recognized by NCCN Clinical Practice Guidelines as Category 1 Preferred Breast Cancer Adjuvant Treatment
NCCN recommends ribociclib as a preferred CDK4/6 inhibitor adjuvant therapy for patients with HR+/HER2- EBC in combination with an aromatase inhibitor.
Published: 10/25/2024
FDA Approves Oral Sulopenem Etzadroxil and Probenecid for Uncomplicated Urinary Tract Infections
Orlynvah is approved for uncomplicated urinary tract infections caused by Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis.
Published: 10/25/2024
Novo Nordisk Calls for FDA to Prohibit Compounding Pharmacies from Providing Semaglutide
The call follows the FDA’s sudden removal of tirzepatide from the drug shortage list, preventing compounding pharmacies from providing the drug.
Published: 10/25/2024
Patients With Generalized Myasthenia Gravis Demonstrate Rapid Response Following Ravulizumab Treatment
Utilizing data from the CHAMPION MG trial, investigators found that many patients had responded to ravulizumab and returned to daily activities within 2 weeks.
Published: 10/25/2024
FDA Grants Orphan Drug Designation to MDL-101 for Congenital Muscular Dystrophy Type 1a
Congenital muscular dystrophy type 1a is a severe, early-onset condition that currently has no treatment, but MDL-101 may serve as a 1-time, durable treatment option.
Published: 10/25/2024
Study: Increase of Vitamin C Deficiency Associated With Cost of Living and Upsurge of Bariatric Surgery
Findings highlight the need for health care providers to continue to educate patients on the risk of scurvy, ensuring proper vitamin C intake.
Published: 10/25/2024
Extended Antiviral Treatment Could Benefit Ocular Shingles Vision Outcomes
Treatment with valacyclovir for a year decreased the risk of new or worsening eye disease by 26%.
Published: 10/24/2024
FDA Recalls Over 7000 Bottles of Duloxetine Because of Chemical Presence
The FDA announces a Class II recall for the lot #220128, which were reported to contain the presence of nitrosamine.
Published: 10/24/2024
Monoclonal Antibodies May Be Significant in the Treatment of Severe Asthma
Researchers discuss how interleukin-5 monoclonal antibodies are a promising approach for patients who have steroid-resistant asthma.
Published: 10/24/2024
ACIP Lowers Pneumococcal Vaccination Recommendation to Age 50
The CDC Advisory Committee on Immunization Practice voted to expand the recommendation, which includes Prevnar 20 and Capvaxive.
Published: 10/24/2024
Women Beginning Chemotherapy for Breast Cancer Self-Report Improved Cognitive Function When Participating in Aerobic Exercise
Despite self-reported improvements in cognitive function, neuropsychological tests showed little differences between 2 patient groups.
Published: 10/24/2024
FDA To Reevaluate Removal of Tirzepatide From Drug Shortage List
The agency does not intend to take action against the plaintiffs for the violation of the Federal Food, Drug, and Cosmetic Act, including the compounding of tirzepatide.
Published: 10/23/2024
FDA Approves Abrysvo to Treat Adults 18 to 59 Years of Age at Increased Risk for RSV
The approval marks Abrysvo as the first and only RSV vaccine designated for adults younger than 50 that are at increased risk for LRTD.
Published: 10/23/2024
Data From 5 Studies Show Benefit of Cell-Based Influenza Vaccines
Benefits include reducing serious health consequences, such as hospitalization and death, as well as the economic burden on health systems due to influenza infection.
Published: 10/23/2024
Clinicians, Pharmacists Should Work to Ensure Safety Compounded GLP-1 Medications
Pharmacists can educate patients about how to recognize unsafe online sources of medications and ensure patients are properly educate on how to administer their medications.
Published: 10/23/2024
What to Know About E Coli Outbreak Linked to McDonald’s Quarter Pounders
Pharmacists will likely be the first contact for many affected patients, and they should be able to provide evidence-based advice on how to manage their infection.
Published: 10/23/2024
Real-World Evidence Presented at IDWeek Demonstrates Efficacy of CAB LA When Used for HIV PrEP
Cabotegravir long-acting when used for HIV pre-exposure prophylaxis (PrEP) showed adherence, effectiveness, and improvements in quality of life by those who received the injection.
Published: 10/23/2024
Montelukast Does Not Shorten Duration of Symptoms in Patients With Mild-to-Moderate COVID-19
Despite suggestions to the contrary in previously conducted small clinical trials, montelukast did not provide benefit in patients with COVID-19 symptoms.
Published: 10/23/2024
Key Sessions and Expert Interviews at the NCODA Fall Summit
Pharmacy Times will be at the NCODA Fall Summit in Orlando from October 23 to October 25, 2024.
Published: 10/23/2024
USP Acquires Stratix Labs, Enhancing Its Microbiology Portfolio With Innovative Technology
New products will expand existing microbiology offerings and integrate new contamination control strategies.
Published: 10/23/2024
Patients With Endometriosis Have an Increased Risk of Developing Cardiovascular Disease
Endometriosis is a systemic disease that can affect multiple parts of the body, not just the pelvis.
Published: 10/22/2024
Mycosis Fungoides and Sézary Syndrome, Subtypes of Cutaneous T-Cell Lymphoma, Compromise Health-Related Quality of Life in Patients
Comprising most cases of this rare form of lymphoma, it is essential that pharmacists and treatment providers are aware of the health-related burdens patients with these subtypes consistently face.
Published: 10/22/2024
Study: Pharmacokinetics, Safety Comparable Between CT-P13 Autoinjector and Pre-Filled Syringe
The FDA previously accepted the biologic license application for CT-P13 as a subcutaneous formulation.
Published: 10/22/2024
FDA Approves Selarsdi as Biosimlar to Stelara in an Intravenous Formulation
In April 2024, the FDA approved ustekinumab-aekn as a subcutaneous injection for the treatment of moderate to severe plaque psoriasis and active psoriatic arthritis.
Published: 10/22/2024
Pneumococcal 21-Valent Conjugate Vaccine Generates Positive Response in Adults at Increased Risk of Disease
Data presented at IDWeek also showed greater disease-prevention effects in the community with PCV21 compared with prior pneumococcal vaccines.
Published: 10/21/2024
Myasthenia Gravis Negatively Impacts Patients and Care Partners Through Clinical, Financial Burdens
Therapy-related complications, in addition to financial obstacles, can complicate myasthenia gravis treatment.
Published: 10/21/2024
Medicaid ACOs Associated With Persistent Insurance-Based Disparities in Routine Pediatric Asthma Visit Rates
The implementation of accountable care organizations (ACOs) also worsened disparities in any emergency department or hospital use for Medicaid-insured children with asthma.
Published: 10/21/2024
Pharmacists Have a Significant Role in the Prevention of Travel-Related Diseases
When helping individuals prepare for travel, pharmacists must make travel health recommendations and know common travel-related immunizations and additional resources.
Published: 10/21/2024
Momelotinib Demonstrates Efficacy, Safety vs Ruxolitinib for Myelofibrosis in Japanese Subpopulation Analysis
The study was conducted on a small subgroup of Japanese patients with myelofibrosis.
Published: 10/21/2024
FDA Approves Companion Diagnostic To Identify Patients With Grade 2 IDH-Mutant Glioma Eligible for Vorasidenib
The diagnostic test is a companion to vorasidenib, an isocitrate dehydrogenase inhibitor that received FDA approval this past summer.
Published: 10/21/2024
RK-33 May Be Significant in Treatment of Breast Cancer Bone Metastasis
In a study, RK-33 demonstrated positive effects against the protein DDX3, which is key in the growth of cancer cells and spreading of disease.
Published: 10/20/2024
Study: Researchers Reveal New Images of RSV, Offering Further Treatment Options
The connection of F proteins could help destabilize the virus prior to infection of the next host.
Published: 10/19/2024
Zolbetuximab-clzb Receives FDA Approval for Treatment of Advanced Gastric and GEJ Adenocarcinoma
Zolbetuximab is the first approved CLDN18.2-targeted treatment for gastric and gastroesophageal junction adenocarcinoma.
Published: 10/18/2024
Pharmacists Can Suggest Increased Vitamin B12 Consumption to Prevent and Treat Acute Pancreatitis
Increasing serum vitamin B12 before and after the onset of pancreatitis reduced the severity of the condition.
Published: 10/18/2024
Researchers Assess Shingles Vaccination Status Among Veterans on Immunosuppressive Medications
The results emphasize the need for pharmacists and health care providers to further educate patients about receiving recommended immunizations.
Published: 10/18/2024
FDA Adds Intravenous Fluids to List of Drug Shortages
The additions include Dextrose 70% intravenous (IV) solution, Lactated Ringers IV Solution, and Peritoneal Dialysis Solution, which were affected by Hurricane Helene.
Published: 10/18/2024
Repeat IVIG Dosing Common in Guillain-Barré Syndrome, Suggesting Harm in Non-Responders
Recognizing repeat dosing efforts is important to improving outcomes in patients with Guillain-Barré syndrome who do not respond to IVIG.
Published: 10/18/2024
Novel Clonal Competition Assays Tool Can Personalize Treatment for Patients with Multiple Myeloma
The tool can detect cell changes and mutations that drive resistance and relapse.
Published: 10/18/2024
Study: Tau Pathology Influences MBI Through Alterations in the Brain’s Salience Network
Disruptions in the salience network function are shown to influence the severity of mild behavioral impairment (MBI) symptoms.
Published: 10/18/2024
Innovative Study Design, Funding, and Community Engagement Needed to Address Systemic Racism in Childhood Asthma
Research funding that aims to understand impacts of systemic racism on pediatric asthma should include plans to undo policies that maintain inequities created by systemic racism.
Published: 10/18/2024
FDA Places Clinical Hold on Novavax COVID-19/Influenza and Standalone Influenza Vaccine Trials
The clinical hold is a result of a reported case of motor neuropathy in a phase 2 trial participant.
Published: 10/18/2024
Nivolumab-Chemotherapy Combination Lengthens Survival, Causes Manageable Adverse Effects in Stage III or IV Classic Hodgkin Lymphoma
Compared with brentuximab vedotin and chemotherapy, nivolumab and chemotherapy had longer progression-free survival and a better safety profile.
Published: 10/17/2024
Study Finds Ezetimib, Rifampin May Increase Coproporphyrin Concentrations in Healthy Patients
The researchers observe that the combination treatment results in higher serum levels compared with ezetimibe alone.
Published: 10/17/2024
FDA Approves Sodium Oxybate to Treat Cataplexy or EDS in Pediatric Patients With Narcolepsy
Patients aged 7 years and older can now be treated for their cataplexy or excessive daytime sleepiness with the extended-release oral formulation.
Published: 10/17/2024
Unmasking Health Care Fraud: RICO Is Increasingly Being Used in the Pharmaceutical Industry
RICO is being leveraged in the pharmaceutical industry with significant implications for insurers and public trust.
Published: 10/17/2024
New Test Shows Promise in Accuracy of Food Allergy Diagnostics
The gold standard of testing for food allergies is an oral food challenge test where patients consume the allergen, such as peanut extract, under supervision.
Published: 10/17/2024
FDA Approves Foscarbidopa/Foslevodopa for Motor Fluctuations in Adults With Parkinson Disease
This approval makes foscarbidopa/foslevodopa the first and only subcutaneous 24-hour infusion of levodopa-based therapy for adults with Parkinson disease.
Published: 10/17/2024
The Heart-Brain Connection: Heart Failure, Atrial Fibrillation, Coronary Heart Disease, and Dementia
Cardiovascular diseases have a significant impact on brain health and function.
Published: 10/16/2024
Risk of Type 2 Diabetes In Children Increases Following SARS-CoV-2 Infection
The increase was observed across multiple subgroups, including those with overweight or obesity and hospitalized patients.
Published: 10/16/2024
Pacritinib Demonstrates Efficacy, Tolerability in Patients with Myelofibrosis and Thrombocytopenia
Published: 10/16/2024
Gepotidacin Receives FDA Priority Review for the Treatment of Uncomplicated Urinary Tract Infections
Gepotidacin could be first-in-class oral antibiotic treatment approved for uUTIs in over 20 years.
Published: 10/16/2024
Loncastuximab Tesirine Demonstrates Promise in Managing Hemophagocytic Lymphohistiocytosis Associated With Diffuse Large B-Cell Lymphoma
The results indicate the potential use of loncastuximab tesirine as a treatment option for the rare hyperinflammatory condition.
Published: 10/16/2024
Building a Future Workforce: Pharmacies Partner with High Schools to Sponsor Students Through Pharmacy Tech Program
A projected shortage of trained staff in the years ahead demands looking beyond normal hiring channels.
Published: 10/16/2024
FDA Approves Imuldosa, Stelara Biosimilar For Treatment of Chronic Inflammatory Conditions
Imuldosa has received approval for all indications of its reference product, including ulcerative colitis, psoriatic arthritis, and Crohn disease.
Published: 10/15/2024
High-Dose IVIG With Glucocorticoids Shown to Benefit Patients With Kawasaki Disease at High Risk For IVIG Resistance
Glucocorticoids improved outcomes for patients with Kawasaki disease at high risk of IVIG resistance without glucocorticoid-related adverse effects.
Published: 10/15/2024
Study: Inactivated Vaccines Prevent Influenza for Children, Remaining Effective After COVID-19 Pandemic
Investigators state that health care providers should consider the potential use of 2 doses to increase the effectiveness against influenza B.
Published: 10/15/2024
Pharmacy Times Launches Behind The Script Campaign to Highlight Pharmacists
Behind The Script is a photo submission campaign designed to feature real pharmacists with candid, HIPAA-compliant photos to celebrate American Pharmacist Month.
Published: 10/14/2024
Outsourcing Facilities Association Sues FDA Over Sudden Removal of Tirzepatide From Drug Shortage List
The lawsuit alleges that the action was taken without the required notice and disputes the agency’s warning of “localized supply disruption,” while calling for more transparency.
Published: 10/14/2024
Women Pharmacists Day: Recognizing the Role of Women in Improving Patient Care Access
This Women Pharmacists Day, Jolynn Sessions, PharmD, BCOP, FHOPA, discussed the crucial role of women in pharmacy.
Published: 10/12/2024
QSM Scans Indicate Brainstem Damage is Key to Long-Lasting Physical, Psychiatric Effects of Severe COVID-19
High-resolution scans can provide a picture of a patient’s brain that typical MRIs cannot, allowing for more detailed insights into the neurological effects of COVID-19.
Published: 10/12/2024
Pembrolizumab Could Provide Benefit For Advanced Head and Neck Squamous Cell Carcinoma
The trial met its primary endpoint of event-free survival, furthering treatment options for resected, locally advanced head and neck squamous cell carcinoma.
Published: 10/12/2024
FDA Approves Marstacimab-hncq for Adults, Adolescents With Hemophilia A or B Without Inhibitors
This approval marks the first and only anti-tissue factor pathway inhibitor approved in the US for the treatment hemophilia A or B, and the first approved hemophilia treatment to be administered via a pre-filled, auto-injector pen.
Published: 10/11/2024
Study: Risk Factors Associated With Developing Ocular Complications Following Shingles Diagnosis
Female and older patients had a greater incidence of herpes zoster ophthalmicus and were more likely to develop ocular complications.
Published: 10/11/2024
AI Algorithm Shows Potential Identifying Women at Risk for Future Breast Cancer
A breast-level artificial intelligence score may be able to estimate the risk of future breast cancer, allowing for patients to take preventative measures.
Published: 10/11/2024
Early Parkinson Disease and the Potential Therapeutic Role of Lixisenatide
Results are promising, particularly because they represent the second clinical trial of a GLP-1 receptor agonist showing potential benefits for PD motor symptoms
Published: 10/11/2024
FDA Accepts New Drug Application for Elinzanetant to Treat Hot Flashes Associated With Menopause
As the first dual neurokinin-1 and 3 receptor antagonist, elinzanetant could provide benefit for women suffering from vasomotor symptoms.
Published: 10/11/2024
Facing Industry Disruptions, FDA Grants Temporary Exemption From DSCSA Requirements For Trading Partners
The exemption allows more time for partners to adhere to enhanced distribution security requirements in the Food, Drug, & Cosmetics Act and prevents possible supply chain disruptions.
Published: 10/11/2024
Disparities Persist in Food Allergen Immunotherapy Trials
Oral immunotherapy is a growing area of research that involves ingesting increasing doses of the allergen to desensitize the patient’s immune system.
Published: 10/10/2024
FDA Approves Inavolisib With Palbociclib and Fulvestrant for Breast Cancer
The FDA also approved the FoundationOne Liquid CDx assay as a companion diagnostic device to identify patients who would benefit from the treatment.
Published: 10/10/2024
Liso-Cel Therapy in the Outpatient Community Setting Demonstrates Durable Response in Patients With R/R Large B-Cell Lymphoma
CAR T-cell therapy on an outpatient basis could lead to greater adherence and less financial and physical burdens.
Published: 10/10/2024
FDA Grants Breakthrough Therapy Designation for Volixibat in Cholestatic Pruritus From Primary Biliary Cholangitis
The regulatory action is based on a positive preliminary analysis of the VANTAGE trial.
Published: 10/10/2024
GSK’s RSV Vaccine Provides Protection Over 3 RSV Seasons in Adults at Increased Risk
A single dose RSV vaccine per year can offer optimal protection against 3 full RSV seasons.
Published: 10/10/2024
Study: Signs of Developing Asthma and Wheeze in Children Can Be Identified Within First Year of Life
Although the findings indicate a potential for predicting asthma or wheezing onset, these trends cannot yet be used for early diagnoses in individual children.
Published: 10/10/2024
Could Semaglutide Offer An Alternative Solution to Opioid Use Disorder?
In previous studies, semaglutide was found to modulate dopamine reward signaling and decreased drug rewards (specifically heroin) in rodents.
Published: 10/10/2024
Ciltacabtagene Autoleucel Demonstrates Promising Efficacy, Safety in Real-World Study
The real-world study results of ciltacabtagene autoleucel are comparable to data from the CARTITUDE-1 trial, emphasizing its efficacy and safety.
Published: 10/9/2024
FDA Grants Marketing Authorization for Rapid COVID-19/Influenza Antigen Test
Healgen Rapid Check COVID-19/Flu A&B Antigen Test is the first OTC test to detect influenza to be granted a marketing authorization outside of Emergency Use Authorizations.
Published: 10/9/2024
Study Finds High Dose Vitamin D3 Does Not Benefit Survival for Metastatic Colorectal Cancer
The addition of high-dose vitamin D3 to standard treatment did not delay the progression of cancer compared with the standard dose of vitamin D3.
Published: 10/9/2024
Increases in Pre-Term Birth Rates Observed in All Races, Higher Increases in Minority Groups
The highest pre-term birth rates were consistently observed among those who were Black, American Indian or Alaska Native, or Native Hawaiian or other Pacific islander with public insurance.
Published: 10/9/2024
Stem Cell-Derived Islets Functionally Cure Patient With Type 1 Diabetes
The analysis assessed the feasibility of autologous transplantation of chemically-induced pluripotent stem cell-derived islets for type 1 diabetes.
Published: 10/9/2024
Dual-Role SARS-CoV-2 Antibody Discovered, Both Assisting and Blocking Virus Depending on Variant
The discovery marks the first time an antibody has been observed to both assist and block viral infection with SARS-CoV-2.
Published: 10/9/2024
Tirzepatide Could Offer a Novel Approach to Sleep Apnea Treatment
Treatment with tirzepatide has led not only to significant reductions in excess body weight, but also improvements in blood pressure and reduction of inflammatory markers.
Published: 10/9/2024
Screen Time Associated With Depressive Symptoms, Study Finds
Video chatting, texting, watching videos, and playing video games were activities most commonly associated with depressive symptoms in adolescents.
Published: 10/9/2024
No Difference Observed for Any Mental Illness and Uptake of First COVID-19 Vaccine Dose For Patients With, Without Mental Illness
However, the results also showed that vaccination rates were lower in those who are unmedicated for their mental illness and those with substance use disorders.
Published: 10/8/2024
Two Scientists Receive 2024 Nobel Prize for Discovery of MicroRNA
Victor Ambros and Gary Ruvkun received the 2024 Nobel Prize in Physiology or Medicine for discovering microRNA and its role in gene regulation.
Published: 10/8/2024
FDA Grants Survodutide Breakthrough Therapy Designation for Treatment of Adults With MASH
Survodutide is a glucagon/glucagon-like peptide-1 (GLP-1) receptor dual agonist that activates the glucagon and GLP-1 receptors to better control metabolic function.
Published: 10/8/2024
Survey: Women More Likely to Receive Misdiagnoses and Unsatisfactory or Poor-Quality Care
Women were also more likely to report concerns of high wait times prior to receiving care.
Published: 10/8/2024
Baloxavir Marboxil Shows Reduction in Influenza Transmission
Investigators report the study met its primary end point, demonstrating that a single, oral dose reduced the transmission by those infected to others in their household.
Published: 10/8/2024
FDA Grants Breakthrough Therapy Designation to Setrusumab for Osteogenesis Imperfecta
Setrusumab could offer a rapid and clinically meaningful decrease in fracture rate in individuals with osteogenesis imperfecta.
Published: 10/7/2024
Treosulfan Improves Survival and Lowers Mortality Prior to Allo-HSCT in Patients With Myelofibrosis
Treosulfan showed superior benefits to busulfan as a conditioning regimen before allogenic hematopoietic stem cell transplantation (allo-HSCT).
Published: 10/7/2024
Zodasiran Demonstrated Safety, Efficacy in Treatment of Patients With Mixed Hyperlipidemia
Zodasiran is an RNA interference therapy targeting the ANGPTL3 loss-of-function mutation.
Published: 10/7/2024
IVIG, Plasmapheresis Comparable in Long-Term Efficacy for Treatment of Myasthenic Crisis
Though both treatments come with positives and negatives, ultimately, individual patient clinical presentation and accessibility will determine the proper treatment for myasthenic crisis.
Published: 10/7/2024
Albuterol/Budesonide Reduces Risk of Severe Exacerbation in Patients With Asthma
Detailed findings will be presented at the American College of Allergy, Asthma & Immunology (ACAAI) Annual Scientific Meeting.
Published: 10/7/2024
Patients Living in Impoverished Areas Have Increased Risk of Breast Cancer-Specific and All-Cause Mortality
Patients in persistently impoverished areas were also more likely to have more aggressive tumor characteristics and receive more invasive surgeries.
Published: 10/7/2024
Emergency Prescription Assistance Program Deployed in North Carolina Following Hurricane Helene
Eligible patients can receive a 30-day supply of covered drugs and medical supplies that can be renewed every 30 days for as long as an Emergency Prescription Assistance Program (EPAP) is active.
Published: 10/7/2024
Study Finds Significant Associations Between Sunlight Exposure, Physical Activity, and Depressive States
According to the authors, being able to identify mood disturbances through passive digital biomarker data can be promising in next-generation predictive, personalized mental health diagnostics.
Published: 10/6/2024
Pelabresib and Ruxolitinib Show Benefit in Treating Patients With JAK Inhibitor-Naïve Myelofibrosis
Pelabresib, a BET inhibitor, demonstrated meaningful reductions in spleen inflammation and anemia.
Published: 10/5/2024
New CDC Data Show Decrease in Vaccine Coverage Among Kindergarteners For 2023-2024 School Year
Significant polarization surrounding COVID-19 vaccinations in late 2020 and early 2021 looked to have had an impact in increasing vaccine hesitancy.
Published: 10/4/2024
Eye of the Beholder: Understanding The Subjective Experience of Acute Ketamine Treatment
When considering the 3-stage framework, perhaps a greater emphasis on pre-treatment phase research could help identify some of the more individual traits used to better predict patient outcomes.
Published: 10/4/2024
Children Conceived Through IVF Are More Likely to Develop Congenital Heart Defects
Research showed that children born via assisted reproductive technology were 36% more likely to develop heart defects.
Published: 10/4/2024
Acalabrutinib-Rituximab Combination Effective in Relapsed/Refractory, Treatment-Naive Follicular Lymphoma
The results show promise for the use of Bruton tyrosine kinase inhibitors in non-Hodgkin lymphoma treatment.
Published: 10/4/2024
FDA Approves Nivolumab for the Treatment of Adult Patients With Resectable NSCLC
Nivolumab is the only PD-1 inhibitor to show statistically significant and clinically meaningful benefits in non-small cell lung cancer compared with chemotherapy.
Published: 10/4/2024
FDA Grants Orphan Drug Designation to LQT-1213 to Treat Patients With Long QT Syndrome
The treatment aims to reduce prolonged QTc interval in patients with long QT syndrome.
Published: 10/4/2024
Plozasiran May Help Reduce Cholesterol Levels in Patients With Mixed Hyperlipidemia
High cholesterol levels are known risk factors for atherosclerotic cardiovascular disease.
Published: 10/4/2024
Cologuard Plus Receives FDA Approval For Non-Invasive Colorectal Cancer Screening
The new screening test provides an easier, convenient option for patients seeking to screen themselves for colorectal cancer.
Published: 10/4/2024
Hospitalized COVID-19 Patients Face Worsened Long-Term Cognitive Function
Major biomarkers for cognitive impairment were observed in hospitalized patients with neurological symptoms.
Published: 10/4/2024
Study Finds Upsurge of Shingles Vaccination in Medicare Part D Following Elimination of Cost Sharing
The Inflation Reduction Act's zero cost-sharing policy resulted in significant increases in shingles vaccines dispensed to individuals under Part D, compared with those who are commercially insured.
Published: 10/3/2024
Poor Sleep Quality and Dementia Linked With Mortality Risk
Poor sleep quality is directly related to mortality risk before adjusting for lifestyle or health-related factors, and dementia was noticeably linked to mortality risk in older White males.
Published: 10/3/2024
Study Results Suggest Rosuvastatin, Cholesin Combination Therapy May Improve Cholesterol Homeostasis
Cholesin, a hormone found in the gut, may enhance the cholesterol-lowering capabilities of statins.
Published: 10/3/2024
Study Findings Suggest Use of Fedratinib as Treatment in the Second Line for Myelofibrosis
Fedratinib is an orally available, small molecule inhibitor of JAK-2 approved for treatment of myelofibrosis.
Published: 10/3/2024
Lower Dose of IVIG Remains Effective in Treating Pediatric Immune Thrombocytopenia Compared With Higher Dose
By utilizing a lower dose, patients can avoid potential adverse events and high financial burden.
Published: 10/3/2024
Eculizumab and Other Therapies for the Treatment of High-Risk Transplant-Associated Thrombotic Microangiopathy
Eculizumab (Soliris; Alexion), a C5 inhibitor preventing cleavage into C5a and C5b, is widely considered the first-line therapy for high-risk TA-TMA.
Published: 10/3/2024
FDA Grants Orphan Drug Designation to PPL-002 for the Treatment of Danon Disease
Currently, Danon disease has a poor prognosis and does not have any pharmaceutical therapeutics for treatment or management.
Published: 10/3/2024
FDA Grants IND for RespiRx Inhalable Nicotine Replacement Therapy
In a phase 1 trial, the nicotine replacement therapy (NRT) demonstrated a higher mean maximum plasma concentration was achieved faster than with an existing inhaled NRT.
Published: 10/2/2024
Data Supports Approval of Biosimilar Aflibercept for Diabetic Macular Edema
In May 2024, the first biosimilars for aflibercept were approved, which included aflibercept-jbvf (Yesafili; Biocon Biologics), known as MYL-1701P.
Published: 10/2/2024
Insufficient Vitamin D Levels in Children Connected to Slow Fracture Healing Process
Pharmacists and health care providers can counsel around vitamin D supplements and natural intake to increase a child’s vitamin D consumption.
Published: 10/2/2024
FDA Grants Fast Track Designation to VLS-1488 For Patients With Platinum-Resistant HGSOC
Currently, VLS-1488 is being evaluated in a phase 1/2 trial (NCT05902988) in various advanced tumors, including high-grade serous ovarian cancer (HGSOC).
Published: 10/2/2024
Decadine Demonstrates Therapeutic Potential for the Treatment of Myelofibrosis
The findings may offer patients treatment options beyond symptom palliation.
Published: 10/2/2024
FDA Grants Priority Review to Trastuzumab Deruxtecan for HER2-low, HER2 Ultralow Breast Cancer
The designation was based on results from the DESTINY-Breast06 trial, evaluating fam-trastuzumab deruxtecan-nxki (Enhertu; AstraZeneca, Daiichi Sankyo) compared with chemotherapy.
Published: 10/2/2024
Study Results Show Flu Vaccination Not Associated With Risk of Adverse Perinatal Outcomes
The findings support current recommendations for pregnant individuals or those who might become pregnant during the influenza season, specifically those with successive pregnancies.
Published: 10/2/2024
FDA Grants Denifanstat Breakthrough Therapy Designation for Treatment of MASH
Positive trial results laid the groundwork for the designation.
Published: 10/2/2024
Lymphoplasmacytic Lymphoma Vaccine Leads to Potential Clinical Benefit as Early Intervention
Patients exhibited improved disease-free progression with minimal adverse effects.
Published: 10/2/2024
Semaglutide Associated With Reduced Risk of Opioid Overdose in Patients With Type 2 Diabetes, Opioid Use Disorder
The weight loss drug continues to show promise in treating a variety of other conditions.
Published: 10/2/2024
Researchers Further Support Findings Showing Cost Savings of RSV Vaccination
RSV vaccination could be cost-effective among adults 60 years and older, with the ability to decrease vaccine costs and sustain efficacy.
Published: 10/1/2024
Navenibart Receives FDA Orphan Drug Designation to Treat Hereditary Angioedema
Navenibart was developed to aid treatment of hereditary angioedema (HAE) to provide swift and sustained HAE attack prevention through administration every 3 to 6 months.
Published: 10/1/2024
FDA Grants Rare Pediatric Disease Designation to BPM31510IV for Primary CoQ10 Deficiency
Treatment for primary coenzyme Q10 (CoQ10) deficiency can include high-dose oral CoQ10 supplementation, but not all patients respond to this treatment.
Published: 10/1/2024
Study Shows Zanubrutinib May Outperform Ibrutinib in Treatment of R/R CLL/SLL
Zanubrutinib demonstrated sustained responses in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL).
Published: 10/1/2024
Real-World Data Confirms Protective Effects of SGLT-2 Inhibitors for Diabetic Kidney Disease
The results validate the protective benefits of the sodium–glucose cotransporter-2 inhibitors on renal function for those with type 2 diabetes.
Published: 10/1/2024
Indoor Allergen Exposure Worsens Respiratory Infections in Children With Asthma
A recent study found that indoor allergen exposure, including mouse and cockroach allergens, led to an increased risk of respiratory viral infections in children with asthma.
Published: 10/1/2024
Accelerated Radiation Therapy Course is Non-Inferior to Traditional Radiation in Patients Undergoing Breast Reconstruction
The accelerated course was safe and effective and did not increase complications in patients with breast cancer post-mastectomy undergoing breast reconstruction.
Published: 10/1/2024
FDA Approves Ustekinumab-Aauz as Biosimilar for Stelara
Ustekinumab is a human monoclonal antibody targeting the cytokines interleukin (IL)-12 and IL-23, which play a rule in the inflammatory and immune responses.
Published: 10/1/2024
SURVEY: Few Adults Plan to Get Respiratory Vaccinations for 2024-2025 Season
Approximately 75% of adults trust their physicians, nurses, and pharmacists either a great deal or a lot, highlighting the importance of pharmacists for patient education.
Published: 10/1/2024
FDA Grants Rare Pediatric Disease Designation to MDL-101 for Congenital Muscle Dystrophy
MDL-101 is a proposed novel precision medicine that targets the LAMA1 gene, causing LAMA2 congenital muscular dystrophy type 1a.
Published: 9/30/2024
American Academy of Pediatrics Releases First Clinical Practice Guideline for Opioid Prescription, Treatment
The guidelines mark a shift in practice by recommending a multimodal approach to opioid prescribing practices.
Published: 9/30/2024
Pandemic-Related Hospital Caseload Strain Attributes to Portion of COVID-19 Deaths
There was a detrimental relationship between COVID-19 caseload and mortality observed across multiple types of hospitals.
Published: 9/30/2024
Expert: Patients With C. difficile Can Have Difficulty Advocating For Themselves
C. diff survivor and Peggy Lillis Foundation Board Member Maryann Webb discusses how her experience with the infection encouraged her to advocate for patients who are struggling to advocate for themselves.
Published: 9/30/2024
Immuno-Polychemotherapy Elicits Favorable Response in Primary Extra-Nodal Non-Hodgkin Lymphomas of Head and Neck
Poorer prognosis was linked to factors such as reduced hemoglobin levels and advanced stage at diagnosis.
Published: 9/30/2024
Survey Shows HCPs Are Preferred Source For Contraceptive Information Among AYAs
The survey demonstrated that adolescents and young adults (AYAs) who preferred health care professionals (HCPs) as sources of information had sufficient knowledge of contraception options available.
Published: 9/30/2024
SARS-CoV-2 Strains With Nirmatrelvir Resistance After Antiviral Therapy Present in Patients at Low Frequencies
Although the investigators commonly detected treatment-emergent resistant variants, they were rare and transient in nature.
Published: 9/30/2024
Zoster Vaccination Lowers Risk of Shingles for Patients With Inflammatory Bowel Disease
Currently, the CDC recommends the recombinant zoster vaccine (Shingrix, RZV; GSK) for the prevention of herpes zoster and related complications.
Published: 9/29/2024
Small Molecule Drugs Remain Vital in Addressing Refractory Multiple Myeloma
Small molecule agents continue to be beneficial additions to multiple myeloma treatment, even with the development of T-cell redirected therapies.
Published: 9/28/2024
Isatuximab-Lenalidomide Demonstrates Strong Efficacy, Tolerability in Smoldering Multiple Myeloma
These interim trial results support the ongoing phase 3 ITHACA trial.
Published: 9/28/2024
Immunotherapy Evolution Continues With Innovative Approaches to Multiple Myeloma Treatment
Experts discuss emerging targets in the immunotherapy landscape and how to improve patient outcomes through innovative approaches.
Published: 9/28/2024
RSV Vaccination Among Older Adults With Chronic Conditions Could be Cost Effective
Adults with underlying medical conditions, resulting in an increased risk of respiratory syncytial virus disease are more likely to be cost-effective than general age-based strategies.
Published: 9/28/2024
Overcoming Treatment Challenges in Multiple Myeloma: Bispecific Antibodies and CAR T-Cell Therapy
Experts discuss immunotherapy advancements and challenges of resistance, efficacy, and toxicity in patient management.
Published: 9/27/2024
FDA Approves Selpercatinib For Pediatric and Adult Patients With RET-Mutated MTC
The indication is for adult and pediatric patients aged 2 years and older with advanced or metastatic RET-mutated medullary thyroid cancer (MTC) who require systemic therapy.
Published: 9/27/2024
Daratumumab Plus Lenalidomide Maintenance in Transplant-Eligible Newly-Diagnosed MM Improves MRD Negativity
Minimal residual disease has been a major topic of discussion during the IMS 2024 Annual Meeting.
Published: 9/27/2024
Talquetamab-Daratumumab-Pomalidomide Combination Led to Durable Response in Patients With Relapsed/Refractory Multiple Myeloma
Promising depth of response and consistent safety profile support the use of talquetamab as a combination agent.
Published: 9/27/2024
Single Dose of MVA-BN Smallpox Vaccine Shows Moderate Efficacy Against Mpox Infection
The estimated vaccine efficacy was approximately 58%, with only 21 patients in the vaccinated group being diagnosed with mpox.
Published: 9/27/2024
Expert: Pharmacists Are Essential When Monitoring Patients On T Cell-Directed Therapies
Banerjee also discussed data being presented at the International Myeloma Society 2024 Annual Meeting that he is particularly excited for this year.
Published: 9/27/2024
CEPHEUS Study Results Show Efficacy of Daratumumab-Based Quadruplet, Triplet Therapeutic Approaches
The CEPHEUS trial also highlights the importance of minimal residual disease (MRD) as a study end point.
Published: 9/27/2024
Teclistamab Demonstrates Continued Deep, Durable Responses in Long-Term Follow-Up From MajesTEC-1 Trial
Notably, of the 38 participants who remained on treatment, 37 have switched to less frequent dosing and all have maintained responses.
Published: 9/27/2024
Expert: Implementing Cost-Effective Care Is Essential to Mitigate Financial Toxicity
Using biosimilars and generics as well as getting patients connected with manufacturer copay assistance or grant programs can reduce their out-of-pocket costs.
Published: 9/27/2024
Pharmacists Can Suggest Vitamin D Supplementation to Benefit Cardiometabolic Health
Vitamin D supplementation improved total cholesterol levels, systolic blood pressure, diastolic blood pressure, and all glycemic parameters.
Published: 9/27/2024
FDA Approves Dupilumab as Add-On Maintenance Therapy For Adults With COPD
Dupilumab is the first biologic medicine for patients with chronic obstructive pulmonary disease to be approved in the US.
Published: 9/27/2024
Integrating SARS-CoV-2 Surveillance Testing Among Patients Receiving Dialysis Feasible, Requires Improvements
Although disease screening reached high-risk patients, uptake was low, necessitating additional incentive to participate in voluntary testing.
Published: 9/27/2024
FDA Approves Cobenfy, Previously KarXT, for Treatment of Schizophrenia
Xanomeline and trospium chloride is the first in a new class, offering a new approach with selectively targeting M1 and M4 receptors.
Published: 9/27/2024
Maternal Influenza Shows Association With Increased Risk of Childhood Seizures
Investigators found a significant association for febrile seizures, but not with epilepsy.
Published: 9/27/2024
Immunotherapies Show Promise in Transforming Early Multiple Myeloma Treatment
Experts discuss current knowledge and future indications for immunotherapies and CAR T in early treatment lines.
Published: 9/26/2024
Multimodal Diagnostic Method Demonstrates Higher Accuracy Predicting Bipolar Disorder Than Single Data Methods
In adolescents, a comprehensive model using behavioral and MRI data had a prediction accuracy of 0.83, which was higher than single data type models.
Published: 9/26/2024
Study Finds Bidirectional Association Between Asthma and Type 2 Diabetes
The authors found that asthma severity was associated with a higher risk of type 2 diabetes, with the risk increasing in line with severity, but not asthma duration.
Published: 9/26/2024
Expert: Biosimilars and Generics Lower Cost of Cancer Care
Clayton Irvine, PharmD, MBA, MS, notes that although these options help to lower the cost of care, quick, widespread implementation remains difficult.
Published: 9/26/2024
Researchers Identify INCA033989 as a Potential Treatment for Myeloproliferative Neoplasms
INCA033989 is a monoclonal antibody that selectively targets mutant calreticulin oncogenic function.
Published: 9/26/2024
Rituximab, Magrolimab With Chemotherapy Modestly Effective and Well-Tolerated in Patients With R/R DLBCL
These results indicate the combination’s long-term effectiveness in a population with limited treatment options.
Published: 9/26/2024
Pfizer Withdraws Voxelotor From Approved Markets, Will Discontinue Trials
The discontinuation comes after a review of the medication by the European Medicines Agency which found that “the total number of deaths was higher than anticipated.”
Published: 9/26/2024
Levacetylleucine Receives FDA Approval as Stand-Alone Therapy for Niemann-Pick Disease Type C
The approval marks the only FDA-approved stand-alone therapy for the treatment of Niemann-Pick disease type C (NPC).
Published: 9/26/2024
PrEP Prescribing Patterns Reveal Disparities in HIV Prevention Across Settings
The study findings signal the need for improved equality in PrEP prescribing across various institutions and settings.
Published: 9/26/2024
FDA Approves Osimertinib for Unresectable EGFR-Mutated Lung Cancer
The decision is based on positive results from the phase 3 LAURA trial.
Published: 9/26/2024
Leveraging AI for More Accurate Multiple Myeloma Predictions
Artificial intelligence shows promise in improving diagnosis and treatment for patients with multiple myeloma.
Published: 9/25/2024
Exploring the Intersection of Pharmacogenomics and Precision Medicine in Oncology Practice and Care Team Collaboration
Automation and artificial intelligence can also aid significantly in reducing time-consuming tasks and improving efficiency for pharmacists, allowing them more time with patients.
Published: 9/25/2024
Potential Changes in Meningococcal, HPV Vaccine Guidelines Could Effect Stability of Adolescent Immunization
The authors note that changes in the adolescent guidelines for meningococcal and human papillomavirus vaccines may cause inconsistencies and nonadherence.
Published: 9/25/2024
Immunocompromised Patients With Persistent COVID-19 Can Harbor Drug-Resistant Variants Following Treatment
Long-term shedding of mutated variants could pose a concern for spread among the public.
Published: 9/25/2024
FDA Grants Rare Pediatric Disease Designation to EXG-34217 for Dyskeratosis Congenita
Treatment is typically tailored to the individuals, with HCT being the only curative treatment bone marrow failure, but long-term outcomes are generally poorer due to toxicities.
Published: 9/25/2024
Pancreatic Cancer Has a Growing Array of Treatment Options
However, early diagnosis still presents challenges and limits treatment options.
Published: 9/25/2024
Biosimilars Provide VA With Cost Savings for Treatment of Psoriasis
Additional education can address ambivalence for patients and providers, which can start at the pharmacist level, as they are essential sources of information for patients.
Published: 9/25/2024
Study Finds Ruxolitinib May Slow Fibrosis Progression in Myelofibrosis
Researchers found that PF4/Cxcl4, a key driver of fibrosis, was up regulated on all proteomes.
Published: 9/24/2024
Women With Prior Knowledge of COVID-19 Vaccine More Likely Receive Vaccination While Pregnant
Investigators reported that more than half of individuals had great knowledge about protecting themselves from COVID-19.
Published: 9/24/2024
Dato-DXd Did Not Achieve Statistically Significant OS in Patients With Breast Cancer
Compared with chemotherapy, datopotamab deruxtecan (Dato-DXd) did not achieve a statistically significant overall survival (OS) in patients with inoperable or metastatic HR+/HER2-low or negative breast cancer.
Published: 9/24/2024
FDA Accepts sNDA of Roflumilast Foam for Scalp and Body Psoriasis
The FDA assigned a Prescription Drug User Fee Act action date of May 22, 2025.
Published: 9/24/2024
Don’t Miss These Key Interviews, Data At the International Myeloma Society 2024 Congress
The meeting will focus on the basic, preclinical, and clinical aspects of myeloma, including precursor disease, high-risk disease, immunotherapies, novel biomarkers, and more.
Published: 9/24/2024
Experts Identify Looming Environmental Impacts of Batteries Within Diabetes Devices
Each stage of the CGM battery lifecycle contains the potential for detrimental environmental impact.
Published: 9/24/2024
Favorable Outcomes Possible With IVIG Treatment for Multisystem Inflammatory Syndrome in Children
Further trials are required to examine the long-term feasibility of intravenous immunoglobulin (IVIG) for multisystem inflammatory syndrome.
Published: 9/23/2024
Study Finds Measles-Rubella Disease Surveillance System Lacks Networking, Partnerships, and Community Involvement
A 95% increase in private health center participation, monitoring, assessment, and vaccine coverage can be significant in improving outcomes.
Published: 9/23/2024
Study: Metered-Dose Asthma Inhalers Make Up Nearly All Inhaler-Related Emissions
Although dry-powder and soft-mist inhalers had significantly lower emissions, they represented nearly two-thirds of inhaler costs but one-third of claims.
Published: 9/23/2024
FDA Accepts New Drug Application for Delgocitinib Cream to Treat Chronic Hand Eczema
If approved, delgocitinib cream would be the first US treatment indicated for moderate to severe chronic hand eczema.
Published: 9/23/2024
CEEVs, Neurovascular Coupling, and Functional Connectivity Are Potential Markers For Mild Cognitive Impairment
The authors note this is the first study to assess cerebrovascular endothelial extracellular vesicles within a cognitive condition.
Published: 9/23/2024
FDA Grants Bimekizumab-Bkzx Approval for Treatment of Chronic Immune-Mediated Inflammatory Diseases
Approved with 3 new indications, bimekizumab-bkzx is the first and only interleukin-17 inhibitor approved for these diseases.
Published: 9/23/2024
PfSPZ Vaccine Shows Efficacy Against P Falciparum and Malaria in Women Who Become Pregnant
The researchers estimate that pregnancy losses because of malaria and parasitemia risk before conception was reduced by 65% to 86%.
Published: 9/22/2024
FDA Approves First At-Home Nasal Spray Flu Vaccine
The approval enables more convenient flu immunization options for patients.
Published: 9/20/2024
FDA Approves Isatuximab With Bortezomib, Lenalidomide, and Dexamethasone for NDMM
The decision expands treatment options for patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM).
Published: 9/20/2024
Ponsegromab Could Offer Further Treatment for Cancer Cachexia
Ponsegromab displayed significant and robust increases in body weight at the completion of the study for all doses.
Published: 9/20/2024
Study: Shingles Reactivation Could Occur in Rare Cases Following RZV
Dermatomal reactions could occur following recombinant zoster vaccine to treat shingles.
Published: 9/20/2024
Mild Cognitive Impairment is Extremely Undiagnosed, Expert Says
The chief product and strategy officer at Linus Health is hopeful that pharmacists can be key players in the detection of mild cognitive impairment.
Published: 9/20/2024
FTC Sues Major Pharmacy Benefit Managers Over Price of Insulin
Three of the largest pharmacy benefit managers ––Express Scripts, Optum, and Caremark––are listed in the suit.
Published: 9/20/2024
Arimoclomol Becomes First FDA Approved Treatment for Neimann-Pick Disease Type C
The rare disease can result in progressive neurological symptoms and organ complications.
Published: 9/20/2024
Inavolisib Shows Promising Disease Control Rates, Safety in Patients With PIK3CA-Mutated Solid Tumors
The CRAFT (NCT04551521) trial is still ongoing to assess findings in the remaining patient arms.
Published: 9/20/2024
No Major Differences Identified Between R-CHOP21 Regimens for Treatment of Advanced-Stage Diffuse Large B-Cell Lymphoma
Improvements in survival outcomes were seen among those at high risk for DLBCL who received 6x R-CHOP21 + 2R.
Published: 9/20/2024
FDA Approves Amivantamab-vmjw for NSCLC With EGFR Exon 19 Deletions or L858R Mutations
Amivatamab-vmjw is a fully-human bispecific antibody targeting EGFR and MET with immune cell-directed activity.
Published: 9/20/2024
Phase 3 Study Displays Positive Results of Co-Administration of RSV and Shingles Vaccine
Results displayed a non-inferior immune response of the co-administered vaccines, compared to administration in individual visits.
Published: 9/19/2024
Study Demonstrates Safety, Efficacy of Luspatercept for MF-Related Anemia
Luspatercept reduced the need for transfusion in patients with myelofibrosis (MF).
Published: 9/19/2024
Nomograms Show Favorable Performance in Predicting Risk of Recurrence in HER2+ Breast Cancer
Using ultrasound and clinicopathological characteristics, the studied nomograms effectively evaluated recurrence risk in HR-/HER2+ and HR+/HER2+ breast cancer.
Published: 9/19/2024
Fam-Trastuzumab Deruxtecan Shows Positive Results for HER2-Positive Breast Cancer with Brain Metastases
Patients with for HER2-positive breast cancer have an increased risk of developing brain tumors.
Published: 9/19/2024
High Seroconversion Observed in Pediatric Patients With Typhoid Conjugate Vaccine
Seroconversion was observed in 95.8% of participants but dropped to 75.6% at the 4-year follow-up.
Published: 9/19/2024
SARS-CoV-2 Wastewater Presence at Highest Levels Since January as COVID-19 Cases Increase
Though hospitalizations and test positivity remain at modest levels, wastewater analysis indicates high circulation of SARS-CoV-2, especially in western states.
Published: 9/19/2024
New Pembrolizumab Data Presented at ESMO Show Promise in a Variety of Cancers
Pembrolizumab is an anti-programmed death receptor 1 (PD-1) therapy designed to increase the immune system’s ability to detect and fight tumor cells.
Published: 9/19/2024
Study Finds Women With Asthma Are More Likely to Need Fertility Treatments
The authors also found that there was a higher frequency of miscarriages compared with women who did not have asthma.
Published: 9/18/2024
Researchers Find Increase in Benzodiazepine Prescriptions Among Postpartum Women During Pandemic
Additionally, the authors are concerned by the lack of increase in depressive or anxiety diagnoses, indicating potential barriers to care.
Published: 9/18/2024
FDA Grants Fast Track Designation to ICT01 in Combination With Azacitidine and Venetoclax for Acute Myeloid Leukemia
The humanized anti-butyrophilin 3A monoclonal antibody selectively activates Vγ9Vδ2 T-cells.
Published: 9/18/2024
Transfusion-Related Acute Lung Injury Requires Prompt Recognition Due to Link With Intravenous Immunoglobulin
In a patient with long-shedding SARS-CoV-2, transfusion-related acute lung injury developed after intravenous immunoglobulin, emphasizing careful treatment considerations.
Published: 9/18/2024
ESMO Data Show Durvalumab Improves Overall Survival, Event-Free Survival in Hepatocellular Carcinoma and Bladder Cancer
In 2 studies, durvalumab improved overall survival for those with unresectable hepatocellular carcinoma and event-free survival for muscle-invasive bladder cancer.
Published: 9/18/2024
FDA Approves Pembrolizumab Plus Pemetrexed and Platinum Chemotherapy for Malignant Pleural Mesothelioma
The approval is based on positive results from the phase 2/3 IND.227/KEYNOTE-483 trial.
Published: 9/18/2024
FDA Approves Benralizumab for Eosinophilic Granulomatosis With Polyangiitis
Eosinophilic granulomatosis with polyangiitis is a rare and immune-mediate vasculitis that can damage multiple organs and be fatal if left untreated.
Published: 9/18/2024
FDA Approves Ribociclib in Combination With an Aromatase Inhibitor for HR+/HER2- Early Breast Cancer
The treatment significantly reduced risk of occurrence by 25% compared with endocrine therapy alone.
Published: 9/17/2024
Long-Term Survival Rates Improve with Dual Immunotherapy in Metastatic Melanoma
Ten-year follow up data showed a sustained survival benefit with nivolumab-ipilimumab in advanced melanoma.
Published: 9/17/2024
FDA Clears First 1-Year Continuous Glucose Monitoring System for Diabetes
Eversense 365 (Senseonics) is the first long-lasting continuous glucose monitoring (CGM) system, which includes a 365-day sensor and only 1 insertion on Day 1 of every year.
Published: 9/17/2024
Cancer Diagnosis Rates Remain Lower Than Expected Due to COVID-19 Pandemic
In 2021, cancer diagnosis rates remained low after major disruptions during the first year of the COVID-19 pandemic.
Published: 9/17/2024
Tim Cernohous, SVP & President, Community Retail & Long-Term Care, Cencora, reflects on ThoughtSpot 2024
Published: 9/17/2024
Expert Outlines Diagnosis and Management of Hair Disorders in Diverse Populations
There is a need for continued research and awareness in the diagnosis and management of alopecia in diverse populations.
Published: 9/16/2024
FDA Grants MM-II Fast Track Designation for Treatment of Osteoarthritis Knee Pain
The non-opioid drug can induce healing of joint cartilage in patients with osteoarthritis.
Published: 9/16/2024
FDA Approves Lebrikizumab for Treatment of Atopic Dermatitis
Lebrikizumab (Ebglyss; Eli and Lilly Company) is a monthly maintenance injection with proven efficacy in adults and children aged 12 to 18 years.
Published: 9/16/2024
Positive Data Highlighting Amivantamab-vmjw With Chemotherapy in Colorectal Cancer, EGFR-Mutated NSCLC Presented at ESMO 2024
Abstracts from the OrigAMI-1 and MARIPOSA-2 trials indicated the treatment benefits of amivantamab-vmjw and chemotherapy in multiple cancer indications.
Published: 9/16/2024
Rising Incidence of Young-Onset Cancer: Exploring the Causes and Generational Risk Factors
At ESMO Congress 2024, Shuji Ogino, MD, PhD, MS, explained that the rising incidence of young-onset cancer may be due to generational risk factors such as lifestyle, diet, and environmental changes, emphasizing the need for long-term research and follow up to understand early-life influences on cancer development.
Published: 9/16/2024
Neoadjuvant Pembrolizumab Plus Chemotherapy Followed by Adjuvant Pembrolizumab Is New Standard of Care for High-Risk Early-Stage TNBC
Overall survival results from the phase 3 KEYNOTE-522 study provide evidence of improved long-term outcomes from this pembrolizumab-based regimen.
Published: 9/16/2024
Advances in the Treatment of Resectable NSCLC: Key Insights From CheckMate 77T, NEOSTAR, and CA209-159 Trials
Clinical research presented at ESMO 2024 highlights the significant survival benefits of perioperative and neoadjuvant immunotherapy with nivolumab and nivolumab plus ipilimumab, while emphasizing the role of biomarkers such as ctDNA and KRAS mutations in guiding treatment decisions.
Published: 9/15/2024
Emerging Frontiers: The Gut Microbiome's Role in Enhancing Cancer Immunotherapy and Treatment Outcomes
An ESMO 2024 presentation explores the growing role of the gut microbiome in immunotherapy response, emerging diagnostic tools such as PCR chips, and innovative therapies such as fecal microbiota transplantation and microbiome-preserving strategies to improve patient outcomes.
Published: 9/14/2024
Experts Highlight the Need for Greater Diversity in Dermatological Clinical Research
Not only do diverse clinical cohorts improve the strength of the data, but it improves public trust in clinicians and the medical system as a whole.
Published: 9/14/2024
Unveiling the Microbiota's Role in Cancer: From Tumorigenesis to Treatment
The gut and intratumoral microbiota influence cancer development, progression, and treatment responses, highlighting the potential for treatment strategies that leverage these microbial interactions to enhance cancer therapies.
Published: 9/14/2024
Investigators Link Early Cholesterol Exposure With Faster Atherosclerosis Development
Exposure to high cholesterol levels is a significant risk factor for atherosclerosis cardiovascular disease.
Published: 9/13/2024
FDA Approves Ocrevus Zunovo for 2 Forms of Multiple Sclerosis
The approval marks the first and only twice yearly, health care professional-administrated injection for both forms of multiple sclerosis (MS).
Published: 9/13/2024
Study Finds Comparable Risk of Secondary Malignancies in CAR T-Cell Therapy and Standard Treatments
Researchers suggest prior treatments and follow-up duration may play a larger role.
Published: 9/13/2024
Study Finds Associations Between Chronic Pain and Anxiety, Depressive Symptoms in Youths
The authors urge that screening, prevention, and treatment of anxiety and depression should be important health care priorities for youth who have chronic pain.
Published: 9/13/2024
Remote Interventions From Pharmacists Shown to Improve Blood Glucose Control for Type 2 Diabetes
Data show the value of the pharmacist is clear for patients with type 2 diabetes, as their role can have a significant impact on reductions in hemoglobin A1c.
Published: 9/13/2024
Expert Discusses Immunotherapy, Antibody Drug Conjugates for Lung Cancer
Christian Rolfo discusses 6 different treatment options that are being developed across immunotherapies and antibody drug conjugates for non–small cell lung cancer and small cell lung cancer.
Published: 9/13/2024
FDA Authorizes OTC Hearing Aid Software Compatible With Apple AirPods
The Hearing Aid Feature can be customized to the user’s needs by amplifying sounds for individuals 18 years or older who have perceived mild to moderate hearing impairments.
Published: 9/13/2024
Experts Develop Multimodal Approach for Treating Long COVID, Other Post-Acute Infectious Syndromes
In the absence of a common treatment for long COVID, researchers from around the world documented the best currently available therapies.
Published: 9/13/2024
Atezolizumab and Hyaluronidase-tqjs Subcutaneous Formulation Receives FDA Approval to Treat Multiple Forms of Cancer
Subcutaneous administration of atezolizumab and hyaluronidase-tqjs had similar efficacy to intravenous administration.
Published: 9/13/2024
Study: Researchers Detect Protein Behind the Spread of Shingles Virus
Immediate-early 62 enclosed inside small extracellular vesicles can transport from the site of infection, causing it to penetrate cells and shut down their antiviral response.
Published: 9/13/2024
HIV Infections Significantly Reduced With Twice-Yearly Lenacapavir in Cisgender Men, Gender-Diverse Participants
These results build off the PURPOSE 1 trial, contributing to the wealth of evidence surrounding lenacapavir’s positive effects in patients with HIV.
Published: 9/13/2024
Treatment Considerations for Patients With Small Cell Lung Cancer, Pre-Existing Interstitial Lung Disease
An overview of the potential treatment strategies for patients were presented at the 2024 World Conference on Lung Cancer.
Published: 9/12/2024
Non-Medical Switch to Infliximab Biosimilar Demonstrates Similar Outcomes for IBD
Investigators obtained real-world evidence to evaluate the clinical outcomes of non-medical switching from the infliximab (Remicade; Janssen Immunology) to a biosimilar.
Published: 9/12/2024
Increased Psychological, Cardiovascular Risks in Relatives of Patients With Cancer
Parents of children with cancer had the highest risk of developing mental illness and cardiovascular diseases.
Published: 9/12/2024
Innovative DLL3 Targeting Mechanisms Will Lead to New Approaches in SCLC, LCNEC
Promising abstracts surrounding DLL3 targeting for patients with lung and neuroendocrine cancer were presented at WCLC 2024.
Published: 9/12/2024
FDA Approves Guselkumab for Treatment of Ulcerative Colitis
Guselkumab (Tremfya; Johnson & Johnson) is the first and only approved fully human and dual-acting monoclonal antibody blocking interleukin-23 and binding to CD64 receptors.
Published: 9/12/2024
Pharmacists Can Recommend Vitamin B1 to Cure Chronic Fatigue Linked With Bowel Conditions
Chronic fatigue is a related symptom with inflammatory bowel disease (IBD).
Published: 9/12/2024
Exploratory Analysis Shows Favorable Outcomes for Amivantamab-Lazertinib Treatment in NSCLC
As of May 2024, follow-up and exploratory analyses of MARIPOSA show improvements in outcomes for patients with EGRF-mutated non–small cell lung cancer (NSCLC).
Published: 9/12/2024
Local Therapy Developments Hold Promise for Survival Improvements for NSCLC
In a session at the 2024 World Conference on Lung Cancer, presenters highlight the most significant developments in local therapy for metastatic non–small cell lung cancer and advanced disease.
Published: 9/12/2024
Advances With Various Therapies Targeting DLL3 in Lung Neuroendocrine Tumors
An overview of the latest developments in targeting DLL3 in lung neuroendocrine tumors were presented at the 2024 World Conference on Lung Cancer.
Published: 9/11/2024
Cutting-Edge Targeted, Cytotoxic, and Immunologic Therapies Form Next Generation of mNSCLC Treatments
Highlights from multiple trials investigating novel treatments for mNSCLC were presented at 2024 World Conference on Lung Cancer.
Published: 9/11/2024
FDA Grants Orphan Drug Designation to AISA-021 for Systemic Sclerosis
The company also submitted data from the ongoing phase 2 study, demonstrating the improvements of the investigational drug for symptoms of overall disease severity.
Published: 9/11/2024
VLA1553 Chikungunya Virus Vaccine Shows Antibody Persistence Up to 2 Years Following Administration
The investigators of the phase 3b trial (NCT04838444) will continue to follow up with patients for up to 10 years.
Published: 9/11/2024
FDA Grants Breakthrough Therapy Designation to Plozasiran for Familial Chylomicronemia Syndrome
FCS is a severe, rare genetic disease in which patients have extremely high triglyceride levels, typically above 880 mg/dL.
Published: 9/11/2024
FDA Grants Rare Pediatric Disease Designation to NS-050/NCNP-03 to Treat Muscle Wasting Disease
NS-050/NCNP-03 is being developed to aid individuals with confirmed gene mutations that are treatable with exon 50 skipping therapy.
Published: 9/11/2024
Tocilizumab Effective in Patients With Inadequate Response to Intravenous Immunoglobulin for MOGAD
Tocilizumab reduced relapses in 4 patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).
Published: 9/11/2024
Patients With Difficult-To-Treat Asthma Require Different Intervention Methods Based on Comorbidities
To help with treatment response and compliance as well as optimize treatment, communication between patients and health care providers is necessary.
Published: 9/10/2024
IVIG Associated With Shorter Hospital, ICU Length of Stay in Immunocompromised Patients With Respiratory Infections
When IVIG was administered within 48 hours of hospital admission, hospital and ICU length of stay were dramatically shortened.
Published: 9/10/2024
FDA Accepts Resubmitted NDA for AXS-07 for Acute Treatment of Migraine
The FDA assigned a Prescription Drug User Fee Action date is January 31, 2025.
Published: 9/10/2024
Positive New Data Highlighting Tarlatamab-dlle Safety, Anticancer Activity Presented at WCLC 2024
Presentations highlighted the potential of tarlatamab in treating solid tumor cancers.
Published: 9/10/2024
New Human Case of H5N1 Bird Flu Confirmed in Missouri, CDC Reports
Despite the new human case, which is not known to be related to animal exposure, the CDC emphasizes that risk to the general public remains low.
Published: 9/9/2024
TROP2 Predictive of Clinical Outcomes in Patients With NCSLC Treated With Datopotamab Deruxtecan
Datopotamab deruxtecan was effective in patients with TROP2-QCS biomarker-positive tumors for non–small cell lung cancer
Published: 9/9/2024
The Future of Bispecific Antibodies in Aggressive B-Cell Lymphomas
Presenter Krish Patel, MD, discusses the use of epcoritamab (Epkinly; AbbVie) and glofitamab (Columvi; Genentech) in aggressive B-cell lymphomas as monotherapies and in combination regimens.
Published: 9/9/2024
Study Finds Annual Mammograms Associated With Lower Risk of Late-Stage Breast Cancer
The study authors suggest that annual screening for women aged 40 and older may be beneficial, but warn of the increased risk of false positive results.
Published: 9/9/2024
Study: Shingles Could Increase Risk of Cognitive Decline
Individuals with a history of shingles was significantly and independently connected with a 20% higher risk of for subjective cognitive decline.
Published: 9/6/2024
FDA Approves Sparsentan, With Data Indicating Slowing of Kidney Function Decline in IgA Nephropathy
Full traditional approval follows accelerated approval of the medication last year.
Published: 9/6/2024
FDA Grants Breakthrough Therapy Designation to Sanbexin for Acute Ischemic Stroke
Edaravone and dexborneol sublingual tablets are an innovative first drug to be designed for treatment of stroke and granted this designation.
Published: 9/6/2024
RSV Vaccination Could Decrease Hospitalization Among Adults 60 Years and Older
RSV vaccination was 75% effective in preventing RSV-associated hospitalizations among adults aged 60 years and older.
Published: 9/6/2024
Disease- and Patient-Related Factors Guide Decisions For Patients With Myelofibrosis Receiving allo-HCT
Disease-related factors include several prognostic scoring systems, such as DIPSS, whereas patient-related factors involve age, comorbidities, spleen size, and anemia.
Published: 9/6/2024
What to Expect As New CMS Hospital Transparency Requirements Take Effect in 2025
New transparency initiatives will go into effect on January 1, 2025, building off previous actions by the Centers of Medicare and Medicaid Services.
Published: 9/6/2024
Oral Treatment Shows Promise in Combating Alzheimer Disease
ALZ-801 has now progressed to the phase 3 APOLLOE4 study, designed to evaluate efficacy, safety, and biomarker and imaging effects.
Published: 9/6/2024
Obesity, Emaciated BMI Associated With Poor Prognosis in Pediatric B-Cell Non-Hodgkin Lymphoma
Surprisingly, those with overweight BMI at diagnosis did not have a poor prognosis.
Published: 9/6/2024
FDA Grants Orphan Drug Designation for ABD-147 for Neuroendocrine Carcinoma
Previously, the FDA granted fast track designation to ABD-147 (Abdera Therapeutics Inc) for extensive stage small cell lung cancer.
Published: 9/5/2024
Navigating the Intricacies of alloHCT in Patients With Myelodysplastic Syndromes
Rather than “trial-and-erroring” transplants for patients, experts should instead select transplants that are precise, personalized, and predictable.
Published: 9/5/2024
Pharmacists Can Counsel Pregnant Individuals Seeking Iron Supplementation
There is no significant impact on maternal or infant health outcomes when taking an additional iron supplement
Published: 9/5/2024
IVIG Shows Promise as Therapy in Patients With Recurrent Implantation Failure
Intravenous immunoglobulin (IVIG) therapy was found to have statistically significant positive effects on live birth rates, implantation rate, and other indicators.
Published: 9/5/2024
Key Strategies Released for Integrating Equity Into Health Technology Assessment
The Center for Innovation & Value Research has released a final report recommending strategies to ensure health equity is integrated into health technology assessment, which can influence drug pricing and selection by payers, as well as patient access to drugs.
Published: 9/5/2024
Bridging Health Equity: Addressing Heart Failure in Native American Communities
New insights into heart failure risks in Native American communities are highlighting the need to address social determinants of health.
Published: 9/4/2024
FDA Grants Regenerative Medicine Advanced Therapy Designation for OBX-115
OBX-115 could offer further treatment options for individuals with advanced or metastatic melanoma by enhancing persistence, antitumor activity, and clinical safety of TIL cell therapy.
Published: 9/4/2024
Women Who Receive False Positive Mammography Results Are Less Likely to Attend Follow-Up Screenings
The authors stress that health care providers should explain false positive results to their patients, reassure them that results may be negative, and stress the significance of continued screenings.
Published: 9/4/2024
FDA Approves Diagnostics for Olaparib, Abiraterone Combination Therapy in Patients With BRCA-Mutated mCRPC
These companion diagnostics are poised to provide simpler and detailed insights into a patient’s genomic alternations, which could improve outcomes for patients with prostate cancer.
Published: 9/4/2024
Tolebrutinib Shows Reduction in Disability Accumulation in Non-Relapsing Secondary Progressive Multiple Sclerosis
In a promising development in multiple sclerosis research, tolebrutinib delayed the onset of disability progression in patients with nrSPMS.
Published: 9/4/2024
Pharmacists' Role in ASCVD Management: Integrating Inclisiran into Patient Care
Pharmacists can enhance ASCVD management by supporting patient adherence through the administration and monitoring of inclisiran.
Published: 9/4/2024
Biosimilar of Xolair shows Similarity in Reducing Asthma Exacerbations
P043 is currently approved for patients 6 years and older with moderate to severe persistent allergic asthma whose disease is inadequately controlled with inhaled corticosteroids.
Published: 9/4/2024
Study: Birthing People With IDD Are Younger With Poorer Obstetric, Mental Health
The findings demonstrate a need for additional health care provider training and resources for birthing people with intellectual and developmental disabilities.
Published: 9/4/2024
Italian Hospital Pharmacists Have Key Roles in Ensuring Access to Medications and Care for Patients with Epilepsy
The hospital pharmacists’ role in treating patients with epilepsy starts with their place on the multidisciplinary team, which identifies appropriate drug selection in the hospital. It continues with counseling and therapy reconciliation to assure smooth transitions upon patient discharge to the community.
Published: 9/4/2024
Insurance Status, Survival Outcomes Linked in Patients With Diffuse Large B-Cell Lymphoma
Patients with DLBCL on Medicaid had worse survival outcomes than those on commercial insurance, but there were no statistically significant differences in survival between races.
Published: 9/3/2024
Weight-Adjusted Waist Index Can Have Prognostic Value in Patients With Asthma
A recent study found that a weight-adjusted waist index was an independent predictor of all-cause-, cardiovascular-, cancer-, and respiratory-related mortality in patients with asthma.
Published: 9/3/2024
FDA Authorizes New Drug Application For Trial to Evaluate Treatment for Long COVID
Bezisterim, an anti-inflammatory insulin sensitizer, will be authorized to proceed to a phase 2 clinical trial.
Published: 9/3/2024
Study Finds Race Impacts Cancer Stage at Diagnosis and Patient’s Overall Survival
The risk of late-stage diagnosis was higher for Asian, Black, and Native Hawaiian or Other Pacific Islander adolescent and young adult patients with cancer.
Published: 9/3/2024
Digital Therapeutics in Diabetes Show Potential for Improved Disease Management
Pharmacists should be aware of these digital therapeutics, which are often used as an adjunct to medication, to better understand the treatment outcomes.
Published: 9/3/2024
CDC Recommends Preventative Action Amid Rising Cases of West Nile Virus
Cases have been detected in 33 US states so far this year, and the virus has recently hospitalized the former Chief Medical Advisor to the President of the US Anthony Fauci.
Published: 9/2/2024
Intravenous Immunoglobulin Demonstrates Effectiveness as Treatment for Unexplained Recurrent Pregnancy Loss
For those with unexplained pregnancy loss, these results could prove promising improvements to birth outcomes.
Published: 9/2/2024
EBCare Smart Mask Assesses Metabolic Conditions, Respiratory Airway Inflammation in Patients With Asthma, COPD
The exhaled breath condensate mask was able to successfully monitor and accurately detect breath for nitrate in patients with asthma or chronic obstructive pulmonary disease.
Published: 9/1/2024
Congress Requests Corrections to Testimony From Three Largest Pharmacy Benefit Manager Executives Following FTC Report
The request comes as increased scrutiny is levied toward pharmacy benefit managers for alleged unfair business practices.
Published: 8/30/2024
New ACIP Recommendations for RSV Vaccines Aim to Solve Challenges With Shared Clinical Decision-Making
Shared clinical decision-making presented drawbacks, resulting in age-based recommendations for adults aged 75 years and older and risk-based recommendations for individuals aged 60-74 years.
Published: 8/30/2024
Study: Higher Risk of Mental Health Conditions Present in Patients With an Aneurysm Diagnosis
Those with an aneurysm diagnosis who were younger than 40 years of age were observed to have an even higher risk.
Published: 8/30/2024
National Academies Progress Report Shows Consequences of Underrepresentation in Clinical Research
The author suggest how to improve the representation of women, older adults, and minorities in clinical research that will require effort from a broad range of stakeholders.
Published: 8/30/2024
Distinguishing Between Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome
Although small intestinal bacterial overgrowth (SIBO) and irritable bowel syndrome (IBS) share many of the same symptoms, SIBO affects the small intestine and IBS affects the large intestine.
Published: 8/30/2024
Nipocalimab Data Submitted for FDA Approval in Generalized Myasthenia Gravis
The application includes data from the Vivacity-MG3 study, demonstrating that individuals who received the drug had superior outcomes compared with the standard of care alone.
Published: 8/30/2024
Twice Yearly Inclisiran Demonstrates Meaningful LDL-C Lowering in Patients With ASCVD Risk
Pharmacists play an essential role in ensuring the medication is dispensed to patients with high atherosclerotic cardiovascular disease risk.
Published: 8/30/2024
Study: Researchers Find New Drug Target to Treat RSV
The findings further the understanding of respiratory virus immune evasion mechanisms and uncover how RSV-NS1 can target therapeutic intervention
Published: 8/29/2024
Patients With Asthma Experience Changes in Airway Inflammation Following Electronic Cigarette Use
Using 1 nicotine-containing electronic cigarette was significantly correlated with an increase in residual volume and total lung capacity in patients with asthma.
Published: 8/29/2024
Study: Children With First Dose of Measles Vaccine May Not Receive Both Globally
Pharmacists can help facilitate more organized efforts to improve measles vaccination uptake for children aged 5 and younger by identifying socio-demographic gaps within this population.
Published: 8/29/2024
Frequent Use of Surrogate Markers Could Create Uncertainty for Breakthrough-Designated Drugs
The use of surrogate markers was observed for breakthrough-designated indications that were approved through both traditional pathways and accelerated pathways.
Published: 8/29/2024
Results of Extension Study Show Roflumilast Suitable for Children Aged 2 to 5 Years
In July 2024, the FDA approved the supplemental new drug application for roflumilast cream 0.15% for patients 6 years and older.
Published: 8/29/2024
HHS Releases Campaign to Promote Vaccine Recommendations for RSV, COVID-19, and Flu
"Risk Less. Do More." plans to partner with national, state, and local organizations to provide resources to families and communities on how to protect themselves from RSV, influenza, and COVID-19.
Published: 8/28/2024
FDA Grants Priory Review for Mirdametinib to Treat NF1-PN
Mirdametinib is an oral, allosteric small molecule MEK inhibitor to treat pediatric patients with neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PN).
Published: 8/28/2024
PQA Issues Call to Action to Improve Medication Therapy Management
Eight areas of improvement were developed as part of national initiative with stakeholder involvement.
Published: 8/28/2024
Activation, Preparedness Following Treatment Lacking Among Lymphoma Survivors
In survivors of lymphoma with fragmented transition of care, preparedness and activation for the next phase of their survivorship was lacking.
Published: 8/28/2024
Community Pharmacist Training Program Enhances Care for Patients With Epilepsy
Community pharmacists can participate in continuing education epilepsy programs, but they are usually not specific to pharmacy practice.
Published: 8/28/2024
FDA Clears Omnipod 5 Automated Insulin Delivery System for Use in Adults With Type 2 Diabetes
Previously, the device was indicated for the management of type 1 diabetes in patients aged 2 years and older.
Published: 8/28/2024
FINTOX May Improve Financial Toxicity Screening in Cancer Treatment
Accurate, effective screening is crucial for connecting patients with needed financial resources and support.
Published: 8/28/2024
Treatment With Pegcetacoplan Could Aid Individuals with C3G and Primary IC-MPGN
Pegcetacoplan is a targeted C3 therapy that is intended to regulate excessive activation of the complement cascade.
Published: 8/27/2024
FDA Approves True Sight Oncology Comprehensive Test to Identify NTRK Solid Tumors
With diagnostic tools, oncology pharmacists and other health care providers can help to identify treatments that have the best probability of working for a specific patient.
Published: 8/27/2024
Updated Cardiovascular Guidelines for Individuals with HIV Expand Statin Eligibility
Medication therapy management reimbursement can be a driving factor to work toward statin implementation in this patient group.
Published: 8/27/2024
FDA Grants Fast Track Designation to BGB-16673 for Patients With R/R CLL/SLL
The indication is for adults with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma who were treated with at least 2 prior lines of therapy.
Published: 8/27/2024
FTC Issues Support Statement for FDA’s Draft Guidance on Interchangeable Biosimilars
The guidance, if finalized, would revise considerations about switching studies for proposed interchangeable biosimilars.
Published: 8/27/2024
Community Pharmacy-Driven Diabetes Intervention Leads Value-Based Care
Clinical improvements for patients with diabetes seen in a collaboration between the University of North Carolina and Blue Cross and Blue Shield of North Carolina.
Published: 8/27/2024
Apremilast Now Available to Treat Pediatrics With Plaque Psoriasis
Pediatric patients weighing 20 kg to <50 kg should take 20 mg of apremilast twice daily and children weighing at least 50 kg should take 30 mg twice daily.
Published: 8/26/2024
Experts: Pharmacists, Community Health Workers Key to Success in Missouri Vaccine Gap Program
In an initiative to close vaccine gaps in local Missouri communities, pharmacists and community health workers proved essential.
Published: 8/26/2024
Tafasitamab, Lenalidomide Combination Modestly Effective in Patients With Large B-Cell Lymphoma
Aligning with previous data, the drug combination was modestly effective in patients with large B-cell lymphoma pre- and post-CAR-T-cell therapy.
Published: 8/26/2024
Fish Oil Supplementation May Reduce Genetic Risk of High Cholesterol
Pharmacists can be essential sources of education for patients, offering them guidance on safe use and proper dosage.
Published: 8/26/2024
Tirzepatide Reduces Risk of Progression to Type 2 Diabetes for Patients with Obesity, Overweight
For adults receiving the 15 mg dose, tirzepatide sustained weight loss with an average reduction of 22.9% in body weight compared with 2.1% for the placebo.
Published: 8/26/2024
Individuals Born in Autumn or Winter More Likely to Develop Asthma, Allergic Rhinitis
In Finland, season of birth, notably autumn and winter, was associated with the development of asthma and allergic rhinitis.
Published: 8/26/2024
FDA Grants Fast Track Designation to 64Cu-SAR-bisPSMA for Prostate Cancer Diagnosis
The proposed diagnostic agent has a long half-life, enables imaging the next day, and correlates to a longer shelf life in the pharmacy.
Published: 8/26/2024
Study: Lack of Nutritional Value Found in Almost 60% of US Baby Food
Pharmacists can help caregivers by recommending a healthy balanced diet containing high vitamin D intake and supplementation when needed.
Published: 8/23/2024
FDA Grants Orphan Drug Designation to RAG-18 for Duchenne, Becker Muscular Dystrophy
This designation follows the drug's rare pediatric disease designation in July 2024.
Published: 8/23/2024
SELECT Trial Shows Similar Cardiac Benefits of Semaglutide for Heart Failure
Investigators compare the impact of semaglutide for preserved ejection fraction and reduced ejection fraction, which both have different causes and responses to treatment.
Published: 8/23/2024
Climate Variability, Extremes Allow Emergence and Propagation of Cholera Strains
The researchers found that unusual and dramatic changes in weather as well as heavy rainfall helped aid in the pathogen’s evolutionary change.
Published: 8/23/2024
Study: mRNA Combination Vaccine Provides Protection Against COVID-19 and Influenza
Researchers assess the safety, tolerability, and immunogenicity of a single combination dose to evaluate its immunogenicity against SARS-CoV-2 and influenza.
Published: 8/23/2024
Cytomegalovirus Infection in Patients with Lymphoma Treated With Bendamustine Are Underdiagnosed, Require Awareness
Bendamustine resulted in a greater risk of treatment complications in patients with lymphoma.
Published: 8/23/2024
Updated COVID-19 Vaccines Approved by FDA to Defend Against Circulating Variants
The acceptance will lead to vaccines that provide better protection against the KP.2 strain of SARS-CoV-2.
Published: 8/22/2024
FDA Accepts Biologics License Application For Nivolumab Plus Ipilimumab to Treat Hepatocellular Carcinoma
The FDA assigned the combination a Prescription Drug User Fee Act goal date of April 21, 2025.
Published: 8/22/2024
Single Dose of Abrysvo Could Provide Immune Protection Against RSV in Immunocompromised Individuals
Individuals with chronic conditions like asthma, diabetes, and chronic obstructive pulmonary disease face an increased risk of developing RSV.
Published: 8/22/2024
Five-Part Action Plan For Patients With Asthma, COPD Helps to Alleviate Wildfire-Related Health Risks
Communities that are impacted by increased wildfires can experience increased health risks, particularly among those who have asthma or chronic obstructive pulmonary disease.
Published: 8/22/2024
Palliative Care Can Improve Health Outcomes for Patients With Cardiovascular Disease
Palliative care is crucial for safe and effective medication management to relieve symptoms and improve quality of life.
Published: 8/22/2024
Study Finds Ketogenic Diets May Increase “Bad” Cholesterol
Pharmacists are key resource points to navigate the nuances of keto diets and chronic health management.
Published: 8/21/2024
Study: Biosimilar Etanercept Shows Equivalence With Reference Product for Rheumatoid Arthritis
Biosimilar etanercept (Sunshine Guojian Pharmaceutical) showed similar therapeutic outcomes compared with etanercept (Enbrel; Amgen) specific to rheumatoid arthritis.
Published: 8/21/2024
Intravenous Immunoglobulin Shows Beneficial Effects In Post-Menopausal Osteoporosis, Indicating Potential as Treatment
The use of intravenous immunoglobulin led to positive protective effects on osteoporosis.
Published: 8/21/2024
IMPT-514 Receives Investigational New Drug Clearance From the FDA
The bispecific CAR T-cell therapy for treatment of multiple sclerosis is the first to target both CD19 and CD20.
Published: 8/21/2024
GSK5764227 Receives Breakthrough Therapy Designation to Treat Extensive-Stage Small–Cell Lung Cancer
The breakthrough therapy designation was granted based on ongoing data from the ARTEMIS-001 phase 1 open-label, multi-center trial.
Published: 8/20/2024
Propofol Injectable Emulsion Single-Dose Vials Receive FDA Approval
Propofol has a history of chronic shortage due to supply chain constraints.
Published: 8/20/2024
FDA Accepts NDA and Priority Review Application for Vimseltinib in Tenosynovial Giant Cell Tumors
Vimseltinib (Deciphera Pharmaceuticals) has a Prescription Drug User Fee Act goal date of February 17, 2025.
Published: 8/20/2024
FDA Grants Orphan Drug, Fast Track Designation to RLS-0071 for aGVHD
The drug is currently undergoing a phase 2 clinical trial for patient 12 years or older who are hospitalized with steroid-refractory acute graft-versus-host disease (aGVHD).
Published: 8/20/2024
FDA Approves Amivantamab-Vmjw and Lazertinib for First-Line Treatment of NSCLC
The combination is the first and only multi-targeted chemotherapy-free regimen that demonstrated superiority compared with osimertinib for non–small cell lung cancer (NSCLC).
Published: 8/20/2024
AR882 Receives Fast Track Designation From the FDA for Treatment of Clinically Visible Tophaceous Gout
The highly potent, selective URAT1 inhibitor may help reduce serum uric acid levels and treat clinically visible tophi.
Published: 8/20/2024
Pharmacists Can Play a Pivotal Role in Providing Value-Based Care
In a session at NACDS Total Store Expo, experts spoke to the success of value-based care models in the pharmaceutical industry.
Published: 8/19/2024
Analysis Finds Bidirectional Association Between Asthma and Psoriasis
The study authors recommend that health care professionals are aware of the connections, notably in adolescent patients and those with moderate to severe psoriasis.
Published: 8/19/2024
FDA Grants Breakthrough Therapy Designation to DS-8201a and T-DXd to Treat Metastatic Breast Cancer
Fam-trastuzumab deruxtecan-nxki has received 4 breakthrough therapy designations, including the latest approval.
Published: 8/19/2024
FDA Grants Orphan Drug Designation to PT217 for Neuroendocrine Carcinoma
Currently, the drug will be studied in the SKYBRIDGE (NCT05652686) trial, a first-in-human, phase 1/2, open-label, dose-escalation and expansion study.
Published: 8/19/2024
Five Quick Facts to Know About Biosimilars
The biosimilar space continues to grow, with key focuses around retina and oncology, but adoption remains slow in the United States.
Published: 8/19/2024
First At-Home Syphilis Test Receives Marketing Authorization From the FDA
The OTC antibody test can detect current or past infection but should be followed by additional testing to confirm diagnosis.
Published: 8/19/2024
Researchers Identify Predictors of Intravenous Immunoglobulin Resistance in Patients With Kawasaki Disease
Noticing indicators of IVIG non-responsiveness can lead to better outcomes among patients with Kawasaki disease as treatment is adjusted.
Published: 8/19/2024
New First-Line Options Emerging for Type 2 Diabetes Care
Glucagon-like peptide-1 receptor agonists and sodium-glucose contransporter-2 inhibitors have been added as first-line therapy recommendation for type 2 diabetes, the first since metformin
Published: 8/19/2024
Pharmacists Can Provide Support Around Anxieties for Reproductive Access
Nurx reproductive access survey reveals 28% of women do not believe their right to contraception is protected.
Published: 8/16/2024
CDC Recommends Use of Lidocaine for IUD Insertion in Updated Guidelines
The updates are based on nationwide reports of extreme pain during IUD insertion.
Published: 8/16/2024
Treatment Benefit for Chronic Inflammatory Demyelinating Polyneuropathy Observed With Intravenous Immunoglobulin, Corticosteroids
Investigators analyzed a series of disease-modifying therapies in a multi-decade trial.
Published: 8/16/2024
FDA Grants 510(k) Clearance for Traumagel to Control Bleeding
The hemostatic gel is plant-based and designed to stop and control bleeding within seconds after applied to wound at the point of care.
Published: 8/16/2024
Durvalumab Receives FDA Approval for Treatment of Non-Small Cell Lung Cancer
Durvalumab is a human monoclonal antibody that targets and binds to PD-L1 to interrupt tumor immune-evasion tactics.
Published: 8/16/2024
World Health Organization Declares New Mpox Outbreak a Global Public Health Emergency
The current outbreak has infected more than 14,000 people and spread to 13 different African countries.
Published: 8/16/2024
Co-Administering RSV and Influenza Vaccines Could Provide Tolerable Immune Responses
RSV and influenza vaccines demonstrated hemagglutination inhibition titers that were noninferior to those with sequential administration.
Published: 8/15/2024
ELM-2 Trial Indicates Odronextamab Effective, Safe in Patients With Follicular Lymphoma
Building off the positive results of ELM-1, the ELM-2 trial found intravenously administered odronextamab was safe and effective in patients with relapsed or refractory follicular lymphoma.
Published: 8/15/2024
FDA Grants Priority Review for Durvalumab to Treat Small Cell Lung Cancer
The supplemental biologics license application was granted based on results from the ADRIATIC phase 3 trial among individuals with limited stage small cell lung cancer.
Published: 8/15/2024
FDA Grants Fast Track Designation for KB-GDT-01 to Treat Patients with Non-Small Cell Lung Cancer
The decision is based positive data from the Deltacel-01 clinical trial.
Published: 8/15/2024
FDA Grants Fast Track Designation for AC699 for Patients With ER+/HER2– Breast Cancer
AC699 is being evaluated for patients with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 negative (HER2–), estrogen receptor 1-mutated advanced or metastatic breast cancer with disease progression on or after at least 1 line of endocrine-based therapy.
Published: 8/15/2024
CMS Announces Negotiated Prices for 10 Drugs Under Inflation Reduction Act
The new prices are expected to go into effect for patients with Medicare Part D on January 1, 2026.
Published: 8/15/2024
FDA Approves Axatilimab-csfr for cGVHD
Axatilimab-csfr (Niktimvo, Incyte Corporation) is a colony stimulating factor-1 receptor-blocking antibody for the treatment of chronic graft-versus-host disease (cGVHD).
Published: 8/14/2024
FDA Grants Seladelpar Accelerated Approval for Primary Biliary Cholangitis
The decision is based on clinical findings demonstrating seladelpar’s ability to effectively regulate of alkaline phosphatase values in patients.
Published: 8/14/2024
Effects of IVIG Treatment and Neurofilament Light Chains as Prognostic Indicators of Guillain-Barre Syndrome
Response to intravenous immunoglobulin treatment and analysis of neurofilament light chains in patients could be used as prognostic indicators of Guillain-Barre syndrome.
Published: 8/14/2024
Pharmacists Can Suggest B Vitamin Intake to Treat Parkinson Disease
Individuals with Parkinson disease reported a decrease in bacterial genes for biosynthesis of riboflavin (vitamin B2) and biotin (vitamin B7).
Published: 8/14/2024
JVC-001 Vaccine Demonstrates Antibody Coverage Against Measles, Mumps, and Rubella
The seroprotection rate of antibody titers was 100% against the 3 viruses, and geometric mean titer also increased from administration to day 43.
Published: 8/14/2024
Machine Learning Models May Predict Disease Progression in Patients With Multiple Sclerosis
Predicting disease progression is essential to improve the health outcomes of patients with multiple sclerosis.
Published: 8/14/2024
Study Supports Bendamustine-Rituximab as Standard-of-Care in Patients With Indolent Non-Hodgkin Lymphoma
The data builds off prior studies supporting bendamustine-rituximab as a first-line treatment for patients with non-Hodgkin lymphoma.
Published: 8/14/2024
Data Show Fremanezumab Converts Chronic Migraine to Episodic, Improves Quality of Life for Patients
The authors determined that 40 patients (74.1%) converted from chronic to episodic migraine.
Published: 8/13/2024
Study Finds Intermittent Fasting May Offset Alzheimer Disease Risk, Support Treatment Goals
The study may serve as a foundation for future investigation regarding dietary recommendations to support the treatment of Alzheimer disease.
Published: 8/13/2024
FDA Approves Afilbercept-Abzv as Interchangeable Biosimilar for Eylea
The treatment is indicated to improve and maintain visual acuity in individuals with neovascular age-related macular degeneration.
Published: 8/13/2024
Nemolizumab Granted FDA Approval For Adults Living With Prurigo Nodularis
Nemolizumab is the first approved monoclonal antibody specifically inhibiting the signaling of IL-31, which drives disease mechanisms in prurigo nodularis.
Published: 8/13/2024
FDA Grants RMAT Designation for KYV-101 to Treat Patients With Progressive Myasthenia Gravis
The autologous, fully human CD19 chimeric antigen receptor T-cell product, KYV-101, is being studied for the treatment of patients with progressive myasthenia gravis.
Published: 8/12/2024
Merck Discontinues Study Evaluating Vibostolimab/Pembrolizumab Combination for SCLC
The trial evaluated a fixed-dose combination of vibostolimab and pembrolizumab in combination with chemotherapy as a first-line treatment for extensive-stage small cell lung cancer.
Published: 8/12/2024
Study Finds Increased Risk of Mental Health Disorders Following Cardiovascular Hospitalization
Risk of developing anxiety or depression is highest within the first year after cardiovascular hospitalization.
Published: 8/12/2024
Potential Role for IVIG in Treating Systemic Sclerosis With Muscular, Digestive Manifestations
The systematic review summarized all available evidence on the subject, finding that intravenous immunoglobulin could have a role in treatment.
Published: 8/12/2024
FDA Approves Palopegteriparatide for Treatment of Hypoparathyroidism
Palopegteriparatide is a prodrug of parathyroid hormone designed to provide continuous exposure of the hormone over a 24-hour dosing period.
Published: 8/12/2024
New Finding for Diabetic Wounds Has Potential for Use in Developing New Therapeutics
Many patients are unaware of wound complication, so it is valuable for pharmacists to communicate prevention methods with all patients with diabetes.
Published: 8/12/2024
Color-Coded Asthma Medication Labels in Pharmacies Enhance Self-Management Education
Pharmacists played a crucial role in providing asthma action plans and enhancing patient education, despite challenges, and study limitations.
Published: 8/12/2024
Study: Sales Price of Originator Declines After Introduction of Biosimilars
Investigators find that this could suggest the biosimilar uptake alone may not be a complete measure of the market competition and lowering prices.
Published: 8/12/2024
The Expanding Role of Continuous Glucose Monitors in Pregnant Patients
The use of CGMs in pregnancy provides clinicians with essential data in real-time, rather than a snapshot given by traditional finger stick testing.
Published: 8/11/2024
FDA Grants Rare Pediatric Disease Designation to SAT-3247 to Treat Duchenne Muscular Dystrophy
The commencement of the phase 1 clinical trial of SAT-3247 is expected in Q3 of 2024.
Published: 8/10/2024
Finerenone Significantly Reduces Cardiovascular Death, Heart Failure in the FINEARTS-HF Trial
Non-steroidal mineralocorticoid receptor antagonist, finerenone, demonstrated improved efficacy compared with existing steroidal treatment for patients.
Published: 8/10/2024
FDA Declines to Approve MDMA for PTSD
Previously, an independent advisory panel for the FDA rejected the use of MDMA-assisted therapy for posttraumatic stress disorder (PTSD), citing concerns of the reliability of the clinical trial data.
Published: 8/9/2024
Clinical Presentation in Patients With Lymphoma Widely Vary, Making Treatment Difficult
A variety of signs and symptoms of lymphoma were reported, including fever, stomach discomfort, and weight loss.
Published: 8/9/2024
New Study Assesses Ifinatamab Deruxtecan for Treatment of Small Cell Lung Cancer
The study is expected to include 460 individuals that will be randomly treated with 12mg of ifinatamab deruxtecan or chemotherapy chosen by the health care provider.
Published: 8/9/2024
New Evidence Supports Cholesterol Absorption Inhibitors in Liver Cancer Prevention
Statins and non-statin cholesterol-lowering agents show potential in reducing the risk of liver cancer.
Published: 8/9/2024
Research Demonstrates Asthma-Related Emergency Room Visits Increase During Peak Pollen Season
A number of asthma-related emergency room visits are a result of viruses, but certain airborne pollens—notably Cupressaceae and tree pollens—are also contributors.
Published: 8/9/2024
Experts: Pharmacists Are Accessible and Valuable Resources in Arthritis Management
A clinical pharmacy specialist and specialty pharmacy manager from Allegheny Health Network urge patients to use their pharmacist in the treatment management of arthritis.
Published: 8/9/2024
Research Identifies Key Genes Linking Hashimoto Thyroiditis and Papillary Thyroid Carcinoma
The findings may lead to the development of diagnostic and therapeutic targets to prevent worsening disease in patients.
Published: 8/9/2024
FDA Approves First Nasal Spray for Anaphylaxis
neffy is an epinephrine nasal spray for the emergency treatment of allergic reactions in adults and pediatric patients.
Published: 8/9/2024
ABS-0871 Receives FDA Orphan Drug Designation for Treatment of Charcot-Marie-Tooth Disease 2C
The FDA also granted rare pediatric disease designation for the drug.
Published: 8/9/2024
QUILT 502 Trial Will Assess N-803 With AdHER2DC Vaccine for Patients With Endometrial Cancer
Investigators will examine the combination with pembrolizumab and lenvatinib in patients with HER2-expressing endometrial cancer.
Published: 8/8/2024
Isatuximab Shows Promise in Enhancing PFS for Patients with Multiple Myeloma
Isatuximab (Sarclisa; Sanofi) in combination with standard-of-care significantly improved progression-free survival in patients with newly diagnosed multiple myeloma.
Published: 8/8/2024
RHB-104 Plus Standard of Care Offers Extended Treatment for Crohn Disease
The primary end point of clinical remission at week 26 was met, with 36.7% of individuals treated with RHB-104 achieving clinical remission.
Published: 8/8/2024
Intravenous Immunoglobulin Shows Safety and Effectiveness as Treatment of Pyoderma Gangrenosum
Intravenous Immunoglobulin as a therapy for patients with pyoderma gangrenosum could open new treatment avenues for the rare and challenging condition.
Published: 8/8/2024
Tirzepatide Meets Both Primary End Points in Phase 3 SUMMIT Trial
Tirzepatide demonstrates statistically significant improvements in adult patients who have heart failure with preserved ejection fraction and obesity.
Published: 8/8/2024
FDA Grants Nalmefene Injection Approval for Emergency Treatment of Opioid Overdose
The injection adds an additional option to address emergency known or suspected opioid overdoses.
Published: 8/8/2024
FDA Grants Accelerated Approval to Iptacopan For the Reduction of Proteinuria in Adults With IgAN
The indication is for the reduction of proteinuria in adult patients who have primary immunoglobulin A nephropathy and are at risk of disease progression.
Published: 8/8/2024
FDA Approves Denileukin Diftitox-Cxdl for the Treatment of T-Cell Lymphoma
Denileukin diftitox-cxdl is the only therapy approved for cutaneous T-cell lymphoma that targets IL-2 receptors in malignant T-cells and Tregs.
Published: 8/8/2024
GLP-1 Agonists Show Promise in Treatment of Neurodegenerative Disorders
Significant commonalities between type 2 diabetes and neurodegenerative disorders suggest that treatments effective for one condition may benefit the other.
Published: 8/7/2024
FDA Approves Carbidopa, Levodopa Extended Release for Parkinson Disease
Carbidopa and levodopa extended-release capsules are a novel, oral formulation that combine immediate-release granules and extended-release pellets.
Published: 8/7/2024
Experts: Pharmacists Have a Crucial Role in the Treatment of Sarcomas in the Pediatric Setting
Pharmacists can personalize supportive care, educate patients and their caregivers, advocate for patients, and collaborate with other health care workers.
Published: 8/7/2024
Study Finds Abacavir Increases Cardiovascular Risk in Patients With HIV
Cholesterol-lowering agents, like statins, reduced the risk of major adverse cardiovascular events and cardiovascular disease in patients with HIV.
Published: 8/7/2024
Results of Study Find Irregular Sleep Patterns Associated With Diabetes Risk
The ADA Clinical Practice Recommendations added sleep assessment for precision medicine in type 2 diabetes, supporting the wealth of information surrounding the association.
Published: 8/7/2024
Study Finds Safe, Effective Way of Infecting Participants With the Parasite Causing Leishmaniasis
This breakthrough can be significant in the development for a vaccine and other preventative measures to protect individuals from leishmaniasis.
Published: 8/7/2024
FDA Approves Vorasidenib for Adults, Pediatric Patients With Grade 2 Astrocytoma, Oligodendroglioma
This marks the first FDA-approved systemic therapy for patients with grade 2 astrocytoma or oligodendroglioma with a susceptible isocitrate dehydrogenase-1 (IHD1) or IDH2 mutation.
Published: 8/7/2024
Vitamin and Mineral Rich Diets Could Aid Younger Biological Age
Following a healthy, vitamin rich diet with less sugar was connected to a lower epigenetic age.
Published: 8/7/2024
PEAM, BEAM Regimens Show Comparable Efficacy In Patients With Hodgkin, Non-Hodgkin Lymphoma
Replacing carmustine with cisplatin in BEAM ((carmustine, etoposide, cytarabine, and melphalan) conditioning could be more cost-effective for patients.
Published: 8/7/2024
Treating Acid Reflux With Over-the-Counter Medications
An overview of acid reflux and gastroesophageal reflux disease, over-the-counter options, long-term effects of proton pump inhibitors, lifestyle recommendations, and when to refer patients.
Published: 8/6/2024
Trial Results Show Potential of Combination Therapy for Chronic Lymphocytic Leukemia
Acalabrutinib plus venetoclax, with or without obinutuzumab, demonstrated significant improvements in progression-free survival.
Published: 8/6/2024
Multiomic Perspective on CD38 Regulation and Targeting Offers New Insights for Treatment With Daratumumab, Isatuximab
CD38 density may indicate the efficacy of monoclonal antibody treatment in patients with multiple myeloma.
Published: 8/6/2024
Imbrium Therapeutics Submits Investigational NDA for Potential Treatment of Alcohol Use Disorder
Sunobinop binds to and activate nociception/orphanin-FQ peptide receptor, which is a known therapeutic target for substance use disorder.
Published: 8/6/2024
Brazilian Literacy Program Improves Executive Function in Low-Educated Population, Reducing Dementia Risk
Improvements were observed in both the intervention and control group, with those who had self-reported learning difficulties showing the least improvement.
Published: 8/6/2024
Biosimilar Market Expected to Grow to $92 Billion by 2031, Data Show
A report from SkyQuest Technology highlights the growth in the oncology and insulin spaces, indicating they will contribute to the most growth.
Published: 8/6/2024
FDA Accepts sNDA for Cabozantinib With 2 Neuroendocrine Tumor Indications
The drug also receives orphan drug designation for the treatment of pancreatic neuroendocrine tumors and a Prescription Drug User Fee Act target action date of April 3, 2025.
Published: 8/6/2024
Intravenous Immunoglobulin Preparations Leads to Varied Effects in Patients With Kawasaki Disease
Two different brands of intravenous immunoglobulin have been investigated, finding Brand P led to significantly longer durations of fever and hospitalization when compared to brand T.
Published: 8/6/2024
Study: How mRNA-1345 RSV Vaccine Compares to Previously Approved RSV Vaccines
The mRNA-1345 vaccine provides a one-off mechanism of protection because of its single-dose prefilled syringes
Published: 8/5/2024
Report: Satisfaction of Mail-Order Pharmacies Rise, Decreases for Community Pharmacies
Customers report that their communication is strong with their pharmacists, but only 51% said their pharmacist was trustworthy.
Published: 8/5/2024
Tumor-Treating Fields Boost Natural Killer Cell Cytotoxicity in Glioblastoma
The findings highlight the potential for developing more efficacious combination treatments for patients with glioblastoma.
Published: 8/5/2024
Developing Relationships With State Boards of Pharmacy Is Valuable for Pharmacies and Pharmacists
A pharmacy's relationship with its state board(s) of pharmacy is crucial for its operation and success, yet it is often overlooked due to the complex demands on pharmacists and pharmacy owners.
Published: 8/5/2024
Human Pluripotent Stem Cell Line Variability Supports Successful Cortical Organoid Production
Small adjustments in human pluripotent stem cell cultures and the molecule concentration patterns in the initial 5 days of differentiation are essential to “rescue” the lines.
Published: 8/5/2024
Research Suggests Alzheimer Disease and Periodontal Disease Are Linked by Inflammation
Periodontitis and AD are both characterized by inflammatory and immunological response by the host.
Published: 8/5/2024
Positive Topline Phase 2 Results Announced for mRNA Immunotherapy Candidate in Patients With Advanced Melanoma
The trial is evaluating the success of BNT111 and cemiplimab in treating unresectable stage III or IV melanoma whose disease had progressed following anti-PD-(L)1-containing treatment.
Published: 8/5/2024
Roundup: Novel Drug Approvals in 2024
In the first half of 2024, the FDA approved 23 novel drugs for conditions including alopecia areata, Alzheimer disease, small cell lung cancer, bladder cancer, and more.
Published: 8/5/2024
Expert: Psychosis in Alzheimer Disease Contributes to Rapid Cognitive, Functional Decline
In addition to a rapid deterioration, psychosis in Alzheimer disease can also lead to poorer quality of life, damaged patient-caregiver relationships, and increased isolation.
Published: 8/3/2024
Lenalidomide With Obinutuzumab Found Safe, Highly Active in Patients With Non-Hodgkin Lymphoma
Investigators determine the efficacy and safety of the combination in a 2-phase trial.
Published: 8/3/2024
Researchers Identify a Potential Therapeutic Target for Multiple Sclerosis
The findings show that inhibiting connexin 43 significantly improves multiple sclerosis symptoms in an experimental mouse model.
Published: 8/2/2024
Innovative Therapy for MAGE-A4+ Synovial Sarcoma: Afami-Cel’s Results in the SPEARHEAD-1 Trial
Afamitresgene autoleucel (afami-cel) is a novel cell therapy for the treatment of patients with synovial sarcoma.
Published: 8/2/2024
Expert: The Definition of Alzheimer Disease is Shifting From Clinical to Biological
Edward B. Lee, MD, PhD, also describes how understanding Alzheimer disease requires the integration of multiple fields including genetics, pathology, epidemiology, pharmacology, and physiology.
Published: 8/2/2024
2-Drug Regimen Shows Comparable Effectiveness With 3-Drug Regimen to Treat HIV-1
Dolutegravir/lamivudine was non-inferior to bictegravir/emtricitabine/tenofovir alafenamide fumarate, meeting the study’s primary end point.
Published: 8/2/2024
BLZ945 Offers New Possibilities for Eradicating HIV From the Brain
The experimental drug successfully reduced levels of SIV, the nonhuman primate equivalent of HIV, in the brain.
Published: 8/2/2024
Open-Label Trial Extension Supports Continued Long-Term Treatment With Lecanemab in Patients with Early AD
Study results demonstrated that lecanemab provided sustained benefits over 36 months, such as improved biomarker profiles and slowed cognitive decline compared with placebo.
Published: 8/2/2024
Intravenous Immunoglobulin Effective in Achieving Viral Clearance, Neutralizing Several SARS-CoV-2 Variants
In an analysis of 16 immunocompromised patients with COVID-19, intravenous immunoglobulin was effective and associated with clinical cure.
Published: 8/2/2024
Afamitresgene Autoleucel, First Gene Therapy to Treat Adults With Metastatic Synovial Sarcoma, Receives FDA Approval
Afami-cel was approved in conjunction with MAGE-A4 IHC 1F9 pharmDx, a diagnostic tool that can identify patients eligible to receive the treatment for synovial sarcoma.
Published: 8/2/2024
CDC Recommends International Travelers Receive MMR Vaccination 2 Weeks Prior to Travel
The CDC says that even if travel is less than 2 weeks away, unvaccinated individuals should still receive a dose of the measles, mumps, and rubella vaccine for protection against the disease.
Published: 8/2/2024
FDA Approves MAGE-A4 IHC 1F9 pharmDx as Diagnostic Tool in Patients With Synovial Sarcoma
The diagnostic tool can aid the identification of patients with synovial sarcoma who may be eligible for treatment with newly approved afamitresgene autoleucel.
Published: 8/2/2024
FDA Extends Approval of Fibryga to Include Bleeding Patients With Acquired Fibrinogen Deficiency
This is the first and only on-demand, virus-inactivated, human plasma-derived concentration option that is indicated for this approval.
Published: 8/2/2024
Fecal Microbiota, Live-jslm for the Prevention of Recurrent C difficile Infection
Pharmacists play a key role in the use of live biotherapeutic products, including fecal microbiota, live-jslm for prevention of recurrent Clostridioides difficile (C difficile) infection.
Published: 8/1/2024
FDA Expands Approval of Dostarlimab-Gxly Plus Chemotherapy to All Adults With Primary, Recurrent Endometrial Cancer
The RUBY trial will continue and analyze the overall population survival after treatment with the drug combination.
Published: 8/1/2024
Clinical Overview: Elfabrio for Fabry Disease in Adults
Fabry disease is a rare X-linked, lysosomal storage disorder that can cause renal failure or stroke.
Published: 8/1/2024
Bilateral Mastectomy Lowers Risk of Contralateral Breast Cancer But Not Mortality
The findings provide guidance for clinicians and patients when navigating therapeutic options to establish treatment plans.
Published: 8/1/2024
Expert: Tau Oligomers Are a Culprit in the Spread of Alzheimer Disease Pathology
Tara Spires-Jones, DPhil, FMedSci, discusses how oligomeric tau clumps inside brain synapses, pointing to indirect evidence that it may be progressing through the brain by jumping between connections.
Published: 8/1/2024
The CLEARMIND Trial and Clinical Implications of Lomecel-B in Alzheimer Disease
The co-founder, chief science officer, and chairman at Longeveron discusses the findings from the phase 2a trial CLEARMIND, as well as next steps to developing the therapy Lomecel-B.
Published: 8/1/2024
Five Ways Cancer Care Teams Can Best Utilize the Expertise of Pharmacists
Pharmacists' roles in community-based cancer centers are expanding, with a more significant role in managing complex treatment regimens, ensuring comprehensive patient care, navigating drug shortages, and collaborating with multidisciplinary teams to enhance patient outcomes and streamline health care operations.
Published: 8/1/2024
FDA Grants Priority Review for Asciminib for Chronic Myeloid Leukemia
The drug previously received breakthrough therapy designation for newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia that is in chronic phase.
Published: 8/1/2024
Pharmacists’ Sense of Meaning, Autonomy, and Pride Correlate With High Self-Evaluations of Pharmaceutical Services
Community pharmacy leaders should focus on improving quality of work-life for their employees.
Published: 8/1/2024
FDA Grants Breakthrough Device Designation for System Maintaining Weight Loss After GLP-1
The system is an outpatient procedure that resurfaces the mucosal lining, making it easier for the body to maintain healthy metabolism and blood glucose levels.
Published: 8/1/2024
FDA Grants Orphan Drug Designation to ZMA001 for Pulmonary Arterial Hypertension
The designation is based on animal model studies that have demonstrated superior efficacy in comparison to sildenafil.
Published: 8/1/2024
The Impact of Bilingualism on Dementia: Integrating a Sociocultural and Biological Framework
Understanding and accounting for linguistic diversity is critical in diagnostics and treatment for dementia.
Published: 8/1/2024
Embracing Digital Transformation: How Pharmacies Can Thrive in an Evolving Health Care Landscape
Pharmacies can adapt by embracing digital self-service options to better engage with patients, meet increasing consumer demand, and enhance revenue streams.
Published: 7/31/2024
Shingles Vaccine May Reduce the Onset of Dementia, Study Finds
The findings indicate that zoster vaccine recombinant reduced dementia risk by 17% in an analysis of over 200,000 patients.
Published: 7/31/2024
FDA Accepts New Drug Application for Suzetrigine to Manage Acute Pain
If approved, the drug would be the first in a new class of medications to treat acute pain in over 20 years.
Published: 7/31/2024
Glutamic Acid Decarboxylase Antibodies Prevalent in Intravenous Immunoglobulin, Affecting Diagnosis of Type 1 Diabetes Mellitus
The presence of glutamic acid decarboxylase antibodies in intravenous immunoglobulin can lead to a misdiagnosis of type 1 diabetes mellitus if a false-positive result is garnered.
Published: 7/31/2024
Expert: How Lomecel-B Stands Out in the Treatment of Alzheimer Disease
Joshua Hare describes how Lomecel-B addresses neuroinflammation, unlike other treatments which typically target amyloid disposition.
Published: 7/31/2024
Implementing Pharmacist Prescribing Programs for Female Contraceptives
Monitoring OTC sales, dispensing contraceptives, and prescribing birth controls drives a need in policy changes to adapt to increases in pharmacist workload.
Published: 7/31/2024
Study Finds Both Chronic and New Anxiety Increases Risk of Dementia
The study also found that there were no associations with increased dementia risk when anxiety resolved.
Published: 7/31/2024
FDA Approves Quadruplet Therapy Daratumumab and Hyaluronidase-fihj with Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma
The decision is based on positive results from the PERSEUS trial.
Published: 7/31/2024
Avutometinib With Defactinib Granted FDA Orphan Drug Designation to Treat Pancreatic Cancer
The designation is based off positive results from the RAMP 205 trial presented at the ASCO Annual Meeting.
Published: 7/30/2024
Global Immunization Coverage Lacking Since COVID-19 Pandemic, Especially in Children
Immunization rates have not returned to pre-pandemic levels, leaving millions of children and infants at risk for measles or diphtheria, tetanus, and pertussis.
Published: 7/30/2024
FDA Approves Preservative-Free, Single-Dose Potassium Phosphates IV Injection Bags
The approval streamlines treatment administration to eliminate compounding steps, reduce preparation time, and enhance safety for clinicians.
Published: 7/30/2024
Cinnamon May Reduce Risk of Cardiovascular Disease in Patients With PCOS
Pharmacists can help patients with polycystic ovary syndrome safely incorporate complementary supplements, such as cinnamon, into their treatment plan.
Published: 7/30/2024
FDA Extends Palforzia Approval to Children 1 to 3 Years Old With Peanut Allergy
The approval marks the first oral immunotherapy treatment to mitigate allergic reactions, including anaphylaxis.
Published: 7/30/2024
Community Pharmacy Managers, Owners Must Address Workplace Violence
Although important for patient health care, pharmacies’ convenient locations leave staff prone to workplace violence.
Published: 7/30/2024
Tezepelumab Reduces Exacerbations in Patients With Severe, Uncontrolled Asthma
Compared with placebo, tezepelumab reduced the annual asthma exacerbation rate in multiple subpopulations and asthma-related comorbidities.
Published: 7/30/2024
FDA Approves Long-Acting Injectable Paliperidone for Schizophrenia Treatment
Paliperidone palmitate (Erzofi; Luye Pharma Group) is approved as a monotherapy for schizophrenia and as an adjunct for schizoaffective disorder.
Published: 7/29/2024
FDA Approves Deuruxolitinib for the Treatment of Severe Alopecia Areata
One-third of patients treated with deuruxolitinib displayed 80% of scalp hair coverage.
Published: 7/29/2024
Study: Consuming Baby Carrots Could Aid Skin Carotenoids
Individuals who consumed 100 grams of carrots displayed an increase in carotenoid scores by 10.8%.
Published: 7/29/2024
Long-Acting Injectable Form of Cabotegravir Safe for HIV Prevention in Pregnant Cisgender Women
An extension of a long-acting cabotegravir study shows safety prior to and during pregnancy in cisgender women, with full results being presented at the 2024 International AIDS Conference.
Published: 7/29/2024
FDA Grants Extended 510k Clearance For Light Chain Assay for the Detection of MGUS
Early identification of monoclonal gammopathy of undetermined significance leads to more efficacious disease monitoring and intervention.
Published: 7/29/2024
Lifileucel: A Novel Therapy for Metastatic Cutaneous Melanoma
Advancements in treatment include immune checkpoint inhibitors and BRAF/MEK inhibitors, though resistance remains a challenge, with lifileucel recently approved for previously treated metastatic cases.
Published: 7/29/2024
Proposed Trastuzumab Biosimilar Shows Pharmacokinetic Similarity to Reference Product
The similarities were shown for both the US formulation and the EU formulation.
Published: 7/29/2024
Minority of Hematology Patients Receive Hepatitis B Screening Prior to Intravenous Immunoglobulin Exposure
A lack of widespread hepatitis B screenings compound with the issue of inaccurate test results, which can complicate treatment with intravenous immunoglobulin.
Published: 7/29/2024
FDA Approves Novel Blood Test as a Primary Screening Option for Colorectal Cancer
The blood test offers patients advanced screening methods capable of detecting colorectal cancer in its earlier stages.
Published: 7/29/2024
FDA Approves Benzgalantamine for Treatment of Alzheimer Disease
Benzgalantamine (Zunveyl; Alpha Cognition) is a cholinesterase inhibitor indicated for the treatment of mild-to-moderate dementia in adults.
Published: 7/29/2024
Prolonged β-Lactam Infusions and Patients Outcomes: Insights From the BLING III Trial
The BLING III trial investigated continuous vs intermittent β-lactam antibiotic infusions in critically ill patients with sepsis, finding no significant difference in 90-day mortality but suggesting potential benefits in clinical cure rates.
Published: 7/28/2024
Improving Hypertension Management: Home Blood Pressure Monitoring and Medication Adherence
One of the most important drivers of a patients’ uncontrolled hypertension is medication nonadherence.
Published: 7/27/2024
Blood Test May Predict CAR T-Cell Therapy Outcomes for Patients With Multiple Myeloma
Increased levels of absolute lymphocyte count are associated with improved response to BCMA-targeted CAR T-cell therapy.
Published: 7/26/2024
Persistent Epigenetic Changes in Immune Cells Following Hepatitis C Recovery
Study finds traces of “epigenetic scars” on the immune cells of patients who recovered from chronic hepatitis C infection.
Published: 7/26/2024
Personalized Simulations Can Predict Outcomes for Treatment in Patients With Diffuse Large B-Cell Lymphoma
The new approach could optimize precision medicine and lead to better outcomes across a variety of disease states.
Published: 7/26/2024
Indole-3-Propionic Acid Shows Long-Term Protection Against Asthma
The molecule can be a potential treatment that counters effects of early-life antibiotics, which can impact the gut microbiota and increase the risk of childhood atopy and asthma.
Published: 7/26/2024
Drugflation Is Soaring, But It Can Be Tamed
Unbridled drugflation, or a point-in-time measure of the rising cost of pharmacy benefits, is taking its toll on corporate bottom lines and household budgets.
Published: 7/26/2024
JNJ-2056, Targeting Tau Protein, Receives FDA Fast Track Designation for Alzheimer Disease
The FDA’s designation builds off positive results in a phase 1b/2a clinical trial, showing that the vaccine can effectively target the Tau protein.
Published: 7/26/2024
Giroctocogene Fitelparvovec Reduces Total Annualized Bleeding Rate for Hemophilia A
The investigational drug achieved non-inferiority compared to routine Factor VIII.
Published: 7/26/2024
Research Results Show Promise Toward Development of a Universal Influenza Vaccine
Despite the century-long period of virus evolution, 6 of the 11 primates that received a cytomegalovirus-expressed flu vaccine survived the exposure to H5N1 flu.
Published: 7/25/2024
Delgocitinib Could Aid Adults With Moderate to Severe Chronic Hand Eczema
The Lancet published data from DELTA 1 and DELTA 2 trials that displayed treatment success among individuals treated with delgocitinib cream.
Published: 7/25/2024
Patient Affordability Program for Adalimumab Biosimilar Is Launched at GoodRx
Patients without insurance may not be able to afford the biosimilar adalimumab-adbm, even if it is available at a more affordable price than its reference product.
Published: 7/25/2024
Twice-Yearly Lenacapavir Effective in Significantly Reducing HIV Infections in Cisgender Women
Adherence and efficacy were both higher in patients with HIV who took twice-yearly lenacapavir compared to those on oral preexposure prophylaxis medication.
Published: 7/25/2024
FDA Grants Regenerative Medicine Advanced Therapy Designation for AIC100 to Treat Thyroid Cancer
AIC100 could meet an unmet medical need to effectively treat individuals with anaplastic thyroid cancer — the most aggressive form of the disease.
Published: 7/25/2024
FDA Approves Cerliponase Alfa for Expanded Indication of CLN2 Disease
In April 2017, the drug was approved to treat the slow loss of the ability to walk for symptomatic patients aged 3 and older who had Batten disease.
Published: 7/24/2024
Analysis Findings Indicate Relationship Between Maternal Asthma and Risk for Autism Spectrum Disorders
Studies show an increased prevalence of autism spectrum disorder in children of mothers; mouse models have shown links between maternal asthma and altered behavior and brain function.
Published: 7/24/2024
Oral Dissolvable Birth Control Pill Receives Approval From the FDA
The decision offers patients with difficulty swallowing their medication expanded options for treatment administration.
Published: 7/24/2024
Intravenous Immunoglobulin Temporarily Improves Bleeding in Patients With Acquired Von Willebrand Syndrome
It is essential for clinicians to properly diagnose patients with suspected AVWS and provide them proper treatment, which could be intravenous immunoglobulin.
Published: 7/24/2024
FDA Approves IncobotulinumtoxinA for the Simultaneous Treatment of Upper Facial Lines
The decision expands the use of incobotulinumtoxinA beyond treatment of frown lines.
Published: 7/24/2024
Proposed Model Would Allow Pharmacists to Become Independent Clinicians
If properly implemented, increasing the pharmacist’s clinical authority could ensure increased access to care for patients and advance the practice of pharmacy.
Published: 7/24/2024
High Levels of β2-Microglobulin May Impact Coagulation Function in Patients With NDMM
β2-microglobulin may be an effective indicator of coagulation dysfunction in patients with newly diagnosed multiple myeloma (NDMM).
Published: 7/24/2024
VP Kamala Harris’s Policies and Stances on Health Care, Reproductive Rights Take Center Stage
Following President Joe Biden’s decision to step down from re-election, VP Kamala Harris has stepped into the Democratic nominee position after support and endorsements from notable delegates and the president himself.
Published: 7/23/2024
Pharmacist-Led DOAC Monitoring Improves Dosing
Patient monitoring significantly improved for patients seen in the pharmacist-led clinic due to greater efforts to order labs per policy and prescribe an appropriate DOAC dose.
Published: 7/23/2024
Analysis Determines Body Dysmorphic Disorder Is the Most Common in Adolescent Girls
The findings also demonstrate that body dysmorphic disorder is also associated with high levels of comorbid psychopathology, risk, and psychosocial impairment.
Published: 7/23/2024
Intermittent Fasting and Meal Replacements Improved Short-Term Glycemia
A 5:2 intermittent fasting plan combined with meal replacement had better positive outcomes compared with metformin and empagliflozin.
Published: 7/23/2024
LGBTQ Inclusion Extends to Student Pharmacists Starting Rotations
In the session at the 2024 American Association of Colleges of Pharmacy Annual Meeting, presenters highlighted the importance of fostering inclusion for LGBTQ students.
Published: 7/22/2024
Post-Roe, How Safe Are Period-Tracking Smartphone Apps?
Study investigators surveyed nearly 200 women on their concern around period-tracking apps’ data practices, as well as whether Roe v Wade being overturned influenced their concerns.
Published: 7/22/2024
Experts: Social Determinants of Health Should Be As Important As Clinical Content in Pharmacy Curricula
Educators should prioritize integrating social determinants of health (SDOH) for the next generation of pharmacists.
Published: 7/22/2024
Eculizumab-Aagh Receives FDA Approval as Biosimilar to Soliris
Eculizumab-aagh does not have an interchangeable designation, though that could be updated in the future.
Published: 7/22/2024
Study Results Indicate Potential Method of Reversing Lupus, Opening Doors to Treatment
The authors note they will continue to investigate treatments for patients with lupus as well as safe and effective methods of delivering these molecules to patients.
Published: 7/22/2024
Education Curricula Need to Incorporate Whole-Person Care Beyond Electives
Students express interest in whole-person care and identify it as a gap in their education.
Published: 7/21/2024
Preparing for PrEP: The Implications of PrEP Medicare Coverage Transition for Pharmacies
The shift is intended to maintain uninterrupted access to PrEP, crucial for preventing HIV, and highlights the ongoing efforts to end the HIV epidemic by improving public health outcomes.
Published: 7/21/2024
Zuranolone Offers a Much-Needed Option For Postpartum Depression
However, the cost of zuranolone makes it challenging to access and justify, given study results comparing it with brexanolone.
Published: 7/20/2024
Study: Omega 3 With Mediterranean Diet Could Possibly Aid Acne Severity
Individuals that followed the Mediterranean diet with EPA-DHA supplements displayed an increase in omega-3 levels which improved clinical appearance.
Published: 7/19/2024
TiNivo-2 Trial Does Not Meet Progression-Free Survival For Patients With Renal Cell Carcinoma
There were positive efficacy and safety results for tivozanib monotherapy consistent with previous analyses.
Published: 7/19/2024
Report Shows Pharmacists Play a Critical Role in Blood Pressure Management
The findings showed that pharmacist-led interventions resulted in the greatest systolic blood pressure reductions.
Published: 7/19/2024
Patients With Mantle Cell Lymphoma Face High Risk of Infections Following Diagnosis
In a study of Swedish patients with mantle cell lymphoma, the participants faced a heightened risk of infection after their diagnosis and associated treatment for the disease.
Published: 7/19/2024
Study Shows Value of Investing in Pharmacogenomics Testing for Tacrolimus Dosing in Kidney Transplant Recipients
More cost effectiveness data is crucial in advocating for better insurance coverage in the United States.
Published: 7/19/2024
CrowdStrike Reports Global Outage, Affecting Hospitals, Businesses Across the World
The cause of the outage was deemed to be due to a defect found in a content update for Windows users.
Published: 7/19/2024
Notable Comorbidities and Unmet Needs in Pediatric Asthma
The authors emphasize that clinical research should focus on real-world difficulties, and pediatric asthma control should be seen as a health care priority.
Published: 7/18/2024
Lomecel-B CLEARMIND Phase 2a Trial Results to Be Presented at AAIC
Safety and efficacy findings on Lomecel-B will be presented at the upcoming 2024 Alzheimer’s Association International Conference, which will be held July 28 to August 1.
Published: 7/18/2024
Researchers Identify the Neurological Mechanism Behind Anorexia Nervosa
Acetylcholine deficit observed in patients with anorexia nervosa suggest potential targeted treatment options.
Published: 7/18/2024
Vonoprazan FDA Approved for Heartburn Relief Associated with Non-Erosive Gastroesophageal Reflux Disease
A large portion of the population of patients in the United States with GERD have the non-erosive type of the disease.
Published: 7/18/2024
New Data Suggest Vaccination Reduces Risk of Developing Long Covid
Investigators found that the risk of long COVID decreased over the course of the pandemic.
Published: 7/17/2024
Study Finds 1 in 10 Pregnant Individuals Who Test Positive For COVID-19 Will Develop Long COVID
The investigators note that the high prevalence of long COVID, including in pregnant individuals, emphasizes a need for health care professionals and patients to closely monitor symptoms.
Published: 7/17/2024
Pembrolizumab and Radiotherapy Treatment Shows Benefit in Patients With Relapsed/Refractory Multiple Myeloma
Radiotherapy may have applications beyond symptomatic relief when used in combination with immunotherapy.
Published: 7/17/2024
Better Prevention Strategies Rely on the Monitoring of Outpatient Adverse Drug Events
Currently, limited data show the effect of adverse drug events in the outpatient setting.
Published: 7/17/2024
Severe Pemphigus Vulgaris Successfully Treated With Intravenous Immunoglobulin
A patient with severe and recurrent pemphigus vulgaris achieved lasting remission with a novel intravenous immunoglobulin preparation that had the added benefit of reducing treatment-related side effects.
Published: 7/17/2024
Comparison Shows Eligibility for Vericiguat Wider Than Expected for Heart Failure
Investigators compared the criteria for eligibility in the VICTORIA trial with guideline and label criterion, finding a wider than expected population with heart failure were eligible for vericiguat therapy.
Published: 7/17/2024
Researchers Identify Potential Link Between Semaglutide and Nonarthritic Anterior Ischemic Optic Neuropathy
Use of semaglutide injections may be linked to an increased risk of blindness in patients with diabetes.
Published: 7/16/2024
High-Dose Polyunsaturated Fats Shows Potential in Migraine Prophylaxis
In a meta-analysis, high-dose eicosatetraenoic acid and docosahexaenoic acid had the highest efficacy and lowest dropout rate among pharmacological interventions for migraine.
Published: 7/16/2024
Slideshow: Pharmacists Report Burnout is a Major Driver of Understaffing in Pharmacy Times Survey
On a scale from 1 to 10, respondents rated their feelings of burnout an average of 7.25 in the second annual Pharmacy Times Burnout and Mental Health Survey.
Published: 7/16/2024
Genetic Insights in Taxane-Related Nerve Damage for Breast Cancer Survivors
Prediction model can accurately predict the risk of nerve damage in patients who received taxane-based chemotherapy.
Published: 7/16/2024
Consumer-Wearable Devices for Patients With Heart Failure, Atrial Fibrillation Have Clinical Implications
Consumer-wearable devices can monitor treatment response and provide continuous health data for patients with heart disease and atrial fibrillation.
Published: 7/15/2024
Biosimilar Ranibizumab Could be More Cost-Effective Than Aflibercept for nAMD
Switching from aflibercept (Eylea; Regeneron Pharmaceuticals) to biosimilar ranibizumab (Lucentis; Genentech) for neovascular age-related macular degeneration could be more cost effective for patients.
Published: 7/15/2024
Biosimilar Disease-Modifying Antirheumatic Drugs Show Potential Cost Savings for Rheumatoid Arthritis
After failure with methotrexate, treatment with leflunomide is typically recommended, but treatment with biosimilars could have greater quality-adjusted life years.
Published: 7/15/2024
From Prescription to Prevention: Pharmacists and ASCVD Prevention
The findings highlight the possibility of pharmacists expanding their responsibilities in the provision of other clinical services in community pharmacy practice.
Published: 7/15/2024
G900 Region In Th2 Differentiation May Have Significant Implications in Asthma, Other Conditions
The findings demonstrate that the mG900 region plays a significant role in Type-2 helper T (Th2) cell differentiation and enhances allergic airway inflammation.
Published: 7/15/2024
Study: Unexpected Safety Signals Identified for Semaglutide in Diabetes, Obesity
The FDA has issued a statement on suicidal thoughts or actions and has launched evaluations for that signal as well as alopecia and aspiration.
Published: 7/15/2024
Evolving Standards of Care in the Systemic Treatment of Metastatic Urothelial Cancer
Treatment of advanced/metastatic urothelial cancer has changed dramatically in recent years. This review discusses the use, risks, and benefits of several novel therapies for this indication.
Published: 7/14/2024
Report Shows Substantial Financial Opportunity in Prioritizing Research, Education on Women’s Heart Health
Increased awareness of women's cardiovascular health and the impact of estrogen fluctuation throughout women’s lives on cardiovascular disease could both boost the economy and improve health outcomes.
Published: 7/13/2024
Heterogeneity Observed in Reporting on Drug-Drug Interactions With Proton Pump Inhibitors
An analysis of interaction checkers and product summaries revealed large differences in the consistency and reliability of providing accurate information on potential drug-drug interactions.
Published: 7/12/2024
A Pharmacist’s Guide to Quality Supplements
The United States Pharmacopeia (USP) offers the industry’s most comprehensive auditing and testing program for dietary supplements with its USP Verified Mark.
Published: 7/12/2024
Study Supports Use of Buprenorphine Injections to Treat Minimal to Mild Opioid Use Disorder
Results show that daily injections of buprenorphine over a 7-day period was safe and well-tolerated in patients who had Clinical Opioid Withdrawal Scale scores of 4 to 7.
Published: 7/12/2024
Researchers Identify Links Between Gut Microbiome and Autism, Potentially Paving the Way for New Diagnostics
Unique gut flora were found in children with autism spectrum disorder (ASD).
Published: 7/12/2024
Phase 3 Trial Highlights Efficacy of Dupilumab for EoE in Children Aged 1 to 11
Dupilumab may improve disease severity in children with eosinophilic esophagitis (EoE).
Published: 7/11/2024
Survey Finds Individuals With Dry Eye Are Unsure How to Prevent or Treat Their Symptoms
Prevalence of dry eye is increasing drastically, especially in younger individuals, because of the current lifestyle and increased technology use.
Published: 7/11/2024
Common Surgical Procedures Account for High Share of Opioid Prescriptions in Children and Adults
In pediatric and adult patients, the top 3 surgical procedures accounted for the highest share of opioid prescriptions, indicating a need for better opioid prescription management and greater awareness of the possible opioid-related adverse events that can stem from prescriptions of the drug.
Published: 7/11/2024
FTC Intends to Sue Biggest Pharmacy Benefit Managers for Unfair Negotiating Tactics
In a follow-up to the interim FTC report documenting the business practices of PBMs and the power they hold in the pharmaceutical industry, the Commission now seeks to sue the 3 largest PBMs in the country for driving up the price of insulin and other essential drugs.
Published: 7/11/2024
High-Dose Intravenous Immunoglobulin Responsive to Platelet-Activating Anti-PF4 Disorder
Intravenous immunoglobulin was effective as an adjunctive treatment to anticoagulation in a patient with post-viral platelet-activating anti-PF4 disorder, indicating the need for accurate diagnosis and treatment selection.
Published: 7/11/2024
Updated Guidelines for Statin Therapy in Patients With HIV
Previous studies have shown that individuals living with HIV are at higher risk for heart disease than individuals without HIV
Published: 7/11/2024
McKesson Shares New Initiative to Support Advocacy Efforts for the Pharmacy Profession
Panelists identify key public policies that pharmacies would benefit from acting on in 2024.
Published: 7/10/2024
Utilize CYP2D6-Guided Opioid Therapy for Adults with Cancer Pain
Roughly one-third of patients with cancer do not achieve adequate pain control.
Published: 7/10/2024
Study Finds Gender and Racial Disparities in Youth Psychiatric Inpatient Admissions
The authors emphasize that these findings suggest a need for targeted resources that help reduce boarding and promote equitable access to care.
Published: 7/10/2024
Cisplatin-Based Chemotherapy Linked to Hearing Loss in Cancer Survivors
Extended treatment with high doses of cisplatin-based chemotherapy is associated with severe and progressive hearing loss.
Published: 7/10/2024
FDA Approves Roflumilast for Atopic Dermatitis in Patients 6 Years and Older
Roflumilast is approved as a once daily and steroid-free cream for rapid disease clearance and significant reduction in itch and for long-term disease control.
Published: 7/10/2024
Generative Artificial Intelligence Accurate in Screening Patients with Heart Failure for Clinical Trial Eligibility
The RECTIFIER framework was able to screen patients with heart failure more accurately and with a cheaper cost than traditional screening methods.
Published: 7/10/2024
Study Connects Multivitamin Use With Mortality Risk
Daily multivitamin users were associated with a 4% higher mortality risk compared to nonusers.
Published: 7/9/2024
FTC Report Acknowledges Impact Pharmacy Benefit Managers Have on Cost, Accessibility of Prescription Drugs
In a new report, the FTC says pharmacy benefit managers act as middlemen in the pharmaceutical industry, leading to the squeezing of independent pharmacies and increases in prices for patients.
Published: 7/9/2024
Slow-Release, Oral Ketamine Tablet May Reduce Severity of Treatment-Resistant Depression
The authors note that the oral, at-home treatment can be a better alternative for patients by reducing inconveniences that come with the injectable and nasal administration methods.
Published: 7/9/2024
Pharmacist-Led Deprescribing Efforts Can Reduce Inappropriate Aspirin Use in Older Adults
Older adults who take aspirin for primary prevention of cardiovascular disease are at an increased risk of bleeding.
Published: 7/9/2024
Pharmacists Boost Hepatitis D Treatment Success with Hands-On Education
Treatment often involves a complex daily routine of reconstitution and subcutaneous injection, along with strict storage requirements.
Published: 7/9/2024
Higher COVID-19 Vaccination Rates May Provide Protection Against Symptomatic Asthma in Pediatric Patients
Higher vaccination rates were associated with less prevalent asthmatic symptoms, but additional research is needed to confirm these findings.
Published: 7/9/2024
Brexanolone and Zuranolone for the Treatment of Postpartum Depression
The American College of Clinical Gynecology recommends consideration of brexanolone or zuranolone in postpartum patients with onset of moderate-to-severe perinatal depression in the third trimester or within 4 weeks postpartum.
Published: 7/9/2024
FDA Grants Fast Track Designation to OBX-115 for Advanced Melanoma
The drug is intended to treat individuals with metastatic or locally advanced melanoma.
Published: 7/9/2024
Tattoo Exposure Associated With Increased Risk of Malignant Lymphoma
Individuals with tattoos were found to have a greater risk of developing malignant lymphoma, with the risk being highest within 2 years of receiving a tattoo.
Published: 7/9/2024
Early Intervention Enhances Recovery for Patients With Chronic Regional Pain Syndrome
Early diagnosis and comprehensive treatment may lead to full recovery for patients.
Published: 7/8/2024
Researchers Create New Model for Fish Consumption in Expectant Mothers
Fish are rich in nutrients that aid in brain development, and the model can help provide more guidance for pregnant individuals when consuming seafood.
Published: 7/8/2024
Upadacitinib Shows Superiority to Dupilumab for Atopic Dermatitis With Dose Escalation
When initiated at a 15 mg dose and escalated to 30 mg, upadacitinib showed superiority compared with dupilumab, achieving Eczema Area and Severity Score (EASI) 90 at week 16.
Published: 7/8/2024
Prefilled Syringe of Faricimab-Svoa Approved by FDA for Leading Causes of Vision Loss
Following the previous FDA approval of faricimab-svoa to treat some of the leading causes of vision loss, the Administration has approved a single-dose prefilled syringe of the drug which could lead to safer and more efficient administration while easing patient burden.
Published: 7/8/2024
Homocysteine Concentration Levels May Predict Risk and Severity of Obstructive Sleep Apnea
The findings show that those with higher plasma homocysteine concentrations experienced more sleep apnea events per hour compared with those with lower concentrations.
Published: 7/8/2024
FDA Grants Breakthrough Device Designation to Cardiac Surgery System for Treatment of Atrial Fibrillation
Pulsed field ablation may offer patients an efficacious treatment option with limited damage to surrounding tissues.
Published: 7/8/2024
Machine Learning Model Accurately Predicts Intravenous Immunoglobulin Non-Responders For Kawasaki Disease
By developing the Shizuoka score, which features a new predictive model using machine learning, patients with Kawasaki disease who are non-responders to intravenous immunoglobulin were able to be accurately identified.
Published: 7/8/2024
Mutations in KLHL6 Associated With Tangible Disease Characteristics in Diffuse Large B-Cell Lymphoma
Researchers found that certain mutations in KLHL6 can lead to an increase in the number of B-cell receptors, resulting in poor outcomes for patients with diffuse large B-cell lymphoma.
Published: 7/8/2024
FDA Grants Fast Track Designation to Potential Treatment for Clear Cell Renal Cell Carcinoma
ADI-270 is a gamma delta CAR T-cell therapy candidate targeting CD70-positive cancers.
Published: 7/8/2024
Mapping the Proteogenomic Landscape of Multiple Myeloma: Implications for Targeted Therapy
Researchers identify significant proteins involved in the growth and survival of malignant multiple myeloma cells.
Published: 7/8/2024
Bulevirtide in Combination With PegInterferon Results In Undetectable Hepatitis D RNA Post-Treatment
In the 2 mg bulevirtide (Gilead Sciences) group, 44% of individuals achieved HDV RNA that was undetectable compared with 70% in the 10 mg group.
Published: 7/7/2024
Data-Driven Development: How Real-World Data and AI Are Transforming Clinical Trials
Real-world data and artificial intelligence (AI) are poised to revolutionize drug development by optimizing clinical trials and regulatory approvals, if data quality and patient privacy challenges are addressed.
Published: 7/6/2024
Study: Vitamin D Could Alleviate Negative Impacts of Monosodium Glutamate
Vitamin D could mitigate negative impacts on neurobehavior and weight gain caused by consumption of monosodium glutamate (MSG).
Published: 7/5/2024
Dupilumab Helps Pediatric Patients With Eosinophilic Esophagitis Achieve Histologic Remission
In 2 different dose groups, the majority of patients with eosinophilic esophagitis aged 1 to 11 achieved histologic remission at week 16 compared with patients treated with placebo.
Published: 7/5/2024
ACIP Releases Updated RSV Recommendations
The ACIP recommendations are designed to improve access to RSV vaccination, emphasizing the need to get vaccinated.
Published: 7/5/2024
Tirzepatide Shows Improvements in MASH Without Worsening Fibrosis
Investigators found improvements over the placebo in metabolic dysfunction-associated steatohepatitis without worsening fibrosis across 3 dosing groups.
Published: 7/4/2024
Sodium Restriction in Patients with Heart Failure Does Not Reduce Mortality, Morbidity
This narrative review dispels the long-held belief that reduction in salt intake leads to better health outcomes in patients with heart failure.
Published: 7/4/2024
INHALE-3 Study Data Shows Diabetes Care Is Not “One-Size-Fits-All”
Many patients who took technosphere insulin saw improvements in hemoglobin A1c, but other patients saw worsening with the drug.
Published: 7/4/2024
ADCs: The New Frontier in Cancer Treatment
Antibody-drug conjugates (ADCs) revolutionize cancer therapy by delivering powerful drugs directly to tumors and minimize damage to healthy cells.
Published: 7/4/2024
Insights on the UK's MHRA International Recognition Procedure
The UK’s Medicine and Healthcare Products Regulatory Agency (MHRA) introduced changes to streamline its drug approval processes.
Published: 7/4/2024
Pharmacists Play Essential Role in Managing Dupilumab for Chronic Obstructive Pulmonary Disease
As dupilumab garners positive clinical trial results in patients with chronic obstructive pulmonary disease, it is increasingly important that pharmacists educate themselves on the treatment.
Published: 7/3/2024
FDA Grants Marketing Authorization for Rapid Hepatitis C Test
The test can be performed in settings that operate under the Clinical Laboratory Improvement Amendments waiver, including community pharmacies.
Published: 7/3/2024
Palliative Care Strategies Can Improve the Management of Cardiovascular Disease
Palliative care may help reduce symptoms and improve quality-of-life for patients with cardiovascular disease.
Published: 7/3/2024
The Role of Language Proficiency Assessment in Improving Pharmacy Patient Communication
Validating language proficiency in bilingual pharmacists is crucial for patient safety and communication.
Published: 7/3/2024
Odronextamab Demonstrates Durable Responses in Patients With R/R FL, DLBCL in Ongoing Trial
The results are promising for patients with relapsed or refractory follicular lymphoma and diffuse large B-cell lymphoma, and the trial is ongoing to assess the efficacy of odronextamab in other subtypes.
Published: 7/2/2024
FDA Approves Donanemab-Azbt for Early Symptomatic Alzheimer Disease
Donanemab-azbt is the first and only amyloid plaque targeting therapy that supports stopping therapy when the plaque is removed.
Published: 7/2/2024
Colder Temperatures May Worsen Asthma Symptoms in Pediatric Patients
However, more research is needed to effectively integrate this biomarker into individualized asthma management strategies for pediatric patients.
Published: 7/2/2024
FoundationOne Liquid CDx Receives FDA Approval as a Diagnostic Tool for Patients With BRCA-Mutated mCRPC
FoundationOne Liquid CDx can be used to identify niraparib and abiraterone acetate eligibility in patients with metastatic castration-resistant prostate cancer (mCRPC).
Published: 7/2/2024
Changes in Gender Identity Not Associated With Depressive Symptoms, Study Finds
The findings suggest that exploring gender identity is a normal part of adolescent development for some youths.
Published: 7/2/2024
Community Pharmacies May Benefit From Embracing AI for Enhanced Profitability
Artificial intelligence (AI) may optimize cash pricing strategies in community pharmacies.
Published: 7/2/2024
Research Reveals US Regions With Highest Drugstore Closures
Pennsylvania, California, and New York were within the top 3 states, according to the findings.
Published: 7/2/2024
ACIP Votes to Recommend Pneumococcal 21-Valent Conjugate Vaccine for Adult Populations
The committee, after being presented evidence by the working group, recommended the vaccine for adults aged 65 and older and those 19 or older who have current recommendations to receive a pneumococcal vaccine.
Published: 7/2/2024
IVIG, Plasmapheresis Effective in Managing Non-Tumor Anti-Tr/DNER Antibody-Associated Ataxia
In a rare case of non-tumor anti-Tr/DNER antibody-associated ataxia, the patient is treated with plasmapheresis and intravenous immunoglobulin (IVIG) for symptoms such as dysarthria and difficulty walking.
Published: 7/2/2024
FDA Grants Fast Track Designation to SYNC-T SV-102 for Metastatic Castration-Resistant Prostate Cancer
The designation was approved based on interim data from a phase 1 study that assessed SV-102 among males with metastatic castrate-resistant prostate cancer (mCRPC).
Published: 7/1/2024
FDA Approves Efgartigimod Alfa and Hyaluronidase-Qvfc for Chronic Inflammatory Demyelinating Polyneuropathy
This is the first novel, precision mechanism of action to be released to treat patients with CIDP in over 3 decades.
Published: 7/1/2024
Ongoing Phase 3 LINKER-MM3 Trial Assesses Safety and Efficacy of Linvoseltamab Monotherapy in Patients With RRMM
The monotherapy is compared with the combination regimen of elotuzumab plus pomalidomide and dexamethasone in adult patients with relapsed or refractory multiple myeloma.
Published: 7/1/2024
FDA Grants Fast Track Designation to ABD-147 for Small Cell Lung Cancer
Small cell lung cancer is initially responsive to platinum-based chemotherapy, but it does develop drug resistance over time, furthering the need for better treatment options.
Published: 7/1/2024
Maltreating, Abusive Mothers May Have Neurological Similarities in Common
According to the authors, this vulnerability may stem from either sporadic occurrences of intergenerational chains of childhood abuse.
Published: 7/1/2024
Babies of Mothers Prescribed GLP-1s Prior to Pregnancy May Have Increased Risk of NICU Stays
Additionally, birth weight was higher in babies born to mothers who were prescribed glucagon-like peptide-1 (GLP-1) medications either 90 days prior to pregnancy or during the first trimester.
Published: 7/1/2024
Routine Immunoglobulin G Testing Reduces Infections in Patients with Non-Hodgkin Lymphomas, Chronic Lymphocytic Leukemia
Increased immunoglobulin replacement therapy led to reduced infections and managed secondary immune deficiencies such as hypogammaglobulinemia.
Published: 7/1/2024
FDA Grants Orphan Drug Designation to RCT1100 For Primary Ciliary Dyskinesia
RCT1100 is designed to deliver DNAI1 mRNA directly to affected airways through an inhaled nebulizer and fills an urgent unmet need in the treatment of those with primary ciliary dyskinesia.
Published: 7/1/2024
FDA Approves Ustekinumab-ttwe as Biosimilar to Stelara
Ustekinumab-ttwe (Pyzchiva; Sandoz) is approved for all of the same indications as Stelara.
Published: 7/1/2024
Perinatal Depression May Increase Risk of Cardiovascular Disease in Women
Perinatal depression increases the risk of cardiovascular disease in women.
Published: 7/1/2024
Redefining the Patient Experience: The Critical Role of Pharmacists and Patient Data in Addressing SDOH
Pharmacists can also play a role in SDOH by replacing drug delivery with something else, such as food or transportation delivery, according to speakers at the ATOPP conference.
Published: 6/30/2024
EU Leads in Biosimilar Market Access While US Lags Behind, Faces Challenges in Adoption
The European Union (EU) has successfully created a competitive market for biosimilars, while the US faces challenging market dynamics and tactics by pharmacy benefit managers that hinder the adoption of lower-cost therapies.
Published: 6/29/2024
Navigating the Rapid Expansion of Cellular Therapies: Challenges and Opportunities for Community and Academic Collaboration
Collaboration between community centers and academic medical centers can improve patient access to these complex therapies.
Published: 6/29/2024
Survey: 86% of Users Satisfied With New Automated Insulin Delivery System
Approximately 81% of individual said Tandem Mobi reduced the burden of managing diabetes and 87% said it helped manage diabetes effectively.
Published: 6/28/2024
Targeted Combination Therapy Leads to Durable Response in Patients With Relapsed Diffuse Large B-Cell Lymphoma
Combining multiple drugs to induce a deep response in patients with diffuse large B-cell lymphoma could open curative pathways for those affected.
Published: 6/28/2024
FDA Approves New Drug Application for Tepylute to Treat Breast, Ovarian Cancer
Tepylute is a ready-to-dilute, injectable formula that reduces preparation time and enable dosing accuracy.
Published: 6/28/2024
IgRT in Patients With CLL, NHL Associated With Lower Odds of Infections and Associated Antimicrobial Use
An increased frequency of immunoglobulin G testing in patients with chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) was also associated with a lower likelihood of severe infections.
Published: 6/28/2024
FDA Grants Fast Track Designation to TUB-040 for Ovarian Cancer
Antibody drug conjugate TUB-040 demonstrated superior biophysical properties for treating platinum-resistant ovarian cancer.
Published: 6/28/2024
The Future of Pharmacy: Enhancing Chronic Disease Management With Food Is Medicine
A report from the Milken Institute highlights the crucial role of pharmacists in advancing food is medicine care.
Published: 6/28/2024
Children With Asthma on Medicaid Less Likely to Receive Specialist Care
The findings show that the largest gaps are among pediatric patients with persistent asthma.
Published: 6/28/2024
Teva Launches Generic Formulation of Liraglutide in US
This marks the first launch of a generic glucagon-like peptide 1 receptor agonist.
Published: 6/28/2024
Attitude, Education Among Non-Economic Barriers Hinder Adoption of Biosimilars
Health professionals have expressed concerns regarding consistent naming standards, the regulatory process surrounding the approval of biosimilar drugs, and the lack of education they have about biosimilars.
Published: 6/28/2024
During Drug Shortages, There Are Resources so Pharmacists ‘Never Need to Ration Life-Saving Drugs’
Laura Bray, founder of Angels for Change, explains that addressing the 4 key economic causes to drug shortages can also help lead to effective solutions long-term.
Published: 6/28/2024
Expert: New Research Helps Understanding of the Gut-Brain Axis and Motivational Behavior
American Diabetes Association Scientific Sessions speaker Ivan de Araujo discusses how regulation of blood glucose levels and the influence of food preferences can be significant for diabetes care.
Published: 6/27/2024
FDA Issues Complete Response Letter for the Patritumab Deruxtecan BLA Submission
A biologics license application (BLA) for patritumab deruxtecan receives complete response letter due to inspection findings at third-party manufacturer.
Published: 6/27/2024
FDA Approves Ensifentrine for Maintenance Treatment of Chronic Obtrusive Pulmonary Disorder
After over 2 decades, the first inhaled product with a novel mechanism of action has been approved by the FDA for the treatment of chronic obtrusive pulmonary disorder.
Published: 6/27/2024
FDA Approves Epcoritamab for Treatment of Relapsed, Refractory Follicular Lymphoma
The approval marks the first and only T-cell engaging bispecific antibody administered subcutaneously to treat patients after 2 or more lines of systemic therapy.
Published: 6/27/2024
The Role of Community Health Workers in Improving Patient Outcomes
Heath Mart, part of McKesson, offers an online resource to locate resources near independent pharmacies.
Published: 6/26/2024
Reni-Cel Single Infusion Gene Editing Therapy Demonstrates Positive Results in Patients With Sickle Cell Disease
These findings build off research from March 2023 that demonstrated efficacy and safety of renizgamglogene autogedtemcel in patients with sickle cell disease.
Published: 6/26/2024
Regulatory Considerations Regarding the 503B to 503A Compounding Model For Community Pharmacies
A review of the requirements for pharmacies considering ordering compounds from a 503B facility.
Published: 6/26/2024
Comprehensive Management of Multiple Sclerosis: The Vital Role of Pharmacists
Multiple sclerosis is a debilitating disease affecting many Americans. Pharmacists can help patients control the symptoms that impact their quality of life.
Published: 6/26/2024
Researchers Develop Bread With Probiotic Properties That Reduce Asthma Symptoms in Mice
Mice with asthma that were fed bread with Saccharomyces cerevisiae UFMG A-905 yeast showed reduced airway inflammation and decreased IL-5 and IL-13 concentrations, and effects increased when combined with microcapsules.
Published: 6/26/2024
The Evolving Role of Pharmacy Technicians in Immunization Administration
Pharmacies can position themselves as leaders in immunization services.
Published: 6/26/2024
Moderna’s RSV Vaccine Could Have Further Implications for mRNA Technology
The recent approval could further the use of mRNA technology across other indications.
Published: 6/26/2024
FDA Accepts sNDA for Brexpiprazole for Adult Patients With PTSD
The supplemental new drug application (sNDA) for brexpiprazole is accepted by the FDA for treatment of patients with post-traumatic stress disorder (PTSD).
Published: 6/25/2024
Empowering Women in Pharmacy as Leaders and Owners
Shahida Choudhry, PharmD, shares her journey in pharmacy ownership.
Published: 6/24/2024
Results From the FLOW Trial Show Benefits of Semaglutide on Chronic Kidney Disease
Benefits of semaglutide on cardiovascular outcomes, such as death, non-fatal myocardial infarction, and non-fatal stoke, were also presented at the session at American Diabetes Association 84th Scientific Sessions.
Published: 6/24/2024
Education on Screening for Type 1 Diabetes Can Facilitate Earlier Treatment
Teplizumab (Tzield; Sanofi) has the potential to delay type 1 diabetes and the onset of stage 3 diabetes, but must be started in stage 1 of the disease.
Published: 6/24/2024
FDA Grants Adagrasib Accelerated Approval for Treatment of KRAS G12C-Mutated CRC
Adagrasib receives accelerated approval for patients with previously treated KRAS G12C-mutated locally advanced or metastatic colorectal cancer (CRC).
Published: 6/24/2024
Nicotinamide Riboside Improves Walking in Patients With Peripheral Artery Disease
Compared to placebo, nicotinamide riboside significantly improved the 6-minute walking capabilities in patients with decreased endurance and muscle function due to peripheral artery disease.
Published: 6/24/2024
Educational Nutrition Programs Targeted at Communities Improve Diabetes Outcomes
Food is medicine is a framework of policy and behavioral interventions, improving population health through access to healthy foods to increase food and nutrition security.
Published: 6/23/2024
Implementing Community Health Workers into Pharmacy Reduces Health Equities, SDOH
Adding a community health worker can improve the overall health equity for your patients.
Published: 6/23/2024
Experts Discuss Serious Adverse Events for GLP-1 Medications
Potential concerns surrounding GLP-include pancreatitis, pancreatic cancer, colorectal cancer, suicide and other phycological effects, and thyroid cancer.
Published: 6/23/2024
ADA Panel: Diabetes Access Has Come a Long Way, But It Is Not Enough
There are approximately 98 million individuals have prediabetes, but approximately only 15 million actually know they have prediabetes.
Published: 6/22/2024
SELECT Trial: Semaglutide Improves Glycemic Control For Patients at High Risk of Cardiovascular Disease
Semaglutide was found to have effects on glycemia, inflammation, and heart failure outcomes in sub analyses.
Published: 6/22/2024
SURMOUNT-OSA: 4 in 10 Who Need CPAP Would No Longer Need It With Tirzepatide
Based on these results, tirzepatide could be first medication approved for treatment of obstructive sleep apnea in patients with obesity.
Published: 6/22/2024
Experts: Treatment with GLP-1 Medications Involves Many Factors Beyond Weight Loss
Managing these treatments involves many considerations, including glycemic control and nutrition, among others.
Published: 6/22/2024
BENEFIT Trial Results Show Quadruplet Regimen for NDMM TI May Require Weighing Efficacy vs Safety
The quadruplet regimen added bortezomib to the current standard of care, which is a triplet regimen of isatuximab, lenalidomide, and dexamethasone for patients with transplant-ineligible, newly diagnosed multiple myeloma (NDMM TI).
Published: 6/21/2024
New Innovative Treatments Are On The Horizon for Diabetic Kidney Disease
Presenters at the American Diabetes Association 84th Scientific Sessions analyzed potential developments in treatment for patients with diabetes and diabetic kidney disease.
Published: 6/21/2024
Navigating the Complex Landscape of Cell and Gene Therapy: Challenges and Solutions
There are numerous challenges with cell and gene therapies in oncology, such as accessibility, cost, and prior authorizations, as well as the need for improved education and training within the oncology community.
Published: 6/21/2024
Insights Into the Evolving Landscape of Hematology Treatment
Tim Mok, PharmD, BCOP, BCPS, discusses innovative therapies that are changing the treatment options available for patients with hematologic malignancies.
Published: 6/21/2024
FDA Commissioner Says the United States Is Failing the Type 2 Diabetes Epidemic
With improved technology and innovations for diabetes, it is essential for health care providers and health agencies to collaborate to combat rising rates of diabetes.
Published: 6/21/2024
FDA Expands Approval of Delandistrogene Moxeparvovec-rokl for Duchenne Muscular Dystrophy
After being previously approved in June 2023 under an Accelerated Approval process, the FDA has granted an expanded approval for non-ambulatory individuals and individuals 4 years of age or older.
Published: 6/21/2024
Expert: Pharmacists Play Key Role in Diabetes Management and Treatment Adherence
American Diabetes Association Scientific Sessions speaker Ivan de Araujo emphasizes the importance of the pharmacist’s role in diabetes care and his hopes for the future of care.
Published: 6/21/2024
5 Key Sessions and Interviews at McKesson ideaShare 2024
Pharmacy Times will be at McKesson ideaShare 2024 Conference in New Orleans, Louisiana from June 23 to June 26, 2024.
Published: 6/21/2024
Lifileucel Shows Promise for Melanoma, Yet Challenges Remain for Community Implementation
Additionally, the high cost of the cell therapy raises concerns for broader access.
Published: 6/20/2024
FDA Approves Sofpironium, First Treatment for Primary axillary Hyperhidrosis
Hyperhidrosis affects an estimated 10 million individuals in the US and is characterized by abnormally increased sweating, beyond what is necessary to regulate body temperature.
Published: 6/20/2024
Study: Ultraviolet-B Radiation Could Improve Widespread Vitamin D Deficiency
Ambient-UVB radiation could improve 25(OH)D prediction in the future, improving widespread vitamin D deficiencies among non-White individuals.
Published: 6/20/2024
Study Finds Relative Age Effect on ADHD Diagnosis and Prescription of Medication in Children
Autism spectrum disorder was also evaluated in the analysis, but further research is required to determine a possible association with relative age effect.
Published: 6/20/2024
Study: No Differences Between Biosimilar TNFα-inhibitor, Reference Products for Long-Term Survival
Investigators compared the reference products of adalimumab (Humira; AbbVie) and etanercept (Enbrel; Amgen) with biosimilar products.
Published: 6/20/2024
5 Key Sessions at the American Diabetes Association 84th Scientific Sessions
Pharmacy Times will be at the American Diabetes Association (ADA) 84th Scientific Sessions in Orlando, Florida from June 21 to June 24, 2024.
Published: 6/20/2024
Acalabrutinib Combination Treatment Improves Progression-Free Survival in Patients With Previously Untreated MCL
Compared with standard of care chemoimmunotherapy, acalabrutinib with bendamustine and rituximab reduced risk of death or disease by approximately 27%.
Published: 6/19/2024
Traditional Chinese Medicine Compound Reduces Risk of Progression for Those With Prediabetes
Impaired glucose tolerance is a significant risk factor for developing diabetes.
Published: 6/19/2024
Axicabtagene Ciloleucel Safe and Tolerable for Relapsed, Refractory Central Nervous System Lymphoma
Participants in the study had durable response for over 1 year, in addition to positive efficacy indicators.
Published: 6/19/2024
The Role of the Planetary Health Diet in Combating Chronic Diseases, Climate Change
Adopting the Planetary Health Diet may reduce overall risk of chronic disease and premature death.
Published: 6/19/2024
Study Finds Asthma Severity is Not Associated With Reactivity to Allergen Skin Testing
The findings also show that skin testing positivity for perennial allergens was higher in patients with childhood-onset asthma compared with those with adult-onset asthma.
Published: 6/18/2024
Exploring the Connection Between Orange Peels, Gut Metabolism, and Heart Health
Study shows that orange peel extract may reduce risk of heart disease and adverse cardiovascular events.
Published: 6/18/2024
FDA Approves Pembrolizumab With Chemotherapy to Treat Adult Patients With Endometrial Carcinoma
The indication is for adult patients with primary advanced or recurrent endometrial carcinoma and is the third indication that pembrolizumab has received for this disease state.
Published: 6/18/2024
FDA Approves V116 for Prevention of Invasive Pneumococcal Disease and Pneumonia
V116 (Capvaxive; Merck) elicited higher immune responses than the comparator for the serotypes that are unique to the vaccine, according to studies submitted to the FDA.
Published: 6/18/2024
E-Cigarette Exposure May Increase Risk of Atopic Dermatitis in Children
Secondhand exposure to e-cigarette smoke may increase risk of pediatric atopic dermatitis in children.
Published: 6/18/2024
FDA Approves Blinatumomab for Adult and Pediatric Patients With B-ALL
The FDA approved blinatumomab for treatment of patients with CD19-positive Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia.
Published: 6/17/2024
FDA Approves Durvalumab Plus Chemotherapy to Treat Endometrial Cancer
Durvalumab plus carboplatin and paclitaxel, continued with durvalumab monotherapy, decreased the risk of disease progression or death by 58%.
Published: 6/17/2024
Study: Mim8 Shows Reductions in Treated Bleeds for Patients With Hemophilia A
Mim8 had a safe and well-tolerated profile, with no deaths or thrombotic events reported for patients with hemophilia A.
Published: 6/17/2024
FDA Approves the Intravenous Immunoglobulin G Yimmugo to Treat Primary Immunodeficiencies
With this approval, Yimmugo is the first approved product from the Biotest Next Level production facility.
Published: 6/17/2024
CDC Evaluates Concerns of Guillain-Barré Syndrome Following RSV Vaccination
Data show that among individuals 60 years and older, the estimated rate of Guillain-Barré syndrome (GBS) after receiving an RSV vaccine was 5.0 and 1.5 per million doses of Abrysvo and Arexvy, respectively.
Published: 6/17/2024
Children Exposed to Weed and Tree Pollen in Urban Areas May Experience Increased Risk of Asthma Onset
The study results also found that exposure to tree canopy area may protect children from asthma development; however, efficacy decreased as weed pollen exposure increased.
Published: 6/15/2024
Zanubrutinib Emerges as Potential First-Line Therapy in Patients with High-Risk CLL/SLL
Zanubrutinib shows potential in treating patients with treatment-naïve high-risk chronic lymphocytic leukemia and/or small lymphocytic lymphoma with del(17p) and/or TP53 mutation.
Published: 6/14/2024
Trametinib Demonstrates Potential as a First-Line Treatment for Pediatric Patients with JMML
Trametinib may become an alternative treatment to hematopoietic stem cell transplantation in patients with relapsed or refractory juvenile myelomonocytic leukemia (JMML).
Published: 6/14/2024
Brentuximab Vedotin Shows 37% Reduction in Risk of Death for DLBCL
Brentuximab vedotin in combination with lenalidomide and rituximab had a favorable safety profile for patients with relapsed/refractory diffuse large B-cell lymphoma.
Published: 6/14/2024
Study Finds Similarities Between SB16 and Denosumab for Osteoporosis Treatment Up to 18 Months
The new findings were presented as an oral presentation at the 2024 European Calcified Tissue Society Congress, held from May 25, 2024, to May 28, 2024.
Published: 6/14/2024
FDA Approves Repotrectinib for NTRK-Positive Locally Advanced, Metastatic Solid Tumors
Repotrectinib has also shown significant efficacy in ROS1 fusion-positive non¬–small cell lung cancer (NSCLC), which was also studied in the TRIDENT-1 trial.
Published: 6/14/2024
Researchers Seek to Understand Clinical Significance of Chromosome 1q Abnormalities in Multiple Myeloma
Amplification of chromosome 1q is associated with poorer treatment outcomes for patients with relapsed/refractory and newly diagnosed multiple myeloma.
Published: 6/13/2024
FDA Approves Tralokinumab-ldrm Autoinjector for Adults With Atopic Dermatitis
The autoinjector will provide another option for adults in addition to the prefilled syringe that is currently available.
Published: 6/13/2024
Supreme Court Rejects Challenge to Limit Mifepristone Access for Abortion
With the new ruling, announced Thursday, the pills will continue to be able to be mailed to patients without an in-person visit with a physician.1
Published: 6/13/2024
Study Finds Association Between Sodium Intake and Risk of Atopic Dermatitis
Reducing sodium intake is associated with decreased risk of atopic dermatitis (AD) and flares.
Published: 6/13/2024
Poor Diet Quality Associated With Structural Brain Changes in Common Mental Health Concerns
Eating a poor diet might lead to structural brain changes that cause the development of common mental disorders (CMD).
Published: 6/13/2024
Understanding Depression: Risk Factors and Evolving Treatments
At ASHP Pharmacy Futures 2024, Mei T. Liu, PharmD, BCPP, highlights the global prevalence and multifaceted nature of depression, its bidirectional relationship with medical conditions, and the need for diverse, evidence-based treatment options.
Published: 6/13/2024
Hepatitis C: Addressing the ‘Silent Syndemic’ and Improving Access to Care
Lindsey P. Sheehan, PharmD, MPA, MBA, discusses ongoing challenges of diagnosing and treating hepatitis C, emphasizing its increased incidence among younger populations and ongoing low rates of diagnosis.
Published: 6/12/2024
FDA Approves Dapagliflozin For Pediatric Patients With Type 2 Diabetes
The indication is for the improvement of glycemic control in pediatric patients aged 10 and older with type 2 diabetes and comes after positive results from the phase 3 T2NOW clinical trial.
Published: 6/12/2024
FDA Gives Clearance to 2 OTC Continuous Glucose Monitoring Systems
Continuous glucose monitoring systems offer timely biofeedback for patients with type 2 diabetes.
Published: 6/12/2024
Valoctocogene Roxaparvovec-Rvox Demonstrates Long-Term Safety and Efficacy in 4-Year Clinical Trial Data
A 1-time infusion of valoctocogene roxaparvovec had demonstrated sustained bleed control and factor VIII expression in patients with hemophilia A.
Published: 6/12/2024
Neurobiologically Informed DMN Effective Connectivity Model Accurately Predicts Individual Development of Dementia
The default-mode network method, which was analyzed using functional magnetic resonance imaging scans, was approximately 80% accurate when predicting dementia up to 9 years prior to a diagnosis.
Published: 6/12/2024
Luspatercept Reduces Transfusion Burden Compared With Epoetin Alfa
Individuals with very low- to intermediate-risk myelodysplastic syndromes treated with luspatercept (Reblozyl; Bristol Myers Squibb) achieved improvements in hemoglobulin levels.
Published: 6/12/2024
Pharmacists Play Crucial Role in Dupilumab Treatment for Infants, Young Children With Atopic Dermatitis
Parents and caregivers sometimes have concerns about their children receiving these injections, but researchers and experts assure that the FDA-approved biologic is safe and effective in young populations.
Published: 6/12/2024
FDA Grants Accelerated Approval for Elafibranor as Treatment of Primary Biliary Cholangitis
Elafibranor (Iqirvo; GENFIT) is a first-in-class, once daily oral peroxisome proliferator-activated receptor for the treatment of primary biliary cholangitis.
Published: 6/12/2024
Navigating the Deluge of Clinical Literature During and After COVID-19: Insights From ASHP Pharmacy Futures 2024
Speakers at American Society of Health-System Pharmacists (ASHP) Pharmacy Futures 2024 discuss the significant increase in published clinical literature during and after the COVID-19 pandemic, and the evolving role and reliability of AI tools such as ChatGPT in providing accurate medical information.
Published: 6/12/2024
FDA Panel Endorses Donanemab to Treat Early-Stage Alzheimer Disease
Donanemab was able to significantly slow clinical progression of Alzheimer disease and amyloid and tau pathology at 76 weeks of treatment.
Published: 6/11/2024
FDA Grants Emergency Use Authorization for 4-in-1 Respiratory Diagnostic Test
The 4-in-1 respiratory diagnostic test is either a single nasopharyngeal or anterior nasal swab that can confirm or rule out SARS-CoV-2, influenza A virus, influenza B virus, and respiratory syncytial virus with a single test.
Published: 6/11/2024
FDA Approves Sarilumab for Active Polyarticular Juvenile Idiopathic Arthritis
Polyarticular juvenile idiopathic arthritis is a form of arthritis that affects multiple joints at one time.
Published: 6/11/2024
Study Finds Link Between Xylitol and Increased Risk of Heart Attack, Stroke
Research has found that increased consumption of sugar alcohols, like xylitol, may increase risk of cardiovascular events.
Published: 6/11/2024
Balancing Trust and Technology: The Role of AI in Patient-Pharmacist Interactions
At ASHP Pharmacy Futures 2024, Casey Olsen, PharmD, explains that AI can affect patient trust in providers, with implications for the importance of learning to balance use of technology with human elements in clinical settings.
Published: 6/11/2024
Addressing Disparities in AI-Driven Diagnostics: Ethical and Practical Implications
At the ASHP Pharmacy Futures 2024 conference, Scott D. Nelson, PharmD, MS, ACHIP, FAMIA, discusses research showed that although AI models can significantly enhance diagnostic accuracy, they can also exacerbate existing disparities.
Published: 6/11/2024
The Disruptive Impact of AI in Health Care
Kenneth A. Richman, PhD, discusses the disruptive nature of artificial intelligence (AI) in health care, highlighting both its transformative potential and the ethical considerations of governability and sustainability in its implementation.
Published: 6/11/2024
Exploring the Expansive Role of AI in Clinical Pharmacy: Insights From ASHP Pharmacy Futures 2024
The impact of artificial intelligence (AI) on health care is growing, from diagnostics to drug discovery.
Published: 6/10/2024
FDA Grants Osimertinib Priority Review for Patients With Unresectable, Stage III EGFR-Mutated Lung Cancer
Osimertinib demonstrates improved progression-free survival for stage 3 epidermal growth factor receptor-mutated (EGFRm) lung cancer.
Published: 6/10/2024
FDA Approves Expanded Age Indication for Arexvy RSV Vaccine
The expanded indication is for the prevention of respiratory syncytial virus-associated lower respiratory tract disease in adults aged 50 through 59 years who are at an increased risk.
Published: 6/10/2024
Early Diagnosis and Intervention in Asthma, COPD Reduces Health Care Utilization
Patients with undiagnosed asthma or COPD who received usual care from their primary providers were more likely to visit the hospital or specialists because of respiratory illness.
Published: 6/10/2024
Vigorous Physical Activity Linked to Reduced Cognitive Decline in Patients with High-Risk Hypertension
Study reveals vigorous physical activity correlates with lower rates of cognitive impairment in hypertensive patients.
Published: 6/10/2024
Conditioning Regimens Followed by alloSCT Demonstrates Long-Term Survival With R/R AML
After allogeneic stem cell transplantation overall survival and relapse-free survival rates in patients with relapsed or refractory acute myeloid leukemia were 52% and 47%, respectively.
Published: 6/10/2024
Uptake of Teplizumab for T1D Requires Better Education About Screening
To qualify for therapy, patients must be screened for type 1 diabetes islet autoantibodies when they are asymptomatic, which requires better education on screening opportunities.
Published: 6/10/2024
FDA Approves Tirbanibulin for Actinic Keratosis on Expanded Area of Face or Scalp
The new approval increases the previous dosing for surface area treatment from 25 cm2 to up to 100 cm2.
Published: 6/10/2024
Study Finds Alterations in Functional Connectivity of Brain Regions in Adolescents With Internet Addiction
The authors noted that these networks have a significant role in intellectual ability, physical coordination, working memory, emotional processing, and overall mental health.
Published: 6/10/2024
Third Person in US Tests Positive for H5N1 Bird Flu, CDC Emphasizes Risk Remains Low
Compared to other cases, the most recent patient reported more flu-like symptoms, including cough, congestion, watery eyes, and sore throat.
Published: 6/9/2024
Study: Larger Lifetime Cost Savings for V116 Compared With PCV20
Serotypes associated with V116 (Merck & Co. Inc.) had higher clinical and economic burden for individuals with invasive pneumococcal disease.
Published: 6/8/2024
FDA Grants Orphan Drug Designation to AGMB-447 for Idiopathic Pulmonary Fibrosis
Currently, the drug is being evaluated in a phase 1 clinical trial to determine the safety and efficacy in patients.
Published: 6/7/2024
Janssen RSV Protein Vaccine Displays Long-Term Efficacy Among Older Adults
A single dose of the vaccine showed long-lasting protection against RSV-associated lower respiratory tract disease in older adults.
Published: 6/7/2024
FDA Approves Imetelstat for Lower-Risk Myelodysplastic Syndromes With Transfusion-Dependent Anemia
Imetelstat (Rytelo; Geron Corp) is a first-in-class telomerase inhibitor.
Published: 6/7/2024
Inebilizumab-Cdon Reduces Risk of IgG4-Related Disease Flares By 87% In Adult Patients
According to investigators, the primary and key secondary end points were met during the 52-week placebo-controlled period of the trial.
Published: 6/7/2024
Computational Drug Repurposing Approaches Can Help Identify New Medications for Opioid Use Disorder
Five medications (tramadol, olanzapine, mirtazapine, bupropion, and atomoxetine) were associated with significantly better OUD remission.
Published: 6/7/2024
Study: Healthy Adults Unlikely to Benefit From Excess Vitamin D
Endocrine Society Guidelines suggest adults 75 years and older should take the recommended daily dose of vitamin D and are unlikely to benefit from more.
Published: 6/7/2024
Cost Remains Significant Barrier to Respiratory Care for Patients
By improving health insurance coverage and cost of inhalers, such as out-of-pocket caps, access to care can be increased. Some companies are aiming to improve access by implementing price caps.
Published: 6/6/2024
Mirikizumab Shows Improvements Across Clinical, Endoscopic Outcomes for Crohn Disease
Mirikizumab met both co-primary end points and all secondary end points at week 52, according to results presented at Digestive Disease Week in Washington DC.
Published: 6/6/2024
Understanding the Connection Between Genetic Risk and Brain Cell Activity in Autism Spectrum Disorder
Over the course of 15 years, epigenetic and transcriptional analysis of postmortem brain samples have revealed underlying molecular differences.
Published: 6/6/2024
FDA Accepts Biologics License Application for Denosumab Biosimilar Candidate
FKS518 (Fresenius Kabi) would be indicated for the treatment of osteoporosis in men and women, including glucocorticoid-induced osteoporosis and bone loss due to prostate or breast cancer.
Published: 6/6/2024
Researchers Find Shared Multiomic Molecular Dysregulations in Brains With PTSD and MDD
The investigators are optimistic that the data can establish stress-related pathways while revealing potential therapeutic options for patients with major depressive disorder and post-traumatic stress disorder.
Published: 6/5/2024
PALOMA-2 Trial Advances SC Amivantamab, Lazertinib for Advanced NSCLC With EGFR Mutations to the First Line
Nicolas Girard, MD, PhD, discusses the results of the PALOMA-2 trial, highlighting the subcutaneous (SC) delivery of amivantamab combined with lazertinib as a first-line treatment for advanced non-small cell lung cancer (NSCLC) with EGFR mutations.
Published: 6/5/2024
Poor Cardiovascular Health in Women Linked to Cognitive Decline in Midlife
Data show women with poor cardiovascular health may have an increased risk of early signs of cognitive decline in midlife.
Published: 6/5/2024
Study: Tezepelumab Reduces Annual Rates of Exacerbations Related to COPD
For patients with a blood eosinophil count of 150 cells/µL or greater, tezepelumab had a significant reduction of approximately 37% in the rate of moderate or severe exacerbations.
Published: 6/5/2024
New Data Show Benefits of Liso-Cel in B-Cell Lymphoma
Lisocabtagene maraleucel is being investigated for mantle cell lymphoma, relapsed or refractory (R/R) large B-cell lymphoma, and R/R follicular lymphoma.
Published: 6/5/2024
Educate Caregivers About Proper OTC Cold and Cough Medications for Children
Approximately 40% of caregivers make dosing errors when administering liquid medication to children.
Published: 6/5/2024
Study: Prevalence of Diabetes Expected to Increase by 59.7% in 2025
Body mass index is the main driver of type 2 diabetes globally, accounting for 52.2% of disability-adjusted life years.
Published: 6/5/2024
FDA Advisory Panel Rejects MDMA-Assisted Therapy for PTSD
The panelists expressed concerns about clinical trial data and concluded that the benefits do not outweigh the risks, but the FDA does not have to follow their recommendation.
Published: 6/4/2024
Pharmacy Technician Immunizers Can Provide The Much Needed Shot In The Arm For Community Pharmacies
The immunizing technicians stated they had greater job satisfaction and had a greater sense of being valuable pharmacy members
Published: 6/4/2024
mRNA-4157 (V940) Plus Pembrolizumab Shows Sustained Improvements in RFS and DMFS in Patients With High-Risk Melanoma
Compared with pembrolizumab alone, the combination treatment showed stronger recurrence-free survival and distant metastasis-free survival in patients with resected high-risk stage III or IV melanoma.
Published: 6/4/2024
Study Finds No Association Between Physical Activity, Coronary Artery Calcium Progression
In prior studies, higher levels of physical activity were associated with higher prevalence of coronary artery calcium.
Published: 6/4/2024
Sustained MRD-Negativity With Sc Daratumumab in Newly Diagnosed Multiple Myeloma
Data from the PERSEUS trial supports use of daratumumab in combination with bortezomib, lenalidomide, and dexamethasone followed by daratumumab and lenalidomide maintenance as a new standard of care for patients with newly diagnosed multiple myeloma.
Published: 6/4/2024
Study Finds Adults Who Use ENDS Have Increased Risk of Asthma Incidence at Earlier Ages
Adults who did not report past 3-day electronic nicotine delivery system use did not have an increased risk of asthma incidence.
Published: 6/4/2024
Phase 3 DREAMM-8 Trial Data Show Superior Efficacy of BPd vs PVd in Relapsed/Refractory Multiple Myeloma
The study showed that belantamab mafodotin plus pomalidomide and dexamethasone (BPd) significantly improved progression-free survival compared to pomalidomide plus bortezomib and dexamethasone (PVd).
Published: 6/4/2024
Asciminib Shows Superior Efficacy, Favorable Safety in Patients With Newly Diagnosed Chronic Myeloid Leukemia
Asciminib demonstrated stronger efficacy, safety, and tolerability, as well as less adverse events in patients compared with those who received investigator-selected standard-of-care tyrosine kinase inhibitors.
Published: 6/3/2024
Daratumumab Treatment Advancements in Newly Diagnosed Multiple Myeloma
Daratumumab in combination with standard treatment regimens shows benefit in multiple myeloma.
Published: 6/3/2024
American Heart Association Says Obesity Care Depends on Addressing Gaps, Reducing Stigma
Providers, the community, health systems, and health policies can all play a part in addressing various challenges in care for obesity.
Published: 6/3/2024
Patients With SCD Who Experience Longer Delays Transitioning Between Care More Likely to Be Hospitalized
Patients with sickle cell disease with more than a 6-month delay transitioning from pediatric to adult care were about twice as likely to be hospitalized.
Published: 6/3/2024
T-DXd New Standard of Care Following ET in HER2-Low, -Ultralow HR+ Metastatic Breast Cancer
Data presented at ASCO 2024 show fam-trastuzumab deruxtecan-nxki (T-DXd) delayed cancer growth in patients with hormone receptor-positive (HR+), HER2-low or -ultralow disease that progressed following endocrine therapy (ET).
Published: 6/3/2024
Osimertinib New Standard of Care for Stage 3, EGFRm NSCLC
The phase 3 LAURA trial data presented at ASCO 2024 showed osimertinib (Tagrisso; AstraZeneca) reduced risk of disease progression or death in patients with stage 3 EGFR-mutated (EGFRm) non–small cell lung cancer (NSCLC) by 84%.
Published: 6/2/2024
REACH PC Trial: Early Palliative Care Via Telehealth Has Equivalent Efficacy to On-Site Visits for Patients With Advanced NSCLC
Results from the trial provide evidence bolstering ASCO’s clinical practice guideline supporting the integration of early palliative care into standard oncology practice.
Published: 6/2/2024
Advancing Targets: Latest FDA Approvals, Strategies in NSCLC Treatment Unveiled at ASCO 2024
Matthew A. Gubens, MD, MS, FASCO, highlights the importance of identifying genetic targets in metastatic non–small cell lung cancer (NSCLC), emphasizing the latest updates and strategies.
Published: 6/2/2024
Research Finds In Utero Exposure to Ocrelizumab Not Associated With Increased Adverse Pregnancy, Infant Outcomes for Women With MS
This is the largest dataset of pregnancy outcomes for an anti-CD20 therapy in MS, enabling a more comprehensive understanding of ocrelizumab’s safety.
Published: 6/1/2024
NATALEE Data Show Ribociclib Reduces Risk of Recurrence for High-Risk Node-Negative Early Breast Cancer
The addition of ribociclib (Kisqali; Novartis) to endocrine therapy demonstrated a 28% risk reduction in invasive disease-free survival.
Published: 6/1/2024
FDA Grants Inavolisib Priority Review for Treatment of PIK3CA-Mutated Breast Cancer
The priority review of inavolisib is for treatment of patients with advanced hormone receptor-positive, HER2-negative breast cancer with a PIK3CA mutation.
Published: 5/31/2024
Cannabis Use Can Exacerbate Cognitive Declines in Patients With Multiple Sclerosis
Although this data seems to overwhelmingly suggest that cannabis use has negative impacts for individuals with multiple sclerosis (MS), listening to patients’ reasoning for using it is crucial.
Published: 5/31/2024
Receiving Epidural Analgesia During Labor May Reduce Serious Maternal Complications
Women who received epidural analgesia during labor were less likely to experience severe maternal morbidity complications, such as heart attack or heart failure and sepsis.
Published: 5/31/2024
FDA Approves mRNA-1345 for Protection Against Lower Respiratory Tract Disease Caused by RSV
This is Moderna's second mRNA vaccine approval and the first mRNA vaccine approved for an indication other than COVID-19.
Published: 5/31/2024
Quadruple Therapies Including Immunotherapy Agents Show Benefit in Multiple Myeloma
Quadruple therapies including immunotherapy agents show promise in treating patients with multiple myeloma.
Published: 5/31/2024
Subcutaneous Ocrelizumab Provides New Administration Opportunities for Multiple Sclerosis
Subcutaneous ocrelizumab can be delivered in approximately 10 minutes and deliver comparable clinical benefit and safety to the IV formulation.
Published: 5/31/2024
Ongoing Phase 2/3 Trial Evaluates Efficacy of mRNA-1345 Vaccine for RSV
The study compares the safety and efficacy of mRNA-1345 compared to placebo.
Published: 5/31/2024
Quality Improvement Methodology Increases Pneumococcal Vaccination for Patients With Rheumatic Diseases
Pediatric patients with rheumatic disease, such as systemic lupus erythematosus, mixed connective tissue disease, juvenile dermatomyositis, and systemic vasculitis are at an increased risk of serious infection.
Published: 5/31/2024
Undercover Shoppers Experience Challenges in Accessing Legal, Clean OTC Needles in Arizona
Study investigators hired undercover shoppers, and the results revealed more education is needed on the Syringe Service Program, which provides legal, clean over-the-counter (OTC) needles to whomever seeks them out.
Published: 5/31/2024
Once Weekly Efsitora Shows Non-Inferiority in A1c Reductions Compared With Daily Basal Insulin
Topline results of QWINT-2 and QWINT-4 met the primary end point of change in hemoglobin A1c compared to degludec and glargine, respectively, for those with type 2 diabetes.
Published: 5/31/2024
Going Back to the Basics: An Asthma Review
A review of asthma guidelines, pharmacotherapy, and the role of the pharmacist.
Published: 5/30/2024
Study: New Tools Aid Development of Drugs for Respiratory Syncytial Virus
Tools provide a safer testing option without using the viral proteins that cause infection.
Published: 5/30/2024
FDA Approves Lisocabtagene Maraleucel for Treatment of Relapsed/Refractory Mantle Cell Lymphoma
Lisocabtagene maraleucel (Breyanzi; Bristol Myers Squibb) is a CD19-directed CAR T-cell therapy that is delivered as a one-time infusion.
Published: 5/30/2024
Pharmacists Compare Experiences With Multiple Sclerosis at Large Academic Institutions, Small Private Practices
Although resources were scarce for teams at smaller private practices, the pharmacists all agreed that patient care is always the priority.
Published: 5/30/2024
Data Show Disadvantaged Groups Have Significant Need for Lung Cancer Screening
Individuals from a lower socioeconomic group showed more benefits from low-dose CT screening relating to lung cancer survival.
Published: 5/30/2024
Carefully Consider Strategies When Switching Disease-Modifying Therapies for MS
There has been a general shift toward earlier treatment and less tolerance for clinically silent disease activity.
Published: 5/30/2024
FDA Approves Deutetrabenazine Once-Daily Extended-Release Tablets to Treat TD and HD Chorea
The treatment is indicated for adult patients with tardive dyskinesia and Huntington disease chorea, with tablets now available in 4 different doses.
Published: 5/30/2024
Baby Steps to a Healthier You: Prioritizing Lifestyle Changes Over Medication
Take these 4 steps to help prevent health conditions and disease naturally.
Published: 5/30/2024
FDA Grants Priority Review for Zanidatamab to Treat HER2-Positive Metastatic Biliary Tract Cancer
If approved, zanidatamab will be the first HER2-targeted treatment indicated for individuals with this type of biliary tract cancer.
Published: 5/30/2024
Mental Health Awareness Month: Reducing the Stigma Starts in Pharmacies
Lenora Newsome, PD, president of the National Association of Boards of Pharmacy, explores how pharmacists can support mental health through private conversations, and educating about prescriptions.
Published: 5/30/2024
Growth of MS Treatment Options Presents Challenges, Opportunities for Pharmacists to Get Involved
Although questions remain about ideal treatment strategies, consistent data have shown that patients should be treated early.
Published: 5/29/2024
FDA Approves Clonidine Hydrochloride For Treatment of ADHD in Pediatric Patients
The treatment is the first liquid non-stimulant for attention deficit hyperactivity disorder to be approved in the United States.
Published: 5/29/2024
Breaking Barriers: Overcoming Gender Discrimination Among Women Oncologists
Gender disparities among oncology health care professionals have significant consequences for both the physicians and the patients they treat.
Published: 5/29/2024
FDA Approves Eculizumab-Aeeb as Interchangeable Biosimilar for 2 Rare Diseases
Eculizumab-aeeb (Bkemv; Amgen) is approved for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.
Published: 5/29/2024
Semaglutide Shows Sustained Weight Loss Over 4 Years
Added data from the SELECT trial helps to increase confidence in safety and efficacy of semaglutide, a glucagon-like peptide 1 medication.
Published: 5/28/2024
Study: Third of Individuals With Actinic Keratosis Unaware of Its Cause
Although sun-protective measures have been increasing, the incidence of skin cancer has also increased, suggesting better targeted interventions and patient education are needed.
Published: 5/28/2024
Study Finds SMART Combination Inhaler Regimen For Asthma Treatment Is Under Prescribed
The study estimates that over 40% of academic pulmonary and allergy providers have not adopted the Single Maintenance and Reliever Therapy combination method in their practices.
Published: 5/28/2024
FDA Accepts Isatuximab for Priority Review for Treatment of Transplant-Ineligible Multiple Myeloma
Isatuximab is used in combination with bortezomib, lenalidomide, and dexamethanose.
Published: 5/28/2024
Breast Cancer Endocrine Therapy Nonpersistence, Nonadherence Associated With Socioeconomic and Behavioral Factors
The authors note further research on technological monitoring methods can help health care providers better optimize patient care and improve nonadherence and nonpersistence.
Published: 5/28/2024
Study Uncovers Demographic Disparities in Access to AutoHCT Therapy for Patients with Multiple Myeloma
UC Davis Health researchers uncover substantial treatment disparities and inequal access to autologous hematopoietic cell transplantation therapy among multiple myeloma patients.
Published: 5/27/2024
Study Finds Guidance Is Needed for Health Technology Assessments of Biosimilars
Australia, Québec, and Sweden have defined processes for reimbursements by health technology assessments, but the United States has a low reliance rate.
Published: 5/27/2024
Omega-3 Supplements Could Benefit Children’s Brain Development
Researchers aimed to explore impacts of omega-3 fatty acids on children’s behavior, mood, and sleep.
Published: 5/26/2024
Study Finds Associations Between Extreme Heat and Asthma-Related Hospital Visits in Children
The findings demonstrated that daytime heat waves were associated with approximately 19% higher odds of asthma-related hospitalizations in children.
Published: 5/25/2024
Palliative Care and Harm Reduction: Improving Outcomes for Patients With Cancer, SUD
Speakers at the 2024 Society of Pain and Palliative Care Virtual Conference discussed advanced treatment opportunities for patients with substance use disorder (SUD) and cancer-related pain.
Published: 5/24/2024
Closing the Gap: Addressing Underrepresentation of Women in Cardiovascular Clinical Trials
Continued disparities of gender representation in cardiovascular research reveal oversights that impact adequate diagnosis and treatment of cardiovascular disease in women.
Published: 5/24/2024
Study Finds Semaglutide Improves Chronic Kidney Disease in Patients With Type 2 Diabetes
The role of semaglutide as a glucagon-like peptide-1 (GLP-1) receptor antagonist could offer further treatment options to improve patient outcomes.
Published: 5/24/2024
Transformative Leadership Can and Should be Practiced by Everyone in the Pharmacy Organization
A transformational leader can make the difference between an efficient, profitable organization and one that is mired in mediocrity.
Published: 5/24/2024
Counsel Patients on Nutrition and Following a Balanced Diet Complementary to GLP-1s
The GLP-1 market is expected to exceed $100 billion by 2023, according to J.P. Morgan Research, with total users in the United States projected to reach 30 million.
Published: 5/23/2024
Nurturing Fertility: Pharmacist's Insights for Women's Health Awareness Month
Fertility pharmacists understand the importance of education, awareness, and support women need to discover in navigating the complexities of fertility.
Published: 5/23/2024
FDA Grants Tina-qant Lp(a) Assay Breakthrough Device Designation
A lipoprotein (a) (Lp[a]) assay has been granted breakthrough device designation to expand identification of patients with elevated Lp(a) and genetic predispositions to cardiovascular disease.
Published: 5/22/2024
Phase 2 Study Demonstrates Oral Rilzabrutinib Reduces Loss of Control Events in Patients With Asthma
According to the investigators, these findings support the investigation of rilzabrutinib in patients with asthma in a phase 3 trial program.
Published: 5/22/2024
Patients Receiving Psychiatric Care May Be at Increased Risk of Pandemic-Related Stress, But Are Not at Increased Risk of Believing in Conspiracy Theories
Experts emphasize the importance of awareness when using social media and make suggestions on how to combat the spread of misinformation and conspiracy theories.
Published: 5/22/2024
Study: Outcomes of RSV Associated with Acute Respiratory Failure
The results showed that during a 1-month hospital stay, 13% of individuals who experienced RSV-associated acute respiratory failure died.
Published: 5/22/2024
FDA Grants Breakthrough Therapy Designation to Inavolisib for PIK3CA-Mutated Breast Cancer
Inavolisib was submitted to the FDA for review as a first-line treatment for advanced HR-positive, HER2-negative PIK3CA-mutated breast cancer.
Published: 5/21/2024
Study Evaluates Use of Milvexian in Secondary Stroke Prevention
The results showed that individuals treated with milvexian had a prolonged aPTT in a dose-dependent manner with limited effects of PT.
Published: 5/21/2024
A Novel Bispecific Anti-GPRC5D × CD3 Antibody: A New Treatment Paradigm in Multiple Myeloma
Investigators assessed the efficacy of BsAb5003 in treating multiple myeloma, with the results showing that the therapy may be an effective treatment approach.
Published: 5/21/2024
Advancement in CAR T Cell Therapy for Patients with Multiple Myeloma Helps Predict Treatment Response and Resistance
Researchers from the University of Leipzig Medical Center identify multiple biomarkers associated with the success of CAR T cell therapy in relapsed multiple myeloma.
Published: 5/21/2024
Health Care Shortage Calls for Diversifying the Role of Community Pharmacists in Treatment of Minor Ailments
New research reveals the potential of community pharmacists in minor ailment treatment, allowing for diversified patient care during growing health care professional shortages.
Published: 5/21/2024
FDA Grants Breakthrough Therapy Designation for Larsucosterol in Alcohol-Associated Hepatitis
The primary outcome was a 90-day incidence of mortality or liver transplant for individuals who received larsucosterol, compared to the placebo group.
Published: 5/21/2024
Program Highlights Opportunities for Community Pharmacies to Deliver Screening, Education, and Referral Interventions
Aligning community pharmacy interventions with top-down findings, payers’ population health priorities, and identified unmet needs can help develop a sustainable pathway.
Published: 5/21/2024
Study Supports Pharmacists’ Roles in Ensuring Appropriate Use of Oral Oncolytics
As value-based health care models become more widespread, these types of interventions will be important to demonstrate the value of pharmacist-embedded HSSPs.
Published: 5/21/2024
FDA Approves First Biosimilars to Eylea
Aflibercept-jbvf (Yesafili; Biocon Biologics) and aflibercept-yszy (Opuviz; Biogen, Samsung Bioepis) are the first interchangeable biosimilars to aflibercept (Eylea; Regeneron).
Published: 5/20/2024
FDA Approves Subcutaneous Belimumab for Patients Aged 5 With Systemic Lupus Erythematosus
Belimumab (Benlysta; GSK) is a B-lymphocyte stimulator-specific inhibiting monoclonal antibody.
Published: 5/20/2024
FDA Approves Self-Collection cobas HPV Test for Early Detection of Cervical Cancer Early
In 2014, the cobas human papillomavirus test was approved by the FDA for first-line, primary screening in women aged 25 years and older.
Published: 5/20/2024
Study Results Find Mood and Sleep Disorders Negatively Impact Asthma Control
Despite the finding, the authors suggest further research is done to better understand the mechanisms behind the interactions between asthma, sleep, and depression.
Published: 5/20/2024
Study Shows Older Patients With AML Respond to Treatment With VEN-HMA
Researchers observed that patients aged 80 years and older with acute myeloid leukemia who were treated with venetoclax and a hypomethylating agent had prolonged overall survival.
Published: 5/19/2024
Rotaxane Actuators Study Unveils Promising Advancements for Drug Delivery Systems
Researchers from the University of Manchester have developed a technique using rotaxane actuators in force-controlled release systems, enabling precise and efficient release of multiple molecules simultaneously.
Published: 5/18/2024
Obesity and Metabolic Syndrome Factors Potentially Associated With Breast Cancer Receptor Subtypes, Mortality
Both MetS and obesity status have independent and differential associations with breast cancer, and may serve as separate targets for breast cancer prediction and prevention strategies.
Published: 5/17/2024
SDOH Framework Highlights Role of Health System Specialty Pharmacists
Future potential directions include measuring the impact of clinical pharmacist interventions on referral utility, disease-specific clinical outcomes, patient satisfaction, medication adherence, and absenteeism.
Published: 5/17/2024
This Skin Cancer Awareness Month, Remind Patients of the Prevention Basics
As summer approaches, remind patients to go back to basics with sunscreen and self-examinations.
Published: 5/17/2024
The FDA Grants Accelerated Approval to Tarlatamab-dlle in Small Cell Lung Cancer
Tarlatamab is a first-in-class immunotherapy that binds to DLL3 tumor cells and CD3 T-cells, to kill DLL3-expressing SCLC.
Published: 5/17/2024
Adiposity in Childhood May Affect the Risk of Developing Breast Cancer in Adulthood
The study data demonstrate that higher adiposity in childhood results in less dense breast tissue forming, reducing the risk of breast cancer.
Published: 5/16/2024
FDA Grants Accelerated Approval for Liso-Cel in Patients With Relapsed or Refractory Follicular Lymphoma
The indication is for adult patients who have received at least 2 prior lines of systemic therapy and is based on the response rate and duration of response shown in a phase 2 trial.
Published: 5/16/2024
May Is Hepatitis Awareness Month
Hepatitis Awareness Month is designed to raise awareness of viral hepatitis and promote testing and vaccination while decreasing the stigma against the virus.
Published: 5/16/2024
Collaboration Is Key When Implementing SDOH Screening Programs
Properly training staff and gaining stakeholder buy-in are crucial steps to successfully designing and launching a program to screen and address health-related social needs.
Published: 5/15/2024
Glucophage Will Activate the Same Pathway as Sprint Exercise to Reduce Appetite
The oral medication activates an “anti-hunger” molecule which may prevent people from overeating.
Published: 5/15/2024
Study: Contact With Children Causes Transmission of Pneumococcal Disease Among Older Adults
The prevalence of transmission was higher for those who had contact with children aged less than 5 years and aged 5 to 9 years compared with children aged older than 10.
Published: 5/15/2024
FDA Ensures Safety and Effectiveness of Laboratory Developed Tests
Under the modification to the Food, Drug, & Cosmetics Act, individuals and health care providers can hopefully have more confidence in in vitro diagnostic devices.
Published: 5/15/2024
Continued Tezepelumab Treatment Benefits Patients With Severe, Uncontrolled Asthma
The continuation of tezepelumab showed stronger benefits after stopping treatment for 2 years and compared with placebo.
Published: 5/15/2024
Pharmacists Need Additional Training to Combat Corticophobia for Patients With Atopic Dermatitis
Corticophobia is defined as a phobia of topical corticosteroids due to negative feelings or beliefs, which can come from misinformation about the long-term effects.
Published: 5/14/2024
Study Finds Biomarkers That May Be Associated Hepatocellular Carcinoma Risk
The authors note that the biomarkers found in the blood were involved in inflammatory processes, immune functions, or vascular processes, and may be pre-diagnostic indicators.
Published: 5/14/2024
Study Finds AI Models May Help Accurately Assess PTSD in Women After a Traumatic Childbirth
The authors note that this finding may have promise for use in assessing mental health conditions and improving patient outcomes.
Published: 5/14/2024
Survey: 1 in 8 Adults Have Utilized a GLP-1 Medication, 6% Currently Are
According to the results, approximately 82% of adults said they have heard at least a little about GLP-1 medications and 32% said they have heard a lot.
Published: 5/14/2024
AACP Delegation Emphasizes Importance of Learning International Pharmaceutical Systems
The American Association of Colleges of Pharmacy led a pharmacy education seminar in Cuba discussing cultural differences and approaches to medication and care.
Published: 5/14/2024
Study: Chemotherapy, Pembrolizumab Adjuvant Therapy Did Not Improve Disease-Free Survival for Endometrial Cancer
The study’s co-primary endpoint of overall survival was not formally tested due to DFS not being reached.
Published: 5/14/2024
Dietary Resistant Starch, RAS Inhibitor Demonstrate Protective Effect on Kidney for Type 2 Diabetes
In diabetic rats, investigators found a decrease in urine biomarkers and expression of proteins that play a part in renin-angiotensin system (RAS).
Published: 5/13/2024
FDA Grants Fast Track Designation for SNB-101 to Treat Small Cell Lung Cancer
SNB-101 is the first nanoparticle anticancer drug that was developed exceedingly insoluble SN-38 into polymer nanoparticles.
Published: 5/13/2024
FDA Approves Updated Label for Altuviiio to include Full Data on Pediatric Patients With Hemophilia A
Antihemophilic factor (recombinant) Fc-VWF-XTEN fusion protein-ehtl was initally approved in February 2023 for adults and children with hemophilia A for prophylaxis and on-demand treatment to control bleeding.
Published: 5/13/2024
Positive Data of Coartem for Malaria in Infants Weighing Less Than 5 kg
The data were previously presented at the Multilateral Initiative on Malaria 8th Pan-African Malaria Conference and have been submitted for regulatory review.
Published: 5/13/2024
Hormone Therapy, Vitamin Supplementation in Postmenopausal Women Did Not Decrease Risk of Cancer, Chronic Disease
Study investigators also found that dietary modifications were not associated in improving risks of certain chronic diseases and cancers.
Published: 5/13/2024
The Role of Complementary and Integrative Health Competency in Pharmacy
Complementary and integrative health has been divided into 5 subcategories, including alternative whole medical systems and mind-body interventions.
Published: 5/13/2024
CVS Health Survey Reports Increases in Mental Health Concerns Since 2020
The survey reported that approximately 65% of participants were concerned about their mental health, which is a 15% increase since 2020.
Published: 5/12/2024
FDA Approves sBLA for Adalimumab-adaz as Interchangeable Biosimilar for Humira
A provisional determination is also provided for the 40 mg/0.4 mL strength due to remaining interchangeability designation for another biosimilar to Humira.
Published: 5/10/2024
FDA Approves WGc-043, EB Virus-Related mRNA Therapeutic Cancer Vaccine for Use in Clinical Trials
This is the first approval of an EB virus-related mRNA therapeutic cancer vaccine and is a landmark achievement in future research on cancer treatment.
Published: 5/10/2024
Tivozanib Shows Benefits in Long-Term Survival for Relapsed/Refractory Renal Cell Carcinoma
Investigators noted that the conditional overall survival also had clinically meaningful improvements compared with sorafenib for advanced renal cell carcinoma.
Published: 5/10/2024
FDA Grants 510(k) Clearance for Rika Plasma Donation System
The Rika system uses an individualized nomogram to help determine the plasma collection volume that is needed for each individual donor.
Published: 5/10/2024
Mental Health Awareness Month: The Importance of Advocating For Yourself and Others
A clinical pharmacist discusses his work in the mental health space while stressing the importance of advocating for and checking in with one another’s emotional well-being.
Published: 5/9/2024
PET Scans Show Promise in Identifying Hidden Inflammation for Those With Multiple Sclerosis
The results also showed that the PET scans could show damage to the individual’s brains, which was correlated with disability and fatigue.
Published: 5/9/2024
Community Pharmacists Tackle Asthma Medication Adherence
This study is the first to preliminarily show that a community pharmacist intervention can produce a positive effect on reducing SABA reliance and improvement of ICS adherence in patients with asthma.
Published: 5/9/2024
FDA Committee to Review Data Supporting New Drug Application for MDMA for PTSD in June
This is the first FDA advisory committee meeting that will review a potential new posttraumatic stress disorder treatment in 25 years.
Published: 5/8/2024
A SMARTer Way to Treat Asthma: Pharmacist-led Initiative Shows Improvement in SMART Prescribing
SMART uses an ICS and a long-acting beta-2 agonist (LABA) product, giving patients 4 years and older with moderate to severe uncontrolled persistent asthma 1 inhaler for dual symptom relief.
Published: 5/8/2024
Officials Release Draft Legislation Aimed at Prescription Drug Shortage Issues
Ongoing and active shortages are currently at the highest number since January 2001.
Published: 5/8/2024
Study: 3 Doses of PCV13 Prevents Vaccine-Type Invasive Pneumococcal Disease in Children
The vaccine protected against serotypes 19A and 19F, but statistical significance was not reached for serotype 3.
Published: 5/8/2024
Acalabrutinib Demonstrates Improvements in PFS in Patients With Previously Untreated MCL
Compared with placebo, acalabrutinib plus standard of care chemoimmunotherapy demonstrated better progression-free survival in patients with mantle cell lymphoma.
Published: 5/7/2024
FCRL5-Directed CAR T-Cell Therapy: A Novel Therapeutic Approach for Multiple Myeloma
CAR T-cells specifically targeting FCRL5, when integrated with IL-15, may improve cytotoxicity, thereby enhancing the therapeutic potency of these cells.
Published: 5/7/2024
Navigating the Long, Bumpy Road to Rare Disease Diagnosis and Treatment
A patient details his experience juggling the roles of caregiver of his wife with cancer and patient struggling to receive a diagnosis for a rare disease.
Published: 5/7/2024
Lung Cancer Action Week: How Individuals Can Aid the Fight Against Lung Cancer
Pharmacists can raise awareness for lung cancer during and after Lung Cancer Action Week.
Published: 5/7/2024
Navigating the Shadows: Understanding the Psychology and Pharmacology of Treating Postpartum Depression
A new treatment for postpartum depression has been developed with rapid onset, cutting down the time it has taken previous treatments to take effect by weeks or months.
Published: 5/6/2024
FDA Accepts Biologics License Application for Subcutaneous Formulation of Nivolumab
The new administration method, which is co-formulated with rHuPH20, is usable in previous approved nivolumab indications for solid tumors in adult patients.
Published: 5/6/2024
CDC Report Finds US Residents in Rural Areas Face Higher Percentages of Preventable Premature Deaths
The authors emphasize that additional research addressing disparities and including race, age, and ethnicity should be conducted.
Published: 5/6/2024
V116 Elicits Noninferiority Immune Response Compared with PPSV23 for Pneumococcal Disease
Merck presented results from the STRIDE-10 phase 3 trial at the 34th European Society of Clinical Microbiology and Infectious Diseases in Barcelona, Spain.
Published: 5/6/2024
Rising Use of Herbal Supplements Creates Awareness of Risks During the Perioperative Period
Pharmacists can get involved by counseling patients on when to halt use of supplements, as well as proper use and selection of products.
Published: 5/6/2024
Understand Patient Experiences With Biosimilar Transitions
Study participants’ overall satisfaction with a mandatory nationwide adalimumab transition in New Zealand varied but was generally low.
Published: 5/6/2024
Environmental and Social Conditions May Help Predict Severity of Asthma in Children
With these findings contributing to the understanding of neighborhood-level asthma risks, the authors note next steps can involve identifying and addressing disparities.
Published: 5/5/2024
Women During Perimenopause Are More Likely to Experience Depression, Study Finds
Compared with women who aren’t experiencing menopausal symptoms, women in the perimenopause stage were approximately 40% more likely to experience depressive symptoms.
Published: 5/4/2024
Study Finds Similar COVID-19 Vaccination Rates in Undocumented Latinx Patients and US Citizens
Additionally, undocumented Latinx patients were also more likely to have at least 1 prior COVID-19 infection.
Published: 5/3/2024
Study Finds Non-Hispanic African American Patients Have Worse allo-, autoHCT Outcomes
Despite the increased survival rates in all 4 evaluated racial groups, both adult and pediatric non-Hispanic African American patients continued to have worse outcomes.
Published: 5/3/2024
Understanding State Regulations and Advocating for Medically Integrated Dispensing
Christie Smith discusses navigating state pharmacy laws and advocating for policy changes to improve patient access and care coordination.
Published: 5/3/2024
Integrating Technicians in Reimbursement Requires Understanding CPT Codes
By empowering pharmacy technicians to actively participate in billing and reimbursement processes, health care practices can streamline operations, mitigate billing errors, and optimize revenue generation.
Published: 5/3/2024
Real-World Evidence Shows 82% Reduction in Infant RSV Hospitalizations With Nirsevimab
The results reinforce other real-world evidence from several broad infant immunization programs in the US, Spain, and France.
Published: 5/3/2024
Bridging the Gap: How Pharmacists Can Expand and Transform Mental Health Services
This expansion of their role goes beyond traditional dispensing duties, positioning pharmacists as an essential bridge between patients and the broader health care system.
Published: 5/3/2024
Expert: Pharmacists Have Vital Role in Multiple Myeloma Treatment
The vice president of pharmacy operations at American Oncology Network says that pharmacists can contribute by educating patients and offering resources for support and treatment adherence.
Published: 5/2/2024
Expert Discusses Payment Models for Cell and Gene Therapies
Joe DePinto discusses innovative payment models like value-based agreements and warranties for cell and gene therapies
Published: 5/2/2024
US Preventive Services Task Force Recommends Breast Cancer Screenings Begin at Age 40
The screenings should be conducted every other year, beginning at age 40 and continuing through age 74, according to the new recommendation.
Published: 5/2/2024
FDA Grants Fast Track Designation to Eneboparatide for Treatment of Patients With Hypoparathyroidism
Currently, the treatment is being evaluated in the phase 3 CALYPSO study to further prove the safety and efficacy in patients with hypoparathyroidism.
Published: 5/2/2024
FDA Approves High-Concentration, Citrate-Free Cyltezo for the Treatment of Chronic Inflammatory Diseases
This citrate-free and high-dose approval of the biosimilar Humira provides another option to treat patients who are living with various inflammatory diseases.
Published: 5/2/2024
The Evolution of Pharmacy From Dispensing to Site of Care
The COVID-19 pandemic spring boarded the evolution of pharmacies toward establishing their position as sites of care.
Published: 5/2/2024
Investment Trends in Women's Health Are Driving Growth in Health Care Innovation
Venture capital investments in women's health are growing, with innovation looking beyond traditional avenues.
Published: 5/2/2024
Navigating Biosimilar Lifecycles: Key Considerations for Sustainable Cost Savings
With 50 biosimilar products approved by the FDA, questions arise regarding biosimilar lifecycles and sustainability of the industry.
Published: 5/2/2024
Walmart Announces Closure of Health Centers and Virtual Services
The decision follows a 2023 statement that announced a plan to increase the number of health center locations beginning in 2024.
Published: 5/1/2024
Pharmacists Should Proactively Educate Themselves About Avian Influenza
Although the CDC continues to emphasize that risk to humans is currently low, patients will have questions.
Published: 5/1/2024
Trastuzumab Deruxtecan Shows Improvement in PFS in Patients With HR+, HER2-Low Metastatic Breast Cancer
The investigators note that additional research is needed to confirm positive overall survival trends in this patient population.
Published: 5/1/2024
FDA Approves Fidanacogene Elaparvovec-dzkt as One-Time Gene Therapy for Adults With Hemophilia B
The 1-time treatment may be a better alternative for patients who don’t want to undergo frequent doses of standard of care intravenous factor IX infusions.
Published: 5/1/2024
Research Suggests Acute Cardiac Events Are Common in Older Adults Hospitalized With RSV
Prevention of acute cardiac events may be another consideration for future postlicensure studies of RSV vaccines.
Published: 4/30/2024
FDA Grants Full Approval to Tisotumab Vedotin-tftv for Recurrent, Metastatic Cervical Cancer
Tisotumab vedotin-tftv is the first antibody-drug conjugate to demonstrate positive overall survival data in patients with previously treated recurrent or metastatic cancer.
Published: 4/30/2024
Study: Probiotic with Vitamin D Supplements Could Aid Individuals with Schizophrenia
Vitamin D deficiency (VDD) is an important factor in the pathogens of schizophrenia.
Published: 4/30/2024
Identifying Food Allergies vs Food Intolerances: Pharmacists Can Play a Critical Role in Education
Pharmacists can help patients distinguish between food allergies and intolerances, as well as facilitate access to life-saving medications and preventative care.
Published: 4/30/2024
Women Lead Vaccine Development Across the Industry
Notable contributions from female leaders in the pharmaceutical industry demonstrate the exceptional competence of women in vaccine innovation.
Published: 4/30/2024
Experts Report Need for Framework to Address CNS Immune-Related AEs Resulting From ICI Treatment
According to the speaker, the complexity of immune-related adverse events resulting from immune checkpoint inhibitors requires a lot of collaborative discussion between patients and providers.
Published: 4/30/2024
Managing Pulmonary Arterial Hypertension: Diagnosis, Classification, and Treatment Strategies
At Asembia's AXS24 Summit, a clinician discusses the pathophysiology and classification of pulmonary arterial hypertension.
Published: 4/30/2024
Experts: Treating Urinary Complications in a Patient With Multiple Sclerosis
Speakers in a presentation discuss a specific patient with MS who experienced urinary complications and the methods used to treat her.
Published: 4/29/2024
FDA Approves Trastuzumab Biosimilar to Treat Forms of HER2-Overexpressing Cancer
Trastuzumab is indicated for adjuvant breast cancer, metastatic breast cancer, and gastric cancer.
Published: 4/29/2024
FDA Accepts Supplemental New Drug Application for Tapinarof Cream, 1%, in Atopic Dermatitis
The acceptance is based on positive data from the phase 3 ADORING 1 and ADORING 2 pivotal trials, as well as interim results from the phase 3 ADORING 3 open-label, long-term extension trial.
Published: 4/29/2024
Recreational Cannabis Legalization Associated with Decreases in Alcohol, E-Cigarette Use
Retail sales were associated with lower e-cigarette use, although recreational legalization also increased the frequency of cannabis use among adolescents.
Published: 4/29/2024
FDA Approves Mavorixafor Capsules to Treat Patients With WHIM Syndrome
The indication is for patients aged 12 years of age and older, and the treatment is intended to increase the number of mature neutrophils and lymphocytes in patients.
Published: 4/29/2024
Guidelines for Medication Disposal: Take Back Day
Those looking to dispense medications should consult the individual guidelines for their local Take Back Bin.
Published: 4/27/2024
Take Back Day: Dispensing Advice on Medication Disposal
Community pharmacists’ influence increases the likelihood of patients safely disposing unused medications and keeping them out of harm’s reach.
Published: 4/27/2024
FDA Grants Accelerated Approval to Tovorafenib for Pediatric Patients With BRAF-Mutated LGG
Tovorafenib is the first systemic therapy to be approved for the treatment of pediatric patients who have low-grade glioma with BRAF rearrangements or fusions.
Published: 4/26/2024
FDA Approves Label Update for Biktarvy as Treatment of HIV in Pregnant Adults
The approval is based on data from Study 5310, evaluating the pharmacokinetics, safety, and efficacy of Biktarvy (Gilead Sciences Inc) in pregnant individuals.
Published: 4/26/2024
Study Highlights Reduced Disease Severity When Vaccinated Against RSV
The severity of RSV disease among adults further highlights how crucial vaccine polices and recommendations are.
Published: 4/25/2024
Study Finds Relationship Between Uncontrolled Severe Asthma, Exacerbations and Health Care Resource Use
The findings emphasize a need for guideline-based care delivery for patients with severe asthma, particularly for patients who are facing social disparities within health care.
Published: 4/25/2024
FDA Accepts sBLA for Dostarlimab With Chemotherapy to Treat Endometrial Cancer
Dostarlimab plus chemotherapy is the only immuno-oncology-based therapy that showed statistically significant and clinically meaningful survival benefit in the overall patient population.
Published: 4/25/2024
FDA Approves Over-the-Counter Naloxone Nasal Spray for Opioid Overdose
Naloxone hydrochloride (Amneal Pharmaceuticals Inc) is the generic equivalent to OTC Narcan (Emergent).
Published: 4/25/2024
Adjuvant Alectinib Could Aid Disease-Free Survival in ALK-Positive NSCLC
A 76% lower risk was displayed with adjuvant alectinib compared to chemotherapy treatment for non–small cell lung cancer.
Published: 4/25/2024
Iptacopan Demonstrates 38.3% Proteinuria Reduction in Patients With IgAN
Iptocopan demonstrated superiority when treating patients with immunoglobulin A nephropathy and is the first drug to specifically target the alternative complement pathway.
Published: 4/24/2024
FDA Approves Pivmecillinam for Treatment of Female Adults With Urinary Tract Infections
Pivmecillinam (Pivya; UTILITY therapeutics Ltd) tablets were approved for female adults with uncomplicated urinary tract infection caused by Escherichia coli, Proteus mirabilis, and Staphylococcus saprophyticus.
Published: 4/24/2024
Recombinant Zoster Vaccine Demonstrates High Protection Against Shingles in Adult Patients
The recombinant zoster vaccine demonstrated a 79.7% efficacy in patients aged 50 years and older cumulatively within the 6- to 11-year period after vaccination.
Published: 4/24/2024
FDA Approves Lutathera for Pediatric Patients With SSTR+ Gastroenteropancreatic Neuroendocrine Tumors
This approval makes lutetium Lu177 the first therapy to be approved for the treatment of gastroenteropancreatic neuroendocrine tumors in pediatric patients.
Published: 4/23/2024
FDA Approves Anktiva Plus Bacillus Calmette-Guérin For Non-Muscle Invasive Bladder Cancer
The approval was based on the QUILT-3.032 study, which included 77 adults with carcinoma in situ with or without papillary tumors after a transurethral resection.
Published: 4/23/2024
Considerations When Treating Migraines in Gender Diverse Patients Receiving Gender-Affirming Hormone Therapy
The AAN speaker highlights what health care providers need to know when treating migraines in populations on hormone therapy, as well as how hormones can influence migraines.
Published: 4/23/2024
Migraine Treatment Comes in Different Forms, Allowing for Patient Preference
With migraine as a leading disability for those under the age of 50, treatment options for migraine should be personalized to the patient and their needs.
Published: 4/23/2024
CDC Confirms Case of H5N1 Bird Flu in the United States, Noting Risk to Public Health Remains Low
Published: 4/23/2024
Study: Frexalimab Shows Sustained Reduction of Disease Activity for Multiple Sclerosis
Frexalimab demonstrated a favorable tolerability profile after approximately 1 year of treatment for individuals with relapsing disease.
Published: 4/23/2024
Study: Ofatumumab Shows Efficacy Up to 6 Years for Multiple Sclerosis
Ofatumumab (Kesimpta; Novartis) demonstrated a sustained efficacy as a first-line, continuous treatment for patients recently diagnosed and treatment-naïve with relapsing multiple sclerosis.
Published: 4/23/2024
Clinical, Economic Burden of Pneumococcal Disease Consistent Across Age Groups
Investigators found that younger age groups had significantly longer lengths of stay compared to those older than 75 years.
Published: 4/22/2024
Samsung Bioepis Initiates Phase 3 Clinical Trial for Proposed Pembrolizumab Biosimilar
The trial will compared the efficacy, safety, pharmacokinetics, and immunogenicity between SB27 and pembrolizumab for metastatic non-squamous non-small cell lung cancer.
Published: 4/22/2024
Optical Sensor Shows Promise in Non-Invasive Continuous Glucose Monitoring
Optical glucose sensing techniques have been reported, but they require complex optical instrumentations found in laboratories, so feasibility for patient use has been challenging.
Published: 4/22/2024
Study Finds Many Individuals With Cardiovascular Disease Consume Twice Daily Recommendation of Sodium
Investigators found that 89% of individuals with cardiovascular disease consumed more than 1500 mg of sodium daily.
Published: 4/22/2024
Ocrelizumab Demonstrates Near-Complete Suppression of Relapses for Multiple Sclerosis
Ocrelizumab (Ocrevus; Roche) is being investigated as a twice yearly 10-minute subcutaneous injection compared to the intravenous infusion formulation.
Published: 4/22/2024
Study: The Role of Vitamin A in Wound Repair
Retinoic acid, an active form of vitamin A, is crucial for the stem cells to depart lineage plasticity which get separated into hair cells or epidermal cells in vitro.
Published: 4/20/2024
FDA Approves Vedolizumab for Maintenance Therapy to Treat Crohn Disease
The primary endpoint of the study was clinical remission at week 52 with vedolizumab
Published: 4/19/2024
Study Examining Glofitamab With GemOX in Patients With R/R DLBCL Meets Primary Endpoint
Previously, glofitamab had received an accelerated approval for patients with relapsed or refractory diffuse large B-cell lymphoma who received 2 or more prior lines of systemic therapy.
Published: 4/19/2024
FDA Approves Alectinib to Treat Patients With ALK-Positive NSCLC
With this approval, alectinib is the first anaplastic lymphoma kinase inhibitor to be approved for patients with ALK-positive, early-stage non-small cell lung cancer.
Published: 4/19/2024
Positive Data Demonstrates Gepotidacin is Non-Inferior to Alternative Treatment in GC
In a trial that compared gepotidacin to ceftriaxone plus azithromycin in patients with urogenital gonorrhea, gepotidacin presented a 92.6% microbiological success rate.
Published: 4/19/2024
Study: Chemotherapy to Treat Breast Cancer Increases Risk of Lung Cancer
Individuals treated with chemotherapy following a breast cancer diagnosis were more at risk of developing second primary lung cancer.
Published: 4/19/2024
Climate Change Increases Rate of Infectious Diseases, Expert Says
Speaker Monica Diaz describes the detrimental impact climate change has on the transmission and increases in infectious disease cases.
Published: 4/18/2024
Durvalumab With Chemotherapy Shows Long-Term Overall Survival at 3 Years
The results were the longest survival follow-up ever reported for a phase 3 trial for biliary tract cancer.
Published: 4/18/2024
RSV Vaccine Could Prevent Increased Risk of Disease Among Individuals Aged 18 to 59
The results displayed well tolerability and safety with Abrysvo, meeting the study’s co-primary endpoint of immunogenicity and primary safety
Published: 4/18/2024
Tirzepatide Demonstrates Reduction in Sleep Apnea-Relate Events
Eli Lilly and Company will submit results of the study to support tirzepatide (Zepbound) for treatment of obstructive sleep apnea later this year.
Published: 4/18/2024
Enfortumab Vedotin With Pembrolizumab Shows Promise as First-Line Therapy For Those Ineligible for Cisplatin
Enfortumab vedotin in combination with pembrolizumab showed a manageable safety profile and promising progression free survival and overall survival for locally advanced or metastatic urothelial cancer.
Published: 4/17/2024
FDA Grants Fast Track Designation for TLX101-CDx, an Investigational Glioma Imaging Product
The product is currently being investigated alongside TLX101 in the IPAX-Linz and IPAX-2 clinical trials, and have previously shown efficacy in the IPAX-1 trial.
Published: 4/17/2024
Analysis Forecasts Up to 16.5% of Population Will Have Chronic Kidney Disease by 2032
IMPACT CKD, a modeling analysis created by AstraZeneca, includes data about chronic kidney disease across 8 countries, including the United States.
Published: 4/17/2024
FDA Approves Ustekinumab Biosimilar to Stelara for Treatment of Plaque Psoriasis
Ustekinumab (Stelara; Janssen Immunology) is a human monoclonal antibody that treats immune-mediated diseases such as psoriasis and psoriatic arthritis.
Published: 4/17/2024
FDA Grants Breakthrough Device Designation to Assay Supporting Earlier Diagnosis of Alzheimer Disease
If approved, the test could provide more timely and accurate diagnosis, hopefully mitigating the impact of Alzheimer disease (AD) on individuals and the community.
Published: 4/17/2024
The Future of Pharmacy: How Advancements in Technology Are Transforming the Field
AI offers many benefits in health professions by efficiently handling time-consuming tasks crucial for patient care.
Published: 4/16/2024
Study Details Benefits, Therapeutic Effects of Medical Marijuana on Patients’ Quality of Life
The study is the first of 5 studies co-published by AYR Wellness and LECOM and showcases improvements in physical, social, and mental well-being with minimal AEs.
Published: 4/16/2024
Semaglutide's New Indication Highlights Growing Role of GLP-1 Receptor Agonists
The latest FDA approval paves the way for expanded use of GLP-1 receptor agonists in patients without diabetes.
Published: 4/16/2024
Extension Trial Analysis Shows Long-Term Safety, Efficacy of Atogepant in Patients With Migraines
The extension trial of atogepant demonstrated an 8.5-day improvement of monthly migraine days at weeks 13 through 16 and no new safety signals were observed.
Published: 4/16/2024
FDA Accepts Application for 5-in-1 Meningococcal Vaccine Candidate
The 5-in-1 meningococcal ABCWY vaccine candidate has an assigned Prescription Drug User Fee Act action date of February 14, 2025.
Published: 4/16/2024
Study: Asthma Diagnosis in Children Does Not Appear Linked to COVID-19 Diagnosis
The authors note that additional research needs to be conducted to confirm whether the findings are consistent in adult patients.
Published: 4/16/2024
Enhancing Breast Cancer Treatment: Expanding CDK4/6 Inhibitor Use in the Early-Stage Setting
Danielle Roman, PharmD, BCOP, discusses the efficacy and safety outcomes of CDK4/6 inhibitors in early-stage breast cancer, as well as key considerations for CDK4/6 inhibitors in this indication.
Published: 4/15/2024
Navigating Operational Challenges With Bispecifics in R/R MM: Insights From HOPA 2024
Kirollos Hanna, PharmD, BCPS, BCOP, FACCC, addresses some common challenges pharmacists may be facing when looking to operationalize bispecifics at their facilities.
Published: 4/15/2024
Study: PCV13 Protects Against Pneumococcal Serotype Causing Invasive Pneumococcal Disease
Investigators also found that the pneumococcal conjugate vaccine 13 protected against nasopharyngeal carriage in children and provided some indirect protection for adults.
Published: 4/15/2024
FDA Grants Orphan Drug Designation for the Active Ingredient in MVD Vaccine
Although the vaccine has not yet been tested in humans, it demonstrated 100% efficacy in protecting primates who were injected with human Marburg virus disease.
Published: 4/15/2024
Study Finds No Differences Between Adalimumab, Biosimilar for Inflammatory Bowel Disease
There was no difference observed between adalimumab (Humira; AbbVie) and adalimumab-aacf (Idacio; Fresenius Kabi) for those who switched to the biosimilar.
Published: 4/15/2024
Study: Cognition Declines When Glucose Levels Are Atypical for Type 1 Diabetes
Investigators found that the individuals’ peak cognitive performance coincided with glucose levels that were slightly above the normal range.
Published: 4/15/2024
SGLT-2 Inhibitors Associated with Reduced Hyperkalemia in Patients With Heart Failure
SGLT-2 inhibitors reduce cardiovascular deaths, heart failure hospitalizations, hyperkalemia, and decline of renal function in patients with HFrEF.
Published: 4/15/2024
Traditional Chinese Medicine Shows Improvements in Airway Remodeling Due to Asthma
Investigators added that additional randomized trials are still needed to confirm the benefits of traditional Chinese medicine, either with or without conventional therapies.
Published: 4/15/2024
Real-World Data on Mavacamten Builds on Clinical, Safety Profile
Bristol Myers Squibb will also present findings on apixaban (Eliquis) at the American College of Cardiology Annual Scientific Session and Expo.
Published: 4/15/2024
COVID-19 Pandemic Brought Changes, Requiring Significant Adjustments in Health Systems
Pandemic-related growing pains were common within health care, bringing unique challenges for health systems.
Published: 4/14/2024
FDA Grants Fast Track Designation for LYT-200 to Treat Head and Neck Cancers
Treatment with LYT-200 is currently being assessed in a phase 1/2 adaptive design trial in advanced/metastatic solid tumors and in a phase 1b clinical trial.
Published: 4/12/2024
Insights, Future Considerations in FLT3 Inhibitors Following Allo-HCT in Patients With AML
In this NCCN session, James M. Foran, MD, described the different FLT3 inhibitors that are available for FLT3-mutated AML, as well as considerations for the future.
Published: 4/12/2024
New, Emerging Treatment Options for Patients With Multiple Myeloma
In addition to emerging treatment options, the speakers addressed the importance of individualized decision-making when treating patients with multiple myeloma.
Published: 4/12/2024
FDA Grants Orphan Drug Designation for CAN-2409 to Treat Pancreatic Cancer
The designation was granted based on overall survival data from an ongoing randomized phase 2 clinical trial.
Published: 4/12/2024
FDA Updates Approval of Antiseizure Medication Cenobamate Allowing for Alternative Administration Methods
In addition to oral administration, patients with partial-onset seizures can now take the antiseizure medication via a nasogastric tube if the tablet is crushed and mixed with water.
Published: 4/12/2024
Durvalumab Shows Improvements in Overall Survival, Progression-Free Survival for Small Cell Lung Cancer
Both dual primary endpoints—progression-free survival and overall survival—were met with durvalumab.
Published: 4/12/2024
Researchers Develop ADC Combination Therapy to Target TRBC1-Expressed Hematologic Cancers
The antibody drug conjugate was used in combination with the anti-cancer drug SG3249, and demonstrated efficacy in mouse models after 1 week.
Published: 4/11/2024
FDA Approves Benralizumab to Treat Pediatric Patients Aged 6 to 11 Years With Severe Asthma
Benralizumab was previously approved by the FDA in 2017 as an add-on maintenance therapy for patients 12 years and older.
Published: 4/11/2024
Study Suggests Patients With Low-Risk CLL May Stop Specialized Follow-Up Visits
The results demonstrated similar overall survival between patients with chronic lymphocytic leukemia who discontinued specialized follow-ups versus those who continued.
Published: 4/10/2024
Peggy Lillis Foundation Holding National C. Diff Advocacy Summit April 2024
The Annual summit is the largest gathering of C diff advocates and allies in industry, academia, and policymaking in the country to discuss urgent public health threats.
Published: 4/10/2024
The Importance of Hemoglobin A1c Management in Type 2 Diabetes
Pharmacists can help to interpret HbA1c and glucose results when patients come to pick up medications and contact prescribers and/or make recommendations based off patient results.
Published: 4/10/2024
Psychedelic Medicine Could Fill Care Gap in Psychiatric Care
However, psychedelic medicine has a variety of barriers, including historical perception, access challenges, legal obstacles, and ethical questions.
Published: 4/10/2024
FDA Approves Cilta-Cel for Treatment of Relapsed, Refractory Multiple Myeloma
The indication is for adult patients with multiple myeloma who are refractory to lenalidomide and have previously received at least 1 line of therapy.
Published: 4/10/2024
Venetoclax With 5-Azacytidine Effective in Treating Patients With Multiple Myeloma
Venetoclax, which is approved for leukemia, blocks a function of the BCL-2 protein and has previously shown efficacy in a small proportion of patients with multiple myeloma.
Published: 4/10/2024
Biosimilars in Retina Space Expected to Grow in 2024, Coming Years
In a review, investigators focused on ranibizumab (Lucentis; Genentech), aflibercept (Eylea; Regeneron), and bevacizumab (Avastin; Genentech) as growth opportunities in the biosimilar space.
Published: 4/10/2024
Study: Inappropriate Diagnosis of Community-Acquired Pneumonia is Common
Investigators found that older adults, adults with dementia, and adults with altered mental status were more likely to be inappropriately diagnosed with CAP when hospitalized.
Published: 4/10/2024
Digital Therapeutics Might Address Gaps in Care for Mental Health Patients
Pharmacists should be well educated on prescription digital therapeutics to better educate patients on software in comparison to traditional pharmacological products.
Published: 4/9/2024
Pharmacists Improve Quality of Depression Care at Patient, Community Levels
Social determinants of health can worsen mental health disorders such as depression, but the effect of depression can also negatively impact social determinants of health.
Published: 4/9/2024
Investigators Find Piezo1 Has Potential for the Future of Asthma Treatment
Piezo1 is a protein produced by type 2 innate lymphoid cells when activated by an allergen and can limit the immune cell’s activity when triggered by a reaction.
Published: 4/9/2024
More Research Needed for Treatment of Clozapine-Resistant Schizophrenia
Current evidence and data regarding clozapine-resistant schizophrenia is unclear, but new treatment options are on the horizon that could show promise.
Published: 4/8/2024
Patient Preferences Play Essential Part in Contraceptive Care
Although there are medical considerations for patients with psychiatric conditions, prescribers must consider patient preference to increase adherence and effectiveness of contraception.
Published: 4/8/2024
FDA Approves Dolutegravir/Lamivudine for Treatment of Adolescents With HIV-1 Infection
The treatment is indicated for adolescents at least 12 years of age who weigh at least 25 kg without a previous treatment history of antiretroviral therapies.
Published: 4/8/2024
Empagliflozin Shows 10% Relative Risk Reduction in Time to First Hospitalization Due to Heart Failure
The finding did not reach statistical significance in the primary composite endpoint.
Published: 4/8/2024
Study: Blended Antioxidant Supplement Could Improve Age-Related Health Decline
Aged mice displayed improvements in their spatial cognition, short-term memory, and muscle durability.
Published: 4/8/2024
Safety Data Confirm Viability of Flu, RSV Vaccines For Patients at Risk of Heart Failure
Investigators reported a low incidence of adverse events after simultaneous vaccination against seasonal influenza and respiratory syncytial virus.
Published: 4/8/2024
Pharmacists Facilitate Harm Reduction for Patients With Anxiety Using Cannabis
Data for generalized anxiety disorders and cannabis use is scarce, but pharmacists can help educate patients on potential benefits and risks of cannabis usage.
Published: 4/7/2024
New Data Shows Positive Results for Sotagliflozin for Patients With Chronic Kidney Disease, Diabetes
The abstracts will be presented at the American College of Cardiology Conference from April 6 to April 8, 2024, in Atlanta, Georgia.
Published: 4/7/2024
Novel Drugs Targeting Different Pathways Show Promise in Schizophrenia
Developments in glycine transporter type 1 inhibitors, D-amino acid oxidase inhibitors, and phosphodiesterase inhibitors are pushing schizophrenia research forward.
Published: 4/7/2024
Study: Empagliflozin Reduces MACE Regardless of Baseline Albuminuria Levels
The results further confirm earlier findings from the EMPA-KIDNEY trial.
Published: 4/7/2024
FDA Approves Fam-Trastuzumab Deruxtecan-nxki for Unresectable or Metastatic HER2-Positive Solid Tumors
This is the fifth indication for fam-trastuzumab deruxtecan-nxki (Enhertu; Daiichi Sankyo and AstraZeneca) approved by the FDA.
Published: 4/6/2024
Addressing the Challenges of Implementing Bispecific Antibodies in Health Care Centers
There are unique complexities when implementing bispecific antibodies, including site of care considerations, monitoring, and management of adverse events.
Published: 4/6/2024
Managing Adverse Event Profiles for Three Bispecific Antibodies Approved for Lymphoma
These FDA-approved therapies are used to treat lymphoma after 2 or more lines of therapy and represent significant advancements in the treatment of lymphoma.
Published: 4/5/2024
Relapsed/Refractory Multiple Myeloma Treatment Advances With Three BiTE Therapy Options
FDA-approved BiTE therapies for relapsed/refractory multiple myeloma show promising response rates, offering off-the-shelf alternatives to CAR T therapy.
Published: 4/5/2024
FDA Approves Idecabtagene Vicleucel for Multiple Myeloma After 2 or More Lines of Therapy
The approval expands the prior indication of idecabtagene vicleucel (Abecma; Bristol Myers Squibb), which will make the drug available to patients in earlier lines.
Published: 4/5/2024
Navigating the Landscape of Cannabis Use in Oncology
Despite being a Schedule I drug, cannabis is increasingly used in oncology for symptom management, although data remains limited.
Published: 4/5/2024
Addressing Ongoing Diversity Gaps in Oncology Clinical Trials
Lisa Janssen Carlson, PharmD, BCOP, discusses some background and history of regulations for the conduct of clinical trials.
Published: 4/5/2024
5 Key Sessions at the American Association of Psychiatric Pharmacists Annual Meeting 2024
Pharmacy Times will be at the American Association of Psychiatric Pharmacists (AAPP) Annual Meeting in Orlando, Florida from April 7 to April 10, 2024.
Published: 4/5/2024
Embracing a Precision Medicine Approach to KRAS G12C–Mutated Advanced NSCLC With Adagrasib
Precision medicine revolutionized NSCLC treatment, targeting specific mutations like KRAS G12C with therapies such as adagrasib to improve patient outcomes.
Published: 4/4/2024
Is 2024 the Year for Psychedelic Medicine?
MDMA-assisted therapy and psilocybin currently lead the way with potential approvals by the FDA.
Published: 4/4/2024
FDA Accepts sBLA for Bimekizumab-bkzx in Hidradenitis Suppurativa Treatment
Bimekizumab-bkzx (Bimzelx; Union Chimique Belge) is a humanized monoclonal immunoglobulin G1 antibody that inhibits interleukin (IL)-17A and IL-17F.
Published: 4/4/2024
Amylyx Voluntarily Discontinues ALS Treatment Relyvrio Following Phase 3 Trial Results
Despite the positive results demonstrated in a prior phase 2 trial, AMX0035 failed to meet the phase 3 trial’s primary end point in treating patients with amyotrophic lateral sclerosis.
Published: 4/4/2024
FDA Approves Zevtera as Antibiotic to Treat 3 New Indications
New indications include Staphylococcus aureus bloodstream (SAB) infections, acute bacterial skin and skin structure infections, and community-acquired bacterial pneumonia.
Published: 4/4/2024
Empower Prospective Pharmacists through Children’s Books
This short story, illustrated by Roth, portrays pharmacists in a variety of settings and was written with the intent to introduce the career in a fun and understandable way for children and inspire kids to pursue their dreams.
Published: 4/3/2024
Study: Biosimilar Competition Did Not Consistently Lower Costs for Patients
The results indicate the need for targeted policies so that biosimilar competition can increase cost savings and affordability for patients with commercial insurance.
Published: 4/3/2024
Study: African American Veterans With PTSD More Likely to be Re-hospitalized With Stroke
Investigators also found that African American and White veterans had different risk factors for re-hospitalization post-stroke.
Published: 4/3/2024
Metronidazole Twice Daily: A Pharmacokinetic and Clinical Justification
This medication is associated with a number of adverse effects, such as gastrointestinal upset and peripheral neuropathies, that may be mitigated by less frequent dosing.
Published: 4/3/2024
Bispecific Antibodies Emerge in the Treatment of Multiple Myeloma
Unlike conventional monoclonal antibodies, BsAbs possess dual binding domains that target 2 distinct antigens simultaneously.
Published: 4/3/2024
Study: Sex-Specific Disparities Found Across Various Cancer Types
Investigators compared the copy number alterations of patients who were male and female using 16 cancer types in The Cancer Genome Atlas Program.
Published: 4/3/2024
Jazz Pharmaceuticals Submits Biologics License Application for Zanidatamab to Treat Biliary Tract Cancer
Study outcomes demonstrated that 80 HER2-postive BTC individuals enrolled in Cohort 1 of the study achieved a confirmed objective response rate of 41.3%
Published: 4/3/2024
Study Shows Diabetes, Pollution, Alcohol Intake Related to Onset of Cognitive Decline
A study about modifiable risk factors on a “weak spot” in the brain network found that diabetes, pollution, and alcohol were most likely to contribute to dementia disorders.
Published: 4/2/2024
FDA Accepts BLA for Dato-DXd to Treat Unresectable, Metastatic HR-Positive, HER2-Negative Breast Cancer
The decision follows phase 3 trial results that demonstrated improved progression-free survival and confirmed the safety of Dato-DXd in patients with breast cancer.
Published: 4/2/2024
As Polypharmacy Grows, Pharmacists Play Essential Role in Medication Education
By implementing easier systems of education for patients, the consequences of polypharmacy could potentially decrease.
Published: 4/2/2024
Study: Mutation Found to Make Follicular Lymphoma More Susceptible to Experimental Drug
The mutation impacts BAF proteins and can lead to progression of follicular lymphoma, according to the investigators.
Published: 4/2/2024
Dostarlimab Plus Chemotherapy Demonstrates Significant Overall Survival Benefit in Endometrial Cancer
In the RUBY phase 3 trial, dostarlimab (Jemperli; GSK) with niraparib (Zejula; GSK) had significant progression free survival compared to the standard of care.
Published: 4/2/2024
Adagrasib Meets Primary Endpoint Among Individuals with KRAS G12C-Mutated Locally Advanced or Metastatic NSCLC
The positive results in both progression-free survival and overall response rate were endorsed in a confirmatory study.
Published: 4/2/2024
AstraZeneca Caps Inhaled Respiratory Portfolio at $35 For Eligible Patients With Asthma, COPD
The Asthma and Allergy Foundation of America applauded the efforts by AstraZeneca, saying accessibility and affordability can help reduce racial disparities in asthma.
Published: 4/2/2024
FDA Approves Danicopan With C5 Inhibitor Therapy to Treat EVH in Adults With Paroxysmal Nocturnal Hemoglobinuria
Positive phase 3 trial results showed that danicopan was more effective than placebo when treating extravascular hemolysis in paroxysmal nocturnal hemoglobinuria.
Published: 4/1/2024
Men With Melanoma Who Receive Enhanced Vaccine Experience Improvements in Overall Survival
It is unclear why the vaccines were less effective in women, but researchers note that the findings can be important when determining immune therapy outcomes in patients with melanoma.
Published: 4/1/2024
Behavioral Interventions Give Hope for Management of Insomnia Beyond the Sleep Specialist’s Office
Stephanie Ashraf, MD, offered clinical experience in managing insomnia at the American Medical Women’s Association (AMWA) 2024 Annual Meeting.
Published: 4/1/2024
Fecal Microbiota Transplantation Could Be the Answer to the Global Threat of Antimicrobial Resistance
Scientists hypothesize that fecal microbiota transplant restores the recipient’s gut microbiota to an environment that mimics the healthy donor’s microbiota
Published: 4/1/2024
Study: Anxiety, Depression Treatment Linked With Heart Disease Outcomes
Investigators aimed to determine the impact of psychotherapy or psychopharmacologic treatments on adverse outcomes in individuals with coronary artery disease or heart failure.
Published: 4/1/2024
Study: Tirzepatide Results in Weight Loss for Individuals With Type 1 Diabetes
Tirzepatide is currently approved for management of type 2 diabetes, improving glucose control, facilitating weight loss, and improving cardiovascular disease outcomes.
Published: 4/1/2024
Study Results Show Low Prevalence of S. Pneumonia Nasopharynx-Oropharynx Colonization
However, investigators found that the prevalence of Streptococcus pneumoniae nasopharynx-oropharynx colonization was higher among younger adults.
Published: 4/1/2024
Experts Establish First Performance Measures of Lifestyle Medicine Treatments
Investigators identify 32 performance measures in the final set grouped into 10 categories of disease or health condition.
Published: 3/30/2024
Utidelone Injectable Granted FDA Orphan Drug Designation for Breast Cancer Brain Metastasis
The recent ODD for the utidelone injectable could offer another treatment option for patients with BCBM.
Published: 3/29/2024
Researchers Identify Two Mutations Potentially Linked to Rare Blood Disorder
The mutations, C594Y and P735R, were found in the GNE gene and may influence sialylation, a process that is crucial for brain development.
Published: 3/29/2024
Exposure to Residential Greenness During Pregnancy Associated With Increased Risk of Asthma
The effects were strongest during the spring season and in the third trimester of pregnancy.
Published: 3/29/2024
Study Finds ALL Genetic Variant That Indicates Why Hispanic, Pediatric Patients Are Likely to Develop Disease
Pediatric patients with the variant were approximately 1.44 times more likely develop ALL compared with children who do not have the variant.
Published: 3/29/2024
Study: mRNA Technology Holds Potential for Delivery of Tau-Targeting Antibodies
Investigators found that mRNA technology for the delivery of antibody therapeutics were used to target tau in Alzheimer disease and can be applied to other tau targets.
Published: 3/29/2024
FDA Grants ODD to AP303 for Treatment of Patients With Autosomal Dominant Polycystic Kidney Disease
The ODD comes after AP303 presented meaningful improvements in renal survival in an ADPKD and the completion of the first study that evaluated healthy human participants.
Published: 3/29/2024
Dramatic Tumor Regression Was Displayed in New Approach to CAR T Therapy
The results displayed a dramatic reduction in the individuals’ tumors within days after single treatment.
Published: 3/28/2024
Bonding of RSV Prefusion F Proteins Display Potency Advantages
Calder’s 3D Vaxlock technology attained 11 times more effective immune response, compared to typical comparator.
Published: 3/28/2024
FDA Approves Expanded Indication for Tenofovir Alafenamide as Hepatitis B Treatment
The new indication includes pediatric patients aged 6 years and older who weigh at least 25 kg and have compensated liver disease.
Published: 3/28/2024
MS Awareness Month: Pharmacists Have an Integral Role in Patient Care, Support
The manager of clinical pharmacy at UPMC Health Plan describes the significance of the pharmacist’s role in multiple sclerosis care and when collaborating with other health care providers.
Published: 3/28/2024
Social Media Users Turn to Twitter for Birth Control Guidance, Education
The authors note that these findings provide opportunities for health care professionals to utilize social media to reach patients and share accurate information.
Published: 3/28/2024
FDA Approves Vadadustat for Oral Treatment of Anemia Due to Chronic Kidney Disease
Vadadustat (Vafseo; Akebia Therapeutics Inc) is indicated for individuals with chronic kidney disease who have been receiving dialysis for at least 3 months.
Published: 3/28/2024
New Research Shows Impact, Efficacy of PERT in Pediatric Patients With Pancreatitis
The authors believe that pancreatic enzyme therapy has potential in managing patient symptoms, altering the disease course, and the development of standardized care.
Published: 3/28/2024
Study Finds COQ2 Essential for Multiple Myeloma Proliferation, Affects Sensitivity to Cell Death
The study authors are hopeful that this finding can help in the development of new drugs or treatments for patients with multiple myeloma.
Published: 3/28/2024
Continuing Education Programming Focuses on Specialty Pharmacy Skills
Just as the pharmacy field is expanding its horizons, CE programs are offering new topics and learning strategies.
Published: 3/28/2024
FDA Issues Letters to 6 Companies for Unapproved, Misbranded OTC Analgesic Products
The agency warns consumers against using these products, which are marketed for topical use to relieve pain associated with cosmetic procedures.
Published: 3/27/2024
FDA Approves Sotatercept-csrk for Pulmonary Arterial Hypertension
Sotatercept-csrk is the first approved activin signaling inhibitor therapy for pulmonary arterial hypertension, which represents a new class of therapy.
Published: 3/27/2024
Adjuvanted RSVPreF3 Vaccine Could Prevent RSV Infection Among Older Adults
The adjuvanted RSVPreF3 vaccine could prevent nearly 3 million symptomatic RSV-ARI cases among US older adults over 3 years’ time, according to study results.
Published: 3/27/2024
Improvements Made in Stem Cell Transplant for Older Patients With AML Since 2000
A study that analyzed data from 2000 to 2021 indicated improvements for both leukemia-free survival and overall survival for older patients with acute myeloid leukemia.
Published: 3/27/2024
Osimertinib With Chemotherapy Could Aid Overall Survival for NSCLC
Benefits throughout post-progression endpoints and outcomes were reported for osimertinib in combination with chemotherapy.
Published: 3/27/2024
Biosense Webster Announces FDA Submission for Approval of the Varipulse Platform
All 20 participants in a 12-month follow-up study attained acute success from ablation procedures.
Published: 3/27/2024
Nirmatrelvir/Ritonavir in Patients With Hematologic Malignancies Improves COVID-19 Outcomes
Early treatment administration with this regimen also promoted a faster decrease in viral load and shorter viral shedding in patients with hematologic diseases who were positive for COVID-19.
Published: 3/27/2024
FDA Approves Cobas Malaria to Help Reduce Risks Infections From Transfused Blood Products
The test scans whole blood samples from individual human donors for the 5 parasite species that can cause malaria in humans and detects Plasmodium RNA and DNA.
Published: 3/26/2024
FDA Grants Fast Track Designation to Nipocalimab for Fetal Neonatal Alloimmune Thrombocytopenia
In December 2023, nipocalimab (Johnson & Johnson) was granted orphan drug designation for fetal neonatal alloimmune thrombocytopenia.
Published: 3/26/2024
Safeguarding Pharmacy Integrity: Strategies Against Drug Diversion
Pharmacists play a pivotal role working alongside the DEA and OIG in enforcing and preventing drug diversion nationally.
Published: 3/26/2024
FDA Grants Orphan Drug Designation to Felzartamab for Kidney Transplant Recipients
Previously, felzartamab received orphan drug designation and breakthrough therapy designation for the treatment of primary membranous nephropathy.
Published: 3/26/2024
Phase 3 Trial of Pembrolizumab with Olaparib Did Not Meet Endpoints Among Individuals with NSCLC
Pembrolizumab in combination with chemotherapy followed by maintenance olaparib did not meet its pre-specified statistical criteria of overall survival or progression free survival.
Published: 3/26/2024
Low Melatonin in the Gut Can Increase Risk of Neurological Disorders
Melatonin is linked to circadian rhythm, mitochondrial function, and neuroinflammation.
Published: 3/26/2024
New York Citizens, Out-of-State Patients Can Receive Birth Control Without a Prescription
The state order was signed on Tuesday and is just a part of an overall mission to strengthen and protect reproductive rights within New York for citizens and those out of state.
Published: 3/25/2024
FDA Grants ODD to Cevidoplenib for the Treatment of Immune Thrombocytopenia
The orphan drug designation (ODD) comes after positive results from a phase 2 trial that showed cevidoplenib improved platelet counts by 63.6% and 40.9% in 2 different dose groups.
Published: 3/25/2024
FDA Approves Macitentan, Tadalafil Combination Tablet for PAH
The combination tablet (Opsynvi; Johnson & Johnson) can also be used for individuals with pulmonary arterial hypertension who are being treated with stable doses of macitentan and tadalafil as separate tables.
Published: 3/25/2024
Vitamin A Derivative May Have a Significant Role in Wound Healing
Vitamin A regulates stem cell differentiation to manage wound healing, although risk of tumor growth may increase if differentiation does not occur.
Published: 3/25/2024
FDA Approves Ravulizumab-cwvz for Neuromyelitis Optica Spectrum Disorder
Zero relapses were reported among individuals that received ravulizumab-cwvz over the 73 weeks of treatment.
Published: 3/25/2024
FDA Grants Pemivibart Emergency Use Authorization for PrEP of COVID-19 in Immunocompromised Patients
The indication is for adults and adolescents with moderate to severe immune compromise due to medical conditions or immunosuppressive medications and treatments.
Published: 3/25/2024
FDA Grants ODD to Utidelone Capsules For Treatment of Gastric Cancer
The orphan drug designation (ODD) is a result of positive findings from a phase 2 clinical trial which demonstrated a 100% clinical benefit rate in patients.
Published: 3/25/2024
Table Salt Fortified With Folic Acid is A Cheap, Effective Way to Prevent Fatal Birth Defects
Fortification with folic acid may be especially beneficial in countries that do not have mandated folic acid fortification regulations.
Published: 3/25/2024
Positive Results Show Blood-Based Screening Test Detected Colorectal Cancer
The test’s sensitivity in distinguishing colorectal cancer, in combination with real-world adherence, showed its ability to detect cancer at a curable stage.
Published: 3/25/2024
FDA Grants Fast Track Designation to PT886 for the Treatment of Pancreatic Cancer
PT886 (Phanes Therapeutics) received fast track designation 2 years after receiving orphan drug designation by the FDA.
Published: 3/25/2024
An FDA Perspective on Improving Workplace Mental Health and Wellbeing
An FDA executive discusses the Surgeon General’s recommendations for promoting mental health and wellbeing for employees in the workplace.
Published: 3/24/2024
Addressing Obesity Through Shared Decision Making in an Interdisciplinary Weight Management Clinic
A pharmacist discusses the impact of comprehensive weight management with a shared decision making approach.
Published: 3/24/2024
The Role of the Pharmacist in Long-Acting Injectable Therapies for Schizophrenia and Bipolar Disorder
These therapies can improve treatment adherence for patients, especially for those with a history of poor or uncertain adherence.
Published: 3/24/2024
Pharmacists' Vital Role in RSV Vaccination: Shared Clinical Decision Making and Education
Shared decision making with patients is a key component of RSV vaccination, which can bring challenges and opportunities.
Published: 3/23/2024
Navigating Cannabis in Pharmacy Practice: State Legislation and Contraindications for Patient Use
Pharmacists can educate patients on current clinical evidence of cannabis’s therapeutic benefit, as well as cannabis’s complexities, risks, and potential adverse effects.
Published: 3/23/2024
FDA Expands Label for Bempedoic Acid to Reduce Cardiovascular Risk, With or Without Statins
Bempedoic acid (Nexletol; Esperion) and bempedoic acid and ezetimibe (Nexlizet; Esperion) are the only LDL-C lowering non-statin drugs indicated for primary prevention patients.
Published: 3/22/2024
FDA Approves Mirvetuximab Soravtansine-Gynx for Patients With Certain Ovarian Cancers
The treatment is indicated for patients with FRα-positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancers.
Published: 3/22/2024
AstraZeneca to Initiate Trial for Triple-Combination Inhaled Therapy for Chronic Obstructive Pulmonary Disease
The company has announced that the first participants have also been dosed in the ATHLOS phase 3 clinical trial, investigating budesonide/glycopyrronium/formoterol fumarate (Breztri Aerosphere).
Published: 3/22/2024
V116 Demonstrates Positive Immunogenicity for 21 Pneumococcal Serotypes
Positive data were presented at the 13th Meeting of the International Society of Pneumonia and Pneumococcal Disease in Cape Town, South Africa.
Published: 3/22/2024
AI, Machine Learning Can Bring Significant Benefits to Pharmaceutical Development, Research
Identifying the best uses for these tools, whether in patient education, data collection, improving efficiencies, or other uses, could significantly improve the future of pharmacy.
Published: 3/22/2024
FDA Approves Givinostat as First Nonsteroidal Drug for Duchenne Muscular Dystrophy
The FDA recommends the dosage of givinostat (Duvyzat; Italfarmaco, ITF Therapeutics) should be based on the individual’s body weight and administered twice daily with food.
Published: 3/22/2024
Cranberry Supplementation Can Boost Athletic Performance During Strenuous Exercise
Cranberry extract improved speed in the 1500-meter time trial by 1.5%.
Published: 3/21/2024
Study: PCR-Based Testing Results in Faster, Targeted Treatment for Community-Acquired Pneumonia
When considering community-acquired pneumonia alone, the PCR test identified 113 bacterial detections compared with 57 for the standard of care test.
Published: 3/21/2024
Study Data Suggests Sustained Safety, Efficacy of Lanadelumab in Adolescents With HAE
The data comes from 2 phase 4 trials, ENABLE and EMPOWER, which evaluated lanadelumab and the outcomes of treatment in adolescents with hereditary angioedema.
Published: 3/21/2024
FDA Approves Rilpivirine for Treatment of HIV for Pediatric Patients 2 and Older
Rilpivirine (Edurant Ped; Johnson and Johnson) is indicated for the treatment of HIV in combination with other antiretroviral therapies in treatment-naïve pediatric patients.
Published: 3/21/2024
FDA Approves Aprocitentan for Treatment of Hypertension in Combination With Other Drugs
The FDA has only approved aprocitentan (Tryvio; Idorsia) in the 12.5 mg dosage as the effects were similar between the 25 mg and 12.5 mg dosages.
Published: 3/21/2024
Celltrion USA Submits Biologics License Application for CT-P39, a Biosimilar to Xolair
The BLA includes all indications for Xolair, including asthma, chronic rhinosinusitis with nasal polyps, immunoglobulin E-mediated food allergy, and chronic spontaneous urticaria.
Published: 3/21/2024
Merck Announces Initiation of Clinical Development for Investigational HPV Vaccine
Merck will also conduct clinical trials in both males and females to evaluate the efficacy of a single dose of their current human papillomavirus vaccine compared with the approved 3-dose regimen.
Published: 3/21/2024
There Is a Need for Better CIN Therapies to Prevent Cervical Cancer
Methods of treating cervical intraepithelial neoplasia are limited and invasive. The need for better treatments is clear; however, there are several promising therapies under development.
Published: 3/20/2024
Study Results Show Certain Interventions Unnecessary in Managing Complications From CAR T-Cell Therapy
Findings show that magnetic resonance imaging and lumbar puncture are not always needed when managing complications of CAR T-cell therapies, but may be beneficial in certain cases.
Published: 3/20/2024
Study Data Suggest SARS-CoV-2 Is Less Severe in Pediatric Patients
Regardless, hygiene practices and prevention measures for SARS-CoV-2 should be strongly practiced to prevent all respiratory viruses.
Published: 3/20/2024
Pembrolizumab, Chemoradiotherapy Meet Overall Survival Endpoint for Cervical Cancer
Previously, the study met the other primary endpoint of progression free survival, showing statistically significant and clinically meaningful improvements compared to chemoradiotherapy alone.
Published: 3/20/2024
New Compound Found in Edible Mushroom May Pave the Way for Antioxidant-Based Medicines
The study represents a new era of research into mushrooms as a resource for pharmaceutical development.
Published: 3/20/2024
Study: Lebrikizumab Demonstrates Improvements in Atopic Dermatitis for Patients of Color
The efficacy data are consistent with other phase 3 studies, reinforcing lebrikizumab's potential as a first-line treatment across a range of skin tones.
Published: 3/20/2024
FDA Approves sNDA for Ponatinib in Adult Patients With Newly Diagnosed Ph+ ALL
The approval comes after positive results from the PhALLCON study, however, further research is needed to confirm immature event-free survival findings.
Published: 3/19/2024
Glucophage Activates the Same Pathway as Sprint Exercise to Reduce Appetite
The oral medication activates an “anti-hunger” molecule which may prevent people from overeating.
Published: 3/19/2024
FDA Approves Expanded Indications for Spesolimab-sbzo Injection for the Treatment of Generalized Pustular Psoriasis
To date, this is the only targeted therapy indicated for the treatment of generalized pustular psoriasis.
Published: 3/19/2024
FDA Approves Atidarsagene Autotemcel for Treatment of MLD in Pediatric Patients
This approval makes atidarsagene autotemcel the only therapy to be approved in the US for early-symptomatic early juvenile metachromatic leukodystrophy.
Published: 3/19/2024
FDA Issues Paper on the Responsible Use of Artificial Intelligence in Medical Research
The agency will focus on collaboration to protect public health; advancing regulatory approaches; developing standards, guidelines, and best practices; and supporting research that evaluates and monitors AI performance.
Published: 3/19/2024
AllianceRx Walgreens Pharmacy to Exclusively Provide Vivjoa for Recurrent Vulvovaginal Candidiasis
Oteseconazole (Vivjoa; Mycovia Pharmaceutical Inc) is the first and only medication for this indication in postmenopausal women and those who do not have reproductive potential.
Published: 3/19/2024
The Care Partner Clinic Addresses Common Barriers to Care
Pharmacists at this clinic work with patients to improve medication education, affordability, and access to care.
Published: 3/19/2024
Study Results Show Evolving DNA Methylation Can Help Understanding of Hematologic Diseases
The authors note that understanding the DNA methylation profile in leukemia can help predict whether or not a patient will respond to treatment.
Published: 3/18/2024
NCPA, Biosimilar Forum Voice Support for PBM Reform Bill
Senators Ron Wyden and Mike Crapo reaffirm their support on 2 health care bills that passed the United States Senate Committee on Finance in 2023.
Published: 3/18/2024
Bacterial Load in Spinal Fluid Could Predict Pneumococcal Meningitis Outcomes
High bacterial load in cerebrospinal fluid was associated with unfavorable outcomes and death for adults with pneumococcal meningitis.
Published: 3/18/2024
FDA Advisory Committee Votes in Favor of Ide-Cel for Adult Patients With Multiple Myeloma
The decision to vote in favor of idecabtagene vicleucel comes after positive phase 3 trial results demonstrating its efficacy compared with standard regimens.
Published: 3/18/2024
Topical Minoxidil Improves Hair Growth in 87% of Pediatric Patients With Chemotherapy-Induced Alopecia
The FDA-approved topical and oral agent is currently indicated for adult patients with patterned alopecia.
Published: 3/18/2024
BCMA-Targeting Therapies, Administration Routes Have Varying CRS Incidence and Severity in Patients With RRMM
Chimeric antigen receptor T-cell therapies were associated with higher incidences, grades of severity, and longer duration of cytokine release syndrome compared with bispecific antibodies.
Published: 3/17/2024
Study: Researchers Identify 25 Air Pollutants Associated With Asthma Symptoms
Investigators found that 1,1,1 trichloroethane; 2-nitropropane; and 2,4,6 trichlorophenol were significantly associated with asthma symptoms for 3 exposure periods.
Published: 3/16/2024
FDA Approves Liso-Cel Therapy for Treatment of Adult Patients With CLL, SLL
In a phase 1/2 clinical trial, lisocabtagene maraleucel helped patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) achieve complete response rates.
Published: 3/15/2024
Study: Only 40% of Adults With Childhood Asthma Experience Remission
The study showed no clinical differences for remission or asthma at age 28 years based on lung function, body mass index, daily smoking, exposure to parental tobacco smoke, or house dampness .
Published: 3/15/2024
Are Community Health Workers The Key to Promoting Diversity in Clinical Trial Enrollment?
Their expansive scope of services can ultimately help to elevate the work of the entire community pharmacy.
Published: 3/15/2024
Risankizumab Significantly Reduces Severity of Psoriasis Symptoms
Compared to placebo, risankizumab significantly reduced symptom severity for patients with moderate to severe disease.
Published: 3/15/2024
Ovarian Function May Be Associated with Lifespan
Women who have longer ovarian function and enter menopause later in life tend to live longer, according to women’s health researcher.
Published: 3/15/2024
FDA Grants Breakthrough Device Designation for Neuroimmune Modulation Platform To Treat MS
The platform is a first-of-its-kind therapeutic approach to promote remyelination among individuals with relapsing/remitting multiple sclerosis.
Published: 3/15/2024
LSD D-Tartrate Receives Breakthrough Therapy Designation From FDA for Generalized Anxiety Disorder
LSD d-tartrate (MM-120) showed rapid improvements in patients with generalized anxiety disorder by day 2 of the study.
Published: 3/15/2024
FDA Approves Tislelizumab-jsgr for Advanced or Metastatic Esophageal Squamous Cell Carcinoma After Prior Chemotherapy
Results from the phase 3 RATIONALE 302 trial showed tislelizumab-jsgr prolonged survival compared to chemotherapy in patients who received prior systemic treatment.
Published: 3/14/2024
FDA Grants Accelerated Approval of Resmetirom for Noncirrhotic Nonalcoholic Steatohepatitis With Moderate to Advanced Liver Fibrosis
The accelerated approval of resmetirom, a once-daily, oral thyroid hormone receptor-β agonist, is the first treatment available for patients with this disease.
Published: 3/14/2024
Elranatamab Maintains or Improves Symptoms and Health Status of Patients With Multiple Myeloma
This finding was evident in both examined groups and regardless of the patients' B-cell maturation antigen-directed therapy status.
Published: 3/14/2024
FDA Approves Maralixibat for Treatment of Pediatric Patients With PFIC
The drug is indicated for patients 5 years of age and older with progressive familial intrahepatic cholestasis and cholestatic pruritus in pediatric patients with Alagille syndrome.
Published: 3/14/2024
New Tool Helps Providers Navigate Adalimumab Biosimilars
The tool consolidates and highlights key features that would be considered when choosing a biosimilar adalimumab.
Published: 3/14/2024
FDA Breakthrough Therapy Designation Granted to Novel Psychedelic Molecule CYB003 for Major Depressive Disorder
At 4 months, 75% of participants achieved remission and no longer showed signs of depression symptoms in a phase 2 clinical trial.
Published: 3/14/2024
Ruxolitinib Cream Could Provide Relief in Children Impacted by Atopic Dermatitis
The findings suggest that ruxolitinib cream could aid itch, pain, and sleep disturbance.
Published: 3/14/2024
SABATO Trial: Implications for Pharmacists in Staphylococcus Aureus Treatment
Study results indicate early swap to oral antibiotics in Staphylococcus aureus bacteremia is just as effective.
Published: 3/13/2024
Study: Lymphoma Patients Recover Longer for Pneumonia
Furthermore, the study authors indicated that patients with lymphoma and community-acquired pneumonia have broader dysregulated responses.
Published: 3/13/2024
Risankizumab Demonstrated Superior to Apremilast for Patients With Moderate Psoriasis
This treatment improved the severity of symptoms in patients with scalp and nail psoriasis.
Published: 3/13/2024
Upadacitinib Can Significantly Improve Clinical Outcomes in Patients With Atopic Dermatitis
Findings originate from phase 3 data that was recently presented at the 2024 American Academy of Dermatology (AAD) Annual Meeting.
Published: 3/13/2024
GZ17-6.02 Effective in Killing Multiple Myeloma Cells, Other Benefits When Combined With Bortezomib
The combination of GZ17-6.02 and bortezomib reduced of HDAC, and as a result ATG13 phosphorylation was enhanced, BAK levels increased, and BCL-XL levels were reduced.
Published: 3/13/2024
Updates to the American Diabetes Association Standards of Care in Diabetes
A notable revision now includes a dual GIP and GLP-1 receptor agonist (tirzepatide) as an additional option for glycemic management, preferred over insulin.
Published: 3/13/2024
Significant Events Throughout Life Increase Chances For Anxiety, Depression, and Cognitive Decline
The findings also indicated that individuals who experienced significant adverse events in childhood were approximately 17% more likely to experience adverse events in adulthood.
Published: 3/12/2024
A New Study Finds That Ruxolitinib Cream 1.5% Is Effective for Most Patients With HS
The cream significantly reduced abscesses and inflammatory nodules, reaffirming its efficacy as a maintenance option for HS.
Published: 3/12/2024
Longevity Science Does Not Only Focus on Living Longer
Health span, wealth span, advocacy, and ethics are all burgeoning topics within the field of longevity.
Published: 3/12/2024
J&J Submits sBLA To FDA for Guselkumab in Ulcerative Colitis
Individuals included in the study reported positive changes in fatigue, and disease activity displayed endoscopic and histologic remission.
Published: 3/12/2024
Innovations in Women’s Health Research Aim to Make Menopause Optional
Menopause can have severe repercussions on female health which impact quality of life and health span, according to an expert of women’s health.
Published: 3/12/2024
Viagra May Alleviate Dysmenorrhea-Related Pain, However Funding Challenges Have Limited Clinical Research
The early phase clinical trial, which ended prematurely in 2013 due to funding challenges, further illustrates disparities in health equity in clinical research.
Published: 3/11/2024
Multiple Myeloma Awareness Month: Raising Awareness, Sharing Stories With #MyelomaActionMonth
This initiative aims to raise worldwide awareness of the disease while trying to strengthen the connection between members of the multiple myeloma community.
Published: 3/11/2024
Navigating Research in Psychedelics: Investigators Face a Mosaic of Regulations, False Perceptions, and Therapeutic Potential
If clinical trials continue to show that psychedelics offer safe and long-lasting results, then psychedelic-assisted therapy could flourish as a treatment in the mental health space.
Published: 3/11/2024
Secukinumab May Significantly Reduce Inflammation in Patients With Hidradenitis Suppurativa
Secukinumab affects levels of inflammatory biomarkers, and monitoring levels can help investigators understand how patients are responding to treatment.
Published: 3/11/2024
Gestational Diabetes Mellitus Could Increase Maternal Susceptibility to Group B Streptococcus
GBS can cause transcriptional adaptations, which may increase risk of poor neonate outcomes.
Published: 3/11/2024
FDA Approves sBLA to Extend Temperature Storage Conditions for Two IVIG Products
The IVIG therapies were previously approved for 4-week room temperature storage conditions of 25º Celsius during the first 24 months of shelf life.
Published: 3/11/2024
Medical Non-Compliance Post-BMT in Pediatric Patients Associated With Annual Income, Insurance Status
The study results also indicated that graft versus host disease status was associated with non-compliance following bone marrow transplantation.
Published: 3/11/2024
Advanced Hidradenitis Suppurativa Increasingly Associated with cSCC
In addition, the length of hospital admissions were greater in patients with hidradenitis suppurativa-associated cutaneous squamous cell carcinoma compared to other admissions.
Published: 3/10/2024
FDA Approves Semaglutide for New Indication Involving Cardiovascular Disease
Semaglutide (Wegovy; Novo Nordisk) reduces the risk of cardiovascular death, heart attack, and stroke in adults with cardiovascular disease and either obesity or overweight when combined with the standard-of-care.
Published: 3/8/2024
President Biden Announces Desire to Cap Drug Prices for All Americans
In the State of the Union Address, President Biden said he wants to expand the $2,000 out-of-pocket cap beyond seniors and allow Medicare to negotiate more costly drugs.
Published: 3/8/2024
Study: SB17 Shows Biosimilarity to Ustekinumab for Plaque Psoriasis
The biosimilarity was evident between SB17 (Samsung Bioepis), ustekinumab (Stelara; Janssen Immunology), and those switching from ustekinumab to SB17.
Published: 3/8/2024
FDA Questions Donanemab Efficacy for the Treatment of Alzheimer Disease
The FDA is convening a committee to discuss phase 3 data after the planned action date, which delays drug availability to patients.
Published: 3/8/2024
Belantamab Mafodotin Regimen Indicates Safety, Improved OS in Patients Treated With Multiple Myeloma
Despite the belantamab mafodotin regimen improving overall survival in patients with relapsed or refractory multiple myeloma, the trial is ongoing to confirm the presented results.
Published: 3/8/2024
Guiding Women Within Health Care and the Significance of Self-Development, Improvement
The vice president and chief pharmacy officer at City of Hope explains how she serves as a mentor for women within health care, the importance of networking, and staying educated.
Published: 3/8/2024
Report: 2024 Projected to Be A Big Year for Biosimilars in the Retina Space
Cardinal Health released its 2024 biosimilars report, including research and in-depth analyses on legislative development, payer landscapes, and new treatments in the pipeline.
Published: 3/8/2024
Female Leadership, Empowerment, and Self-Advocating Key to Overcoming Gender Inequities in Health Care
The vice president and chief pharmacy officer of City of Hope discusses obstacles women face in health care and how diversity, equity, and inclusion can be promoted within the space.
Published: 3/8/2024
FDA Approves Nivolumab-Based Regimen for First-Line Treatment in Adult Patients With Urothelial Carcinoma
Patients with urothelial carcinoma who were treated with the nivolumab-based regimen had better OS and PFS compared with those who received cisplatin with gemcitabine alone.
Published: 3/7/2024
FDA Grants Accelerated Approval to Zanubrutinib for Relapsed, Refractory Follicular Lymphoma
The application was previously granted fast track designation and orphan drug designation.
Published: 3/7/2024
Telemedicine Usage Increased for Pediatric Asthma Following COVID-19 Pandemic
Individuals with persistent asthma and at least 1 complex comorbidity were more likely to use telemedicine, the results of the study showed.
Published: 3/7/2024
Study: Belumosudil Decreased Collagen, IL-17 Levels for Skin, Oral cGVHD
The study is a companion study to the ROCKstar study, which investigated the drug in individuals with cGVHD who received 2 to 5 prior lines of therapy.
Published: 3/7/2024
Clinical Pharmacist Specialists Are Providing Disease-Specific Support For GI-Related Malignancies
“I see clinical pharmacy specialists (CPS) to be more like the frontline folks that would pretty much work very closely with the providers,” according to a CPS at City of Hope.
Published: 3/7/2024
FDA Grants Orphan Drug Designation for Avutometinib Alone or With Defactinib in Recurrent LGSOC
The designation is for all patients with low-grade serous ovarian cancer, regardless of their KRAS status and after 1 or more prior lines of therapy.
Published: 3/7/2024
FDA Approves Tocilizumab-aazg as Biosimilar to Actemra for Multiple Indications
Tocilizumab-aazg (Tyenne; Fresenius Kabi) is the first approved biosimilar to tocilizumab (Actemra; Genentech) as both intravenous and subcutaneous.
Published: 3/7/2024
Small Vessel Disease, Amyloid Pathology Can Independently Reduce Cognition in Adults With T2D
Diabetes is a known risk factor for cognitive decline and small vessel disease.
Published: 3/6/2024
Vitamin D May Prolong ‘Honeymoon Phase’ of Type 1 Diabetes in Patients With Recent Diagnosis
Vitamin D preserved insulin-producing cells and cell function, which can reduce complications in young patients.
Published: 3/6/2024
Researchers Compare Reimbursement and Access to New Treatments in European Lung Cancer Care
They also compared the approach of the European Medicines Agency and the FDA in drug approvals.
Published: 3/6/2024
FDA Grants Breakthrough Device Designation for Phospho-Tau 217 to Help Detect AD
The device conducts blood biomarker tests that accurately diagnose amyloid pathology and can assist in diagnosing Alzheimer disease in patients with cognitive impairment.
Published: 3/6/2024
Study Analyzes Use of a Single At-Home Rapid Test for RSV, COVID-19, Flu
The at-home test offers the availability to assess for all viruses using one tool.
Published: 3/6/2024
Pharmacists Take the Lead When Monitoring Patients with Multisensor Implantable Cardioverter Defibrillators
Findings showed that pharmacists frequently communicated with patients to implement complex plans.
Published: 3/6/2024
Proposed Biosimilar for Denosumab Has Similar Safety, Efficacy as Reference
A phase 1 study previously demonstrated that MW032 and denosumab were bioequivalent in pharmacokinetics, pharmacodynamics, safety, and immunogenicity.
Published: 3/6/2024
Study: AI-Based Recommendations Can Reduce Recurrent Strokes, Heart Attacks
Artificial intelligence (AI) recommendations resulted in fewer recurrent strokes, heart attacks, or vascular death within 3 months of a previous ischemic stroke.
Published: 3/6/2024
FDA Clears First OTC Continuous Glucose Monitoring, Dexcom Stelo Glucose Biosensor System
The continuous glucose monitoring system will be available for purchase online and without a prescription starting in summer 2024.
Published: 3/5/2024
CORe Initiative Looks to Transform Cancer Research Through Increased Diversity and Data Sharing
The CORe initiative is aimed at promoting inclusivity, reducing startup time for clinical trials, and facilitating data sharing to address recruitment and retention challenges in cancer research at community oncology sites.
Published: 3/5/2024
FDA Approves Two Denosumab Biosimilars for All Indications of Reference Products
Denosumab-bbdz (Wyost; Sandoz) and denosumab-bbdz (Jubbonti; Sandoz) are approved as interchangeable for all indications of denosumab (Xgeva and Prolia; Amgen).
Published: 3/5/2024
FDA Grants Orphan Drug Designation for CBL-514 to Treat Adult Patients With Dercum Disease
This designation makes CBL-514 the first drug to receive both Orphan Drug Designation and Fast Track Designation for the treatment of Dercum disease.
Published: 3/5/2024
Understanding the Persistence of Pneumococcal Disease in Vaccinated Adults
Investigators also found that those with community-acquired, radiology-confirmed pneumonia with lower respiratory tract infections had worse outcomes.
Published: 3/5/2024
FDA Grants Fast Track Designation For EP0031/A400 to Treat RET-Altered NSCLC
The next-generation SRI was previously granted an Orphan Drug Designation in November 2023 and its safety and efficacy are currently being evaluated in clinical trials.
Published: 3/5/2024
CAR T-Cell Therapy A2B530 Receives Orphan Drug Designation for the Treatment of Colorectal Cancer
The novel therapy is also being evaluated for the treatment of solid tumors in pancreatic and non-small cell lung cancers.
Published: 3/5/2024
Environmental Toxin BPA Affects Gut Microbial Communities in Children
Children with normal weight had different community relationships compared to children with overweight or obesity.
Published: 3/5/2024
Prenatal Exposure to General Anesthesia Increases Risk of Subsequent ADHD, Behavioral Disorder Diagnosis
There have been ongoing concerns about the long-term effects of prenatal exposure on neurodevelopment.
Published: 3/5/2024
FLOW Trial Results Demonstrate Positive Kidney Outcomes With Semaglutide
In the study, investigators found superior kidney outcomes with injectable semaglutide (Ozempic) for individuals with type 2 diabetes and chronic kidney disease.
Published: 3/5/2024
Health Care Transparency Comes in Many Forms, But Is Much Needed in Patient Care
Laws can help eliminate common barriers to transparency but are not the only way to achieve health care transparency.
Published: 3/5/2024
FDA Approves Hyaluronic Acid Injection to Improve Temple Hollowing
Juvéderm Voluma XC (AbbVie) is the first and only hyaluronic acid dermal filler to receive FDA approval for this indication with results lasting up to 13 months.
Published: 3/5/2024
Study Evaluates Connection Between Smoking With DNA Changes Among Varying Racial and Ethnic Groups
Study findings could provide scientists more knowledge on why some populations face a higher risk of lung cancer compared to others.
Published: 3/4/2024
Study Results Indicate Daylight Saving Time Has Little Effect on Adverse Cardiovascular Events
According to the researchers, making changes to the daylight saving time system to accommodate heart health is unnecessary.
Published: 3/4/2024
Second-Line Bedaquiline-Based Regimens Demonstrates Microbiological Response in Patients With TB
The regimen, which was used as second-line treatment in patients with drug-resistant TB, had a similar microbiological response to those with drug-sensitive TB taking first-line regimens.
Published: 3/4/2024
Metabolites May Predict Risk of Developing Diabetes in Patients With Sleep-Disordered Breathing
In some instances, metabolites can predict risk in patients who still have normal glucose biomarkers.
Published: 3/4/2024
AAO-HNSF Publishes Clinical Practice Guidelines for Allergen Immunotherapy
AAO-HNSF guideline development group included 17 panel members, including experts from otolaryngology and allergy, those who have knowledge in clinical practice guideline development, and patient representatives.
Published: 3/4/2024
Approximately 25% of Pregnant Women Are Not Getting Enough Omega-3 Fatty Acids
Omega-3s are important during pregnancy because they can reduce risk of preeclampsia and other negative health outcomes.
Published: 3/4/2024
Study: Overgrowth of Bladder Nerve Cells Could Cause Recurring UTI Symptoms
Investigators at Duke University and the University of North Carolina determine what causes recurrent UTIs, even after antibiotics cleared the bacterial infection.
Published: 3/4/2024
CBT Intervention During Pregnancy Decreases Probability of Developing Postpartum Anxiety, Depression
The CBT-based intervention, compared with routine pregnancy care, demonstrated reductions of 81% and 74% for depression and anxiety, respectively.
Published: 3/4/2024
Study Shows Low Number of Older Americans Are Vaccinated Against RSV
Only 9% of older adults who reside in the United States had been vaccinated to protect themselves from RSV this fall and winter.
Published: 3/4/2024
Study Shows an Increase in Chronic Fatigue Syndrome Following COVID-19 Pandemic
Study findings suggest that biomarkers could provide greater insight into different disease mechanisms and how treatments options could be more beneficial for certain patients.
Published: 3/4/2024
Veteran Affairs Formulary Exclusively Includes Hadlima, Biosimilar to Humira
Jon Martin, US commercial lead of biosimilars at Organon, discusses how making their biosimilar Hadlima the preferred product on the Veteran Affairs formulary will help lower treatment costs.
Published: 3/4/2024
Integration of DBS Shows Promise Identifying Dysfunctional Brain Circuits, Treating Brain Disorders
Using deep brain simulation, study authors identified networks in the brain that can be used to better treat Parkinson disease, dystonia, Tourette syndrome, and OCD.
Published: 3/4/2024
Results Show Dupilumab Reduces Airway Inflammation In Asthma
Dupilumab (Dupixent; Sanofi) showed greater reductions in mucus plugs and greater improvements in airway volume and flow for individuals with uncontrolled moderate-to-severe asthma.
Published: 3/3/2024
FDA Approves Rybrevant as First-Line Treatment for NSCLC
The FDA also granted traditional approval to amivantamab-vmjw for adults whose disease has progressed on or after platinum-based chemotherapy.
Published: 3/1/2024
FDA Grants Second Orphan Drug Designation For Therapeutic to Treat H-ABC
Hypomyelination with atrophy of the basal ganglia and cerebellum is the most severe form of TUBB4A leukodystrophy that currently has no curative treatment.
Published: 3/1/2024
Increased Brain Network Dynamics Found in Individuals Taking Antidepressants
The dynamic reconfigurations in individuals taking antidepressant were higher than in non-users and controls, with no significant differences between those with MDD or an anxiety disorder.
Published: 3/1/2024
Walgreens and CVS Will Start Dispensing Mifepristone Within the Month
Walgreens will start dispensing the abortion pill as soon as a week.
Published: 3/1/2024
Balancing Health Tech Innovation With Safety: Navigating the Intersection of AI and Patient Care
Although regulation takes time, real safety concerns for patients in the rapid development of AI technology in health care are present today.
Published: 3/1/2024
Acupuncture May Reduce Risk of Stroke Associated With Rheumatoid Arthritis
The effects of acupuncture were independent of sex, age, medication use, and coexisting conditions, according to the results of the study published in BMJ Open.
Published: 3/1/2024
Study: Indigenous Individuals May Be More Likely to Experience Stroke
The investigators included 24 studies across 7 countries, including Australia, Canada, New Zealand, Norway, Singapore, Sweden, and the United States.
Published: 3/1/2024
Changes in Streptococcus Pneumoniae Carriage Show Effectiveness of PCV10
Investigators determined that the vaccination reduced the prevalence of vaccine serotypes with an effectiveness of 89.6% based on the study results.
Published: 3/1/2024
Addressing Cancer Mortality Disparities in Appalachia: The Role of AI and Machine Learning in Unraveling SDOH
Although cancer death rates have decreased in the United States overall, they continue to rise in rural Appalachia, engendering a malaise of fatalism in the region.
Published: 3/1/2024
Persistent COVID-19 Symptoms Objectively Linked to Worse Cognition
Individuals with persistent COVID-19 symptoms had an objectively greater cognitive deficit than individuals had never had COVID-19.
Published: 3/1/2024
Implement the 3C Model of Vaccine Hesitancy, RSV Risk in Older Adults
The finding highlighted the importance of RSV risks among older adults, and aids pharmacists’ awareness when patients are hesitant to receive the RSV vaccine.
Published: 3/1/2024
Unlocking the Potential of Machine Learning and Large Language Models in Oncology
Will Shapiro, vice president of Data Science at Flatiron Health, provides context into the terminology and history of these models.
Published: 2/29/2024
Gilead Set to Donate $12.6 Million In Funding for HIV Prevention for Black Cisgender, Transgender Women
This grant funding is a part of the company’s 3-year Setting the P.A.C.E. initiative.
Published: 2/29/2024
Investigational GLP-1 Medication Found to Reduce Body Weight
VK2735, a dual agonist of glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide, is being developed as a potential treatment for various metabolic disorders.
Published: 2/29/2024
Novel Chemotherapy Method Could Decrease Lung Cancer Tumor Size
The findings suggest that the CAR T-cell membrane-coated PLGA nanoparticles reduced tumor size after 1 dose of treatment.
Published: 2/29/2024
Analysis Identifies International Treatment Outcomes, Patterns in Individuals With NDMM
The authors found that overall survival in patients with newly diagnosed multiple myeloma was longest for those receiving first-line autologous stem cell transplantation.
Published: 2/29/2024
Longevity Science Is Trying to Strike A Balance Between Innovation and Traditional Health Care
There is a growing number of technologies, processes, and treatments being discovered in the quest to extend life.
Published: 2/29/2024
Refined Grains, Cheese Linked to Hypertensive Disorder During Pregnancy In Hispanic Population
Dietary interventions can reduce the risk of preeclampsia and other hypertensive conditions that occur during pregnancy.
Published: 2/28/2024
FDA Grants Breakthrough Therapy Designation to NVL-520 for ROS1-Positive NSCLC
NVL-520 is a novel brain-penetrant ROS1-selective TKI being investigated for ROS1-positive metastatic non–small cell lung cancer in patients who have previously been treated with 2 or more ROS1 TKIs.
Published: 2/28/2024
Plant-Derived Extracellular Vesicles Offer a Promising Treatment for Irritable Bowel Disease
Repairing the intestinal epithelial barrier is paramount in the treatment of IBD.
Published: 2/28/2024
FDA Grants Priority Review to Epcoritamab-bysp for Relapsed or Refractory Follicular Lymphoma
If approved, epcoritamab (DuoBody CD3xCD20; AbbVie, Genmab) would be the first and only subcutaneous bispecific antibody for treatment in this patient population.
Published: 2/28/2024
FDA Accepts sBLA For Bimekizumab-Bkzx in 3 New Spondyloarthritides Indications
The 3 bimekizumab indications include psoriatic arthritis, non-radiographic axial spondyloarthritis, and ankylosing spondylitis.
Published: 2/28/2024
Pharmacists Are Key Access Point for Patients Amid Alabama Ruling on IVF
In LePage v. Center for Reproductive Medicine, the Alabama Supreme Court ruled that “extrauterine embryos” are considered children, causing some infertility clinics to halt IVF processes.
Published: 2/28/2024
“People Are Screaming Out for Alternatives” In Mental Health Care, And Psychedelics May Fill The Gap, Expert Suggests
Many psychedelics being studied for clinical use are not "magic mushrooms", rather clinical drugs formulated using good manufacturing practice standards.
Published: 2/27/2024
Survodutide Improves Liver Disease Progression in More than 80% of Patients with MASH
After 48 weeks of treatment with survodutide, patients demonstrated histological improvement, a reduction in liver fat content, and did not experience worsening fibrosis.
Published: 2/27/2024
Top 5 Sessions, Interviews at the ACCC 50th Annual Meeting & Cancer Center Business Summit
The ACCC 50th Annual Meeting & Cancer Center Business Summit is taking place in Washington, DC from February 28 to March 1.
Published: 2/27/2024
Gepotidacin Demonstrates Non-Inferiority Treating Uncomplicated Urogenital Gonorrhea in Phase 3 Trial
Gepotidacin was compared with the combination of ceftriaxone and azithromycin in adolescent and adult patients with uncomplicated urogenital gonorrhea.
Published: 2/27/2024
Data From OUtMATCH Study Show Benefits of Xolair for Common Food Allergies
The data follow the FDA approval of omalizumab for the reduction of allergic reactions, including anaphylaxis, that can occur after exposure to 1 or more foods.
Published: 2/27/2024
Positive Results Show Benefits of Benralizumab for Eosinophilic Granulomatosis With Polyangiitis
The results were presented as a late-breaking poster presentation at the American Academy of Allergy, Asthma, and Immunology Annual Meeting.
Published: 2/27/2024
FDA Approves Expanded Indication for Biktarvy for HIV Treatment
The new indication includes individuals with HIV who have suppressed viral loads with known or suspected M184V/I resistance.
Published: 2/26/2024
Experts: Current Treatment Regimens and the Future for Plaque Psoriasis, Atopic Dermatitis
In addition to current treatment regimens, 2 experts discuss how available options can vary between adult and pediatric patients.
Published: 2/26/2024
Cardiology Pharmacists Can Optimize, Educate Patients With Heart Failure
Experts sheds light on gaps in gender and use of referrals, health literacy, and medication access in the treatment of patients with heart failure.
Published: 2/26/2024
Short Sleep Duration May Reduce Lifespan, Study Shows
Investigators found genetic evidence that certain sleep behaviors can be risk factors for lifespan.
Published: 2/26/2024
FDA Accepts Supplemental New Drug Application for Adagrasib for Colorectal Cancer
The sNDA was based on results from the KRYSTAL-1 study, evaluating the drug alone or in combination with other anti-cancer therapies in those with advanced solid tumors who have KRASG12C mutations.
Published: 2/26/2024
FDA Withdraws Approval of Melphalan Flufenamide for the Treatment of Multiple Myeloma
The withdrawal comes after clinical trial results failed to demonstrate the safety and efficacy of melphalan flufenamide when combined with dexamethasone.
Published: 2/26/2024
FDA Approves Adalimumab-ryvk as Interchangeable Biosimilar for Humira
Adalimumab-ryvk is the first high-concentration, citrate-free biosimilar to Humira that has been granted interchangeability status for the 40 mg/0.4 ml injection.
Published: 2/26/2024
Ciltacabtagene-Autoleucel Recommended for Approval to Treat Relapsed/Refractory Multiple Myeloma
The recommendation comes after positive phase 3 trial results in adult patients with relapsed and refractory multiple myeloma.
Published: 2/26/2024
Expert Predicts Psychedelics Will Be Integrated into Current Regimens for Treating Mental Health Diseases
Investigators continue to conduct regulated and controlled clinical trials to build compelling, high-quality evidence on their therapeutic potential.
Published: 2/26/2024
Samsung Bioepis Initiates Phase 1 Trial for Proposed Keytruda Biosimilar
As of January 2024, Keytruda has been approved for 6 indications in NSCLC across the metastatic and earlier stages of the disease.
Published: 2/26/2024
Experts: The Impact of Plaque Psoriasis, Atopic Dermatitis on Patients’ Quality of Life
In addition to highlighting the difficulties patients face when managing plaque psoriasis and atopic dermatitis, 2 experts describe how pharmacists play a crucial role in treatment.
Published: 2/23/2024
Real-World Evidence Enters the Discussion for Biosimilar Switching
Dedicated clinical trials in IBD cohorts that scrutinized biosimilar use in real-world clinical practice have direct implications on decision making.
Published: 2/23/2024
Adult Hepatitis B Vaccine Recommendations: Identify, Strongly Recommend, Protect
Published: 2/23/2024
FDA Accepts Priority Review for Linvoseltamab to Treat Adult Patients With R/R MM
Currently, the safety and efficacy of linvoseltamab in adult patients with relapsed or refractory multiple myeloma is being compared to elotuzumab, pomalidomide, and dexamethasone in a phase 3 clinical trial.
Published: 2/22/2024
Adverse Childhood Experiences Can Lead to Poor Behaviors As Parents
These experiences can impact mental health, which can mediate parenting behaviors like inconsistent discipline.
Published: 2/22/2024
Offering Children Vegetables at Breakfast Could Boost the Likelihood That They Grow to Like Them
The practice could become routine if parents promote morning vegetable consumption while the children are still in a developmental stage of life.
Published: 2/22/2024
FDA Grants Orphan Drug Designation for Ocifisertib to Treat Patients With AML
Currently, ocifisertib is being evaluated in a phase 1b and 2 trial to confirm the safety and tolerability profiles in patients with acute myeloid leukemia.
Published: 2/21/2024
The Gut Microbiome Looks Different for People With Treatment-Resistant Schizophrenia
Investigators suggested that this difference is caused by a common medication for treatment-resistant schizophrenia.
Published: 2/21/2024
Parasite That Causes Malaria Extracts Fatty Acids From Human Hosts for Growth
Malaria has a large global burden, affecting hundreds of millions of people each year.
Published: 2/21/2024
FDA Approves sBLA for Reduced Dosing Frequency of Teclistamab-cqyv for Patients With RRMM
Teclistamab was previously approved in October 2022 for the treatment of adult patients with relapsed or refractory multiple myeloma who received at least 4 prior therapies.
Published: 2/21/2024
A Bevacizumab Biosimilar Shows Promise for Non-Small Cell Lung Cancer
BAT1706 was clinically equivalent to the reference bevacizumab for efficacy, safety, pharmacokinetics, and immunogenicity.
Published: 2/21/2024
HOPA and Cancer Support Community Bring Together Patient and Pharmacist Points of View
HOPA has partnered with CSC for a live video interview with an oncology pharmacist and cancer patient via Zoom on Tuesday, February 27 at 5 pm CST.
Published: 2/21/2024
Study Results Show Current Smoking Increases the Risk of Death from Melanoma
Smoking 20 cigarettes per day significantly increased risk of death caused by certain types of melanomas.
Published: 2/21/2024
FDA Accepts BLA for Datopotamab Deruxtecan for the Treatment of NSCLC
Datopotamab deruxtecan is an investigational TROP2 directed antibody drug conjugate that showed positive survival impact compared to chemotherapy.
Published: 2/20/2024
FDA Accepts Application, Grants Priority Review to Vorasidenib for IDH-Mutant Diffuse Glioma
If vorasidenib receives full approval, it would be a first-in-class target therapy to treat individuals with IDH-mutant gliomas.
Published: 2/20/2024
Phase 3 EVOKE-01 Study in Metastatic NSCLC Falls Short of Primary Endpoint
Researchers from Gilead remain confident for positive results as they continue the phase 3 EVOKE-03 study in 1L metastatic PD-L1-high NSCLC.
Published: 2/20/2024
Understand Links Between RSV, Pediatric Asthma, and COVID-19
RSV can exacerbate asthma development by causing damage to the tissue in the airways, promoting inflammation and increasing airway hyper-responsiveness
Published: 2/20/2024
Higher Dietary Niacin Associated With Reduction in All-Cause Mortality Among Patients with Liver Disease
However, increasing dietary niacin did not reduce risk of mortality from cardiovascular disease, the primary cause of death associated with nonalcoholic fatty liver disease.
Published: 2/20/2024
Has C. difficile Met Its Match?
Living organisms rely on iron for survival and replication. Can new research discoveries disrupt C. difficile’s ability to maintain iron homeostasis?
Published: 2/20/2024
Study: Gastric Bypass Surgery Put Approximately 75% of Patients With Type 2 Diabetes Into Remission
Nearly 60% of patients who regained all the weight stayed in remission at 5 years post-surgery, according to study results.
Published: 2/20/2024
FDA Approves Osimertinib With Chemotherapy for EGFRm NSCLC
Osimertinib was previously approved as a monotherapy, the first-in-line global standard of care, for non–small cell lung cancer indications.
Published: 2/19/2024
Environmental Disinfection Can Be an Affordable, Effective Way to Reduce C Difficile Infections in Hospitals
Targeted use of ultraviolet light and sporicidal treatment can reduce disease transmission alongside existing interventions.
Published: 2/19/2024
Making “Rheum” for Biosimilars: Overcoming Reluctance
Despite the proven efficacy of biosimilars, both patients and health care providers often have some reluctance when switching from an originator drug to a biosimilar.
Published: 2/19/2024
FDA Grants Accelerated Approval to Lifileucel For Treatment of Advanced Melanoma
This marks the first and only time that an individualized T cell therapy has been approved by the FDA for a solid tumor cancer.
Published: 2/16/2024
FDA Approves Omalizumab to Reduce Food-Based Allergic Reactions in Adult and Pediatric Patients
This marks omalizumab’s fourth FDA-approved indication for allergic and inflammatory conditions, such as severe persistent allergic asthma, with its initial approval being in 2003.
Published: 2/16/2024
Complex Congenital Heart Disease Linked to Increased Early-Life Stress
Children with heart disease who received infant open-heart surgery had more stress and neurodevelopmental impairments compared with children who did not undergo surgery.
Published: 2/16/2024
Pharmacists Can Help to Optimize the Total Health of Patients with Heart Conditions
Pharmacists can host community events and try different marketing efforts to drive community awareness about heart health and total health.
Published: 2/16/2024
FDA Grants Orphan Drug Designation to Tigilanol Tiglate for Soft Tissue Sarcoma
Tigilanol tiglate is a novel, small molecule drug for the intratumoral treatment of solid tumors, inducing tumor cell death and stimulating immune response.
Published: 2/16/2024
PEGGY LILLIS FOUNDATION APPOINTS LEADING C. DIFF EXPERTS AND CLINICIANS TO ITS BOARD OF DIRECTORS
Published: 2/16/2024
Research Examines Disparities in Mental Health Care for Some Gender Identities
One significant difference was an increased rate of bupropion prescriptions for transgender females.
Published: 2/16/2024
Pharmacy Focus: Food as Medicine
This episode highlights strategies for pharmacists and pharmacies to address social determinants of health barriers through leveraging PQA's SDOH Resource Guide.
Published: 2/16/2024
Study Shows 40% of Participants Sustain Cognitive Improvement After Surgery-Induced Weight Loss
Sustained cognitive improvement is likely a result of lower inflammation, remission of comorbidities, higher physical activity, and better mood.
Published: 2/15/2024
Patients With NDMM Who Fail QUAD Treatment Within 18 Months Show Poor Response to Subsequent Treatments
The investigators note that patients with newly diagnosed multiple melanoma who receive quadruplet treatment have unmet needs that must be further examined in future research.
Published: 2/15/2024
Healthier Lifestyle Associated With Better Cognitive Function, Independent of Alzheimer Disease Pathology
The authors emphasize that further research on a diverse population that focuses on the role of duration and lifestyle choices and neuroinflammatory markers should be performed.
Published: 2/15/2024
Lifesaving Medication Plus Lifestyle Encourages Health in a “Food Plus Pharmacy” Relationship, According to Expert
Nutrition is foundational to health, but healthy eating does not look the same for everyone.
Published: 2/15/2024
Pharmacist Involvement in Infectious Diseases Improves Outcomes, but Reimbursement Is an Obstacle
The researchers made a connection between positive outcomes for infectious disease patients, higher reimbursement class, and the presence of pharmacists in care teams.
Published: 2/15/2024
FDA Approves Irinotecan Liposome for Metastatic Pancreatic Adenocarcinoma
The approval of irinotecan liposome offers an improved first-line treatment option for individuals diagnosed with metastatic pancreatic adenocarcinoma.
Published: 2/14/2024
FDA Approves Iloprost Injection For the Treatment of Adults With Severe Frostbite
Iloprost had also received Priority Review and Orphan Drug Designations for this indication, and FDA approval in 2004 for the treatment of pulmonary arterial hypertension.
Published: 2/14/2024
Natural Food Preservative May Harm Beneficial Gut Bacteria
Researchers will continue to research how lantibiotic’s antimicrobial effects can be harnessed for good.
Published: 2/14/2024
Common Osteoporosis Treatment May Reduce Risk of Incident Diabetes
Continued doses of denosumab reduced the incidence of diabetes by more than 1000 patients compared to an initial dose alone.
Published: 2/14/2024
Tirzepatide May Be More Cost-Effective Than High-Dose Semaglutide for Type 2 Diabetes
In a projective model, tirzepatide saved patients more than $15,000 per quality-adjusted life-year.
Published: 2/14/2024
Eliminating Hepatitis C Virus Infections in Individuals who Inject Drugs: A Novel Model of Community Pharmacy Care
In this model, community pharmacists deliver all aspects of treating HCV infection in individuals who inject drugs.
Published: 2/14/2024
FDA Grants Priority Review to Repotrectinib for the Treatment of NTRK-Positive Solid Tumors
Repotrectinib led to a durable anti-tumor response in patients with NTRK-positive locally advanced or metastatic solid tumors.
Published: 2/14/2024
Diabetes Self-Management Education Accreditation Provides Billable Opportunity for Pharmacists
This accreditation allows pharmacists to give diabetes education to patients with Medicare and receive Medicare reimbursement.
Published: 2/14/2024
IRd Regimen Shows No Significant Advantage in Frail Patients With NDMM Compared With IDd Regimen
Progression-free survival in the ixazomib/pegylated liposomal doxorubicin/dexamethasone group was shorter than in the ixazomib/lenalidomide/dexamethasone group.
Published: 2/13/2024
Subcutaneous Blinatumomab Demonstrates Safety, High Efficacy in Patients With Pretreated R/R B-ALL
The results indicate promising rates of complete response, manageable adverse events, and dose-dependent exposure in both dose groups.
Published: 2/13/2024
Gargling With Mouthwash Can Improve Oral Environment, Reduce HbA1c in Adults with Type 2 Diabetes
Mouthwash that contains chlorhexidine gluconate was especially effective at improving hyperglycemic status in younger patients with diabetes.
Published: 2/13/2024
Researchers Announce Results of New COVID-19 sa-mRNA Vaccine
The findings suggest that 6 months after vaccination with ARCT-154, individuals had a longer immune response.
Published: 2/13/2024
Telehealth Tool Shows 50% Reduction in Cardiovascular Hospital Readmissions
Cardiac Solutions, a physician-owned practice specializing in personalized treatment plans, used RevUp Remote Patient Monitoring and Chronic Care Management to achieve these cardiovascular readmission rates.
Published: 2/13/2024
FDA Accepts New Drug Application for MDMA-Assisted Therapy for PTSD
If approved, this would mark the first MDMA-assisted therapy and psychedelic-assisted therapy approved, calling for a reschedule of MDMA from Schedule I. A PDUFA was set for this summer.
Published: 2/13/2024
FDA Accepts Priority Review Application for RSV Vaccine to Prevent Illness in Adults
The updated indication for the respiratory syncytial virus vaccine is for adults aged 50 to 59 with underlying conditions who are at an increased risk of contracting the virus.
Published: 2/12/2024
Vitamin K2 Can Protect Against Non-Alcoholic Fatty Liver Disease, Study Shows
The vitamin improved lipid metabolism to slow the progression of the disease.
Published: 2/12/2024
FDA Grants Fast Track Designation to Bepirovirsen for Chronic Hepatitis B
Bepirovirsen is a triple action investigational antisense oligonucleotide and is being evaluated in the B-Well phase 3 clinical trial program for the treatment of chronic hepatitis B.
Published: 2/12/2024
AI Algorithm Demonstrates Ability to Predict the Efficacy of Sertraline in Patients With Depression
Despite the tool’s ability to predict efficacy of sertraline in patients with major depressive disorder, the investigators note that future research will seek to improve the algorithm.
Published: 2/12/2024
FDA Approves Budesonide Oral Suspension for Eosinophilic Esophagitis
The FDA approval marks the first and only FDA-approved oral therapy for this patient population, and the drug is expected to be available by the end of February.
Published: 2/12/2024
Expert: Everyone Would Need to Become a Pharmacist to Really Understand How to Eat For Their Own Body
AI can pair people to foods that are best suited for their unique needs, according to a food-as-medicine entrepreneur.
Published: 2/12/2024
D-VRd Treatment Regimen Demonstrates Better Progression-Free Survival Among Transplantation-Eligible Patients With Multiple Myeloma
In addition to improved progression-free survival, patients treated with this regimen also showed improved complete response or stronger and were minimal residual disease-negative.
Published: 2/12/2024
USP Expert Discusses Concerns on Biosimilar Safety and Efficacy Through Quality Standards
Fouad Atouf, senior vice president of global biologics at US Pharmacopeia, discusses the importance of robust quality standards in addressing concerns regarding biosimilar safety and efficacy.
Published: 2/12/2024
One of the Most Advanced Specialty Pharmacies in the Region Opens in Westchester, Accelerating Access to Life Altering Medications
Published: 2/9/2024
FDA Grants Breakthrough Therapy Designation to Nipocalimab for the Treatment of Rare Disease in Pregnancy
In a study, nipocalimab helped more than 50% of patients with high-risk of hemolytic disease of the fetus and newborn achieve a safe live birth.
Published: 2/9/2024
Study: The Pandemic Disrupted Children’s Readiness for Kindergarten
Between 2018 and 2021, kindergarten-readiness dropped by 10%.
Published: 2/9/2024
Biosimilar Adalimumab, Etanercept Have Equivalent Effectiveness to Reference Drugs Over 48 Months
The levels of disease activity after 6 months of tumor necrosis factor-α inhibitors could help predict the response to therapy at 4 years for those who have long-standing rheumatoid arthritis.
Published: 2/9/2024
DSME Accreditation Allows Pharmacists to Help Patients Self-Manage Diabetes, Enjoy The Foods They Love
Diabetes self-management education works with patients own goals to manage the condition, prevent cardiovascular risk, and stay safe.
Published: 2/9/2024
Researchers Find Benefits for Newborns of COVID-19–Vaccinated Mothers
A decrease in mortality and a lower risk of neonatal complications were reported among infants with vaccinated mothers.
Published: 2/9/2024
Assessment-Guided Interventions for Elderly Multiple Myeloma Patients Highlight Benefit of Oncology Pharmacists
Patients readily accepted physical interventions and referrals to oncology clinical pharmacy practitioners.
Published: 2/9/2024
Biosimilar SB8 Is Comparable to Bevacizumab for Non–Small Cell Lung Cancer
Bevacizumab is a recombinant humanized G1 monoclonal anti-vascular endothelial growth factor antibody that is used in combination with chemotherapy to treat solid tumors.
Published: 2/9/2024
Enhancing Patient Care With Medication Safety, Convenience Through Delivery Services
The pharmacy director of Baptist Health South Florida details the features and successes of medication delivery services they provide.
Published: 2/8/2024
Study Finds High Antimicrobial Resistance Against Pneumococcal Diseases, Despite Vaccination
Investigators found high incidences of non-susceptibility with penicillin and increasing resistance to macrolides for pneumococcal diseases.
Published: 2/8/2024
Combination Therapy Reduces Blood Pressure for Those Taking Ibrutinib
Ibrutinib and other Bruton tyrosine kinase inhibitors can cause the development of or worsen pre-existing hypertension.
Published: 2/8/2024
Walgreens Focuses Attention on Pharmacy School Enrollment With Walgreens Deans Advisory Council
The company said the council members will meet quarterly to identify ways to attract, recruit, and create a dynamic workplace for both current and future pharmacists.
Published: 2/8/2024
Heparanase Inhibitors May Reduce Risk of Diabetic Kidney Disease, Diabetic Retinopathy in Patients with Diabetes
This agent can prevent the depletion of heparan sulphate in the endothelial glycocalyx layer of endothelial cells, ultimately protecting against vision loss and renal failure caused by diabetes.
Published: 2/8/2024
Culturally Appropriate Diet Recommendations Can Help Multi-Ethnic Patients Manage Diabetes During Pregnancy
Providing continuity of care with the involvement of midwives also appeared to reduce inequities in care for multi-ethnic patients.
Published: 2/8/2024
Study: Hydrocortisone Associated With Lower Risk of All-Cause Mortality for Community-Acquired Pneumonia
Corticosteroids can reduce the need for mechanical ventilation, incidence of shock, and length of hospital stay, especially for younger patients with community-acquired pneumonia.
Published: 2/8/2024
Immune-Related Mechanisms Associated with Functional Connectivity in Patients With Anxious Depression
The study authors noted that further research with larger populations should be conducted to boost the reliability and generalizability of the results.
Published: 2/8/2024
Researchers Highlight Need for Additional Research in Advanced Non–Small Cell Lung Cancer
A survey that analyzed treatment options and research for patients with NSCLC was conducted with medical oncologists.
Published: 2/8/2024
Policy Changes Can Help Implement Continuous Glucose Monitoring
By involving pharmacists, patients can see improved medication adherence, improved outcomes, and, as a result, reduced health care costs
Published: 2/7/2024
Cardiovascular Mortality Rates Increased From 2020 to 2022, Correlating With Pandemic
Investigators also found that the mortality rates for cardiovascular disease from 2020 to 2022 reversed the improvements of reduced mortalities in the preceding decades.
Published: 2/7/2024
FDA Accepts Supplemental Biologics Applications for Nivolumab-Based Regimens for Treatment of Resectable Lung Cancer
The FDA assigned a Prescription Drug User Fee Act (PDUFA) goal date of October 8, 2024.
Published: 2/7/2024
Heart Failure Biomarkers Improve Prediction of Cardiovascular Disease Associated With Type 2 Diabetes
The investigators identified 4 prognostic factors with high predictive ability and supported by moderate to high strength evidence beyond what is already available for cardiovascular disease.
Published: 2/7/2024
Multivitamins May Slow Cognitive Aging, According to Recent Meta-Analysis
Patients who took a multivitamin for 2 to 3 years showed improvements in global cognition and episodic memory compared with placebo.
Published: 2/7/2024
Safety Analysis Shows PPSV23 Is Not Associated With Higher Risk of Serious Outcomes
The 23-valent pneumococcal polysaccharide vaccine was most likely associated with a higher risk of immunological events for those who were immunocompromised, but the events were low.
Published: 2/7/2024
Black Women Experiencing Racism in 3 Categories Have Increased Risk of Coronary Heart Disease
The investigators found that perceived racism in everyday life was not associated with a higher risk of coronary heart disease—only racism in the 3 specific categories.
Published: 2/6/2024
CMS Announces Cell and Gene Therapy Access Model Will Focus on Sickle Cell Disease
The model was designed to help improve health outcomes, improve access to care, and lower costs for gene therapy.
Published: 2/6/2024
More Youth at Risk of Psychosis Are Accessing Mental Health Services Than Previously Thought
Early signs of psychosis may be used to predict the risk of developing a full psychosis spectrum disorder.
Published: 2/6/2024
Research Develops Key Points to Address RSV Vaccine Hesitancy in Older Adults
Addressing complacency, confidence, and convenience are all crucial to increasing vaccine uptake.
Published: 2/6/2024
Breathing Pattern of Longer Exhales Can Relieve Symptoms of Long COVID
This breathing pattern is called resonant breathing and has been shown to improve heart rate variability.
Published: 2/6/2024
Study: Leg Compression Therapy Helps Improve Heart Failure Symptoms
Leg compression therapy was associated with decreased brain natriuretic peptide levels without any adverse events for patients with stable chronic heart failure.
Published: 2/6/2024
Negative Childhood Experiences Could Impact Cardiovascular Health in Adulthood
In a study, more than 28% of participants met an ideal cardiovascular health score at the beginning of the study, with only 16% having ideal cardiovascular health at the 20-year mark.
Published: 2/6/2024
Celltrion Seeks Approval From FDA for CT-P47 as Biosimilar of Tocilizumab
The company seeks the approval for both the intravenous and subcutaneous administration routes.
Published: 2/6/2024
As Antibiotic Resistance Grows, Investigators Work to Understand Its Role in Pneumonia
Investigators from the University of Liverpool tested the effect of meropenem, an antibiotic used for hospital-acquired pneumonia, to determine how resistance emerges.
Published: 2/6/2024
Adalimumab Biosimilar Shows Efficacy in Noninfectious Uveitis
Switching from adalimumab originator to SB5 did not cause clinically significant differences in treatment efficacy and safety for patients with noninfectious uveitis.
Published: 2/5/2024
BTK Degrader NX-2127 May Be Therapeutic for Patients With CLL Who Are Drug-Resistant
Approximately 41% of enrolled patients responded to NX-2127, and the BTK degrader overcame resistance to nearly all BTK mutations that were identified to cause resistance.
Published: 2/5/2024
RNA Sequencing Demonstrates Accurate Diagnosis of B-ALL Subtypes in Pediatric Patients
According to the authors, the test has promise in guiding treatment but needs further refining to obtain information beyond molecular subtyping.
Published: 2/5/2024
Study Highlights Importance of Greater Adherence To Cancer Prevention Recommendations
The findings suggest that greater adherence to the WCRF/AICR Cancer Prevention Recommendations could greatly reduce the risk of all cancers combined, along with 14 others.
Published: 2/5/2024
Study Results Highlight Importance of Overcoming Stigma When Addressing Brain Health
The study authors note that to effectively implement tools, processes, and strategies within practices, the stigma surrounding cognitive impairment must be addressed.
Published: 2/5/2024
Pharmacist-led Primary Care Team Improves Clinical Outcomes in Severe Mental Illness
This approach may help prevent premature deaths attributed to preventable or treatable cardiovascular disease.
Published: 2/5/2024
Persistent Childhood Exposure to Passive Smoke From Heated Tobacco Products Can Increase Cardiovascular Risk in Adulthood
These heat-not-burn cigarettes are incorrectly assumed to be healthier than traditional tobacco cigarettes.
Published: 2/5/2024
Manufacturers Did Not Anticipate Such a High Demand for Semaglutide, Says Diabetes Educator
The diabetes/weight loss drug has surged in popularity, and new trials are evaluating it for certain pediatric patients.
Published: 2/5/2024
Online Weight Loss Interventions Offering Social Support Are Most Effective Among Middle-Aged Adults
There are 2 features of weight loss interventions which are most likely to improve weight loss outcomes—having access to professional health coaches and social support from other users.
Published: 2/5/2024
Biogen Reprioritizes Alzheimer Disease Franchise, Discontinuing Aducanumab and Advancing Lecanemab
The company will discontinue the development and commercialization of aducanumab-avwa (Aduhelm) for intravenous use and will terminate the ENVISION clinical study.
Published: 2/5/2024
Cardiovascular Outcomes in Patients Intolerant to Statins Treated with Bempedoic Acid
In December 2023, the FDA granted expanded indications for bempedoic acid and bempedoic acid plus ezetimibe in the treatment of primary hyperlipidemia.
Published: 2/5/2024
Diabetes Expert on Semaglutide: “I don't think that companies anticipated this much of a demand.”
The diabetes/weight loss drug is be evaluated in trials for pediatric patients who are at least 10 years of age.
Published: 2/2/2024
Black Patients More Likely to Experience Delays in Multiple Myeloma Treatment Initiation
Survival rates were similar between non-Hispanic African American and non-Hispanic White patients who received treatment, indicating a need to address barriers to multiple myeloma treatment and racial disparities.
Published: 2/2/2024
FDA Accepts sBLA for Daratumumab, Hyaluronidase-fihj for Treatment of Multiple Myeloma
Daratumumab and hyaluronidase-fihj in combination with other therapies was previously approved by the FDA in May 2020 for 8 indications in multiple myeloma.
Published: 2/2/2024
Inconsistent Supplementation Recommendations for Women During Pregnancy Raises Questions
However, different recommendations may actually be valuable, as different countries have different population-based needs.
Published: 2/2/2024
Maternal Vitamin D, Multivitamin Supplementation May Reduce Risk of Autism in Offspring
Supplementation during pregnancy also reduced communication warning behaviors in children who developed autism compared to the children of women who did not take supplements.
Published: 2/2/2024
FDA Accepts BLA for Afami-Cel for Priority Review as Treatment of Advanced Synovial Sarcoma
Afami-cel had engineered t-cell receptor T-cells target MAGE-A4+ tumors, which are highly expressed in synovial sarcoma with HLA-A*02.
Published: 2/2/2024
Study: Hydroxyurea Reduces Severe, Invasive Infections by 60% in Children with Sickle Cell Disease
The findings suggest that further research on additional intervention methods and expanding access to hydroxyurea in Africa could benefit young patients with sickle cell disease.
Published: 2/1/2024
Researchers Utilize New Technology to Track Inhibition Process in Brain Cells
The study used optogenetics to repeatedly activate and inhibit cells, revealing rapid changes in a protein called pyruvate dehydrogenase when cells were inhibited.
Published: 2/1/2024
The Pharmacist Can Assist Patients With Diabetes To Manage A New Lifestyle
A growing number of adult and pediatric patients are being diagnosed with type 2 diabetes, despite increases in care modalities.
Published: 2/1/2024
Researchers Highlight Need for Greater Research Into RSV Among Older Adults, Vaccine Management
The burden of RSV in the older population is becoming highly recognized as studies have assessed higher-risk individuals in industrialized and developing countries.
Published: 2/1/2024
FDA Grants Orphan Drug Designation to ‘1104, First-In-Class Peptide for Eosinophilic Esophagitis
The designation offers support in developing potential new medicines, treatment, and diagnosis to prevent rare conditions, like EoE.
Published: 2/1/2024
Pembrolizumab Improves Disease-Free Survival for Muscle-Invasive Urothelial Carcinoma
The late-breaking data at the 2024 American Society of Clinical Oncology Genitourinary Cancers Symposium included the results of KEYNOTE-123 for locally advanced resectable urothelial carcinoma.
Published: 2/1/2024
Recurrent C difficile Infection Prevention: Efficacy and Administration of Fecal Microbiota Therapy
Sharon Rimon, NP, shares insights on the rectal administration of fecal microbiota therapy, highlighting its efficacy, ease of adoption in clinical practice, and benefits for patients.
Published: 1/31/2024
FDA Approves Shorter Manufacturing Process for CAR T-cell Therapy Axicabtagene Ciloleucel
Less manufacturing time could be the difference between a patient receiving this life-saving therapy vs not.
Published: 1/31/2024
Survey: 90% of Patients Are Concerned About Effectiveness of Cold and Cough Ingredients
The FDA revisited the use of phenylephrine in OTC medications and called for more substantial evidence supporting its efficacy when taken orally.
Published: 1/31/2024
Behavioral Psychotherapy, Antidepressants Yield Minimal Differences in Depression Treatment Coinciding With Heart Failure
Investigators determined the effectiveness of behavioral activation psychotherapy versus antidepressant medication management for inpatients with heart failure and depression.
Published: 1/30/2024
Researchers Suggest New Theory on the Development of Type 1 Diabetes
Defective RNA editing in cells in the pancreas may spur the body to initiate an inflammatory attack against its own cells.
Published: 1/30/2024
Vitamin K Supplementation May Improve Insulin Resistance in Older Patients With Type 2 Diabetes
Inadequate levels of zinc, vitamin D, vitamin E, and vitamin B were also associated with risk of diabetes or diabetes-related complications.
Published: 1/30/2024
Systemic Treatment Plus Embolization Reduces Risk of Death in Patients With Hepatocellular Carcinoma
Compared to embolization alone, the systemic treatment combination nearly doubled progression-free survival among patients with unresectable liver cancer.
Published: 1/30/2024
Neoadjuvant Nivolumab May Boost Survival Outcomes in Patients With Renal Cell Carcinoma
The immune checkpoint inhibitor increased inflammation within the tumor, which may be linked to better response to nivolumab treatment.
Published: 1/30/2024
Supplementation of Vitamin C, Vitamin D May Reduce Risk of Fracture in Patients With Diabetes
Dual supplementation can reduce bone loss more than supplementation with vitamin D alone.
Published: 1/30/2024
Optimizing Patient Care: The Pharmacist’s Role in the Meds-to-Beds Program
Two directors of outpatient services at Allegheny Health Network highlight the significance of Meds-to-Beds in promoting medication adherence while improving patient experience.
Published: 1/29/2024
Expert: Everyone Has a Unique Headache
Providers can consider the patient’s medication history, comorbidities, or migraine type to help choose a first line treatment or refer the patient to specialized care.
Published: 1/29/2024
Lutetium Lu 177 Dotatate Reduced Risk of Death By 72% Compared to Comparator in Patients With Advanced GEP-NETs
Radioligands may be able to deliver radiation to advanced tumor cells anywhere in the body.
Published: 1/29/2024
Take the 2024 Burnout and Mental Health Survey
Please take 10 minutes to complete the 2024 Burnout and Mental Health Survey.
Published: 1/29/2024
Durvalumab Treatment Regimen Reduces Risk of Disease Progression, Death in Patients With HCC
Compared to TACE alone, durvalumab plus TACE and bevacizumab reduced the risk of disease progression or death by 23%; however, further research is needed to assess OS.
Published: 1/26/2024
Women With Gestational Diabetes Mellitus May Have 2 Categories of Genetic Risk Factors
These patients may have a similar genetic susceptibility for type 2 diabetes.
Published: 1/26/2024
FDA Approves Dupilumab for Pediatric Patients with Eosinophilic Esophagitis
The approval marks dupilumab as the first and only FDA-approved medicine to treat pediatric patients with eosinophilic esophagitis.
Published: 1/25/2024
ADC Drug Candidate Enters Phase 3 Trial for the Treatment of HER2-Low Breast Cancer
The candidate has already demonstrated anti-tumor activity in chemotherapy-naïve patients.
Published: 1/25/2024
Breast Cancer Screening Should Be Based on Each Patient’s Individual Risk Level
A risk-stratification screening approach that considers screening at an earlier age based on risk factors might increase the likelihood of catching the cancer before it turns symptomatic.
Published: 1/25/2024
A Growing Number of Studies Are Evaluating the Burden of Migraine Headaches
Migraine headaches are considered a leading cause of disability around the world.
Published: 1/25/2024
FDA Adds Boxed Warning to Denosumab for Increased Risk of Hypocalcemia in Patients With CKD
According to the FDA review, patients with CKD receiving denosumab for osteoporosis who are on dialysis or have CKD-MBD are at the highest risk of severe hypocalcemia.
Published: 1/24/2024
Nivolumab Plus Ipilimumab Improves PFS in Patients with MSI-H/dMMR mCRC
Compared with chemotherapy, nivolumab plus ipilimumab reduced the risk of disease progression or death by 79%, but further research is needed to assess overall survival.
Published: 1/24/2024
Patients With Migraines Often Experience Stigma Related to Symptoms
Migraines are not a one-size-fits-all condition, and there is no one-size-fits-all solution.
Published: 1/24/2024
The Public May Be Exposed to 90% of 921 Chemicals That Can Increase the Risk of Breast Cancer
A recent study sheds light on an alarming number of hormone-disrupting chemicals that are found in everyday settings.
Published: 1/24/2024
‘Jiffy Lube of — of therapies, yes’: Complex Sentences Can Generate a Higher Brain Response Than Simple Sentences
New sentences that had different linguistic properties than traditional sentences drove brain activity, according to the study authors.
Published: 1/23/2024
Dysbiosis in the Gut Microbiome May Lead to Development of Various Liver Diseases
There may be a pathophysiological basis for therapy relating to the to the gut-liver axis.
Published: 1/23/2024
Circadian Disruption May Be Significantly Linked to Chronic Kidney Disease
Increased waist circumference and high blood pressure can disrupt circadian rhythm, which can increase risk of progression to poor renal outcomes.
Published: 1/23/2024
Fertility Preservation May Not Need to Delay Breast Cancer Treatment
Patients should work with clinicians to discuss controlled ovarian stimulation because there is still limited research.
Published: 1/23/2024
Chlorine-Treated Drinking Water Might Change Species Diversity in Gut Microbiota
Findings from a recent murine model may translate to the human gut microbiome, but assessing chlorine’s effects on the gut microbiome remains complex.
Published: 1/23/2024
Triple-Negative Breast Cancer May Be Less Aggressive in Patients With SOX9-AS1 Overexpression
This RNA type might act as an onco-suppressor, and higher levels may indicate better prognosis.
Published: 1/22/2024
Berberine May Reduce Inflammation of Lung Tissues in Patients With Metastatic Colorectal Cancer
Berberine was associated with a reduction in inflammatory markers in the lungs, which was caused by the colorectal cancer.
Published: 1/22/2024
Three-Dose Hybrid Immunity Provided Older Adolescents With Robust Protection Against SARS-CoV-2 Infection
Infection-induced immunity with 2-dose vaccination still offered protection against the circulating variant.
Published: 1/22/2024
Report: Oncology, Immunology Projected to Lead Global Spending From 2024 to 2028
The IQVIA Global Use of Medicines report for 2024 predicts that loss of brand exclusivity will negatively impact global market growth.
Published: 1/22/2024
Study Findings Suggest Liver Creates Palmitic Acid, Maintaining Brain Health
The results from the preclinical trial can provide a new method of measuring dietary sources of nutrients in the tissue, but further research is needed to confirm the findings in the human brain.
Published: 1/22/2024
ACIP Releases Updates On Vaccine Recommendations, 2024 Adult Immunization Schedule
The schedule includes RSV vaccination, along with updated versions of the COVID-19 vaccine.
Published: 1/22/2024
Analysis Indicates Daily Multivitamin Benefits Global Cognition, Episodic Memory in Adults
Compared to placebo, a daily multivitamin showed consistent benefits in global cognition and episodic memory across a clinical trial and meta-analysis of 3 trials.
Published: 1/19/2024
PQA Releases Third Edition of Social Determinants of Health Resource Guide
The third edition of the Pharmacy Quality Alliance resource guide includes 40 total SDOH services and 8 new services, as well as 10 initiative updates from the previous 2 editions.
Published: 1/19/2024
FDA Grants Fast Track Designation to Avutometinib Plus Sotorasib for Treatment of NSCLC
The treatment is for patients with KRAS G12C-mutant metastatic NSCLC who have previously received at least 1 systemic therapy and were not treated with a KRAS G12C inhibitor.
Published: 1/19/2024
Standardized Onboarding Reduces Turnover of Pharmacy Technicians
The primary point of contact, called the Technician Success and Onboarding Coordinator (TSOC), is a new role created specifically to improve pharmacy technician retention.
Published: 1/19/2024
Study: Ultraviolet Light Could Destroy Coronavirus Particles
The researchers found that the genomic material was extremely sensitive to the degradation.
Published: 1/18/2024
No Significant Differences in Efficacy Shown Between Reference Drug, Biosimilars in Patients With IBD
Despite the insignificant differences in efficacy, biomarkers, therapeutic drug level, and ADAs, patients reported a significant number of nocebo effects.
Published: 1/18/2024
For Patients With Chronic Inflammation, Poverty Increases Cardiovascular Risk
In general, poverty negatively impacts physical and mental health, and those in poverty have greater risks of mental illness, heart disease, hypertension, and stroke.
Published: 1/18/2024
Global Prevalence of Sleep Disorders Demands a Team-Based Approach
Because medications to treat these conditions are often controlled substances, including pharmacists on the multidisciplinary team (MDT) is invaluable.
Published: 1/18/2024
Study: Serotype 3 Remains Prevalent Among Older Adults With Community-Acquired Pneumonia
Individuals with PCV20-serotype disease were generally younger compared to those who had PCV13 serotype community-acquired pneumonia.
Published: 1/18/2024
Beetroot Juice Supplement May Be Beneficial for Patients With COPD
A 12-week supplement improved systolic blood pressure in this patient group more than placebo.
Published: 1/17/2024
Investigators Discover Mechanisms Connecting Impaired Autophagy, Heart Failure
A signaling pathway linking autophagy to nicotinamide adenine dinucleotide (NAD+), found indications that NAD+ depletion can lead to heart muscle cell dysfunction.
Published: 1/17/2024
Study: A Plant-Based Diet Could Reduce COVID-19 Infection
Individuals that lived on a majority plant-based or vegetarian/vegan diet were 39% less likely to be infected with COVID-19.
Published: 1/17/2024
FDA Grants Orphan Drug Designation to PTX-252 for Treatment of Acute Myeloid Leukemia
PTX-252 is a novel molecular drug designed to increase cancer cells' sensitivity to chemotherapy in the treatment of acute myeloid leukemia.
Published: 1/17/2024
FDA Approves IgG-Hyaluronidase Recombinant for the Treatment of Adult Patients With CIDP
Previously, IgG-hyaluronidase recombinant was approved by the FDA in 2014 for the treatment of primary immunodeficiency in adult patients and has expanded to include some pediatric patients.
Published: 1/16/2024
AHA: Snow Shoveling Increases Risk of Heart Attack, Sudden Cardiac Arrest
An American Heart Association scientific statement cautions individuals with known or suspected cardiovascular disease or risk factors against shoveling snow.
Published: 1/16/2024
FDA Approves Pembrolizumab Plus Chemoradiotherapy to Treat FIGO 2014 Stage III-IVA Cervical Cancer
The approval was based on the results of a phase 3 trial that found an improvement in progression-free survival among individuals treated with pembrolizumab.
Published: 1/15/2024
Guiding Principles in the Management of cGVHD
In addition to the current principles and treatment regimens, there are upcoming data on myelofibrosis drugs that could be reported as early as 2024.
Published: 1/15/2024
Individuals With Obesity More Likely to Have MGUS, A Multiple Myeloma Precursor
Not only were individuals with BMIs of 30 and higher likely to have MGUS, but those who reported heavy smoking and short sleep were also more likely to have detectable levels of MGUS.
Published: 1/15/2024
Food Programs in Elementary Schools Can Influence Healthy Eating Behaviors in Children, Which Can Carry into Adulthood
At a young age, hands-on learning about nutrition can promote long term appreciation of fresh food and food experiences.
Published: 1/12/2024
FDA Approves BrainSee, First-in-Class Test to Predict Progression of Alzheimer Disease
BrainSee creates a new standard for progression prediction in Alzheimer disease, marking a step forward in brain health management with non-invasive screening.
Published: 1/12/2024
Nearly a Third of Patients With Breast Cancer Who Need Breast-Conserving Surgery Bypass Local Care
The separation between those who travel for care compared to those who go to the local hospital may drive inequalities in health care.
Published: 1/12/2024
Researchers Find RSV Could Cause Inflammation by Infecting Nerve Cells
RSV could interact with nerve cells, causing nerve damage and possible entry to the spinal cord.
Published: 1/12/2024
Study: Women Using IUI, IVF With More Stress Have Higher Blood Sugar Levels
The results also indicated that stress and blood sugar levels were higher among women who had a college degree and women with a higher income.
Published: 1/12/2024
Study: Childhood PVC13 Did Not Affect Burden of Pneumococcal Disease for Adults
According to the study investigators, findings indicat that pneumococcal vaccination in older adults and other interventions should be considered for reducing the disease burden.
Published: 1/12/2024
History of Infertility Holds Potential as New Cardiovascular Biomarker
The findings show a greater association with less ideal cardiovascular health scores for those who experienced their first infertility before age 35.
Published: 1/12/2024
Study Finds High HIV Viral Loads Associated With Higher Recombination Rates, May Influence Viral Evolution
According to the authors, the findings may have broad implications for understanding recombination and viral evolution within various organisms.
Published: 1/12/2024
Food Programs in Elementary Schools Can Influence Healthy Eating Behaviors in Children, Carrying into Adulthood
At a young age, hands-on learning about nutrition can promote long-term appreciation of fresh food and food experiences.
Published: 1/11/2024
Patients With Gestational Diabetes May Have 2 Categories of Genetic Risk Factors
These patients may have a similar genetic susceptibility for type 2 diabetes, although they have an individual risk for GDM independent of the risk of type 2 diabetes.
Published: 1/11/2024
Study: Skin-Deep Resilience Can Have Physiological Impact on Youth in Early Adolescence
To have skin-deep resilience is to overcome adversity to achieve success, be it psychological or academic.
Published: 1/11/2024
Phase 3 Results Show First-Line Amivantamab-vmjw Plus Chemotherapy Prolongs Survival In Patients With Advanced or Metastatic NSCLC
A majority of patients who received first-line chemotherapy switched to amivantamab-vmjw plus chemotherapy as second-line therapy.
Published: 1/11/2024
Analysis Indicates Liso-Cel is a Cost-Effective, Second-Line Treatment Option for Patients With R/R DLBCL
In addition, patients who were treated with liso-cel therapy had a higher average life expectancy and QALYs, compared to those who were treated with standard care.
Published: 1/11/2024
Study: HIIT Program Improves Outcomes for Patients With Heart Failure
High intensity interval training (HIIT) showed improved heart failure outcomes compared to medium chain triacylglycerol, used for endurance performance among athletes, and the usual care.
Published: 1/11/2024
Guideline Update: KDIGO 2024 Management of Lupus Nephritis Includes Belimumab for Triple Therapy
The update includes a recommended triple therapy with belimumab as a first line treatment for class III or IV lupus nephritis following the approvals of belimumab and voclosporin.
Published: 1/11/2024
Study: Causal Relationship Found Between Pneumonia, Gestational Diabetes
The data also suggest that further studies investigating a plausible causal relationship between pneumonia and type 1 diabetes are needed.
Published: 1/11/2024
Pharmacy Involvement Can Improve Patient Outcomes When Treating Leukemia
The pharmacist can assist with managing drug interactions, patient education, therapy selection, physician education, and more.
Published: 1/10/2024
Difficulty Administering OTC Acetaminophen and Ibuprofen in Children Leads to Dosing Errors
Community pharmacists have a unique opportunity to counsel caregivers on liquid OTC children’s products.
Published: 1/10/2024
Asciminib Demonstrated Better MMR Rates in Patients With Newly Diagnosed Ph+ CML-CP
Compared to standard of care TKIs, asciminib also presented favorable safety and tolerability profiles with fewer reported AEs among patients.
Published: 1/10/2024
Once-Weekly Insulin Icodec, Semaglutide Regimen Reduced HbA1c in Patients With Type 2 Diabetes
This combination regimen, which was compared to once-daily insulin glargine U100 with insulin aspart, had also demonstrated a safe and well-tolerated profile with mild AEs.
Published: 1/10/2024
Patients With HIV, Undergoing Cardiac Surgery Have Increased Risk of Pneumonia
Investigators also found that those with HIV were more likely to be readmitted to the hospital within 30 days of cardiac surgery.
Published: 1/10/2024
Researchers Assess Second Primary Lung Cancer Among Survivors Without Smoking History
The 10-year cumulative incidence rate was equally high between both cohorts of smoking and nonsmoking individuals.
Published: 1/10/2024
Eli Lily Releases Statement Regarding Tirzepatide Use for Cosmetic Weight Loss
Eli Lilly & Co. has been one of the first companies to address the off-label use of their tirzepatide drugs, Mounjaro and Zepbound, for cosmetic weight loss.
Published: 1/10/2024
Researchers Connected Radon, A Known Cause of Lung Cancer, to Additional Health Condition
Individuals with ischemic stroke that resided in areas with an indoor radon concentration greater than 4 pCi/L had an increased risk of developing clonal hematopoiesis of indeterminate potential.
Published: 1/10/2024
Adults Diagnosed With Coronary Heart Disease Could Have Increased Risk of Dementia
Adults diagnosed with coronary heart disease before age 45 have an especially increased risk of developing dementia, Alzheimer disease, and vascular dementia.
Published: 1/10/2024
FDA Accepts sBLA for Tisotumab Vedotin-tftv for the Treatment of Recurrent, Metastatic Cervical Cancer
The accepted sBLA comes after phase 3 clinical trial results which demonstrated better overall survival, progression-free survival, and confirmed overall response rate than chemotherapy in patients with cervical cancer.
Published: 1/9/2024
FDA Approves New LASIK Device Teneo for Vision Correction Surgery
Teneo Excimer Laser Platform is a new laser assistance in situ keratomileusis for vision correction surgery for those who have myopia and myopic astigmatism.
Published: 1/9/2024
Isatuximab Plus KRd Treatment Improved Rate of MRD Negativity in Patients With Newly Diagnosed MM
The study results also demonstrated isatuximab had safety and tolerability profiles that were consistent with other clinical trials.
Published: 1/9/2024
Study Data Show Telemedicine Endocrinology Care Not as Effective as In-Person Care
Patients who received telemedicine alone had worse glycemic control and less improvement in hemoglobin A1c levels.
Published: 1/9/2024
Understanding the Impact of Allelic Gene Variants on Pediatric Pain Relief
Studies have shown that higher expression of CYP2D6 alleles in adults results in excessive production of active metabolites, leading to either therapeutic failure, increased exposure, or more severe adverse effects.
Published: 1/9/2024
Study Evaluates Oncology Pharmacist Prescribing Tendencies in Ambulatory Care in Canada
In the ambulatory setting, oncology pharmacists independently prescribe medications to support and manage therapy toxicities for cancer patients.
Published: 1/9/2024
FDA Approves Berdazimer Topical Gel as First Treatment for Molluscum Contagiosum
Berdazimer topical gel, 10.3% (Zelsuvmi; Ligand Pharmaceuticals Inc) has been approved for the treatment of molluscum contagiosum in individuals aged 1 year and older.
Published: 1/9/2024
Study: COVID-19 Vaccination Not to Blame for Worsening Migraines
Stress may have more of an effect on migraines than COVID-19 infection or vaccination.
Published: 1/8/2024
Researchers Publish Recommendations on Low-Dose Computed Tomography Screenings for Lung Cancer
The report allows management to provide guaranteed assessments throughout the screenings that could aid early detection, diagnosis, and lung cancer treatment.
Published: 1/8/2024
Study: If 66% of Adults 60 and Older Receive RSV Immunization, Infections Can Be Reduced
If vaccination coverage was increased by 100%, outpatient care could be reduced by 81.2%, hospitalizations by 91.7%, and deaths by 91.3%.
Published: 1/8/2024
Study: Stomach Bacteria Linked With Higher Risk of Alzheimer Disease
Those who were exposed to the clinically acquired stomach bacteria had a 24% increased risk of Alzheimer disease after a decade of onset.
Published: 1/8/2024
Mosunetuzumab Led to Durable Complete Response in Majority of Patients with Lymphoma During Follow-Up Study
Nearly 75% of patients who had an initial complete response with mosunetuzumab maintained that complete response after 3 years.
Published: 1/5/2024
STRONG-HF: High-Intensity Care Leads to Higher Doses of Guideline Heart Failure Therapy
Conclusions could not be made regarding whether lower risk was associated with improvement in heart failure or if the success of optimal medications led to better clinical outcomes.
Published: 1/5/2024
Study: Bundled Payments for Care Improvement Not Associated With Improved Quality Performance, Outcomes
In-hospital mortality and the Medicare Bundled Payments for Care Improvement (BPCI) model are not associated with changes in odds for Black individuals or female individuals.
Published: 1/5/2024
New Identity Assay Simplifies Process to Identify Polysaccharide Pneumococcal Serotypes in Vaccines
Investigators optimized the assay during development and qualification to be used in the clinical setting for pneumococcal conjugate vaccines.
Published: 1/5/2024
Study: Machine Learning Can Predict Early Alzheimer Disease, But Has Racial, Ethnic Unfairness
Although machine learning models demonstrate potential to improve early detection of Alzheimer disease, sample sizes that underrepresent ethnic and racial groups result in unfairness.
Published: 1/5/2024
Sesame Oil Supplementation Prevented Postmenopausal Osteoporosis in Animal Models
Findings may translate to a safe intervention for older women at risk of osteoporosis.
Published: 1/5/2024
Study: Researchers Find Benefits in Lung Nodule Program to Aid Lung Cancer Diagnosis
The prospective observational study assessed a 2-year increasing lung cancer diagnosis risk, lung cancer characteristics, and the overall survival between LNP and LDCT screening.
Published: 1/5/2024
Removal of RUNX1 TF, Gene Targeting May Contribute to Eradication of AML Cancer Cells
Eliminating certain factors within the GRN resulted in the network shutting down, potentially leading to cancer cell death due to an inability to replicate, according to the study authors.
Published: 1/5/2024
Dual-Acting CAR T-Cell Therapy May Address Unmet Need in the Treatment of Patients with B-Cell Malignancies
New CAR T development method infuses immune T cells from healthy people into patients to improve outcomes.
Published: 1/5/2024
Study: Genetics Could Be Used to Inform Precision Medicine for Hypertension
Genetic risk, pertaining to sodium and potassium pathways, could help tailor interventions specifically to patients for the management of hypertension.
Published: 1/5/2024
Study: Biosimilarities Found Between Yusimry and Humira for Immune, Rheumatic Conditions
Adalimumab-aqvh (Yusimry; Coherus Biosciences) entered the market in July 2023, following approval by the FDA in December 2021.
Published: 1/5/2024
Poor Sleep Quality in Early Adulthood Linked With Worse Cognitive Performance in Middle Age
The risk of poor cognitive performance was nearly double in participants who had the greatest number of sleep disturbances compared to the least.
Published: 1/4/2024
COVID-19 May Be Linked to a Long-Term Decrease in Cognitive Abilities in Hospitalized Patients
However, cognitive performance was not significantly worse than patients hospitalized for other conditions of a similar severity.
Published: 1/4/2024
Biologics Treatment Response Patterns Comparable in Patients With ACO, Asthma
The efficacy of biologics suggests a potential for biologic-based treatment for patients with asthma-chronic obstructive pulmonary disease overlap.
Published: 1/4/2024
Study: Prophylactic Use of Doxycycline Did Not Lower Incidence of Chlamydia, Gonorrhea in Cisgender Women
The results have been highly anticipated, following other studies showing that doxycycline increased protection against sexually transmitted infections for cisgender men and transgender women.
Published: 1/4/2024
Cognitive Tests Via Smartphone Help Identify Early Amyloid Changes Associated With Alzheimer Disease
The pattern for the diminished learning curve, associated with elevated amyloid levels, was consistent across 3 memory tasks, with strongest results for recalling digit-signs and groceries prices.
Published: 1/4/2024
No Difference Observed Between Branded, Biosimilar Enoxaparin for Post-Operative Thrombosis
There was no statistically significant difference between Lovenox (Sanofi–Aventis Pharmaceuticals, France) and biosimilar enoxaparin in the occurrence of post-operative thrombosis for digestive cancer.
Published: 1/4/2024
Statins Could Potentially Slow Deterioration of Cognitive Function for Those With Alzheimer Disease
Due to the observational nature of the study, the study authors said they cannot determine causal relationships between statins and cognitive decline for patients with Alzheimer disease.
Published: 1/4/2024
Study: Energy Drinks Before Pregnancy Associated With Risk of Gestational Hypertension
Investigators did not find any association between energy drink consumption during pregnancy and any adverse pregnancy outcomes.
Published: 1/3/2024
Study: Low RSV Vaccination Coverage Among Nursing Home Residents
The study highlights the ongoing need for health care providers to recommend respiratory illness vaccinations to increase protection among nursing home residents during the peak season of infection.
Published: 1/3/2024
Proposed Biosimilar Liraglutide Shows Non-Inferiority to Reference Drug for Type 2 Diabetes
Liraglutide, a glucagon-like peptide 1 receptor agonist, has shown a clinically and significant reduction in glycated hemoglobin for those with type 2 diabetes.
Published: 1/3/2024
Study: Statin Use Associated With Reduced Breast Cancer Mortality
Investigators found that those who used statins post-breast cancer diagnosis had a lower risk of breast cancer death when the median total cholesterol decreased.
Published: 1/3/2024
Smaller Doses of Monkeypox Vaccine Elicits Equal Immune Response in People Living With, Without HIV
The study results also determined that those who were previously vaccinated against smallpox had a 2.7 times higher immune response than those who were not previously vaccinated.
Published: 1/3/2024
Addiction to the Internet May Be Associated With Less Sleep, Worse Quality of Life in Adolescents
Sleep duration is positively associated with quality of life in adolescents.
Published: 1/3/2024
Bendamustine Treatment Before CAR T-Cell Therapy Results in Poorer Outcomes in Patients with LBCL
The investigators advise that the use of bendamustine should be avoided when possible in patients with refractory LBCL who are potential candidates for CAR T-cell therapy.
Published: 1/3/2024
Immune Cells Shape Lung Development and Growth, Allow Developments for Treatment of Asthma, COPD
The new understanding of immune cells could not only contribute to the development of lung disease treatments, but treatments for other organ systems as well.
Published: 1/2/2024
Deep Brain Stimulation May Benefit Patients With Alzheimer Disease, But More Research Is Needed
Patients who receive stimulation at different parts of the brain may reap benefits.
Published: 1/2/2024
Revumenib Led to Durable Remission in Patients with Acute Leukemia, According to Expert
In the Augment-101 phase 2 study, 63% of patients experienced overall response rate with revumenib.
Published: 1/2/2024
More than 80% of Patients with Diffuse Large B-cell Lymphoma Responded to Novel Therapeutic, according to the Results of a Preclinical Trial
This therapeutic could work for diseases of the B cell receptor signaling transduction pathway that do not respond well to single-agent BTK inhibitor.
Published: 1/2/2024
Education Improves SGLT2 Inhibitor and GLP1-RA Prescribing, Benefits Cardiology Patients
A study published in the American Journal of Preventive Cardiology found a systematic educational approach overcomes obstacles in prescribing guideline-directed antihyperglycemic medications.
Published: 1/2/2024
Venetoclax Improves Gap in Racial Overall Survival Disparity in Patients with AML
According to the findings, the use of venetoclax, as well as other new therapies, improved overall survival from 28.6% to 45.3% in non-Hispanic Black patients with AML.
Published: 1/1/2024
Alcohol Intervention in People With HIV Reduced Alcohol Use, Did Not Affect Viral Suppression
Because alcohol is a driver of HIV-associated comorbidities, the reduction interventions may improve the health of people with HIV.
Published: 1/1/2024
Top 5 Pharmacy Times Pneumococcal Articles of 2023
From newsworthy moments to groundbreaking research, these were the most-read pneumococcal-related articles on Pharmacy Times in 2023.
Published: 12/27/2023
Top 5 Pharmacy Times Cardiovascular Articles of 2023
From newsworthy moments to groundbreaking research, these were the most-read cardiovascular-related articles on Pharmacy Times in 2023.
Published: 12/26/2023
Growing Body of Data Suggest Nicardipine is Safe, Effective for Hypertensive Crises in Adults With Reduced Ejection Fractions
In a study, most patients had specified SBP targets of less than 160 mmHg and all patients attained goal within a relatively short period of time.
Published: 12/22/2023
FDA Approves Eplontersen for the Treatment of Adult Patients With ATTRv-PN
The drug is the first medicine to be approved for the treatment of adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis that can be self-administered.
Published: 12/22/2023
Researchers Link Pandemic-Associated Financial Hardships to Severe, Persistent COVID-19
Families that reported a lower income before the pandemic were more likely to experience hardships if headed by an adult with COVID-19 illness.
Published: 12/22/2023
FDA Updates Label for Axicabtagene Ciloleucel for R/R LBCL Following Positive Long-Term Survival Data
The CAR T-cell therapy improved relative overall survival by more than a third compared to standard of care.
Published: 12/22/2023
Quality Over Quantity: Expert Weighs in on Luspatercept for Myelodysplastic Syndromes
Expert discusses positive, real-world findings from a claims-based study looking at this therapeutic.
Published: 12/22/2023
Phase 2 Study Results Show Psilocybin Reduces Depressive Symptoms in Adult Patients With Cancer
The investigators note that psilocybin’s effectiveness in treating depressive symptoms and the positive reception among patients with cancer are encouraging continued research.
Published: 12/22/2023
FDA Approves Targeted Release Budesonide for Treatment of Primary Immunoglobulin A Nephropathy
Tarpeyo is now the first fully FDA-approved treatment for primary immunoglobulin A nephropathy, based on measures of kidney function.
Published: 12/21/2023
Study: Children with Private Insurance Are More Likely to Outgrow Food Allergies Than Publicly Insured Children
Overtime, children can outgrow food allergies, like milk and eggs—however, children with private insurance are more likely to outgrow allergies than those with public insurance.
Published: 12/21/2023
Study: Daily Toothbrushing Associated with Lower Rates of Hospital-Acquired Pneumonia
The study included data on ventilator-associated pneumonia and nonventilator hospital-acquired pneumonia, finding lower rates associated with daily toothbrushing.
Published: 12/21/2023
Fewer Than 7 Hours of Sleep May Increase Mortality Risk In Patients with Sleep Apnea
The majority (86.7%) of patients in the study got less than 7 hours of sleep each night.
Published: 12/21/2023
Inquiry By Senate Finance Representatives Finds Pharmacies Fail to Protect Privacy of Medical Records
The pharmacies, which include 8 major chains, were revealed to provide prescription records to law enforcement agencies without court orders or warrants.
Published: 12/20/2023
Study: Neighborhoods With Lower Socioeconomic Status Linked to Lower Adherence Rates for Those With Heart Failure
The results of the study show the importance of considering neighborhood-level disparities to address and improve medication adherence, according to investigators.
Published: 12/20/2023
Study Results Suggest New Opportunities to Improve Future HIV Vaccine Candidates
The study authors note that the findings could be significant in future HIV vaccine design and development, as well as new approaches to HIV immunotherapy.
Published: 12/20/2023
Formulated Toothpaste Could Improve Allergic Reactions to Peanut Allergy
The results found that INT301 met both its primary and secondary endpoints and could be a safe and effective option for individuals that experience food allergies.
Published: 12/20/2023
Study: Telemonitoring After Heart Failure Comparable to Standard of Care
Individuals received 4 daily short messages that reminding them to participate in self-care, active engagement, and early intervention for the first 30 days of the study.
Published: 12/20/2023
Experimental Pneumococcal Vaccine Successfully Prevents Disease in Animal Models
Investigators aim to find a substitution for incomplete Freund adjuvant, which is not suitable for use in humans but shows a strong response to antigen-specific systemic immune responses.
Published: 12/20/2023
Trial-In-Progress Looks to Prophylactic Tocilizumab to Reduce CRS in Patients with Multiple Myeloma
Investigators will evaluate prophylactic tocilizumab prior to treatment with teclistamab.
Published: 12/20/2023
Researchers Find Language Gaps Could Interfere with Pediatric Allergy Diagnoses
Language gaps resulted in barriers and underdiagnosing in children with common allergies, limiting support for these patients and their families.
Published: 12/20/2023
FDA Approves Birch Triterpenes Topical Gel for Treatment for Adult, Pediatric Patients With JEB, DEB
This approval makes birch triterpenes the first treatment for wounds associated with junctional epidermolysis bullosa to be approved by the FDA.
Published: 12/19/2023
FDA Grants Priority Review to New Biologics License Application for V116 Against Pneumococcal Disease
If approved, V116 would offer significant improvements in safety and effectiveness for the prevention of pneumococcal disease.
Published: 12/19/2023
Study Investigates Amiodarone As a Potential Toxin Inhibitor for Clostridioides difficile Infections
Amiodarone also provides pan-variant protection against toxins, a potentially growing area of research in C. difficile infection treatment.
Published: 12/19/2023
Associations Found Between Frailty, Chronic Lung Conditions Such as COPD, Asthma
The study authors note that interventions to reverse frailty, such as screening and assessments to identify issues, can help in the management of COPD and asthma and lead to better prognoses.
Published: 12/19/2023
FDA Accepts BLA for Garadacimab as a Once-Monthly Treatment for Hereditary Angioedema
Previously, garadacimab was granted an orphan drug designation as a therapy for hereditary angioedema by both the FDA and EMA.
Published: 12/19/2023
Doxycycline for Treatment of Pneumococcal Infection Could Reduce Clostridioides difficile Infection
Less than 1% of individuals developed Clostridioides difficile infection (CDI), but for those who previously had a CDI the year before, 12% developed a new infection.
Published: 12/19/2023
Interrupting Immune-Suppresser Treatment Could Boost Effects of COVID-19 Booster
The antibody response among those that interrupted treatment was doubled at 4 weeks and 1.5 times greater at 26 weeks.
Published: 12/19/2023
Expert: The Evolution of HIV Care, Treatment Options, How Pharmacists Can Assist in Providing Care
Using information from clinical studies and her experiences working in the field, Stephanie Kirk describes treatment options that are on the horizon, and how removing stigma is key in HIV care.
Published: 12/18/2023
To Test or Not to Test—The Million Dollar Question for Patients with C. diff
In the study, a new policy empowered unit-based pharmacists to evaluate the patient’s needs and, when safe, switch from a PPI to an H2 blocker.
Published: 12/18/2023
Researchers Evaluate New Advancements for RSV Management, Treatment
The most recent advances included an approved vaccine that could immunize both the elderly and pregnant women, along with the release of nirsevimab.
Published: 12/18/2023
FDA Approves Enfortumab Vedotin, Pembrolizumab for Treatment of Urothelial Cancer
The approval marks the first for an alternative to platinum-containing chemotherapy.
Published: 12/18/2023
Individuals Previously Infected with COVID-19 Face Increased Risk of Heart Rhythm Disruption
Older individuals and individuals that experienced severe COVID-19 are at high risk of increased cardiac disturbances.
Published: 12/18/2023
New Biomarker Shows Potential in Therapeutic Development for Alzheimer Disease
Investigators analyzed the effects of harmful accumulation of HDAC6 in the brains of mouse models with Alzheimer disease to determine any changes in disease progression.
Published: 12/18/2023
PrEPVacc HIV Vaccine Trial Halted Due to Potential Inefficacy, But Oral PrEP Regimens Continue
The study, which consists of 3 trials, will continue with oral PrEP regimens; however, the vaccination trials have stopped due to the unlikely chance of the vaccine showing efficacy.
Published: 12/18/2023
Study Results Find Different Mechanisms of Action in 2 Immune Checkpoint Inhibitor Regimens
The differences between the regimens, anti-PD1/CTLA-4 and anti-PD1/LAG-3, can be used to optimize outcomes for patients with melanoma, particularly in those who develop drug resistance.
Published: 12/18/2023
Moderate Intensity Exercise May Improve Cognition Following a Night of Poor Sleep
Moderate cycling improved cognitive function in patients who got partial or no sleep.
Published: 12/15/2023
Researchers Share Recommendations to Combat Health Misinformation Spread to Adolescents on Social Media
The researchers emphasized that individuals must advocate for new policies that could aid regulation of harmful information being shared through social media platforms.
Published: 12/15/2023
FDA Approves Belzutifan for Treatment of Advanced Renal Cell Carcinoma
Belzutifan (Welireg; Merck) demonstrated superior progression-free survival compared to everolimus in advanced renal cell carcinoma.
Published: 12/15/2023
Regulation, Inhibition of STAT3 Can Lead to Development of Anticancer Treatments
The protein STAT3 is present in approximately 70% of tumors, with elevated levels of the protein being an indicator of poor prognoses in patients.
Published: 12/15/2023
Study: Stem Cell Therapy Shows Improvement in QoL for Those With Heart Failure
Investigators also found that the results demonstrated lower death and hospitalization rates for those with advanced heart failure treated with cell therapy.
Published: 12/15/2023
Expert: Updates for Zotatifin ER+/HER2- Breast Cancer Treatment
Douglas Warner, MD, chief medical officer at eFFECTOR, provides a comprehensive overview of zotatifin and its current status in a Phase 1/2 dose escalation and expansion study, with a focus on ER+/HER2- breast cancer.
Published: 12/15/2023
Removing Stigma of C. Diff Can Provide Opportunities for Discussion, Developing Treatment Options
Feldman, who previously had C. diff, urges individuals to begin having conversations to help remove the stigma of the disease and raise awareness of its prevalence.
Published: 12/14/2023
FDA Approves Elfornithine for the Treatment of High-Risk Neuroblastoma in Adult, Pediatric Patients
This is the first FDA approval for a therapy intended to reduce the risk of relapse in patients with high-risk neuroblastoma.
Published: 12/14/2023
Navigating C. Diff During the COVID-19 Pandemic, The Impact of Antibiotic Usage and Surgeries
Feldman details her experience with C. diff, how the COVID-19 pandemic slowed the timeline of care, and how her surgical history and the use of antibiotics played into the disease’s onset.
Published: 12/14/2023
FDA Approves Updated Label for Bempedoic Acid, Ezetimibe Tablets
The update also removed the maximally tolerated qualifier for statin use and the statement that said morbidity and mortality was not yet determined.
Published: 12/14/2023
Researchers Find Infants in Intensive Care for RSV Did Not Have Preexisting Conditions
Out of the 600 infants, 169 were born prematurely, 487 did not have underlying medical conditions, and 143 had to receive invasive mechanical ventilation.
Published: 12/14/2023
Researchers Design Flu Vaccine With Improved Protection From Influenza A Strains
The results found that the M2e nanoparticle injection could efficiently protect individuals from influenza A viruses.
Published: 12/14/2023
Hispanic Patients with Philadelphia (Ph)-Like B-cell Acute Lymphoblastic Leukemia Continue to Experience Poor Outcomes, According to Expert
There is progress being made regarding research on immunotherapies and the mutation, which adversely affects a higher number of patients in this population.
Published: 12/13/2023
Researchers Find Allergy Medication Could Aid Treatment for Lung Cancer
Immune cells in lung cancer are connected to allergic conditions found in eczema and asthma.
Published: 12/13/2023
Investigational Vaccine Has Non-Inferior Immune Response Compared to PCV20 for Pneumococcal Disease
Clinical trial results show the immunogenicity, tolerability, and safety of V116 compared to a pneumococcal 20-valent conjugate vaccine for adults who had not previously received a pneumococcal vaccine.
Published: 12/13/2023
FDA Approves IVIG for Pediatric Patients Aged 2 and Older With Primary Humoral Immunodeficiency
Bivigam was initially approved by the FDA in May 2019 for the treatment of primary humoral immunodeficiency, including a group of genetic disorders.
Published: 12/13/2023
Disparities Across European NEAT ID Centers Impact Implementation, Roll-Out of PrEP
Both individual and structural barriers were the most common hindrances to PrEP roll-out, and the investigators emphasize that efforts to remove the obstacles as well as further research can help improve PrEP implementation.
Published: 12/13/2023
Researchers Find Similar Immune Response in Half-Dose COVID-19 Vaccine as Full-Dose
Fractional COVID-19 dosing resulted in fewer adverse effects and costs while producing similar immune responses compared to a full dose vaccine.
Published: 12/13/2023
Tirzepatide Results in Superior Mean Percent Change in Body Weight for Those with Obesity
In the phase 3 SURMOUNT-4 trial, investigators included individuals with at least 1 weight-related complication, including hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease.
Published: 12/13/2023
Recent Vaccine Approvals Present New Potential Errors
Prefilled diluent and vaccine syringes may be easily mixed up
Published: 12/13/2023
Study Results Demonstrate Population-Based Effects of SCS on Melanoma Mortality Minimal, Not Significant
The study authors note that low skin cancer screening (SCS) participation, the participants’ better health than nonparticipants, and examination biases may be contributing factors to the insignificant results.
Published: 12/12/2023
MAPS PBC Submits NDA to the FDA for MDMA-Assisted Therapy for PTSD
An FDA approval of 3,4-Methylenedioxy-methamphetamine (MDMA)–assisted therapy would require the Drug Enforcement Administration to reschedule MDMA in acknowledgement of its medical use, making it available for prescription medical use.
Published: 12/12/2023
Study: IL-23 Inhibitors Associated With Lowest Risk of Paradoxical Eczema in Patients With Plaque Psoriasis
Biologics for plaque psoriasis has been associated with an atopic dermatitis phenotype, paradoxical eczema, but the risk factors are not well known.
Published: 12/12/2023
Subcutaneous Daratumumab Plus VRd Significantly Improved PFS, Increased Depth of Response in Patients With Newly Diagnosed Multiple Myeloma
These data support the combination of daratumumab plus VRd followed by daratumumab and lenalidomide maintenance as a new standard of care for transplant-eligible patients.
Published: 12/12/2023
Quizartinib Plus Chemotherapy Improved OS in Patients with AML, Little Hindrance to QOL
Compared to placebo plus chemotherapy, quizartinib plus chemotherapy improved OS without significant AEs and impact on QOL in patients with AML.
Published: 12/12/2023
Social Determinants of Health May Not Reduce the Likelihood of Receiving Newer Treatments In Some Cases, According to Expert
In a recent study, people who lived in disadvantaged or rural areas were just as likely to receive the second-generation medications as people in urban areas.
Published: 12/12/2023
Drug Sequence Might Not Significantly Impact Survival Outcomes of Patients with Lymphoma
However, a survival benefit was observed with using a signaling inhibitor in general for patients with angioimmunoblastic T-cell lymphoma.
Published: 12/12/2023
CAR-T Cell Therapy is Safe, Effective in DLBCL, Including High-Risk Patients
The authors note that CAR-T cell therapy could change the treatment standard for patients with DLBCL, who previously had few options if standard chemotherapy treatment was ineffective.
Published: 12/12/2023
Study: Black Patients Undergo Later, Less Frequent Imaging for Cognitive Decline
Investigators found that individuals who self-identified as Black were less frequently imaged for cognitive impairment with MRI and at an older age compared with White and Hispanic patients.
Published: 12/12/2023
AI Model Can Differentiate Prefibrotic Primary Myelofibrosis From Essential Thrombocythemia With High Accuracy
The model may help clinicians identify patients who would benefit from disease-specific therapies or enrollment into clinical trials.
Published: 12/12/2023
Benralizumab May Be Significant in Helping Patients With Severe Asthma Reduce Regular, Inhaled Steroids
The study results demonstrated that 92% of patients treated with benralizumab were able to safely reduce inhaled steroid dose, and more than 60% could stop use entirely.
Published: 12/11/2023
High-Risk Pediatric Patients With Antiphospholipid Syndrome Present Risk of Severe Health Issues
The results found that 93% of individuals in the high-risk group presented persistently positive antiphospholipid antibodies, compared with 47% of individuals in the lower-risk group.
Published: 12/11/2023
Advise Patients on Supplements for Cardiovascular Health
Encouraging patients to take a proactive approach to their heart health can have great benefits
Published: 12/11/2023
Community Oncology Pharmacists Should Learn How to Manage Adverse Events Related to New Therapies for Acute Myeloid Leukemia
The pharmacist can help patients to manage symptoms throughout the entire treatment journey.
Published: 12/11/2023
Investigators Determine Best ACT-S is a Valid Questionnaire for Asthma Control in Children, Adolescents
The study authors note that the Best ACT-S questionnaire complements the Best ACT-P questionnaire, a previously developed questionnaire that assesses preschool-aged patients with asthma.
Published: 12/11/2023
Financial Burden May Be the Largest Barrier to CAR T-Cell Therapy for the Treatment of Multiple Myeloma
Expert breaks down these findings and more from the GLAMM1 study at the 2023 ASH Annual Meeting.
Published: 12/11/2023
Shorter Sleep Duration May be Linked to Worse Mental Well-being in Women Newly Diagnosed with Breast Cancer
Only 20% of the patient population were reported as being “very good” sleepers when it comes to sleep disturbances.
Published: 12/11/2023
New Findings on C Difficile Physiology ‘Flips the Field of Microbiology on its Head,’ According to Investigator
The bacteria were shown to contain a membrane-bound organelle structure that is like those found in eukaryotic cells.
Published: 12/11/2023
Ibrutinib Plus Venetoclax With MRD-Directed Duration of Treatment Is a New Standard of Care Regimen for Previously Untreated CLL
This is the first trial to show that a measurable residual disease (MRD)–guided approach with treatment beyond MRD negativity has a significant advantage over chemotherapy, both in terms of progression-free survival and overall survival.
Published: 12/11/2023
Gender Gap in NIH-Awarded Research Grants Persists in the Field of Non-Malignant Hematology
The study results shine a light on the potential need for further policy changes that promote gender equity and bridge the gap in R01 funding awarded to female applicants.
Published: 12/10/2023
NATALEE Trial Data Demonstrate Reduction in Recurrence Risk Across Subgroups With Breast Cancer
Almost 80% of patients have now stopped treatment with ribociclib, but benefit persists and is greater than it was 6 months ago, according to the presenter.
Published: 12/10/2023
Golidocitinib Demonstrates Significant Survival Benefits For Patients with Peripheral T-cell Lymphoma
Median overall survival is set to be more than 2 years, which is more than double the overall survival of current frontline therapies.
Published: 12/10/2023
ASH President Speaks on Pharmacists, Novel Innovations in Hematology
He also provides insight for students training in classical hematology, oncology hematology, or oncology pharmacy.
Published: 12/10/2023
Assessing Clinical Trial Efficacy vs Real-World Effectiveness in the Treatment of Multiple Myeloma
The efficacy of treatments, which is the outcomes in the ideal clinical trial setting, are known to often be better than the effectiveness of those treatments, which are the outcomes of patients in the real-world setting.
Published: 12/10/2023
Prenatal Folate May Program Hematopoietic Stem Cell Function Into Adulthood
The study findings have implications for the identification of novel pathways with which to selectively target folate-metabolism blood cancers.
Published: 12/10/2023
2023 President of the American Society of Hematology Discusses Sickle Cell Disease Treatments for the 65th ASH Annual Meeting
The president highlights a new curative treatment option for sickle cell disease while also expanding on the changing treatment landscape for hematologic conditions.
Published: 12/9/2023
FDA Approves Isavuconazonium Sulfate to Treat Invasive Aspergillosis, Invasive Mucormycotic
The approval marks isavuconazonium sulfate as the only granted azole antifungal therapy for pediatric patients with invasive aspergillosia and invasive mucormycotic who are as young as age 1.
Published: 12/8/2023
No Significant Differences at 5 Year Follow-Up Between Palbociclib-Based Treatment Regimens
Study results indicate insignificant differences between PFS and OS in patients with HR[+]/HER2[-] breast cancer who received either palbociclib-letrozole or palbociclib-fulvestrant treatment.
Published: 12/8/2023
Study Reinforces Safety of Taxane-Based Chemotherapies for Pregnant Patients With Breast Cancer
In an interview at the 2023 San Antonio Breast Cancer Symposium, Ana Ferrigno Guajardo, MD, discussed research into the safety and efficacy of taxane-based chemotherapy use in pregnant patients with breast cancer.
Published: 12/8/2023
Early ART Is Safe, Key to Suppressing HIV to Undetectable Levels in Infants
This finding can be a first step toward getting more infants to HIV remission, allowing them to remain off antiretroviral drugs for longer periods.
Published: 12/8/2023
FDA Approves Casgevy, Lyfgenia for the Treatment of Sickle Cell Disease
This FDA approval represents the first cell-based gene therapies for the treatment of sickle cell disease in patients 12 years of age and older.
Published: 12/8/2023
The Future of Immunotherapy in Breast Cancer Involves Engineered T-Cell Therapies, Better Prediction of Adverse Effects
As the use of sequencing, proteomics, and immunopeptidomics increases, more targets will also be discovered, as well as more biomarkers that predict responses to treatments.
Published: 12/8/2023
Final Data From NATALEE Trial Show Benefit of Ribociclib Across Subgroups
Gabriel N. Hortobagyi, MD, MACP, FASCO, a professor at the University of Texas MD Anderson Cancer Center, discussed the final data on invasive disease-free survival from the NATALEE trial of ribociclib in combination with a nonsteroid aromatase inhibitor (NSAI).
Published: 12/8/2023
5 Key Sessions, Interviews at 65th American Society of Hematology Annual Meeting
ASH is happening December 9 through 12 in San Diego, California.
Published: 12/8/2023
Researchers Identify Cell Signaling Pathway Controlling Metastatic Spread of Melanoma Cells to Brain
The study authors note that stress conditions result in an increased activity of the protein HDAC8, which promotes melanoma cell survival.
Published: 12/8/2023
Study Results Demonstrate Neurodevelopment Comparable Between CHEU, CHUU at 1 Year
The study authors note that addressing environmental factors, such as IPV and food insecurity, can provide further benefits in neurodevelopment regardless of maternal HIV status.
Published: 12/7/2023
Tucatinib, Trastuzumab Combination Improves Progression-Free Survival in HER2+, Locally Advanced or Metastatic Breast Cancer
Improvements in PFS were also seen among patients with brain metastases.
Published: 12/7/2023
Adding Pembrolizumab to Chemotherapy Increased Pathological Complete Response, Improved Residual Cancer Burden in Early-Stage, High-Risk ER+/HER2- Breast Cancer
pCR rates were improved with the addition of pembrolizumab regardless of whether patients received the full chemotherapy doses.
Published: 12/7/2023
Abemaciclib, Nonsteroidal Aromatase Inhibitor Extends Overall Survival for Patients With HR+, HER2- Advanced Breast Cancer
MONARCH 3 final OS data show that the combination of abemaciclib and a NSAI in the first-line resulted in numerically longer OS compared to an NSAI alone.
Published: 12/7/2023
Pausing Endocrine Therapy for Pregnancy Did Not Increase Risk of Recurrence for Those With HR+ Breast Cancer
Individuals with HR+ breast cancer could pause endocrine therapy for up to 2 years to become pregnant, without increasing the risk of recurrence.
Published: 12/7/2023
Study: Patients With PD-L1-Positive, High-Risk, ER+/HER2- Breast Cancer Can Achieve Substantial Complete Response Rates With Addition of Nivolumab
Patients with an estrogen receptor measure greater than 8% and those with little to no TIL expression showed no benefit with the addition of nivolumab.
Published: 12/6/2023
MONALEESA Pooled Analyses Show Quality of Life Is Maintained in Elderly Patients Receiving Ribociclib, Endocrine Therapy
The investigational combination also delayed the median time to first chemotherapy in all age groups.
Published: 12/6/2023
New Capivasertib Approval Benefits Patients With Breast Cancer, PIK3CA/AKT1/PTEN Alterations
Biologic rationale, biomarker precision, and efficacy results in the biomarker-negative population all helped FDA officials decide the final indication.
Published: 12/6/2023
FDA Approves Iptacopan for the Treatment of Paroxysmal Nocturnal Hemoglobinuria in Adult Patients
During clinical trials, individuals treated with iptacopan had increased hemoglobin levels and did not need to receive blood transfusions.
Published: 12/6/2023
Experts Say More Research Is Needed to Understand Obesity-Cancer Link
Evidence has shown that reversing pro-cancer effects requires significant weight loss as well as substantial metabolic reprogramming.
Published: 12/6/2023
Patients With Breast Cancer Who Skipped RNI Did Not Experience Increased Risk of Disease Recurrence
Patients with breast cancer who underwent chemotherapy and skipped RNI did not face an increased risk of disease recurrence or death 5 years post-surgery.
Published: 12/6/2023
Study Results Indicate Combined Therapy of Tucatinib, T-DM1, Extended PFS in Patients With Breast Cancer
Although PFS was improved in patients with unresectable locally advanced or metastatic HER2-positive breast cancer, OS data were immature, requiring further research.
Published: 12/6/2023
Study: Older Patients With Actinic Keratoses at Increased Risk of Skin Cancer
Patients enrolled in the study had substantial absolute risks and elevated relative risks, suggesting that AKs may be a clinical marker of UV exposure and increased skin cancer risk.
Published: 12/5/2023
FDA Experts Review Data, Regulatory Insights for New Metastatic Breast Cancer Treatments
Trastuzumab deruxtecan and elacestrant both represent important new treatment options for subgroups of patients with breast cancer.
Published: 12/5/2023
Study Finds Inavolisib Combination Treatment Improved PFS in Patients With Breast Cancer
In the first-line setting, inavolisib plus palbociclib and fulvestrant improved PFS in patients with HR-positive breast cancers; however, further research is needed to understand the trends in OS.
Published: 12/5/2023
FDA Approves 2 Label Changes to Levothyroxine Sodium for the Treatment of Hypothyroidism
The approval marks levothyroxine sodium as the only FDA-granted LT4 therapy that does not have a labeled interaction with PPIs and can be taken 15 minutes prior to eating breakfast.
Published: 12/5/2023
People With Epilepsy May Have Mechanisms Within Their Brain to Reduce Epileptic Activity
These patients have slow brain wave activity during wakefulness, which can reduce the firing of nerve cells to protect against the pathology of epilepsy.
Published: 12/5/2023
Long-term Chia Seed Supplementation May Significantly Lower Systolic Blood Pressure
Chia seeds are a nutrient dense product that are rich in fiber and omega-3 fatty acids, and could have a hypocholesterolemic effect when ingested.
Published: 12/5/2023
Removing Barriers That Limit Young Men at Risk for HIV Will Improve Access to PrEP
The study authors note that increasing education, implementing online services, and removing stigma can help improve the uptake of PrEP in this population.
Published: 12/5/2023
FDA Grants Orphan Drug Designation to LP-284 for Treatment of HGBL With MYC, BCL2 Rearrangements
Currently, there is no established standard of care treatment approach of HGBL, with frontline interventions consisting of chemo-immunotherapies.
Published: 12/5/2023
New Risk Factor Found for Future Cardiovascular Disease in Patients With Systemic Lupus Erythematosus
Investigators found that positive antiphospholipid antibodies and traditional risk factors were associated with atherosclerotic cardiovascular disease.
Published: 12/5/2023
Top 5 Sessions, Interviews From the 2023 San Antonio Breast Cancer Symposium
Pharmacy Times will be covering the 2023 San Antonio Breast Cancer Symposium (SABCS), happening December 5 through 9 in Texas.
Published: 12/4/2023
Novel Technology Could Reduce Weight Control Drug Injections for Patients With Diabetes
A new hydrogel drug delivery system could change the way diabetes is managed.
Published: 12/4/2023
Reduced Structural Stigma Against Sexual Minorities Is Associated With Greater Rates of Male PrEP Prescriptions
The study authors note that additional policies to reduce structural stigma against sexual minorities could continue to improve the rate of individuals who initiate PrEP use.
Published: 12/4/2023
FDA Approves Pirtobrutinib For Treatment of Adult Patients With CLL, SLL
Pirtobrutinib is the first and only non-covalent BTK inhibitor to be approved by the FDA and is indicated for adult patients who already received at least 2 prior lines of therapy.
Published: 12/4/2023
Study: Substantial Deficiencies in Capture of Cognitive Safety in Drug Trials
Despite nearly one-third of reversible dementia cases being drug induced, cognitive safety is a neglected aspect of clinical trials.
Published: 12/4/2023
Migraine Medication Could Be More Effective Than Ibuprofen for Treatment of Attacks
Three classes of drugs could be 2 to 5 times more effective than ibuprofen for the treatment of migraine attacks, according to results of a study.
Published: 12/4/2023
Survey Finds Individuals Worried About Infection During Upcoming "Tripledemic"
Fewer individuals have received the flu shot this season, compared to previous years.
Published: 12/4/2023
Certain Personality Traits May Lower the Risk of Developing Dementia
Although personality was linked to cognitive performance on tests, it was not linked to dementia pathophysiology.
Published: 12/4/2023
Radiation Therapy Could Potentially Improve Heart Function for Heart Failure
In mice with heart failure, radiation therapy demonstrated improved heart function, specifically in the left ventricle, and reduced inflammation in the heart.
Published: 12/4/2023
Medicare Part D Claims Have Increased, But 340B Prescriptions Increased Faster
The proportion of prescriptions by a 340B-affiliated physician increased from 9.4% in 2013 to 19.3% in 2020, but the prescriptions filled by 340B pharmacies increased from 18.4% to 49.9%.
Published: 12/4/2023
Pharmacist-Prescribing Intervention Leads to Cost-Effective Savings in Blood Pressure Care
The study authors reported a 50% uptick in pharmacist prescribing was associated with approximately $1.137 trillion in savings over a 30-year time period.
Published: 12/4/2023
Phase 2 Trial Data Show That Novel Antibiotic Led to 96% Cure Rate for C diff Infection
Iberzaplstat was non-inferior to standard of care vancomycin, was safe and tolerable, and will advance into a phase 3 trial.
Published: 12/1/2023
Potential Host, Viral Mediators of NSV Identified, May Represent Targets to Disrupt HIV Persistence
Further research of these mechanisms could be significant in developing future strategies to disrupt the viral persistence in individuals living with HIV.
Published: 12/1/2023
Gene Associated With Autism Spectrum Disorder May Disrupt Early Brain Development
Patients with this genetic variant have impaired neuronal excitability, a trait that has been linked to malfunctional synapses.
Published: 12/1/2023
Study Finds Asthma-Related Mortality Rates High in US, Factors Include High BMI, Smoking
The study also showcases a significant decline in asthma mortality rates in China, which were previously higher than the United States from 1990 to 2019.
Published: 12/1/2023
FDA Offers Priority Review to Enfortumab Vedotin-Ejfv, Pembrolizumab Combination for Metastatic Bladder Cancer
If approved, this combination will become a first-line treatment option for patients who are cisplatin eligible.
Published: 12/1/2023
Biosimilar Candidate GP40141 Found Similar to Romiplostim for Idiopathic Thrombocytopenic Purpura
The aim of developing GP40141 as a biosimilar is to help reduce the cost of the drug and make treatment more affordable for those with idiopathic thrombocytopenic purpura, according to investigators.
Published: 12/1/2023
Removing Medicaid Prior Authorizations for Buprenorphine May Not Increase Prescribing
Non-expansion states had an increase in prescriptions after PA removal at 27.3% and Medicaid expansion states demonstrated a 22% decrease in prescriptions.
Published: 12/1/2023
Equity-Centered Approaches Can Help Improve Care for MSM Living with HIV
According to the authors, current HIV care methods demonstrate that the mean age at death for Black MSM was 68.8 years, whereas the mean age for White MSM was 75.6 years.
Published: 12/1/2023
Acoustic Stimulation May Significantly Impact Adults Who Have Persistent Symptoms Following Concussion
Following acoustic stimulation intervention, many patients experienced a reduction in neurobehavioral symptoms.
Published: 12/1/2023
Study: Cholesterol in Brain Associated Alzheimer Disease, Brain Damage
Investigators believe lowering cholesteryl ester levels could help prevent brain damage and behavioral changes, reducing the risk of Alzheimer disease.
Published: 12/1/2023
Study: Income Associated With Cardiologist Care for Those With Heart Failure
Although involvement of a cardiologist for heart failure has been associated with reduced rates of in-hospital mortality, not all patients see a cardiologist when hospitalized, according to the investigators.
Published: 12/1/2023
Early-Life Stress Combined With Traumatic Brain Injury Could Increase the Brain’s Vulnerability to Negative Programming
An animal study shows that early-life stress may increase risk-taking behaviors in adulthood; in humans, this could translate to risk of substance use disorder.
Published: 11/30/2023
Data From Phase 3 Trials Demonstrate Efficacy of Dupilumab for Treating COPD, Type 2 Inflammation
Patients with uncontrolled chronic obstructive pulmonary disease and type 2 inflammation had significantly better lung function at least a year into dupilumab regimen.
Published: 11/30/2023
Supplement Derived From Mollusks Could Reduce Age-Related Osteoporosis
Nacre may combat cortical bone loss and improve bone strength to reduce risk of fragility fractures.
Published: 11/30/2023
Study Finds Potential New Target, Drug Candidate to Treat Patients with Barth Syndrome
These findings could make a significant difference in treating patients with Barth syndrome, which is an incurable genetic disease.
Published: 11/30/2023
One Night of Sleep Deprivation May Significantly Impact Decision Making
Neuroimaging showed that people who lacked sleep had altered risk-taking behaviors.
Published: 11/30/2023
Survey Results Find High Rate of Inadequate Health Care Coverage Among US Children
There is a great need to protect families and children that are commercially insured following the COVID-19 pandemic.
Published: 11/30/2023
Study: Age Negatively Associated with Contralateral Breast Cancer Development After Primary Treatment
Further research is necessary to better understand the development and factors that contribute to CBC after PBC treatment.
Published: 11/30/2023
FDA Issues Warning Of Antiseizure Medications Causing Rare, Serious Reactions
Drug reaction with eosinophilia and systemic symptoms can start as a rash and quickly progress, affecting the internal organs and requiring hospitalization, even resulting in death.
Published: 11/30/2023
Survey Results Show Significant Number of Children Are Using Melatonin for Sleep
Melatonin is not fully regulated by the FDA, and there are concerns about children taking the supplement due to associated risks, such as dependency and overdose.
Published: 11/30/2023
Treatment for Traumatic Brain Injury May Be Informed By Glucose Variation
Patients hospitalized for traumatic brain injury have different brain injury biomarkers and rates of glucose variation.
Published: 11/30/2023
FDA Grants Orphan Drug Designation to KRP203 Following allo-HSCT in Patients with Hematologic Malignancies
This is KRP203’s second Orphan Drug Designation and it is the only S1P receptor modulator being developed as an adjunctive and maintenance treatment for blood cancers.
Published: 11/30/2023
Home Monitoring of Asthma Symptoms Found Effective with Use of AI-Aided Stethoscope
This innovation could be useful for optimizing the collaboration between patients with asthma and their health care providers through remote telemedicine consultations.
Published: 11/29/2023
Melanoma LIMS, Algorithmic-Based Classification Achieves Specificity, Precision in Skin Cancer Diagnosis
The study authors are encouraged by the findings, noting that LIMS with algorithmic-based classification can aid in early and accurate diagnosis of skin cancer, improving patient prognosis.
Published: 11/29/2023
HLA-DQA1*05 Genotype Does Not Influence Clinical Response to Ustekinumab, Vedolizumab
No significant demographic or phenotypic differences were found between HLA-DQA1*05 carriers versus non-carriers, in either treatment group.
Published: 11/29/2023
Novel Artificial Intelligence Tool Predicts Outcomes in Invasive Breast Cancer
In addition to predicting breast cancer outcomes, the AI tool can help determine effective treatment options in patients, sparing them from unnecessary treatments.
Published: 11/29/2023
Researchers Announce Positive Trial Data for the Use of Remibrutinib In Chronic Spontaneous Urticaria
Individuals treated with remibrutinib demonstrated symptom control improvement in week 2 of the trial
Published: 11/29/2023
Belantamab Mafodotin Met Primary Endpoint for Those with Relapsed, Refractory Multiple Myeloma
Belantamab mafodotin (Blenrep; GlaxoSmithKline) demonstrated that, when combined with bortezomib and dexamethasone (BorDex), the time to disease progression or death was extended.
Published: 11/29/2023
FDA Grants 510(k) Clearance for CARE Oral Appliances to Treat Adults with Severe OSA
This FDA clearance comes about 11 months after another clearance for appliances to treat mild-to-moderate obstructive sleep apnea (OSA)—the first clearance for oral appliances to treat OSA with supplemental therapies.
Published: 11/29/2023
Combination Prevention Efforts Significant in Reducing HIV Incidence, But Further Action Necessary
Combination prevention strategies reduced the number of new HIV infections among gay and bisexual men who have sex with men; however, improvement of current methods is needed to meet the 2025 and 2030 reduction goals.
Published: 11/29/2023
Vaccination Status of Patients with Hematologic Malignancies Not Correlated with Severity of COVID-19 Infection
Although vaccination status and the severity of COVID-19 infection were not correlated, the timing of vaccine administration influenced whether patients had severe COVID-19 infection.
Published: 11/28/2023
FDA Approves First Therapy for Rare Invasive Tumor Type With High Risk of Recurrence
In a phase 3 trial, none of the patients receiving nirogacestat reached median progression-free survival, indicating that it may effectively reduce disease progression.
Published: 11/28/2023
Antibodies That Can Prevent HIV-1 Infection Remain Detectable Even at Low Antigen Levels
The finding indicates that a potential vaccine can trigger a permanent response in individuals living with HIV-1.
Published: 11/28/2023
Study: Food Insecurity Associated With Increased Risk of Dementia
Food insecurity was associated with an increased risk of dementia, poorer memory function, and faster memory decline in older adults.
Published: 11/28/2023
Peanut Protein Therapy Provides Safe and Effective Treatment for Peanut-Allergic Children
Peanut sublingual immunotherapy offers a practical treatment option for peanut-allergic toddlers, reducing symptoms in 80% of children.
Published: 11/28/2023
Doxycycline for Post-Exposure Prophylaxis of Sexually Transmitted Infections
In addition to growing rates of STIs, there is concern for antimicrobial resistance to STIs.
Published: 11/28/2023
Empathy, Uncertainty Reductions Promote Psychological Well-Being in Patients with Breast Cancer
The investigators note that continued support during breast cancer treatment is necessary for patient comfort beyond diagnosis and the initial phases of treatment.
Published: 11/28/2023
FDA Grants Breakthrough Therapy Designation to Epcoritamab for Follicular Lymphoma
The update followed results from the phase 1/2 EPCORE NHL-1 clinical trial evaluating the safety and preliminary efficacy of the drug, including in individuals with relapsed or refractory follicular lymphoma.
Published: 11/28/2023
Study Indicates Potential of Pembrolizumab in Advanced Melanoma
A change in recurrence-free survival was also observed, with an 89% rate at 24 months in patients who achieved a complete pathologic response.
Published: 11/27/2023
Study Results Demonstrate Early Potential of Breast Cancer Treatment With Minimal Adverse Effects
TcdBFBD, derived from a toxin found in Clostridium difficile, was tested in mouse models that mimicked different subtypes of breast cancer.
Published: 11/27/2023
Progressions in HIV Research Compromised by COVID-19 Pandemic
Study results indicate that outcomes were worse among those who inject illicit drugs and Black patients living with HIV.
Published: 11/27/2023
Study: Cost of Permanent Pacemakers for Pediatric Patients Grows After Congenital Heart Surgery
Heart failure is a major cause of morbidity and mortality for adults with congenital heart disease (CHD), with the highest risk being for those with complex CHD lesions.
Published: 11/27/2023
Prior Authorizations Pose Barrier to Access for HIV Preexposure Prophylaxis
The study authors reported that plans in the South had the highest rates of exclusive PAs for either emtricitabine/tenofovir disoproxil fumarate or emtricitabine/tenofovir alafenamide even if the plan covered both, from 2018 to 2020.
Published: 11/27/2023
Patients’, Health Care Professionals’ Reporting of Comorbidities, Symptoms Varies in Breast Cancer
The study findings indicate that health care professionals significantly underreport symptoms compared to patients with breast cancer, with reported comorbidities varying.
Published: 11/27/2023
There Are Increasing Opportunities for Community Pharmacies to Help Patients With Anemia in Condition Management
Pharmacies have the potential to introduce testing services, promote public health campaigns, collaborate with anemia-led clinics, and get more prescribing rights to diagnose anemia.
Published: 11/27/2023
Children Remain High Risk for Antiphospholipid Syndrome
Pediatric individuals that are higher risk for APS must be followed to better understand affects
Published: 11/23/2023
FDA to Review sBLA For Idecabtagene Vicleucel in the Early Treatment of Adult Patients with RRMM
The review comes after phase 3 trial results that indicate an improvement in overall survival and progression-free survival, reducing the risk of disease progression and death.
Published: 11/22/2023
FDA Issues Fast Track Designation to ADP101 for Mono-, Multi-Food Allergies
The designation allows expedited development of ADP101 as a treatment for food allergy in children ages 4 to 17 with confirmed allergy to 1 or more of the 15 foods in the drug product.
Published: 11/22/2023
Study: Pneumococcal Vaccines Do Not Prevent Development of Otitis Media in Infants
According to the investigators, Streptococcus pneumoniae and non-typeable Haemophilus influenzae are dominant pathogens of otitis media after birth.
Published: 11/22/2023
Researchers Create Growth Chart from AI-Based Tool to Measure Muscle Mass
The growth chart could be a fast and accessible resource to indicate lean muscle mass in children.
Published: 11/22/2023
Nutrition, Treatment Effectively Reduce Pneumonia Transmission in Children, Elderly
Use of both nutrition and treatment can help children and elderly populations, especially those in developing countries where vaccine availability is limited.
Published: 11/22/2023
RSV Season 2022: Most US Infants in ICU Were Full-Term, Previously Healthy
Additionally, infants that were less than 3 months and born prematurely were more at risk of intubation when in the intensive care unit for respiratory syncytial virus.
Published: 11/22/2023
CDC, FDA Announce 77,000 Additional Doses for Nirsevimab as Infant Treatment of RSV
Additional doses for the prophylaxis of respiratory syncytial virus will immediately be distributed to physicians and hospitals through commercial channels and the Vaccines for Children Program.
Published: 11/22/2023
Pneumococcal Conjugate Vaccines Reduce Invasive Disease, Though Coverage Not Optimal
Serotype 19A is still the most prevalent serotype for pneumococcal disease, with study authors calling for additional studies to determine the full burden of invasive pneumococcal disease.
Published: 11/22/2023
Oncology Pharmacists Play a Unique Role in Addressing SDOH in the Community Setting
Pharmacists address aspects of patient care that are unique to the focus of the pharmacist, such as financial toxicity and data collection for components of social determinants of health (SDOH).
Published: 11/21/2023
Current Trends, Treatment Strategies for C diff Infection
Paul Feuerstadt, MD, FACG, AGAF, discusses insights in current treatment practices for CDI at the Peggy Lillis Foundation’s 2023 State of C diff Virtual Town Hall.
Published: 11/21/2023
Extended-Release Buprenorphine Found Well-Tolerated for Fentanyl Opioid Use Disorder
Eligible individuals with opioid use disorder using fentanyl received a single 4 mg dose of transmucosal buprenorphine followed by the extended-release buprenorphine 300 mg injection after approximately 1 hour.
Published: 11/21/2023
Vitamin B5 May Be Associated with Tumor Growth In Certain Types of Cancer Cells
Mice with human breast cancer tissue and high levels of the Myc cancer-driving gene who received a vitamin B5-deficient diet had slower tumor growth.
Published: 11/20/2023
Minimizing Terms in Multiple Myeloma Clinical Trials May Inaccurately Reflect Tolerability, Rates of AEs
The study authors suggest that future research should instead emphasize event rates and patient-reported outcomes to better evaluate the tolerability and frequency of AEs.
Published: 11/20/2023
Patients With Melanoma, Clinicians Report Telehealth Consultations Are Beneficial When Combined With In-Person Care
Despite patients and clinicians preferring in-person consultations, most patients reported that clinicians answered all questions and effectively resolved issues during remote consultations.
Published: 11/20/2023
AB-1002 Demonstrates Improvements for Congestive Heart Failure in First-in-Human Study
Improvements were seen in left ventricular ejection fraction, NYHA Functional Class, and Minnesota Living with Heart Failure Questionnaire at 1-year post-dose.
Published: 11/20/2023
Telemedicine Shows Increase in Curing Hepatitis C Virus Related to Opioid Use Disorder
The results suggest that telemedicine could be used to help improve access for other populations that might be stigmatized, beyond hepatitis C virus and opioid use disorder.
Published: 11/20/2023
Common Food Allergy Reactions Could Increase Risk of Cardiovascular Disease
Investigators believe that the activation of mast cells drives inflammation and contributes to plaque buildup, causing heart attacks and other damage to the heart.
Published: 11/20/2023
Artificial Intelligence Shows Promise in Predicting Sudden Cardiac Death
Artificial intelligence could help detect a trend in medical information for individuals that would help physicians predict an increased risk of sudden cardiac death.
Published: 11/20/2023
Knowledge of PrEP Guidelines Leads to Higher Likelihood of Prescribing PrEP to Young Adults, Adolescents
Study investigators found that health care professionals who were assigned male at birth and practiced in the Western region of the United States were more likely to prescribe PrEP to this high-risk population.
Published: 11/20/2023
FDA Approves Pembrolizumab Plus Chemotherapy to Treat Metastatic HER2-Negative Gastric, Gastroesophageal Junction Adenocarcinoma
The approval makes pembrolizumab the first-line treatment for individuals with this cancer.
Published: 11/17/2023
FDA Accepts Priority Review Application for Lisocabtagene Maraleucel for Relapsed or Refractory CLL, SLL
The acceptance comes after results from TRANSCEND CLL 004, which is the first trial to demonstrate clinical benefit with a CAR T cell therapy in patients who were previously treated for CLL or SLL.
Published: 11/17/2023
FDA Approves Enzalutamide for Nonmetastatic Castration-Sensitive Prostate Cancer
The approval makes enzalutamide the first and only androgen receptor-signaling inhibitor approved for the treatment of nonmetastatic castration-sensitive prostate cancer with biochemical recurrence at high risk for metastatic.
Published: 11/17/2023
FDA Approves Capivasertib With Fulvestrant for PIK3CA/AKT1/PTEN Alterations Breast Cancer
Capivasertib is indicated for hormone receptor-positive, human epidermal growth factor 2-negative locally advanced or metastatic breast cancer with 1 or more PIK3CA/ALT1/PTEN-alterations.
Published: 11/17/2023
New Blood-Based Rapid Test Can Simultaneously Detect HIV, TB
Not only is the test significant for identifying HIV and TB, but it can be safer for patients living with HIV due to their suppressed immune systems.
Published: 11/17/2023
New Synthetic Molecule Shows Promise in Treatment of Heart Failure
In human heart tissues, investigators found that the mechanism associated with heart failure can be reversed and Dicer activity can be restored when AD-9308 was used.
Published: 11/17/2023
FDA Approves At-Home Collection System to Test for Chlamydia and Gonorrhea
The approval marks the first authorized at-home sample collection test for sexually transmitted diseases.
Published: 11/16/2023
Language Barriers May Influence Diagnosis of Allergies in Children
In addition to language barriers, pharmacy translation software errors may cause further complications when filling patient prescriptions.
Published: 11/16/2023
Early-Life Exposure to Manganese May Improve Neurobehavioral Outcomes
While manganese can sometimes be considered toxic, prenatal exposure may be linked to better memory at adolescence.
Published: 11/16/2023
FDA Approves Repotrectinib for Treatment of ROS1-Positive NSCLC
Repotrectinib is a tyrosine kinase inhibitor (TKI) that targets ROS1 and is administered as an oral therapy for treatment of locally advanced or metastatic ROS1-positive non–small cell lung cancer.
Published: 11/16/2023
New Survey Indicates 42% of Primary Care Physicians Unfamiliar with Asthma Treating Biologics
The study also found that 82% of the surveyed physicians reported not getting labs to help determine treatment options for their patients.
Published: 11/16/2023
Phase 1b Trial Results Prove Safety, Tolerability of VERVE-101 Treatment in Patients with High-Risk HeFH
A single infusion of VERVE-101, a gene editing tool, improved both blood PCSK9 protein levels and blood LDL-C levels in 10 individuals with high-risk HeFH.
Published: 11/16/2023
FDA Approves PD-L1 IHC 22C3 to Identify Gastric or Gastroesophageal Junction Adenocarcinoma
The approval marks the sixth cancer type PD-L1 IHC 22C3 pharmDx has been granted, and the first for GEJ
Published: 11/15/2023
FDA Approves Defencath for Catheter-Related Infections for Those With Kidney Failure
Taurolidine and heparin (Defencath; CorMedix) is indicated to reduce catheter-related bloodstream infections for adults with kidney failure who are receiving chronic hemodialysis via central venous catheter
Published: 11/15/2023
FDA Approves Liquid Form of Antibiotic for The Treatment of Infection
The approval will benefit patients who have difficulty swallowing, dysphagia, or high taste sensitivities and struggle to adhere to the original antibiotic.
Published: 11/15/2023
Adult Insomnia Is Related to Sleep Problems in Childhood, Suggesting Insomnia Has a Genetic Component
The genes that predispose a person to sleep problems can impact that person across their entire lifetime, so interventions targeted toward a younger audience could be beneficial.
Published: 11/15/2023
Experts Update Guidance on COVID-19 Treatment and Therapies
Researchers provided recommendations based on the current status of COVID-19 infection and role of therapies.
Published: 11/15/2023
The US Oncology Network Extends Its Reach into Tennessee with The Addition of Nashville Oncology Associates
The Network continues its strong growth trajectory and its mission to enhance community-based cancer care.
Published: 11/15/2023
Disproportionate Burden of Cardiovascular-Kidney-Metabolic Factors in Patients with Adverse SDOH
Session speaker Powell-Wiley explains how screening for SDOH in patients as cardiovascular-kidney-metabolic syndrome stages progress can help better understand their individual social needs.
Published: 11/15/2023
Data Show an Increased Risk of Skin Cancer in Patients with Lower Extremity Lymphedema
According to the authors, these results contribute to developing information that associate lymphedema with localized changes in immunity and a susceptibility for cancer.
Published: 11/14/2023
Vitamin D Supplementation During Pregnancy Reduced Rates of Asthma, Wheezing in Children
Compared to the standard prenatal vitamin alone, vitamin D supplementation with the prenatal vitamin reduced the risk of asthma and wheezing in children by approximately 50%.
Published: 11/14/2023
Data From VOYAGER PAD Can Help Underdiagnosed, Untreated Individuals with Peripheral Arterial Disease
Ince describes why patients who are considered fragile are often underdiagnosed and undertreated, and that the VOYAGER PAD analyses can encourage the treatment of the fragile population.
Published: 11/14/2023
From the Pharmacy Counter to the World Stage: Public Speaking Champion Discusses Being a Go-Getter in Pharmacy
Lessons from the pharmacy taught her about good communication. Now it’s her turn to educate pharmacists.
Published: 11/14/2023
Abelacimab Demonstrates Significant Reduction in Bleeding vs Rivaroxaban in Patients With Atrial Fibrillation
The AZALEA-TIMI 71 randomized trial evaluated the safety and tolerability of 2 blinded doses of the novel factor XI inhibitor abelacimab compared with open-label rivaroxaban.
Published: 11/14/2023
Air Filter Box Introduces Innovative Technique to Trap Viruses
Homemade indoor air filters can trap and remove 99% of airborne viruses.
Published: 11/14/2023
Genetic Biomarker Could Predict Food Allergy Reactions
The presence of the TPSAB1 gene could help clinicians identify increased food allergies.
Published: 11/14/2023
Rivaroxaban Demonstrates Favorable Benefit-Risk Profile in Fragile Populations with Peripheral Arterial Disease
Bonaca also notes that pharmacists can play a key role in educating patients and clinicians about the appropriate use and dosing of antithrombotic drugs for vascular protection.
Published: 11/13/2023
Upcoming Phase 3 Trials to Evaluate Efficacy, Safety of Milvexian in Patients with Cardiovascular Conditions
Harrington discusses how the performance of milvexian in prior phase 2 trials focused on different patient populations creates the foundation for future research.
Published: 11/13/2023
Phase 3 Trial Demonstrates Benefits to Mavacamten Treatment in Hypertrophic Cardiomyopathy
Sehnert emphasizes that mavacamten treatment benefits were present in both patients with sarcomere mutation positive HCM and sarcomere mutation negative HCM.
Published: 11/13/2023
Data Show Effect of Dietary Sodium Reduction on Blood Pressure Was Comparable to First-Line Medication
Clinically meaningful lowering of blood pressure through reduction in dietary sodium was achieved safely and rapidly in 1 week in a middle-aged and elderly cohort.
Published: 11/13/2023
Data Show Lepodisiran Was Well Tolerated, Substantially Lowered Lipoprotein (a)
Elevated Lp(a), which was previously untreatable, may become treatable in the near future, according to the study investigator.
Published: 11/13/2023
Data Show Benefit of Intensive Blood Pressure Reduction Is Consistent in East Asian Population With Hypertension, High Cardiovascular Risk
The SPRINT trial was the first to demonstrate the benefit of further reduction in blood pressure, but it included a limited Asian population and excluded patients with diabetes or history of stroke.
Published: 11/13/2023
SELECT Trial Data Show Benefit of Semaglutide in Patients With Obesity
The SELECT trial expands on existing literature that have shown safety and cardiovascular benefit in individuals with diabetes to now also show benefit in obesity.
Published: 11/13/2023
FDA Expands Indication of Regional Analgesic to Reduce Postsurgical Pain Without Opioids
Bupivacaine liposome injectable suspension was shown to reduce opioid use after surgery and significantly improve pain.
Published: 11/13/2023
Cardiovascular-Kidney-Metabolic Syndrome Requires a Collaborative Approach to Treatment
The American Heart Association published a statement describing the cardiovascular-kidney-metabolic (CKM) construct, specifically highlighting treatment challenges for CKM syndrome.
Published: 11/12/2023
FDA Approves First Vaccine to Prevent Infection from Chikungunya Virus
The vaccine provides treatment prevention for individuals that are high risk of exposure to the chikungunya virus.
Published: 11/10/2023
FDA Approves Prophylactic Treatment for Adults, Pediatric Patients With Extremely Rare Blood-Clotting Disorder
The on-demand enzyme replacement therapy reduced acute thrombotic thrombocytopenic purpura events in patients who experience potentially fatal blood clotting.
Published: 11/10/2023
Interactions Between Tumor Genes, Microenvironment Impact Treatment Response in Multiple Myeloma
The study findings provide the first in-depth look at the relationship between chromosomal changes in tumor cells and immune components of the tumor microenvironment.
Published: 11/10/2023
Study Reports Higher Risk of Respiratory Disease Fatality in Summer Than Winter
Health policies to adapt to climate change must be altered to protect individuals with respiratory diseases in the warmer season.
Published: 11/10/2023
FDA Accepts Supplemental Biologics License Application for Hadlima for Interchangeability With Humira
The sBLA was based on data from a clinical study assessing the pharmacokinetics of switching between adalimumab and adalimumab-bwwd for patients with moderate to severe plaque psoriasis.
Published: 11/10/2023
New COVID-19 Vaccines Will Keep Pharmacy Staff Busy
Both newly approved shots possess activity against subvariant EG5.1, which represents an estimated 21.5% of currently circulating variants
Published: 11/10/2023
Simultaneous Inhibition of Proteins May Slow Growth of Aggressive, Drug-Resistant Breast Cancer
Researchers determined that simultaneously targeting the BRD4 and LOXL2 proteins disrupts their interaction and inhibits the growth of triple-negative breast cancer cells.
Published: 11/10/2023
Researchers Link Inflammation With Long Covid Symptoms in Women
Women with inflammation during COVID-19 infection are at higher risk for Long Covid symptoms, according to study results.
Published: 11/9/2023
FDA Approves Use of Fruquintinib for Adult Patients With Previously-Treated Metastatic Colorectal Cancer
With this approval, fruquintinib is the first and only selective inhibitor of all 3 VEGR receptor kinases to be approved in the United States for previously treated mCRC, regardless of biomarker status.
Published: 11/9/2023
Study Finds Higher Rates of Complications Following Scoliosis Surgery in Teens Due to Disparities
Socioeconomic, racial, and insurance disparities impact individuals' health before and after receiving surgery to treat adolescent idiopathic scoliosis.
Published: 11/9/2023
Domvanalimab-Containing Regimen Shows Positive Preliminary Data for Upper Gastrointestinal Cancers
Domvanalimab plus zimberelimab with chemotherapy demonstrated a positive overall response rate and 6-month progression free survival rate for patients with upper gastrointestinal cancers.
Published: 11/9/2023
Treatment With Anifrolumab-fnia Shows Promising Rates of Remission for Lupus
More individuals with systemic lupus erythematosus treated with anifrolumab-fnia reached remission compared to the placebo.
Published: 11/9/2023
Researchers Announce Safety and Efficacy of Ophthalmic Solution to Treat Dry Eye Disease
Perfluorohexyloctane is the first and only treatment that targets tear evaporation to provide relief for dry eye disease
Published: 11/9/2023
Study: Preventative Drug Lists Improve Affordability, Adherence to Asthma Medication
Preventative drug lists were associated with a modest increase in adherence to combination inhaled corticosteroid long-acting β2-agonists.
Published: 11/9/2023
Study Finds Patients With Severe Sickle Cell Disease Show High Interest in Potentially Curative Gene Therapies
Data show patients are willing to accept associated risks for a chance at a cure.
Published: 11/8/2023
FDA Approves Tirzepatide for Chronic Weight Management
Tirzepatide is already approved under the brand name Mounjaro (Lilly) to be used along with diet and exercise to improve blood sugar in adults with type 2 diabetes.
Published: 11/8/2023
Men Who Develop Asthma Later in Life Are More Likely to Have Harmful T Cells in Their Lungs
CD4+ tissue-resident memory T cells may trigger severe, and potentially fatal, asthma attacks in men aged 40 years and older.
Published: 11/8/2023
Researchers Assess Innate Immune System Changes Following Severe COVID-19
Changes in gene expression could ultimately boost the production of inflammatory cytokines.
Published: 11/8/2023
Survey: 2.8 Million Middle, High School Students Use Tobacco Products, Usage Declining
More individuals who used e-cigarettes have reported pulmonary diseases compared with those who never smoked, including asthma.
Published: 11/8/2023
Studies Show Association Between Regular Cannabis Use, Heart Failure
Regular usage of cannabis may increase the risk of heart failure, stroke, or heart attack, even after adjusting for other cardiovascular disease risk factors.
Published: 11/8/2023
TAK-279 Demonstrates Improvements in ACR 20 Response for Psoriatic Arthritis
TAK-279 is an investigational oral allosteric tyrosine kinase 2 inhibitor for active psoriatic arthritis.
Published: 11/8/2023
Limited Research Suggests Vitamin D Could Have Positive Impact on Progression of Parkinson Disease
More studies are needed to show conclusive benefits on patient functionality.
Published: 11/7/2023
American Oncology Network’s Specialty Pharmacy Reports Zero Drug Waste After Value-Based Trial, Secures Unchanged Reimbursement Rate for 2024
AON’s specialty pharmacy reports success in reducing drug waste like unnecessary and early prescription refills.
Published: 11/7/2023
Researchers Classify Children Most at Risk for Respiratory Syncytial Virus
Infants younger than 6 months old are the highest risk for severe RSV infection, so researchers aim to target this group for prevention methods
Published: 11/7/2023
Metformin Cessation Has Been Associated With Increased Dementia Incidence
Investigators found that there was no association of dementia incidence in insulin use at 5 years after stopping metformin and an association at 0.07 years for HbA1C level at year 1.
Published: 11/7/2023
Brexpiprazole Demonstrates Clinically Meaningful Improvements for Agitation Due to Alzheimer Disease
In May 2023, the FDA approved brexpiprazole as the first and only drug to receive approval for treatment of agitation associated with Alzheimer Disease dementia.
Published: 11/7/2023
The Ketogenic Diet Could Be an Effective Lifestyle Approach to Manage Advanced-Stage Chronic Kidney Disease, Diabetes
A low carbohydrate diet plus a sodium glucose contransporter-2 (SGLT2) inhibitor was found to be safe and effective for weight loss and glycemic control in patients with diabetes and chronic kidney disease.
Published: 11/6/2023
Study: Risk of Atrial Fibrillation Remains High After 3 Years, Including Those With Heart Failure
Risk of atrial fibrillation with 1 of the independent predictors, including congestive heart failure and left atrial enlargement, resulted in greater than a 4-fold increased detection.
Published: 11/6/2023
Influenza Vaccination Status Reveals Disparities Among Individuals with Kidney Disease
Individuals that are younger in age, Black, have low levels of education, and low income were associated with a lower chance of getting the flu shot each year.
Published: 11/6/2023
Researchers Create App to Predict Whether Child in Acute Liver Failure Will Need Transplant
Children with a score of higher than 30 on the CHALF Score scale will need an emergency transplant.
Published: 11/6/2023
Benefits, Mechanisms of SGLT2 Inhibitors in Diabetic Kidney Disease, Other Communities
Although SGLT2 inhibitors are not a cure of diabetic kidney disease, this treatment can help reduce the risk and manage the disease either alone or with complementary therapies.
Published: 11/6/2023
Systemic Issues Contribute to Health Inequities in LGBTQ+ Community
Deep-rooted discrimination and stigma can contribute to stressors that worsen disease progression and access to care, according to experts.
Published: 11/5/2023
Improving Care for Patients with Kidney Disease Who Are Pregnant, Undergoing Dialysis
Other than dialysis, Shah notes that patients with kidney disease who are pregnant can receive either nifedipine or labetalol to control blood pressure.
Published: 11/5/2023
Novel Biomarkers, Diagnostic Approaches for Subtyping Bone Turnover, Improving Patient Outcomes
Nickolas also describes how the use of novel imaging technologies, microRNA, and transcriptomics help experts better understand underlying pathogenesis of ROD.
Published: 11/5/2023
New Weight Loss Drugs May Have Cardiorenal Benefits for Patients with Kidney Disease
Understanding the mechanisms leading to weight loss could help identify potential benefits for cardiorenal health in patients with chronic kidney disease.
Published: 11/4/2023
Common Medications for Diabetic Kidney Disease May Be Linked to Increased Risk of Hyperkalemia
Sodium-glucose cotransporter-2 inhibitors and sodium zirconium cyclosilicate may be paired with these kidney disease medications to reduce high serum potassium.
Published: 11/4/2023
Exercise May Reduce Mortality Among Patients on Dialysis, But Low Compliance Makes Concrete Recommendations Difficult
Exercise has the potential to improve physical performance and fitness at the very least, but a multidisciplinary intervention may work better for patients with chronic kidney disease.
Published: 11/4/2023
Navigating Medication Challenges in Kidney Disease, Updating Prior Drug Dosing Consensus
Awdishu describes the implementation of new equations to accurately drug dose in patients as well as provide updated guidance on the dosing of older medications.
Published: 11/4/2023
Various Cancer Types, Drugs May Cause Thrombotic Microangiopathy, Impact Kidney Health
Leung discusses that various cancer types and drugs can cause thrombotic microangiopathy and impact kidney health and the renal complications connected to hematologic malignancies.
Published: 11/4/2023
Serotypes 3, 19A Most Common for Pneumococcal Community-Acquired Pneumonia
Pneumococcal serotype 3 was prevalent regardless of vaccination status, with the most common cases being in those with chronic lung disease.
Published: 11/3/2023
Expert: ‘We Can Do Better’ to Assess Risk of Acute Kidney Injury
Nephrotoxic care can be improved with better risk score assessment and provider education.
Published: 11/3/2023
Older Adults Remain at High Risk for Hospitalization or Death if Infected with COVID-19
Oldest adults should be prioritized for vaccinations as they remain high risk for severe conditions if infected.
Published: 11/3/2023
Machine Learning Models Can Improve Efforts to Offer Dynamic, Precise Kidney Care
Improvements in AI could change the way pharmacists and providers interact with, and care for, patients.
Published: 11/3/2023
Pharmacy Focus: AMCP Nexus 2023 - Recap on Biosimilar Updates
On this month's episode, Pharmacy Times covers the Academy of Managed Care Pharmacy Nexus 2023 conference, highlighting the updates on biosimilars.
Published: 11/3/2023
Inflation Reduction Act Could Cause Delay in New Oncology Treatments Under Medicare Negotiations
In an article by The New England Journal of Medicine, the authors discuss how drug companies could delay the approval of new oncology drugs under the IRA, delaying patient care.
Published: 11/3/2023
Precision Medicine, Biomarkers, Advancements in Chronic Kidney Disease Treatment
Coca notes the importance of precision medicine in CKD risk assessment and describes the potential impact multiple therapies can have on future CKD prediction and treatment in the future.
Published: 11/3/2023
Non-Coding RNA, Other Therapeutics Can Impact Acute Kidney Injury Treatment, Recovery
The principal investigator of the Centre for Cardiovascular Science at the University of Edinburgh notes that enhancing endogenous repair can lead to a breakthrough in AKI treatment.
Published: 11/3/2023
Hyperkalemia Recurrence in Patients With CKD Contributes to Increased Health Care Resource Utilization, Cost
The increased costs for patients with recurrent hyperkalemia were driven by the increased inpatient medical cost of additional time spent in the hospital following recurrence.
Published: 11/2/2023
Patients With CKD, Hyperkalemia Have Higher Rates of Major Adverse Cardiovascular Events
An analysis of the REVOLUTIONIZE II study data showed that there is an unmet need for long-term outpatient treatment of hyperkalemia in patients with CKD.
Published: 11/2/2023
FDA Approves Vonoprazan for Erosive GERD
The approval marks the first major innovation in the United States for the treatment of erosive GERD in over 30 years.
Published: 11/2/2023
Building a Path to Cure for Patients With NSCLC Who Have Never Smoked
How patients acquire NSCLC plays a role in health outcomes, with never-smoker patients having genetically different disease than the same disease in smokers.
Published: 11/2/2023
Implantable Artificial Kidneys, An Alternative Treatment Method for Kidney Disease
Outside of dialysis and transplantations, implantable artificial kidneys present an additional option for treating kidney disease, according to an expert.
Published: 11/2/2023
5 Key Sessions, Interviews at ASN 2023 Kidney Week Annual Meeting
Pharmacy Times will be at the American Society for Nephrology’s (ASN) 2023 Kidney Week Annual Meeting in Philadelphia, Pennsylvania, from November 2 to 5.
Published: 11/2/2023
Asymptomatic Carriers of C diff Have 24-times Greater Risk for Developing C diff Compared to Noncarriers
Routine screenings for C diff on admission to the hospital could possibly prevent C diff transmission in the hospital setting.
Published: 11/1/2023
FDA Approves Interchangeable Biosimilar Ustekinumab-auub for Inflammatory Diseases
The biosimilar, now legally available at the pharmacy level, demonstrated similar safety, purity, and potency to the reference product.
Published: 11/1/2023
FDA Approves Pembrolizumab for Biliary Tract Cancer
The approval marks the sixth indication for pembrolizumab in gastrointestinal cancers.
Published: 11/1/2023
Study Data Show That Time-Restricted Eating May Be Effective for Weight Loss in Patients With Type 2 Diabetes
This “refreshing alternative” to calorie restriction does not include calorie counting, yet it is naturally associated with greater energy restriction compared to the latter.
Published: 11/1/2023
Cardiovascular-Related Deaths Due to Extreme Heat Projected to Double Between 2036 and 2065
Without policies to reduce greenhouse gas emissions, the number of cardiovascular-related deaths due to extreme heat could even triple by mid-century.
Published: 11/1/2023
Study Findings Show High Oral PrEP Initiation in Adolescent Girls, Young Women Who Are Pregnant, Postpartum
Although the initiation was high, only 33% of adolescent girls and young women continued PrEP use through the 6-month follow-up.
Published: 11/1/2023
Subcutaneous Lecanemab Demonstrates Greater Amyloid Plaque Removal Than Intravenous Lecanemab
Study also showed that 76% of individuals treated with lecanemab-irmb had no deterioration in the tau positron emission tomography (PET) subset.
Published: 11/1/2023
FDA Approves Secukinumab for Hidradenitis Suppurativa
The approval marks the first new biologic treatment option for this patient population in nearly a decade.
Published: 11/1/2023
FDA Approves sBLA for Abatacept in the Treatment of Juvenile Psoriatic Arthritis
The approval is supported by safety data from clinical trials assessing abatacept in the treatment of patients aged 2 to 17 with psoriatic arthritis.
Published: 10/31/2023
Study Data Suggest That Cancer, Irritable Bowel Disease Are Associated With Risk of C Diff Infection
Patients who are immunocompromised generally had worse risk and severity of CDI.
Published: 10/31/2023
Peggy Lillis Foundation Announces 14th Annual Gala To Mark the Beginning of C. diff Awareness Month and Launch of “See C. Diff” Campaign
The annual gala returns to spread critical C. diff awareness and honor those who work tirelessly to combat this deadly infection.
Published: 10/31/2023
Patients, Pharmacists, and Other Caregivers Beginning to Realize Potential of AI
A well-executed, human-like digital relationship can transform patient engagement to patient activation.
Published: 10/31/2023
FDA Approves Reformulation of Vonoprazan Tablets For Regimen Treatment of Helicobacter Pylori
In a clinical trial, 2 vonoprazan-based regimens demonstrated higher rates of eradication as well as low rates of adverse effects compared to lansoprazole triple therapy.
Published: 10/30/2023
Reduced Exercise Capacity Contributes to Worse Outcomes Anemic Individuals With HFpEF
Anemic individuals with heart failure with preserved ejection fraction displayed unique pathophysiological features that led to reduced exercise capacity.
Published: 10/30/2023
Physical Health, Mental Health Associated With Insomnia in Veterans
Study finds that probable insomnia disorder was associated with physical health problems and difficulty with anger in veterans.
Published: 10/30/2023
Patients With Complicated Diabetes, Colorectal Cancer May Have Significant Risk of Death From Any Cause
However, uncomplicated diabetes was not significantly linked to a greater risk of all-cause mortality or death from colorectal cancer.
Published: 10/27/2023
Data Show Rectal Administration of Fecal Microbiota for Recurrent CDI Safe, Simple for Routine Clinical Practice
With a new administration protocol created specifically for the routine clinic, infectious disease physicians can treat recurrent clostridioides difficile infection in less than 3 weeks.
Published: 10/27/2023
FDA Approves Faricimab for Macular Edema Following Retinal Vein Occlusion
Faricimab is the first and only bispecific antibody granted FDA approval for treatment of the eye.
Published: 10/27/2023
FDA Approves Mirikizumab for Moderately to Severely Active Ulcerative Colitis
Mirikizumab-mrkz (Omvoh; Eli Lilly and Company) is the first IL-23p19 antagonist approved for adult patients with moderately to severely active ulcerative colitis.
Published: 10/27/2023
Arexvy Shows Non-Inferior Immune Response Against Lower Respiratory Tract Disease From RSV
Arexvy shows efficacy in helping protect adults aged 50 to 59 years with an increased risk for respiratory syncytial virus lower respiratory tract disease.
Published: 10/27/2023
National Prescription Drug Take Back Day: Pharmacists and Communities Unite for Safer Communities
A critical aspect of National Prescription Drug Take Back Day is the focus on Naloxone training.
Published: 10/27/2023
New Study Heralds Phentermine-Topiramate as Most Cost-Effective Antiobesity Agent for Adolescents
Semaglutide was found to be the most effective drug for weight loss, but the benefits may not outweigh the cost associated with treatment.
Published: 10/27/2023
FDA Approves Vamorolone for Treatment of Duchenne Muscular Dystrophy in Patients Aged 2 Years and Older
The drug’s mode of action is different than other types of corticosteroids because it’s based in the differential effects on glucocorticoid and mineralocorticoid receptors.
Published: 10/26/2023
Meeting the Challenges in Behavioral Health Care With Hybrid Pharmacy Approach
The hybrid pharmacy model represents a significant step forward in providing the best possible care for individuals struggling with behavioral health conditions, ultimately improving their outcomes and overall well-being.
Published: 10/26/2023
Subcutaneous Lecanemab Found Equally Effective as IV Version in Alzheimer Disease Treatment
A weekly dose of injectable lecanemab-irmb (Leqembi) could allow patients with Alzheimer disease to receive the drug at home instead of visiting an infusion center twice per month.
Published: 10/26/2023
FDA Approves Vosoritide for Children With Achondroplasia
Vosoritide is a daily injection for children with achondroplasia who have open epiphyses, given under the skin and administered by a caregiver.
Published: 10/26/2023
Tirzepatide With Diet and Exercise Could Boost Weight Loss
Long lasting weight reduction was reported in individuals that were treated with tirzepatide with diet and exercise, compared to placebo.
Published: 10/26/2023
Expert: Combination of Lenvatinib, Pembrolizumab Outperformed Sunitinib in the Treatment of Advanced RCC
Viktor Grunwald, MD, PhD, discusses the post-hoc analysis of the phase 3 CLEAR trial investigating the combination treatment in the first-line setting for advanced renal cell carcinoma.
Published: 10/25/2023
Amivantamab Plus Chemotherapy Reduced Risk of Disease Progression, Death in Patients With NSCLC
Compared to chemotherapy alone, amivantamab plus chemotherapy treatment with and without lazertinib had also demonstrated positive trends in OS and ORR in patients with NSCLC.
Published: 10/25/2023
Amivantamab With Lazertinib Can Reduce Risk of Disease Progression By 30% in Patients With NSCLC
Compared to osimertinib alone, first-line treatment with amivantamab plus lazertinib was also shown to improve progression-free survival and have an increased duration of response.
Published: 10/25/2023
Phase 3 Study Results Show Tebentafusp Provides Long-Term Survival Benefit in Patients With Metastatic Uveal Melanoma
Patients with previously untreated HLA-A*02:01+ mUM saw improvements in OS, PFS, and ctDNA clearance.
Published: 10/25/2023
Nivolumab Plus Chemotherapy Treatment Followed By Surgery Improved EFS in Patients With NSCLC
Compared to placebo plus chemotherapy, nivolumab plus chemotherapy had also improved event-free survival and both pathological complete response and major pathologic response rates.
Published: 10/25/2023
Phase 3 Trial Results Show Lutetium Can Reduce Risk of Disease Progression in Patients With Prostate Cancer
According to investigators, additional research is necessary to further understand how lutetium impacts overall survival in patients with metastatic prostate cancer.
Published: 10/25/2023
Abemaciclib With Endocrine Therapy Decreases Risk of Long-Term Recurrence of Early Breast Cancer
The oral, twice-daily tablet reduced the risk of long-term breast cancer recurrence by approximately 32%, and at 5 years, improved invasive disease-free survival by 7.6%.
Published: 10/25/2023
FDA Grants Breakthrough Therapy Designation to Novel Drug for Progressive Pulmonary Fibrosis
BMS-986278 (Bristol Myers Squibb) is a potential first-in-class treatment for progressive pulmonary fibrosis and idiopathic pulmonary fibrosis.
Published: 10/25/2023
Lenacapavir Demonstrates Small Margin of Resistance for Those Heavily Treated With HIV
Patients with HIV who were resistant to treatment with lenacapavir (Sunlenca; Gilead Sciences Inc) were found to have inadequate adherence to optimized background regimen or did not have a fully active antiretroviral.
Published: 10/25/2023
Phase 3 Study Supports Pembrolizumab Plus Lenvatinib as Standard of Care in Patients With Advanced Endometrial Cancer Who Received Prior Platinum Therapy
The trial data showed ongoing clinical benefit in patients with advanced endometrial cancer who completed pembrolizumab and continued on lenvatinib vs chemotherapy alone.
Published: 10/24/2023
Amivantamab Plus Chemotherapy Reduced Risk of Disease Progression By 60% in Patients With NSCLC
Compared to chemotherapy alone, amivantamab plus chemotherapy had a better objective response rate and prolonged progression-free survival and overall survival.
Published: 10/24/2023
CDC Issues Alert to Address Shortage of RSV Treatment Nirsevimab
Nirsevimab-alip (Beyfortus; Sanofi and AstraZeneca) is a monoclonal antibody approved to prevent against respiratory syncytial virus (RSV) lower respiratory tract disease in newborns and infants under 8 months of age born during or entering their first RSV season.
Published: 10/24/2023
Combination Therapy More Than Doubles Survival in Patients With Metastatic Colorectal Cancer Compared to Standard of Care
This is the first phase 3 trial to evaluate a KRAS G12C-inhibitor plus an anti-epidermal growth factor receptor antibody for this type of colorectal cancer.
Published: 10/24/2023
Nivolumab Combination Regimen Improved Survival of Patients with Bladder Cancer By A Third Compared to Chemotherapy Alone
The novel combination met the co-primary endpoints of progression-free survival and overall survival during the CheckMate -901 trial, also demonstrating sizeable improvement in objective response.
Published: 10/24/2023
Study Links Long COVID With Short Sleep Duration
Risk of long COVID was 3 times higher in those who had pre-existing conditions and a short sleep duration, compared to those with no pre-existing conditions and adequate sleep.
Published: 10/24/2023
Phase 3 Trial Begins for Combination Influenza and COVID-19 Vaccine
mRNA-1083 is an investigational combination vaccine designed to prevent influenza and COVID-19.
Published: 10/24/2023
Phase 2 Trial Results Demonstrate Taletrectinib Decreased Tumor Sizes in Patients with NSCLC
Not only did taletrectinib shrink tumors in 92% of patients who were tyrosine kinase inhibitor -naïve, but 89.5% of patients continued to respond to treatment at 12 months.
Published: 10/24/2023
Ribociclib With Endocrine Therapy Improved Invasive Disease-Free Survival in Patients With Early Breast Cancer
Compared to endocrine therapy alone, the combination of ribociclib and endocrine therapy lowered the risk of cancer recurrence in patients with early breast cancer by 25.2%.
Published: 10/23/2023
FDA Approves Infliximab-dyyb for Inflammatory Bowel Disease
Infliximab-dyyb (Zymfentra; Celltrion USA) is a subcutaneous treatment for the maintenance treatment of adults with moderately to severely active ulcerative colitis and Crohn disease.
Published: 10/23/2023
Clinical Overview: Preventative Tools for Respiratory Syncytial Virus
RSV can create a problematic infection among children 12 months of age or younger, older adults, and in patients with immunocompromised conditions.
Published: 10/23/2023
American Heart Association Publishes Presidential Advisory Defining the Overlaps of Cardiovascular Disease, Kidney Disease
This marks the first time that experts have defined cardiovascular-kidney-metabolic syndrome, including the overlap of cardiovascular disease with kidney disease, type 2 diabetes, and obesity.
Published: 10/23/2023
Pembrolizumab With Chemotherapy Before Surgery Significantly Improves Response Rate in Patients With Breast Cancer
Published: 10/23/2023
FDA Approves Pentavalent Vaccine for Most Common Serogroups That Cause Meningococcal Disease
Penbraya (Pfizer Inc) is the first and only approved pentavalent vaccine that confers protection against the most common meningococcal serogroups—A, B, C, W-135, and Y, in individuals 10 through 25 years of age.
Published: 10/20/2023
Phase 3 Trial Results Support Subcutaneous Nivolumab Treatment for Patients With Metastatic ccRCC
Subcutaneous nivolumab had demonstrated noninferiority of Cavgd28, Cminss, and ORR compared to the intravenous form of treatment.
Published: 10/20/2023
Study: Women, Men Experience Different Forms of HIV-Related Stigma
Women with HIV reported higher rates of physical abuse than men with HIV, but women had more social support from family and friends.
Published: 10/20/2023
Common Live Vaccines May Be Safe for Specific Pediatric Patients Who Are Recipients of Solid Organ Transplant
In a recent study, approximately 99% of children who received solid organ transplant and live vaccination against rubella had antibodies 1 to 3 months post-vaccination.
Published: 10/20/2023
Nasopharyngeal Swabs Most Sensitive for Pneumococcal Detection in Infants
Study authors suggest that saliva samples can be a complementary testing method to provide additional information on pneumococcal carriage and serotypes that may be undetected by nasopharyngeal testing.
Published: 10/20/2023
Novel Oral Medication Reduces Risk of Death by 76% in Patients With ALK-Positive Lung Cancer
The statistically significant and clinically meaningful improvement in disease-free survival is “practice-changing” and may represent a “paradigm shift” in treatment, according to experts.
Published: 10/20/2023
Data Support Biktarvy Tablets for Virologic Suppression Among Patients With HIV
Biktarvy was found both effective and safe for long-term use in HIV, as well as for patients with mental health conditions.
Published: 10/20/2023
Similar Pneumococcal Serotype-Specific Responses Observed Between Shared Serotypes in Patients Administered PCV13, PCV15 Vaccines
Study data suggest that both vaccines induce similar functional antibody responses against pneumococcal serotype 3.
Published: 10/19/2023
Pharmacists’ Involvement with Gene Therapies, Potential Candidates, Forecasting Effectively
In this field, Marshall notes that pharmacists can help by building forecasts and assist with managing members’ care before and after gene therapy.
Published: 10/19/2023
RBX2660 Leads to Recurrent-Free Outcomes for Patients With Clostridioides difficile Infection
Among individuals who received systemic antibiotics within 8 weeks, 6 months, 12 months, and 24 months of receiving fecal microbiota, RBX2660 prevented recurrence.
Published: 10/19/2023
More Biosimilars Are Entering the Pharmacy Side of The Market
Biosimilars in the pharmacy benefit are as effective as their reference drug, but it’s important for the pharmacist to clarify this to patients.
Published: 10/19/2023
Study Results Indicate Precision Therapies Make Up Approximately Half of FDA-Approved Oncology Drugs
This finding underlines the need for methods that address multiple genomic alterations and targeted therapies effective in tumors driven by variations in suppressor genes or transcription factors.
Published: 10/19/2023
Expert: Improving Efficiency of Biosimilar Operations, Advancing Interchangeable Biosimilar Development Among Top Priorities for FDA
The biosimilar landscape is growing, but the FDA should leverage analytical data to efficiently determine the quality of these products and propel them toward approval, according to a session at the Academy of Managed Care Pharmacy’s Nexus 2023 conference.
Published: 10/19/2023
Experts Highlight Need for Increased Screening for Dementia, Alzheimer Disease
Approximately 96% physicians feel it is important to assess patients aged 60 years and older for cognitive impairment, but 48% of these patients have no had assessments from their physician.
Published: 10/19/2023
Interchangeability Designation Still Widely Debated, Prescribers Hesitant About Biosimilars
The FDA is the only authority that can designate a biosimilar as interchangeable with its reference product, which requires that the product has similar clinical results for the same indication.
Published: 10/19/2023
Mental Health Issues During Adolescence Could Lead to Future Unhealthy Behaviors
Latinx teens suffering with mental health issues are at risk of developing cardiovascular conditions in their future.
Published: 10/19/2023
Pharmacists Play Important Role in Behavioral Health Care, Preventing Over- or Under-Prescribing
There are 3 main medication-related issues for mental health care, which includes polypharmacy, nonadherence to prescribed medication, and underutilization of medications.
Published: 10/19/2023
Key Market Trends for the Current Specialty Drug Pipeline
Areas of focus for specialty medications include biosimilars, cancer treatments, and drugs across disease states such as inflammatory conditions, HIV, and multiple sclerosis.
Published: 10/18/2023
FDA Approves Pilocarpine Hydrochloride Ophthalmic Solution to Treat Presbyopia
Pilocarpine improves near visual acuity by pupil modulation, leading to an increased ability to focus on nearby objects.
Published: 10/18/2023
FDA Approves Tenapanor for Chronic Kidney Disease
Twice-daily tenapanor tablets are recommended for patients with chronic kidney disease who are on dialysis, unresponsive or intolerant of any dose of a phosphate binder therapy.
Published: 10/18/2023
Expert Reviews Upcoming Approvals, Trends in Biosimilars
Jensen notes that although she expects there will be a lot of FDA approvals in 2023 and 2024, there likely will not be another biosimilar “boom” until 2025.
Published: 10/18/2023
Biosimilar Drugs Found as Clinically Effective as Reference Drugs, More Affordable
Following the results of a meta-analysis that reviewed biosimilar trial design and endpoints, investigators urge for greater biosimilar uptake initiatives.
Published: 10/18/2023
FDA Approves Zilucoplan for Generalized Myasthenia Gravis in AChR Antibody-Positive Adults
The approval marks the first and only once-daily target therapy for generalized myasthenia gravis for self-administration in this patient population.
Published: 10/18/2023
Medically Integrated Dispensing Pharmacies Access Patient Medical Records To More Effectively Manage Patients
Medically integrated dispensing specialty pharmacies can connect patient medical and pharmacy records to improve medication adherence and help patients to safely stay on them for longer.
Published: 10/18/2023
Alternative Model for Lung Cancer Screening Shows Higher Sensitivity Than Current Model
PLCOm2012 uses additional parameters to predict the risk of lung cancer and was found more effective when identifying both Indigenous and non-Indigenous individuals with lung cancer.
Published: 10/18/2023
FDA Approves Bimekizumab for Moderate-To-Severe Plaque Psoriasis
Bimekizumab is a novel, humanized monoclonal IgG1 antibody that potently and selectively neutralizes both IL-7A and IL-17F, which are key cytokines driving inflammatory processes in plaque psoriasis.
Published: 10/18/2023
Artificial Intelligence Helps Simplify Managed Care Pharmacy Workflow, Processes
Artificial intelligence and machine learning can significantly benefit managed care pharmacy, specifically in contract reading and interpretation.
Published: 10/18/2023
Current Perceptions Affect Managed Care of Obesity as Chronic Condition
Obesity is a chronic disease comprised of dysregulated adipose tissue, increasing the risk of developing serious health conditions, and requires more than just losing weight.
Published: 10/18/2023
Access Barriers to Rifaximin May Increase Risk of Hospitalization from Overt Hepatic Encephalopathy
In a recent study, 97% of patients had to wait a day before receiving their prescription, and this may worsen the risk of hospitalization.
Published: 10/18/2023
Older Adults Who Disagree With Deprescribing Medication More Interested in Additional Communication, Alternative Strategies
According to the authors, identifying the degree of disagreement with physicians’ deprescribing recommendations can improve the communication among older adults and their physicians.
Published: 10/17/2023
AMCP Session Provides Updates on PBM Reform Efforts Currently Stalled in Congress
Reform efforts to consider how health care plans may capitalize on disclosures, balancing out-of-pocket spending access, and how pharmacists can help plan members with the increased transparency of pharmacy benefit managers.
Published: 10/17/2023
Medically Integrated Specialty Pharmacies Can Leverage Electronic Medical Records to Improve Quality of Care
![[Technology can] aid and support to improve clinicians' workload and to reduce burnout, [which] is vital to retaining clinicians in many facilities. Image Credit: © woravut - stock.adobe.com](https://cdn.sanity.io/images/0vv8moc6/pharmacytimes/cfd2075f5bc7a307a231a88b9692a62f465d2ca3-530x396.png)
These pharmacies can use electronic medical records to work more directly with providers, monitoring adverse medication effects and assessment schedules and being more tuned into patient needs.
Published: 10/17/2023
Updates in Federal Legislation Addressing Digital Therapeutics, Access to Care
Although all legislation is currently on hold in Congress, there are important actions under consideration for pharmacy, including digital therapeutics, access to care, and health care disparities.
Published: 10/17/2023
Research Links Poor Sleep With Anxiety, Depression in Older Individuals With Obesity
Poor sleep patterns were related to anxiety, depression, body fat gain, and loss of muscle mass in older individuals who are obese.
Published: 10/17/2023
Experts Assess Association of Recurrent Clostridioides Difficile with Gut Microbiota
Health-related quality of life scores were positively associated with log MHI and Bacteriodia, and negatively with Gammaproteobacteria and Bacilli.
Published: 10/17/2023
FDA Approves Pembrolizumab Resectable Non–Small Cell Lung Cancer
Pembrolizumab (Keytruda) gains its sixth approval in non–small cell lung cancer (NSCLC), with the latest indication in combination with platinum-containing chemotherapy as neoadjuvant treatment, and then continued as a monotherapy for the post-surgical adjuvant treatment of patients with resectable NSCLC.
Published: 10/17/2023
FDA to Create Digital Health Advisory Committee By 2024
The committee will help the FDA address issues related to digital health technologies, including artificial intelligence, virtual reality, cyber security, and patient-generated health data.
Published: 10/17/2023
The Value of a Pharmacy Technician
Pharmacy Technician Day celebrates the myriad contributions of the unsung heroes of health care.
Published: 10/17/2023
Rite Aid Initiates Voluntary Chapter 11 Process to Aid Company Financial Restructuring
Rite Aid filed for bankruptcy protection and said it plans to close several hundred retail stores.
Published: 10/16/2023
Rebyota Found Safe, Effective in Preventing Recurring Clostridioides Difficile Infection
Treatment-emergent adverse events associated with Rebyota for Clostridioides difficile infection were more prevalent in those with renal comorbidities than in those without and were moderate in severity as well as related to pre-existing conditions.
Published: 10/16/2023
Ocrelizumab Found to Suppress Immune Activity That Worsens Multiple Sclerosis Symptoms
A subcutaneous injection of ocrelizumab was markedly effective at suppressing brain lesions in patients with multiple sclerosis, according to data from a phase 3 trial.
Published: 10/16/2023
Simplified Model Successfully Predicts Risk of Asthma Exacerbations
Investigators created a model to predict asthma exacerbations that can be integrated in WhatsApp chatbot and relies on self-reported data.
Published: 10/16/2023
FDA Approves Nivolumab for Completely Resected Stage IIB or Stage IIC Melanoma in Adult, Pediatric Patients
In clinical trials, nivolumab (Opdivo) demonstrated a statistically significant improvement in recurrence-free survival compared to placebo in eligible patients with stages IIB, IIC, III, and stage IV completely resected melanoma.
Published: 10/16/2023
Accessibility of OTC Short-Acting Beta-2 Agonists Contributes to Overuse for Asthma
Many patients would like more education about managing their asthma, which can help to reduce the overuse of short-acting beta-2 agonists.
Published: 10/13/2023
Study: Individuals With Inflammatory Disease Did Not Have Higher Risk of VTE Following COVID-19 Infection
The study results also indicate no significant difference of venous thromboembolism risk between individuals with immune-mediated inflammatory diseases and individuals without.
Published: 10/13/2023
Deep Sleep With Pink Noise Increases Benefits to Cardiovascular System
A study shows a significant increase in left ventricular ejection fraction when using pink noise stimulation with deep sleep.
Published: 10/13/2023
Uptake, Acceptability of HIV Pre-Exposure Prophylaxis Treatment Influenced by Knowledge, Perception of Risk in MSM
Although increased knowledge and understanding could increase uptake and acceptability of pre-exposure prophylaxis for HIV, action is needed to remove barriers and improve accessibility.
Published: 10/13/2023
Study Finds Mental Health-Related Emergency Department Visits Dropped in 2020, Began Increasing in Mid-2021
Adolescents with mental health conditions must be monitored as they are at a higher demand for the need of mental health care.
Published: 10/13/2023
Phase 3 Trial Findings Support Nivolumab Treatment in Multiple Cancer Types
Trial data bolster the role of nivolumab and nivolumab-based combinations in both early and metastatic stages of multiple cancer types, especially in patient groups with high unmet needs.
Published: 10/13/2023
Follow-Up Survey Indicates Cancer Centers Continue to Experience Chemotherapy Shortages
Larger institutions have continued to treat patients who needed carboplatin or cisplatin; however, the survey results don’t include smaller cancer centers that may face access challenges.
Published: 10/12/2023
Phase 3 Trials of Survodutide for Overweight, Obesity to Begin Recruiting Patients
SYNCHRONIZE-1, SYCHRONIZE-2, SYNCHRONIZE-CVOT will evaluate survodutide for overweight and obesity.
Published: 10/12/2023
Bacille Calmette–Guérin Vaccine May Prevent Most Common Cause of Death in Patients With HIV
Investigators suggest that the Bacille Calmette–Guérin vaccine, which prevented tuberculosis in nonhuman primates infected with SIV, can also protect against HIV.
Published: 10/12/2023
Survey Results Highlight Value of Experience, Certifications for Pharmacist Salaries
Although education and training have historically been considered the primary factors influencing pay, the survey results challenge this notion.
Published: 10/12/2023
FDA Approves Encorafenib Plus Binimetinib Combination for Non-Small Cell Lung Cancer
Encorafenib (Braftovi; Pfizer Inc) and binimetinib (Mektovi; Pfizer Inc) approved for the treatment of patients with metastatic non-small cell lung cancer who harbor a BRAF V600E mutation.
Published: 10/12/2023
Physical, Social Environments Impact Racial Disparities in Cardiovascular Health
Black men had 27% lower odds of an ideal cardiovascular health score compared to White men, whereas Black women had 55% lower odds compared to White women.
Published: 10/11/2023
Study: Antibiotic Exposure During Pregnancy Associated With Increased Risk of Childhood Respiratory Allergies
The study authors note that it is important for expectant mothers to use antibiotics appropriately and when necessary, as well as monitor their child after birth.
Published: 10/11/2023
Interventions to Improve Health Promotion for HIV Testing Should Consider Cultural Factors, Community Testing
Health promotional strategies should account for social contexts and cultural perspectives to increase the number of individuals who choose to test for HIV.
Published: 10/11/2023
Study Finds PrEP Boosts Confidence of Having HIV Transmission-Free Sex Among At-Risk Populations
Pre-exposure prophylaxis found to provide peace of mind for patients at risk of HIV, and coupled with frequent HIV testing in the health care setting, lowers the perceived risk of contracting the disease.
Published: 10/11/2023
Five Key Sessions at the Academy of Managed Care Pharmacy Nexus 2023 Conference
Pharmacy Times will be providing exclusive session coverage and interviews with presenters for the Academy of Managed Care Pharmacy Nexus 2023 conference.
Published: 10/11/2023
Study Uses Data to Examine Mental Health Trends in Patients With HIV Before, After COVID-19 Outbreak
Study shows that interventions may help to personalize care that meets the individual needs of patients with HIV and to improve mental health outcomes.
Published: 10/10/2023
Study: Pre-Exposure Prophylaxis Significantly Under-Prescribed to Prevent HIV in Eligible Patients
Primary care physicians, particularly in family medicine, offer PrEP at a significantly low rate, despite US Preventive Services Task Force recommendations.
Published: 10/10/2023
Bring QTc Prolongation to the Forefront in Mental Health Prescribing
Patients under the care of psychiatric facilities, particularly those taking antipsychotic and antidepressant medications, face the risk of prolonged QTc intervals.
Published: 10/10/2023
Nirmatrelvir, Ritonavir Treatment Associated With Reduced Risk of COVID-19 Hospitalization, Death in Extremely Vulnerable Patients
Study authors suggest that immunocompromised patients may greatly benefit from nirmatrelvir and ritonavir; however, there was no significant benefit shown in lower-risk patients.
Published: 10/10/2023
Study: Black Children Less Likely Than White Counterparts to Receive EMS Transportation to Hospital for Asthma Episode
Investigators hope that continued research and addressing disparities can improve equitable access to asthma treatments for all pediatric patients.
Published: 10/10/2023
A Collaborative Care Model Recognizes That the Oncology Patient’s Journey Does Not End At Remission
Within this care model, pharmacists can serve an important role in caring for patients, whether it is identifying adverse medication interactions or pushing patients to seek additional support.
Published: 10/9/2023
Pennsylvania Hospital Shows That Community Cancer Centers Can Conduct Phase I Clinical Research
Providing clinical trials at community locations allows patients with travel restrictions to access novel treatments that are typically studied academic institutions.
Published: 10/9/2023
Esketamine in Combination with Oral Antidepressant Could Aid Treatment-Resistant Depression
Individuals treated with esketamine were more likely to reach remission and remain relapse-free at 8 weeks of treatment.
Published: 10/9/2023
Use of Antidepressants in Older Adults Linked to Driving Impairment on a Road Test
Use of antidepressants and other classes of prescription drugs can increase the risk of driving impairment compared to nonuse, so clinicians and pharmacists should review these risks with older adults.
Published: 10/9/2023
Survey Finds Lack of Parental Awareness of Meningitis Risk in Children
Parents are not fully educated on the risk of meningitis infection and preventive efforts for their children.
Published: 10/9/2023
Study: No Difference Found in Safety of Reference Biologic, Biosimilar
In the first systematic review using statistical methods, investigators found switching from a reference biologic to a biosimilar was comparable in safety, but no conclusion on immunogenicity could be drawn.
Published: 10/9/2023
FDA Approves Secukinumab as First Intravenous Interleukin-17A Antagonist for Rheumatic Diseases
The intravenous formulation of secukinumab is administered in monthly 30-minute, weight-based dosing and requires no pre-medication or lab monitoring.
Published: 10/9/2023
FDA Expands Indication for Non-Steroid Cream to Treat Psoriasis In Children as Young as 6 Years of Age
Roflumilast is the first topical agent indicated to treat psoriasis in sensitive intertriginous areas of the skin.
Published: 10/6/2023
Webinar: Demand of Respiratory Illness Vaccines Exceeds Availability
Expert discuss access barriers for the COVID-19, respiratory syncytial virus, and influenza vaccines, and ways to facilitate uptake.
Published: 10/6/2023
Study Finds IVIG, Therapeutic Plasma Exchange Have Comparable Efficacy for Neurological Disorders
Choice of therapy should be selected based on patient needs and conditions.
Published: 10/6/2023
Bariatric Surgery Could Lower Risk of Cardiovascular Disease Caused by LDL Interactions
Harmful LDL functionality contributes to an increase of cardiovascular disease in those with obesity but could decrease within weight loss.
Published: 10/6/2023
Researchers Test Microdosing Psilocybin on Rats to Create Treatment for Mental Disorders
The use of psilocybin, repeated at a low dose, could offer a new form of treatment for individuals with differing forms of mental disorders.
Published: 10/6/2023
Navya-PPT May Help Patients With Early Breast Cancer Choose Between Breast-Conserving Surgery, Mastectomy
Not only did the Navya-Patient Preference Tool help patients with decision-making, but groups who used the tool were more likely to receive their preferred form of surgery.
Published: 10/6/2023
SARS-CoV-2-Associated Sepsis More Common, Deadly During the Early Pandemic
Study is the first to compare SARS-CoV-2–associated sepsis and presumed bacterial sepsis on mortality and incidence.
Published: 10/6/2023
Obstacles to Care Due to COVID-19 Pandemic Should Be Addressed to Improve Time-to-Care of Heart Attack Patients
Study findings indicated that many health care facilities are recovering from the COVID-19 pandemic and shortage of staff, which has caused door-to-balloon times to lag.
Published: 10/5/2023
Clinical Overview: Turmeric for the Management of Osteoarthritis
Patients often turn to dietary supplements for the management of osteoarthritis, one of which is turmeric.
Published: 10/5/2023
Researchers Explore Oncolytic Polymers as the Key to Fighting Tumor Heterogenicity
Oncolytic polymers may be the answer to circumventing therapeutic resistance in cancer treatment.
Published: 10/5/2023
Dapagliflozin Significantly Reduced A1C in Children, Adolescents With Type 2 Diabetes
Investigators found that the adjusted mean change in A1C was –0.62% for dapagliflozin compared to 0.41% for a placebo in patients with type 2 diabetes.
Published: 10/5/2023
Metformin Monotherapy With GLP1RA, SGLT2I, DPP4I More Effective Than Sulfonylurea When Managing Diabetes
Compared with sulfonylurea, these add-on treatments were also associated with fewer diabetes-related cardiovascular and renal complications as well as avoiding hypoglycemia.
Published: 10/5/2023
Study Highlights Impact of Preventive Strategies for RSV Hospitalizations in Pediatric Patients
Study shows a a significant burden of hospitalizations associated with respiratory syncytial virus during the 2021-2022 season compared with the prepandemic period.
Published: 10/5/2023
Moderna’s mRNA-1083 Vaccine Shows Positive Results for Influenza, COVID-19
mRNA-1083 (Moderna) was found comparable to the standard dose of Fluarix (GSK) in adults aged 50 to 64 years and Fluzone HD ( Sanofi) for influenza and Spikevax (Moderna) for COVID-19.
Published: 10/4/2023
Beyond Depression: Antidepressants and Their Diverse Indications
An overview of antidepressant medications and their indications to inform health care professionals of their wide use and to better understand which antidepressant to recommend based on patient-specific characteristics.
Published: 10/4/2023
Study Finds Increased GI Cancer Risk Among Individuals With Overweight, Obese BMIs Throughout Adulthood
The results also indicate an association with increased risk of colorectal and noncolorectal gastrointestinal cancers as body mass index increases over time.
Published: 10/4/2023
Pharmacist-Led Intervention Could Improve Type 2 Diabetes Outcomes for Hispanic Patients
Hispanic individuals have been found to be more likely to develop complications as a result of diabetes compared to those who are non-Hispanic White.
Published: 10/4/2023
Pharmacists Could Be Solution to Polypharmacy in Patients With Cancer
Up to 81% of patients with cancer take medications to treat their other comorbidities.
Published: 10/4/2023
The Use of Nirmatrelvir or Molnupiravir Could Prevent Mortality in Severe COVID-19
The use of nirmatrelvir or molnupiravir can aid treatment for individuals that are at high risk of developing severe COVID-19, regardless of varying demographics.
Published: 10/4/2023
Study: Out-of-Office Blood Pressure Monitoring Beneficial for Those Without Hypertension
White-coat hypertension was diagnosed in 17 of 35 patients who completed out-of-office blood pressure monitoring.
Published: 10/4/2023
Expert: Reaching Out for Healthy Women, A Data-Driven Approach to Helping Women Access Health Care
The manager of patient support services at St. Luke’s Cancer Center discusses the significance of Reaching Out for Healthy Women and how female patients can receive support from this initiative.
Published: 10/4/2023
FDA Issues Emergency Use Authorization to Novavax’s COVID-19 Vaccine 2023-24 Formula
NVX-CoV2601 vaccine adjuvanted 2023-2024 formula granted EUA for the prevention of COVID-19 in those 12 years of age and older.
Published: 10/3/2023
APhA, ASHP, NABP Publish Report Aimed at Improving Strategies for Pharmacy Workforce
The new report includes actions to implement that could improve workplace conditions, which are the leading causes of high stress and occupational burnout across the pharmacy profession.
Published: 10/3/2023
Study Results Indicate Palliative Care Less Common Among Racial Minority Patients With Metastatic Breast Cancer
Lack of awareness, cultural beliefs, and physician preferences may influence whether minority patients receive palliative care during metastatic breast cancer treatment.
Published: 10/3/2023
Survey Highlights Need for Improved Working Conditions, Communication in Pharmacies
Although respondents reported no impacts on patient safety, workload significantly increased during the COVID-19 pandemic and led to major burnout challenges.
Published: 10/3/2023
Early-Phase Cancer Trials Show More Diversity in 2022 Compared to 2000
Diversity in patient populations, including age, race, ethnicity, and underrepresented regions, have increased in early-phase National Cancer Institute-sponsored trials.
Published: 10/3/2023
Alcohol Consumption Not Found to Impact Sustained Virologic Response for Patients with Hepatitis C
The study investigators said that restricting access to direct-acting antiviral therapy due to alcohol consumption could create unnecessary barriers for those with hepatitis C virus.
Published: 10/3/2023
Survey Shows 22% of Individuals Worried About Contracting Flu in 2023 Season
Similarly, the results of a survey by the National Foundation for Infectious Diseases demonstrated that approximately 23% were worried about COVID-19 and 19% for respiratory syncytial virus.
Published: 10/3/2023
Study Finds Enterococci Enhance C. Difficile Pathogenesis, Promoting Colonization
Not only did enterococci promote C. difficile pathogenesis, but it was also shown to provide fermentable amino acids, facilitating its virulence agitated gastrointestinal tracts.
Published: 10/3/2023
FDA Approves Nedosiran for Patients With Primary Hyperoxaluria Type 1
Nedosiran (Rivfloza; Novo Nordisk Inc) injection is designed to inhibit the expression of liver enzyme lactate dehydrogenases leading to oxalate overproduction in patients 9 years of age and older with PH1.
Published: 10/2/2023
Expanding How to Assess Adherence in Older Adults With Home Medication Management
“There is method to this madness” describes routines that affect adherence to medication regimens.
Published: 10/2/2023
Two FCS Manuscripts Published in NEJM Within Two Months Co-Authored by Manish R. Patel, MD
Manish Patel, MD is the co-author for 2 manuscripts published in the New England Journal of Medicine within 2 months.
Published: 10/2/2023
Raphael Bosse, MD, PhD Joins Naples-Goodlette
Raphael Bosse, MD, PhD has joined the Florida Cancer Specialists & Research Institute, LLC statewide practice.
Published: 10/2/2023
Clinical Research Demonstrates Positive Impact of Genomic Testing for Patients with Non-small Cell Lung Cancer
Researchers utilize data from Florida Cancer Specialists & Research Institute to inform results.
Published: 10/2/2023
Intravenous Immunoglobulin Reduces Risk of Severe Infection When Used with BCMA Bispecific Antibody for Multiple Myeloma
Intravenous immunoglobulin could potentially be given throughout the duration of anti-BCMA bispecific antibody therapy for the treatment of multiple myeloma.
Published: 10/2/2023
Study: Structural Racism Increases Cancer Mortality within Racial Minoritized Groups
Cancer mortality rates increased by 3.3 deaths per 100,000 individuals and was higher for historically minoritized populations.
Published: 10/2/2023
An Untold Cost Center in Pharmacy: Shipping. Yes, Shipping.
Our wacky health care system can’t pay pharmacies a few more dollars to survive, but we can spend billions of dollars on shipping costs.
Published: 10/2/2023
AI and Precision Medicine Are Changing What’s Possible for Breast Cancer Treatment
Ongoing studies utilizing large-scale health databases that incorporate environmental, lifestyle, biological, and phenotypic data may provide insight that leads to better cancer prevention and treatment.
Published: 10/2/2023
AI May Be One of Our Most Powerful Tools in the Battle Against Cancer
Artificial intelligence has helped ensure a data-driven methodology for evaluating eligibility criteria for clinical trials, facilitating more inclusive trial design.
Published: 10/2/2023
Celebrate the Everyday Work of Pharmacists
October offers us a chance to take a step back to admire the hard work and dedication that pharmacists show day in and day out.
Published: 10/2/2023
Nobel Prize Awarded to Scientists Whose Work Led to Development of mRNA COVID-19 Vaccines
Katalin Karikó, PhD, and Drew Weissman, MD, PhD, win Nobel Prize for discoveries in the area of nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
Published: 10/2/2023
Topline Data Demonstrate Survival Improvement With Amivantamab-vmjw for NSCLC
The MARIPOSA study evaluated amivantamab-vmjw (Rybrevant; Janssen Pharmaceutical) in combination with lazertinib compared to osimertinib and compared to lazertinib monotherapy in the first-line treatment of EGFR-mutated non–small cell lung cancer.
Published: 9/29/2023
Study Shows Association Between Alpelisib Treatment, Hyperglycemia in Patients with Metastatic Breast Cancer
The study authors suggest that after initiating alpelisib, patients should be proactive by improving glycemic status to reduce the risk of developing hyperglycemia.
Published: 9/29/2023
Researchers Reframe the Definition of Clinical Remission for Asthma
A workgroup of asthma treatment experts introduced 6 new criteria that those diagnosed with asthma must meet to be in remission.
Published: 9/29/2023
Study: Trigonelline Demonstrates Improvements in Learning, Memory, Suppressing Inflammation
Investigators said that these results were promising, indicating that trigonelline could help to alleviate cognitive decline associated with aging.
Published: 9/29/2023
FDA Accepts Biologics License Application for Priority Review of Sotatercept in Treatment of Pulmonary Arterial Hypertension
The FDA has issued a Prescription Drug User Fee Act fate of March 26, 2024, for sotatercept (Merck) as treatment for adults with pulmonary arterial hypertension.
Published: 9/29/2023
Incidence of Type 2 Diabetes Increased Significantly Following COVID-19 Pandemic
Investigators also found that rates of type 1 diabetes have been on the rise since 2016.
Published: 9/29/2023
Analysis Indicates Sleep Duration, Health Influenced by Environmental Changes
Environmental factors may change sleep patterns over time, which subsequently affects rapid eye movement sleep.
Published: 9/29/2023
Study Finds Individuals Prefer PrEP Over Other HIV Prevention Methods
Individuals taking HIV prevention prefer the PrEP oral daily dose compared to new treatment methods.
Published: 9/29/2023
Lutathera Met Primary Endpoints in Progression Free Survival for Gastroenteropancreatic Neuroendocrine Tumors
Lutetium Lu177 dotatate demonstrated significant and clinically meaningful progression-free survival for those with SSTR-positive and inoperable midgut neuroendocrine tumor.
Published: 9/28/2023
Trial Results Find Enfortumab Vedotin-ejfv, Pembrolizumab Combination Effective in Urothelial Cancer
The combined enfortumab vedotin-ejfv and pembrolizumab treatment is recommended for patients with locally advanced or metastatic urothelial cancer who are ineligible for cisplatin-containing therapy.
Published: 9/28/2023
FDA Approves Gepirone Extended-Release for Treatment of Major Depressive Disorder
Gepirone hydrochloride ER (Exxua; Fabre-Kramer Pharmaceuticals Inc) is in a new class of antidepressants, making it the first and only approved antidepressant that selectively targets serotonin 1A receptors.
Published: 9/28/2023
Intervention with Supplemental Creatine Found Effective, Safe for Symptom Reduction After COVID-19 Infection
At a 6-month follow-up, supplemental creatine intervention significantly improved scores for fatigue symptoms and tissue bioenergetics related to COVID-19 infection.
Published: 9/28/2023
Clinical Overview: Teprotumumab Provides a Breakthrough Treatment for Thyroid Eye Disease
Teprotumumab (Tepezza) is a promising treatment for thyroid eye disease , although its precise mechanism of action remains incompletely characterized.
Published: 9/28/2023
Possible Link Between Depression, Limited Social Interactions During COVID-19 Pandemic
Study findings showed a 10% increase in the proportion of individuals staying home due to COVID-19 policy restrictions being associated with a 0.27 increase in PHQ-9 scores for depression.
Published: 9/28/2023
JAK1 Inhibition May Treat Patients With Food Allergy
Abrocitinib can reduce allergic responses in patients with a peanut allergy by decreasing cytokine activity and maintaining regulatory T cell activation.
Published: 9/28/2023
Independent Pharmacy Files Lawsuit Against CVS Health, Caremark, Aetna Based on DIR Fees
The National Community Pharmacists Association said the action was sent into motion by wrongful penalties for Medicare Part D prescriptions, called pharmacy direct and indirect remuneration fees.
Published: 9/28/2023
Bosutinib Approved by FDA for Pediatric Patients With Chronic Myelogenous Leukemia
Bosutinib (Bosulif) is indicated to treat pediatric patients with Philadelphia chromosome–positive chronic-phase chronic myelogenous leukemia that is newly diagnosed, resistant, or intolerant to previous therapy.
Published: 9/27/2023
Study Results Indicate Purpose in Life Declines with Emergence of Cognitive Impairment
Maintaining a purpose in life has the potential to reduce apathy related to dementia and cognitive decline.
Published: 9/27/2023
New Paper Urges CMS to Reconsider Anti-Obesity Medications as Treatment for Chronic Disease
Current federal statutes exclude anti-obesity medications for coverage when used for anorexia, weight loss, or weight gain.
Published: 9/27/2023
Large Review Suggests IVIG is Effective for Neurological Diseases Following COVID-19 Infection
Intravenous immunoglobulin found to provide fast and long-lasting relief for COVID-19-related neurological conditions, although investigators are still uncovering the pathology of many of these conditions.
Published: 9/27/2023
Yoga Could be an Effective Natural Treatment for Individuals with Heart Failure
Routine yoga therapy has shown endurance, strength, balance, symptom stability and quality of life improvements in individuals with heart failure.
Published: 9/27/2023
Researchers Create Hydrogel That Could Improve HIV Therapy Compared to Current Treatments
The hydrogel injection has had a lasting drug concentration of 42 days with almost no adverse effects.
Published: 9/27/2023
Study Links Immune Checkpoint Inhibitors to Asthma, Chronic Obstructive Pulmonary Disease
A patient with lung adenocarcinoma who was treated with an immune checkpoint inhibitor developed symptoms related to asthma and breathing obstruction.
Published: 9/27/2023
Encephalitis Can Change How the World Thinks About Complex Neuropsychiatric Disorders
This disease can, at the very least, help researchers to “identify” the floodgates to definitive tests and therapies for complex psychological and neurological diseases, expert says.
Published: 9/26/2023
Genetic Biomarkers Can Help Define Severity of an Individual’s Food Allergy
Researchers find correlation of increased anaphylaxis with the use of a-tryptase.
Published: 9/26/2023
Physical Rehabilitation Interventions Could Aid Individuals with Post-COVID-19 Condition
Functional exercise resulted in more improvements for individuals with PCC compared to standard treatment, although individuals must be monitored for adverse events.
Published: 9/26/2023
Enfortumab Vedotin-ejfv, Pembrolizumab Combination Shows Promise Treating Urothelial Cancer
Investigators reported that enfortumab vedotin-ejfv (Padcev; Astella Pharma Inc, Seagen Inc) in combination with pembrolizumab (Keytruda; Merck & Co Inc) met the dual primary endpoints of overall survival and progression-free survival in patients with previously untreated locally advanced or metastatic urothelial cancer.
Published: 9/26/2023
New Vaccine Significantly Improved Lifespan of Patients With Multiple Myeloma in Phase 1 Trial
Most patients had improved clinical response within 90 days of receiving the dendritic cell vaccine and ASCT.
Published: 9/26/2023
Pharmacists to Take the Reins of Leading Clinical Trials for Children’s Oncology Group
As the resident medication experts, pharmacists are qualified to answer any medication-related questions and conduct data analyses.
Published: 9/26/2023
Datopotamab Deruxtecan Demonstrates Improvement in Progression-Free Survival in HR+, HER2- Breast Cancer
Datopotamab deruxtecan (Dato-DXd; AstraZeneca, Daiichi Sankyo) also demonstrated improved overall survival compared to chemotherapy.
Published: 9/25/2023
Study Finds Obesity Remission Rates Are Lower Than Overweight Remission Rates in Children
Only 1% of children experienced obesity remission and lower socioeconomic status was connected to a worsened trajectory.
Published: 9/25/2023
Clinical Overview: Cannabis May Interact With Prescription Medications
An increase in cannabis use has led to growing concerns surrounding interactions between its components, THC and CBD, and prescription medications.
Published: 9/25/2023
COVID-19 Pandemic Associated With Worsening Mental Health Outcomes for Adolescents
To promote positive mental health outcomes, researchers urge for policy interventions that focus on home connectedness, peer friendship, and school climate while avoiding full school closures.
Published: 9/25/2023
Testosterone Loss in Aging Men May Increase Risk of Cognitive Decline, Dementia
Testosterone may protect the brain against dementia pathology, but the association has not been proven.
Published: 9/25/2023
Phase 3 Trial Shows Neoadjuvant, Adjuvant Nivolumab Can Improve Survival in Patients With Lung Cancer
Nivolumab has also demonstrated efficacy in immunotherapy-based combinations for the treatment of certain types of melanoma and bladder cancers.
Published: 9/25/2023
Survey: 72% of Pharmacy Technicians’ Workflow Affected by Drug Shortages
Chemotherapy, medication for attention deficit/hyperactivity disorder, glucagon-like peptide-1 agonists for weight loss and diabetes, and local anesthetics were among the drugs most affected by shortages.
Published: 9/22/2023
FDA Approves Empagliflozin for Adults With Chronic Kidney Disease at Risk of Progression
Empagliflozin (Jardiance) demonstrated a 28% relative risk reduction, with an absolute risk reduction of 3.6% per patient-year at risk in the treatment of chronic kidney disease.
Published: 9/22/2023
Community Pharmacy Can Help Solve National Health Equity Challenges Facing Clinical Research
The people who come to the community pharmacy represent the surrounding population at large, making the pharmacy an ideal place to identify and recruit underrepresented patients.
Published: 9/22/2023
House Committee Hearing Addresses PBMs, Anticompetitive Drug Pricing Tactics
The House Committee members examined pricing tactics by PBMs and how they are harming patients across the country.
Published: 9/22/2023
Study: Monoclonal Antibodies Benefit Those Previously Treated for HIV
Monoclonal antibody treatment resulted in suppression of HIV for more than 3 months, with some continuing to suppress the virus for more than 18 months after treatment stopped.
Published: 9/22/2023
Study: Coffee Consumption Should Occur 9 Hours Before Sleep, Reducing Disturbances
Standard amount of pre-workout should be taken at least 13.2 hours before bedtime to avoid sleep disruptions; however, there was no cut-off time for a cup of black tea.
Published: 9/22/2023
Axicabtagene Ciloleucel Demonstrates High Response Rate in Relapsed/Refractory Large B-cell Lymphoma
Axicabtagene ciloleucel achieved a complete metabolic response of 71% at 3 months versus 12% expected with standard of care among transplant ineligible patients with relapsed/refractory large B-cell lymphoma.
Published: 9/22/2023
FDA Grants Priority Review for Pembrolizumab in Progressive Cervical Cancer
The approval of pembrolizumab with brachytherapy could aid individuals who were newly diagnosed with progressive cervical cancer.
Published: 9/21/2023
Dormant HIV Infections Elicit Small Immune Response, Though Not Significant
Two separate study findings reported that a subset of dormant CD4+ cells could spontaneously produce HIV RNA and proteins, impacting a patient’s HIV-specific immune responses.
Published: 9/21/2023
FDA Grants Priority Review to New Drug Application for Belzutifan for Advanced Renal Cell Carcinoma
The sNDA is based on data that evaluated belzutifan (Welireg; Merck) compared to everolimus (Afinitor; Novartis) for the treatment of advanced renal cell carcinoma.
Published: 9/21/2023
Researchers Compare PrEP Treatments for Hypertension Risks
If taking tenofovir alafenamide fumarate, a close monitoring of blood pressure and lipid levels are essential due to greater risk of hypertension.
Published: 9/20/2023
Report: Gen Z Knows Least About HIV Compared to Older Generations
Investigators of the GLAAD and Gilead COMPASS Initiative survey tracked the progress against HIV stigma, the transmission and prevention of HIV, and the attitudes and knowledge of those living with HIV in the United States.
Published: 9/20/2023
Trastuzumab Deruxtecan Shows Clinical Benefit as Second-Line Therapy for Lung Cancer
In many countries, trastuzumab deruxtecan is the only HER2-targeted therapy approved for patients with this HER2–mutant metastatic non-small cell lung cancer.
Published: 9/20/2023
Phase 3 Trial Reinforces Favorability of Roflumilast Cream 0.05% for Atopic Dermatitis in Children
A supplemental New Drug Application will be submitted for roflumilast cream 0.05% for the treatment of mild to moderate atopic dermatitis in children 2 to 5 years of age.
Published: 9/19/2023
Clinical Overview: Potentially Harmful Medications in Heart Failure
An average patient with heart failure can take up to 6 medications for guideline-directed medical therapy; however, they may have other comorbidities that require pharmacologic management.
Published: 9/19/2023
IVIG Therapy Shows Insignificant Benefit to Reducing Mortality, Length of Hospitalization in Patients with COVID-19
The analysis results showed no statistically significant impact on either outcome, but results from prior prospective studies suggest that intravenous immunoglobulin may lengthen hospital stay for patients with severe COVID-19.
Published: 9/19/2023
Study: Shared Decision-Making in Cardiovascular Health is Infrequently Utilized, Despite Benefits
Shared decision-making can be better incorporated into cardiovascular care guidelines by including decision aids, such as informational flyers or online tools to help patients.
Published: 9/19/2023
Moderna Announces Expansion of mRNA Research Across Respiratory, Oncology, Rare Disease Franchises
Moderna has advanced 6 programs into late-stage development, including for respiratory conditions, latent and other viruses, oncology, and rare diseases.
Published: 9/19/2023
First Interchangeable Biosimilar to Insulin Found Noninferior Insulin Glargine for Diabetes
Insulin glargine-yfgn is more affordable than the reference product and patients do not require prescriber authorization switch.
Published: 9/19/2023
Hospital-Diagnosed Infections Associated With Increased Incidence of Dementia
Infections were associated with a 1.49-fold increase in the rate of dementia in both the short- and long-term rates, however, the increases were greater in the short term.
Published: 9/19/2023
FDA Accepts Supplemental Biologics License Application of Altuviiio for Children With Severe Hemophilia A
Supplemental biologics license application is based on positive results from the phase 3 XTEND-Kids study, demonstrating highly effective bleed protection with once weekly dosing of Altuviiio for children with severe hemophilia A.
Published: 9/19/2023
Study Demonstrates Insufficient Sleep, Circadian Misalignment Associated with Obesity
In addition to identifying strategies to reduce the adverse effects of sleep and circadian disruption, the study authors identify the impact of obesity on sleep.
Published: 9/18/2023
Analysis Indicates Highly Cited COVID-19 Research is Trending Downwards Compared to Early in Pandemic
Research shows a peak of highly cited COVID-19 studies at the end of 2021 and a significant downward trend by the end of 2022.
Published: 9/18/2023
Research Identifies Multiple Barriers Preventing Patients From Using PrEP to Prevent HIV
Strategies include improving compliance, convenience, symptom management, and reducing stigma around pre-exposure prophylaxis for HIV.
Published: 9/18/2023
Focus on Human Papillomavirus Virus Vaccination in Adults and Young Adults
Combining strong evidence-based recommendations with caring, compassionate, and frequent counseling opportunities hopefully will increase vaccine acceptance and ultimately reduce the incidence of HPV and associated cancers among our patients.
Published: 9/18/2023
New Update Changes Terminology for Some Cutaneous Lymphomas
Improved classification of different lymphoma types can improve the potential of targeted therapies and help predict patient responses.
Published: 9/18/2023
FDA Approves Momelotinib to Treat Myelofibrosis Patients With Anemia
Most patients with myelofibrosis will develop anemia over the course of the disease, with more than 30% discontinuing treatment as a result.
Published: 9/18/2023
MDMA-Assisted Therapy Demonstrates Significant Reductions in Post-Traumatic Stress Disorder Symptoms in Phase 3 Study
Study results could lead to an FDA approval for MDMA to treat post-traumatic stress disorder by the end of 2023.
Published: 9/15/2023
Expert: Artificial Intelligence Changing the Field of Medical Writing
The CEO of Yseop discusses how AI can have a positive impact in the development of high quality medical writing due to its efficiency and ability to reduce long, tedious tasks for writers.
Published: 9/15/2023
Propanolol Oral Solution (Hemangeol): A Breakthrough in Treating Infantile Hemangioma
As research and clinical experience continue, Hemangeol's role in the management of infantile hemangioma is likely to expand, further improving the lives of affected children.
Published: 9/15/2023
Clinical Overview: Fecal Microbiota Transplantation vs Live Biotherapeutic Products for Management of Recurrent C Difficile Infection
Although antibiotics are the standard-of-care treatment for Clostridioides difficile infection, they can cause further microbiota changes that predispose patients to recurrence.
Published: 9/15/2023
The Promise of Biosimilars Is Within Reach for Health Systems
A collaborative exercise with 16 health care organizations nets millions in savings.
Published: 9/15/2023
Experts Predict Multiple Myeloma Outcomes Will Improve With Greater Use of Bispecific Antibodies
Bispecific antibodies have 2 distinct binding domains, which interact with either CD3 on T cells or a tumor-associated antigen on the tumor cell surface.
Published: 9/15/2023
Orforglipron Associated With Significant Weight Loss
As a once-daily oral treatment, orforglipron could help address barriers to injectable medications, such as semaglutide and liraglutide.
Published: 9/15/2023
Experts Discuss Updates In COVID-19 Immunization
Expert panelists addressed concerns about the COVID-19 vaccine costs, availability, efficacy, and timing.
Published: 9/15/2023
Artificial Intelligence Is Revolutionizing Controlled Substance Diversion Detection
AI is able to quickly analyze, identify, and route data for investigation.
Published: 9/14/2023
Impact of the Inflation Reduction Act on Vaccinations: What Pharmacists Need to Know
By educating their patients on the provisions of the Inflation Reduction Act, pharmacists can have an even greater impact by increasing vaccine uptake in historically underserved groups.
Published: 9/14/2023
Researchers Assess Connection Between Socioeconomic Status, Cardiovascular Health
Heart disease prevention efforts should acknowledge non-biological factors that can cause issues within cardiovascular health rather than relying on decreasing socioeconomic disparities.
Published: 9/14/2023
Biosimilars Could Provide Huge Savings in Future, But Patient Education is Needed
Clinicians raise concerns about immunogenicity, product quality, and reimbursement for biosimilars.
Published: 9/14/2023
SARS-CoV-2, Seasonal Influenza Vaccine Coadministration is Safe, Effective in Protection Against Viruses
Compared with COVID-19 vaccination alone, recent study findings show health care workers who received both a COVID-19 booster and influenza vaccinations did not have lower immune response or more frequent adverse events.
Published: 9/14/2023
Researchers Rule Out Gefapixant to Help Unexplained Chronic Cough
The use of gefapixant reduces cough frequency but increases adverse events in individuals suffering from a chronic cough.
Published: 9/14/2023
Study Suggests Base-Edited T Cells Could Minimize Immunotherapy Complications in Leukemia Treatment
The use of base editing to generate universal, off-the-shelf CAR T cells is a promising approach for relapsed leukemia, with potential implications for the future of gene therapy.
Published: 9/14/2023
Cancer Diagnoses Significantly Decreased in First Few Months of COVID-19 Pandemic
Investigators found an approximately 23% decrease in overall cancer incidence in April 2020, specifically for breast, colon, rectal, head and neck cancers, as well as melanoma and endocrine cancer diagnoses.
Published: 9/14/2023
Caregiver, General Population Flu Vaccination Rates Not Significantly Different
Evidence-based programs and policies to improve vaccine uptake are necessary for both caregivers and the general public because influenza vaccine coverage remains low for both groups.
Published: 9/14/2023
Patients With Cancer Using Nonmedical Stimulants Can Continue Using Opioids, Regardless of Prognosis
Experts agreed that it was appropriate for patients who use methamphetamine or cocaine to continue opioid use if clinician monitoring was increased and tapering was avoided.
Published: 9/13/2023
CDC’s ACIP Votes in Favor of Universal Recommendation for 2023-2024 Monovalent COVID-19 Vaccines
The CDC emphasized the need for protein-based vaccine options in endorsing a vote by the Advisory Committee on Immunization Practices for the universal recommendation of the 2023-2024 monovalent, XBB containing COVID-19 vaccines.
Published: 9/13/2023
AACR Releases Annual Cancer Progress Report, Urges Expansion in Cancer Research
AACR has urged Congress to provide billions more in funding for cancer research, prevention efforts, and expedited review of cancer-related medical products.
Published: 9/13/2023
Cognitive Training Programs Have No Long-Term Benefit for Children Born Very Preterm
Children born at 24- through 34-weeks’ gestation could have neurobehavioral problems and developmental dysfunctions, including language, executive function, attention, and behavioral disorders.
Published: 9/13/2023
Walgreens and Pearl Health Partner to Expand Value-Based Care
Pearl Health will offer technology and insight solutions while Walgreens provides clinical services.
Published: 9/13/2023
Wellness Pharmacists Synergize Prevention with Patient Care: What to Know About This New Branch of Pharmacy
The wellness pharmacist uniquely focuses on patient quality of life and personalized care to help patients achieve health beyond a prescription alone.
Published: 9/13/2023
Bispecific Antibodies Achieve High Response Rates, Tolerable Adverse Effects in Multiple Myeloma
Bispecific antibodies have offered a new treatment approach in relapsed/refractory multiple myeloma, with promising results in preclinical studies for multiple cancers and hematological malignancies.
Published: 9/13/2023
Developing and Implementing Immunization Standing Orders and Protocols
Vaccine administration provides benefits at the patient and public health levels, and pharmacists are critical members of health care teams that provide these vital biologic medications.
Published: 9/13/2023
Study: Monitor Real-Time User Data to Optimize Digital HIV PrEP Programs
Telemedicine approaches for HIV can help reduce stigma that is often a challenge in face-to-face clinical settings and eliminate common logistical barriers, such as transportation.
Published: 9/13/2023
Neuraminidase Inhibitor, Polymerase Inhibitor Use for Influenza Treatment Continues, Other Methods Considered
While monitoring influenza virus resistance as it develops, researchers are prioritizing further investigations to decrease the risk of resistant strains.
Published: 9/13/2023
Vax-Innovation: Incorporating the Newly Approved RSV and Pneumococcal Vaccines Into Community Pharmacy Workflow
Best practices to train staff and team members to engage patients and to ease the new vaccine offerings into the workflow are also discussed.
Published: 9/12/2023
Despite a Lack of US Guidelines, Implementing β-Lactam Therapeutic Drug Monitoring Remains Key
This step-by-step primer describes the implementation process for β-lactam TDM.
Published: 9/12/2023
Study Shows Not All IVIG Products Are Created Equal in Alzheimer Disease
One IVIG product showed overall improvement in neuroprotection, including alleviating cognitive decline and ameliorating AB deposition in Alzheimer disease.
Published: 9/12/2023
Resistance Mechanisms, Host Interactions Remain Elusive for Clostridioides difficile Research
Investigators said that understanding virulence factors, resistance mechanisms, and host interactions can help establish the development of novel therapeutics for Clostridioides difficile.
Published: 9/12/2023
Neuraminidase Inhibitors, Endonuclease Inhibitors Significant for Influenza Pandemics, Foundational for Further Antiviral Support
Having 2 drug classes available for influenza is significant, but it is important to investigate other treatments prior to the pandemic, a new study indicates.
Published: 9/12/2023
Amgen to Initiate Phase 3 Study of Sotorasib for NSCLC, Based on Results From CodeBreaK 101 Trial
Sotorasib (Lumakras) plus carboplatin and pemetrexed shows promise in the first line treatment of advanced non–small cell lung cancer.
Published: 9/12/2023
Preventing Respiratory Syncytial Virus at a Young Age May Reduce Risk of Developing Asthma
Pediatric and maternal respiratory syncytial virus (RSV) vaccines are being studied to reduce the burden of RSV, and more research is needed to understand whether this can reduce wheeze and asthma.
Published: 9/12/2023
Phase 3 Trial Shows Combined Nivolumab, Ipilimumab Treatment Improved OS in Patients With mNSCLC
Compared to chemotherapy alone, the combined nivolumab and ipilimumab treatment more than tripled the overall survival rate at 6 years in patients with PD-L1 expression <1%.
Published: 9/12/2023
Researchers Connect High Particulate Matter Levels to Development of Breast Cancer
Researchers found an increased risk of breast cancer in women who had higher particulate matter levels near their home.
Published: 9/12/2023
California Bill to Decriminalize Natural Psychedelics Passes State Legislature on the Heels of Phase 2 Data Showing Safety, Efficacy of Psilocybin for MDD
California is possibly on the verge of signing a bill that would decriminalize the personal possession of natural psychedelics for those aged 21 years and older.
Published: 9/11/2023
FDA Authorizes Updated COVID-19 Vaccine Formulations for Current Variants
FDA grants updated Moderna and Pfizer-BioNTech COVID-19 vaccines with emergency use authorization to target currently circulating variants of the virus.
Published: 9/11/2023
Osimertinib, Chemotherapy Show Survival Benefit for Patients With Advanced, Mutated Lung Cancer
The study met its primary endpoint of progression-free survival, and overall survival is continuing to be evaluated.
Published: 9/11/2023
Clinical Overview: Ongoing Review of GLP-1 Receptor Agonists for Suicidal Ideations
Although GLP-1 receptor agonists have shown promise in promoting weight loss, they are prescription medications and should be used under the guidance of health care professionals.
Published: 9/11/2023
FDA Approves IND for CT7439, a Novel CDK12/13 Inhibitor to Treat Multiple Types of Advanced Solid Tumors
The CDK12/13 inhibitor will be tested for efficacy and safety in patients with advanced solid tumors, such as breast, ovarian, and Ewing Sarcoma.
Published: 9/11/2023
Study Examines Links Between Sleep, Testosterone, and Cortisol in Aging Men
Hypercortisolemia during the late afternoon and early evening is harmful and believed to cause insulin resistance observed with advanced age.
Published: 9/11/2023
Intravenous Immunoglobulin Can Induce Biological Response Due to Anti-Inflammatory Mechanisms
Research into the mechanisms of intravenous immunoglobulin is often challenging due to the complexity of polyclonal preparations, including diversity, repertoires, blocking, or anti-idiotypic antibodies.
Published: 9/11/2023
Inhibiting PI3K/mTOR, SIRT2 Pathways May Be Effective in Treating Aggressive AML
A low dose of the combination treatment inhibited AML cell cycle and increased apoptosis.
Published: 9/11/2023
Insulin Sensitizers May Be Making a Comeback
Researchers have identified new uses for insulin sensitizers, including in the treatment of polycystic ovary syndrome and infertility.
Published: 9/8/2023
Increased Vitamin D Intake Can Decrease Symptoms of Depression, Anxiety
Although findings indicate a relationship between vitamin D and mood disorders, further research is needed to clarify efficacy of specific vitamin D levels, as well as supplement dose and form.
Published: 9/8/2023
Phase 2 Study Shows Promising Results to Lower SBP, Treat Hypertension with Zilebesiran
The Phase 2 KARDIA-1 Study met its primary endpoint of lower systolic blood pressure with the use of zilebesiran.
Published: 9/8/2023
Study: Financial Incentives Increases PrEP Initiation, Adherence for HIV
Applying novel and effective behavioral economics for pre-exposure prophylaxis dissemination programs could help to tailor the programs to the populations and settings of high HIV burden areas.
Published: 9/8/2023
Phase 3 Study of Macitentan 75mg to Treat CTEPH Will Stop Research
A phase 3 study assessing macitentan 75mg treatment for CTEPH was stopped, although another study using macitentan will continue.
Published: 9/8/2023
Point-of-Care Test Reagents Could Aid Risk Assessment for In-Home Care of Older Adults
In addition to improving risk evaluation in older adults at home, point-of-care testing may help clinicians manage patients with dementia who cannot communicate and those living in depopulated areas.
Published: 9/8/2023
Research Identifies Defined Subtypes of Follicular Lymphoma, Marginal Zone Lymphoma
Correctly diagnosing specific follicular lymphomas and marginal zone lymphomas requires knowledge of the clinical context, including the site of involvement, age, and clinical presentation.
Published: 9/8/2023
Next-Generation Therapy Analyzes Intestinal Phages, Propelling Future of C. difficile Treatment
Using metagenomic information, the technology isolates phages whose enzymes can specifically target the bacteria that causes C. difficile infection.
Published: 9/8/2023
Study: IVIG Worth Considering for Severe, Critical COVID-19 Infection
Multiple studies show that it might be more effective to administer intravenous immunoglobulins at an earlier stage of disease progression.
Published: 9/8/2023
Current Everolimus, Niraparib Combination Is Too Toxic for a Phase 2 Clinical Trial
Investigators must find a different combination or treatment regimen using a dual blockade of the PARP and PI3K/AKT/mTOR pathway.
Published: 9/7/2023
Maximizing REMS Potential to Reduce Risk of Errors, Patient Harm
Incorporate Program Requirements Into Systems and Workflows.
Published: 9/7/2023
Moderna’s mRNA Vaccine Shows Promise Against the Pirola Variant of COVID-19
With the emergence of BA.2.86, and the growing prevalence of EG.5 and FL1.5.1, there is a need for updated vaccines against COVID-19 to help decrease severe disease and hospitalizations.
Published: 9/7/2023
Phase 3 Study Demonstrates Amivantamab-vmjw is Safe, Effective in Improving PFS in Patients With NSCLC
Patients who received amivantamab plus chemotherapy or amivantamab without chemotherapy presented better outcomes compared to chemotherapy alone.
Published: 9/7/2023
Obesity-Related Cardiovascular Disease Deaths Tripled in US From 1999 to 2020
Black women had the highest rates of obesity-related cardiovascular disease deaths whereas other racial groups had more men experiencing obesity-related CVD deaths than women.
Published: 9/7/2023
Who is Using FAIR Data in Life Sciences R&D Today?
The importance of findability, accessibility, interoperability, and reusability has become even more significant to academics as government agencies increasingly require data openness and accessibility for funding eligibility.
Published: 9/7/2023
Current HIV-1 Vaccine Designs Aim to Improve Breadth of Broadly Neutralizing Antibodies
Combining T and B cell vaccines could induce a strong enough immune response and protect against HIV-1 infection, although the science is not fully developed.
Published: 9/7/2023
FDA Accepts Biologics License Application for Crovalimab for Paroxysmal Nocturnal Hemoglobinuria
Crovalimab achieved disease control and non-inferiority compared to eculizumab, which is the current standard-of-care for individuals with paroxysmal nocturnal hemoglobinuria.
Published: 9/7/2023
Study: African Ancestry Associated With Aggressive Breast Cancer Subtypes
African ancestry was associated with higher odds of estrogen receptor-negative and triple-negative breast cancer; however, social environments were strongly associated with the survival of Black individuals with breast cancer.
Published: 9/6/2023
Clinical Overview: Opill as First OTC Contraception in United States
Norgestrel (Opill) for pregnancy prevention will be accessible at various retail locations, including drug stores, convenience stores, grocery stores, and online platforms.
Published: 9/6/2023
Results of a 10-year Follow-Up of Gardasil Vaccine Show Peak Antibodies At Month 7
Cases of certain HPV-related high-grade disease were not found in the 10-year follow up for girls and boys who received 3 doses of the Gardasil 9 injection.
Published: 9/6/2023
Research Seeks to Aid Management of Type 2 Diabetes Through Dietary Education
An upcoming large-scale clinical trial of the Glucose Everyday Matters program will evaluate its safety and efficacy in managing type 2 diabetes.
Published: 9/6/2023
Researchers to Evaluate Connection Between Respiratory Syncytial Virus and Asthma in Infants
The upcoming study seeks to analyze whether immature lungs in infants infected with respiratory syncytial virus increases the likelihood of developing asthma later in life.
Published: 9/6/2023
Phase 3 Trial Results Show Tisotumab-Vedotin Improved OS in Adult Patients With Recurrent or Metastatic Cervical Cancer
In addition to overall survival, main efficacy outcomes, such as progression-free survival, objective response rate, and time to response, were compared to chemotherapy alone.
Published: 9/6/2023
Study: Blood Cancer Treatment Found to Kill Latent HIV-Infected Cells, Possible New Treatment
Although antiretroviral therapies are the standard of care treatment for those with HIV, the drugs cannot target latent infections; however, venetoclax, a blood cancer treatment, shows promise.
Published: 9/6/2023
FDA Issues Tentative Approval to Abacavir/Dolutegravir/Lamivudine Combo to Treat HIV in Pediatric Patients
The fixed-dose abacavir/dolutegravir/lamivudine combination is indicated for the once-daily treatment of children weighing at least 6 kg to <25 kg with HIV-1 infection.
Published: 9/6/2023
Phase 3 Trial Results Show Adjuvant Alectinib May Reduce Recurrence in Early-Stage ALK-Positive NSCLC
If approved, alectinib would be the only anaplastic lymphoma kinase inhibitor to show reductions in risk of recurrence or death for those with early-stage lung cancer.
Published: 9/5/2023
Study Finds Inadequate Emotional Support, Lower Health-Related Quality of Life, Increased Odds of Depression in Adults With Gastrointestinal Cancers
Additional research is needed to further evaluate whether adequate emotional support is linked to improvements in health-related quality of life in adults diagnosed with other cancer.
Published: 9/5/2023
SARS-CoV-2 Fusion Peptide Could Further Elucidate Process of COVID-19 Infection
Understanding the virus protein’s insertion mechanisms can be useful in creating new COVID-19 vaccine targets.
Published: 9/5/2023
Researchers Compare Treatment Options to Minimize Risk of Gestational Diabetes
The risk of developing gestational diabetes was similar between both group prenatal care and traditional individual prenatal care, however, group care may benefit some patients as a treatment option.
Published: 9/5/2023
Early Evidence Shows Mezigdomide With Dexamethasone Effective for Treatment-Resistant Multiple Myeloma
Mezigdomide boosted T cell activity and worked in patients with multiple myeloma who were resistant to prior therapeutic agents.
Published: 9/5/2023
New Technology for Mapping the Tumor Ecosystem Can Improve Cancer Research
Spatially resolved technology based on next-generation sequencing has the potential to benefit clinical practice and improve the prognosis for cancer patients.
Published: 9/1/2023
Study: COVID-19 Pandemic Associated With Worse Treatment, Outcomes in Patients With Acute Myocardial Infarction
Although the pandemic has negatively influenced the care that patients with cardiovascular conditions receive, the study authors found that there were not significant inequities regarding patients’ race.
Published: 9/1/2023
Clinical Overview: Arexvy for Respiratory Syncytial Virus
Pharmacists play a critical role in educating patients on RSV prevention, how to recognize early symptoms, and when to seek medical help.
Published: 9/1/2023
SGLT2 Inhibitors Not Associated With Improved Survival in Patients Hospitalized With COVID-19
In a previous trial, DARE-19, investigators reported that the SGLT2 inhibitor dapagliflozin did not benefit patients with COVID-19 who had cardiometabolic risk factors.
Published: 9/1/2023
Presymptomatic Atherosclerosis May Contribute to the Development of Alzheimer Disease Later in Life
Heart health may influence long-term brain health as early as middle age.
Published: 9/1/2023
Study: More Than 1 in 6 Toddlers Do Not Complete Childhood Vaccine Series
Pharmacists can play a crucial role in educating parents and helping remind them about the childhood vaccine schedule, which can be quite complex.
Published: 9/1/2023
Study: Statin Use Lowers Risk of a Second Stroke, Including Ischemic Stroke
Study finds that statin use is associated with a 12% reduction in the risk of another stroke.
Published: 9/1/2023
Long-Term Follow-Up Data Show Consistent, Durable Response to Mavacamten in Patients With Obstructive Hypertrophic Cardiomyopathy
Results from the VALOR-HCM LTE trial at 56 weeks demonstrated that with longer follow-up, mavacamten continued to reduce patient eligibility for invasive septal reduction therapy.
Published: 9/1/2023
COVID-19 Vaccination Reduces Serious Disease, But Lymphoma Patients Continue to Be Vulnerable
Patients with lymphoma can be immunocompromised due to their disease, anti-cancer therapy, and concomitant immunosuppressive treatments, which make them more vulnerable to developing a COVID-19 infection.
Published: 8/31/2023
Insufficient Data on Cannabis Products’ Reduction of Symptoms in Pediatric Cancer, Further Research Necessary
Despite the limited data, prior research indicates there are no serious cannabis-related adverse effects in pediatric patients.
Published: 8/31/2023
Semaglutide Found Effective for Weight Loss in Patients With Heart Failure, Obesity
After 1 year of treatment, semaglutide significantly improved physical function, which can improve quality of life outcomes and risk of death.
Published: 8/31/2023
Researchers Confirm Positive Outcomes With SSRI Treatment for Postnatal Depression
SSRI treatment for postnatal depression brought long-term benefits for mothers and their offspring in the following years after childbirth, study findings showed.
Published: 8/31/2023
Statin Therapy Can Reduce Risk of a Major Adverse Cardiovascular Event in Patients With HIV
A combination of statin therapy and antiretroviral therapy may decrease the naturally higher risk of cardiovascular disease in patients with HIV.
Published: 8/31/2023
Study: More Sleep Could Lessen Impulsive Behavior in Children
When children got less than the recommended 9 hours of sleep or took more than 30 minutes to fall asleep, there was a strong link to impulsive behaviors later in life.
Published: 8/31/2023
Revolutionizing Drug Development Through Artificial Intelligence, Machine Learning
The seamless integration of artificial intelligence and machine learning has the potential to accelerate research and enhance efficiency in a new era of personalized medicine.
Published: 8/31/2023
Ferric Carboxymaltose Therapy Does Not Significantly Improve Heart Failure Mortality
Ferric carboxymaltose was not found to have a significant impact on 6-minute walk distance, which is part of the primary outcome’s hierarchical composite of death and hospitalizations from heart failure.
Published: 8/31/2023
Researchers Find Increased Risk of Atrial Fibrillation After Menopause
Stressful life events and poor sleeping patterns are linked to the development of atrial fibrillation in older women.
Published: 8/30/2023
FDA Approves 0.9% Sodium Chloride Injection in 10, 20 mL Single-Dose Vials
Sodium chloride injection contains sodium chloride in water and is administered intravenously, which is intended for a single-dose injection to replenish fluids and electrolytes.
Published: 8/30/2023
CMS Announces First 10 Drugs To Undergo Price Negotiations Under Inflation Reduction Act
Any new prices established after negotiations will be effective on January 1, 2026.
Published: 8/30/2023
Upcoming Phase 3 Clinical Program Will Examine Efficacy of Oral PCSK9 Inhibitor MK-0616 in Patients With Hypercholesterolemia
The phase 3 clinical program, CORALreef, consists of 3 trials and is likely the first of its kind for an oral PCSK9 inhibitor, according to the study authors.
Published: 8/30/2023
Opioid Settlement May Spur Cannabis as Potential New Pharmacy Revenue Stream
The opioid settlement framework could have a significant impact on the future of cannabis distribution and its role in health care.
Published: 8/30/2023
RBX2660 Demonstrates Safe, Effective Results Treating Recurrent Clostridioides difficile Infection
Investigators will continue to research RBX2660 in patients who are immunocompromised or who have chronic conditions with Clostridioides difficile infection.
Published: 8/30/2023
COVID-19 Infection May Cause Hypertension in Adults With No Pre-Existing Conditions
Despite study findings showing that 1 in 5 patients hospitalized for COVID-19 developed persistent high blood pressure, many had underlying risk factors.
Published: 8/30/2023
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Published: 8/29/2023
Patients With Cancer Engaging in Administrative Payment Tasks May Choose to Delay or Not Adhere to Treatment
Patients with cancer and survivors of cancer that had engaged in administrative tasks to effectively estimate costs or pay for care was associated with an 18% increase in cost-related treatment delays or treatment nonadherence.
Published: 8/29/2023
CDC Recommends Beyfortus for Routine Use to Protect Infants, Young Children Against Respiratory Syncytial Virus
Nirsevimab (Beyfortus) is the first respiratory syncytial virus (RSV) preventative drug to be approved by the FDA, and can protect infants through their first RSV season for up to 5 months.
Published: 8/29/2023
Supplemental Biologics License Application Submitted to Expand Approval of Rybrevant for NSCLC
The supplemental biologics license application for amivantamab-vmjw (Rybrevant) is supported by data from the phase 3 PAPILLON trial, evaluating the efficacy and safety of the drug in combination with chemotherapy for those with non–small cell lung cancer.
Published: 8/29/2023
Janssen Seeks FDA Approval for Kinase Inhibitor to Treat Metastatic, Genetically-Altered Bladder Cancer
The kinase inhibitor is already approved for patients who experienced recurrence following 1 or more lines of standard of care platinum-containing chemotherapy.
Published: 8/29/2023
Study: New Vaccine Modality Using Biopolymer Particles Shows Promise in Group A Streptococcus
Investigators from Griffith University stated that technology has helped the development of vaccines that are safe to use and induce strong immune responses against Strep A.
Published: 8/29/2023
FDA Approves Luspatercept-aamt for First-Line Treatment of Anemia in Adults With Lower-Risk Myelodysplastic Syndromes
Luspatercept-aamt (Reblozyl) approved to treat adults with very low- to intermediate-risk myelodysplastic syndrome who may require regular red blood cell transfusions.
Published: 8/29/2023
Study: Women With Chronic Fatigue Tend to Have More Symptoms, Co-Occurring Conditions Than Men
Women with myalgic encephalomyelitis/chronic fatigue syndrome for more than 10 years are more likely to have increased severity in their symptoms as they age.
Published: 8/29/2023
Novel Spray Technique Has Potential to Deposit Bioactive Materials With 100% Efficiency
This technique may be applied to transdermal applications, such as shot-free vaccines.
Published: 8/28/2023
FDA Announces Delayed Enforcement of DSCSA to 2024
The start date of the package-level electronic tracking system will shift from November 27, 2023 to November 27, 2024.
Published: 8/28/2023
Transforming Medication Safety into a Value-Driver
Advanced technology can automate many pharmacovigilance tasks to build workflow efficiencies, reduce manual intervention, and free up team members for more strategic activities.
Published: 8/28/2023
The Growth of Biosimilars Continues to Create Hope for Lower Drug Costs
Perhaps the most significant development in the pharmaceutical industry in decades, crops of biosimilars are being approved and are ready for distribution. What lies next, in terms of legislation and the impact on pharmacists, remains to be seen.
Published: 8/28/2023
Living Alone With Cognitive Impairment Can Be as Impactful to Health as Poverty
This social determinant of health could have the same level of negative impact on health as the experience of racism, poverty, or low education.
Published: 8/28/2023
Study: One-Third of ChatGPT’s Cancer Treatment Recommendations Did Not Align With National Comprehensive Cancer Network
Investigators found that artificial intelligence chatbots did not consistently provide recommendations for cancer treatment that correspond with NCCN guidelines.
Published: 8/28/2023
Researchers Announce Positive Results from Phase 2 At-Home Ketamine Trial
KET01 could successfully treat treatment-resistant depression while limiting adverse effects in the home environment, according to the study.
Published: 8/28/2023
Study: Non-O Blood Type Transfusions, Higher Intravenous Immunoglobulin Lead to Increased Risk of Hemolytic Reactions
Although the patient demographics are similar for the 3 categories of hemolytic reactions with intravenous immunoglobulin, the reaction with delayed hemolytic transfusion reactions was highest compared to the other 2 hemolytic reactions.
Published: 8/28/2023
Study Data Shows Potential of Gene Signatures to Predict Treatment Response in Patients With Recurrent Prostate Cancer
The research was aided by the Decipher Genomics Resource for Intelligent Discovery, which helped derive the gene signatures used during the analysis.
Published: 8/25/2023
FDA Approves First Biosimilar of Natalizumab for the Treatment of Relapsing Multiple Sclerosis
The FDA is the first regulatory agency globally to approve natalizumab-sztn as a biosimilar for natalizumab.
Published: 8/25/2023
FDA Clears Investigational New Drug Application to Treat Amyotrophic Lateral Sclerosis
The drug can now be tested for safety, tolerability, and efficacy in a phase 1 study.
Published: 8/25/2023
Expert: Pharmacists Should Be Using a Holistic Approach for Women’s Health
There is lots of information about matters of women's health online, both true and untrue, but pharmacists remain a credible source for educating women about health matters.
Published: 8/25/2023
Study: New Digital Tobacco Cessation Program Leads to 44% Quit Rate of Smoking Compared to Control Program
The digital cessation platform is the first FDA-cleared OTC device to help individuals quit smoking tobacco.
Published: 8/25/2023
Scientists Identify New Cause for Inherited Neurodegenerative Diseases
The recent discovery could aid further research on the cause of Huntington’s disease and other inherited conditions.
Published: 8/25/2023
Study: Some Health Care Professionals Found to Spread COVID-19 Misinformation Via Social Media
Investigators determined that there needs to be an evaluation of harm caused by pharmacy professionals who are in unique positions on social media, propagating misinformation about COVID-19, vaccines, treatment, masks, and other conspiracy theories.
Published: 8/25/2023
Interpersonal, Community Factors Influence PrEP Engagement
Participants indicated that they would be more likely to accept PrEP-related information if it was recommended by a trusted person.
Published: 8/25/2023
FDA Approves Remdesivir to Treat COVID-19 in Patients with Hepatic Impairment
The drug is the first approved antiviral COVID-19 treatment that could be used across all stages of liver disease.
Published: 8/24/2023
Vaccine Candidate Shows Promise for Slowing Cognitive Decline in Mild Alzheimer Disease
UB-311 has shown to be well-tolerated with a durable antibody response in a previous phase 1 trial, and new results from a phase 2a study support its continued development.
Published: 8/24/2023
Researchers Advance Survodutide Use for Obesity into Phase III Study
The phase 3 study will advance the safety findings of survodutide reported in the phase 2 study to aid overweight and obesity.
Published: 8/24/2023
Patients Want a More Direct Relationship With Their Health Data
Consumerization of health care solutions is connected to a growing desire of patients to have accessible health care/health data and an individualized care experience.
Published: 8/24/2023
Study: Belzutifan Demonstrates Improvement in Progression-Free Survival for Advanced Renal Cell Carcinoma
Belzutifan also demonstrated statistically significant improvements in objective response rate compared to everolimus for advanced renal cell carcinoma.
Published: 8/24/2023
Study: Multilevel Data Model Helps Estimate Likelihood of Delays in Cancer Treatment
In the study, investigators incorporated data from electronic health records and social determinants of health into the model to determine the likelihood in delays when starting cancer therapy.
Published: 8/24/2023
Study: Pain After Heart Attack Linked With Long-Term Survival
Notably, 65% of the participants experiencing pain at the 2-month follow up were also experiencing pain at their 12-month follow up, suggesting persistent and long-term pain.
Published: 8/24/2023
FDA Grants CAR T-Cell Therapy NXC-201 Orphan Drug Designation for Fatal Multiple Myeloma
During the phase 1b/2 trials, CAR T-cell therapy demonstrated significant and clinical survival benefits.
Published: 8/23/2023
Novel Mechanism of Action of FloraStilbene Suggests Potential for Enhancing Efficacy of Checkpoint Inhibitor, CAR-T Therapies
Protection of T cells from tumor-induced suppression suggests potential for enhancing efficacy of therapies, with plans to initiate a phase 1/2 clinical trial in patients with advanced breast cancer.
Published: 8/23/2023
FDA Accepts New Drug Application for Imetelstat for Treatment of Lower Risk Myelodysplastic Syndromes
The drug showed statistically significant and clinically meaningful efficacy results across key subgroups.
Published: 8/23/2023
Patients, Pharmacists Do Not Need to See Generative AI to Understand It’s Potential in Pharmacy
Generative artificial intelligence is a type of self-learning software that can increase the time pharmacists can allocate to patients, improve medication adherence, and allow patients to access health data on a whim.
Published: 8/23/2023
Study: Anti-Obesity Medication Normalizes Sensory Learning for Those With Obesity
Investigators aimed to determine whether liraglutide, an anti-obesity medication, could impact the learning process for individuals who had reduced insulin sensitivity due to obesity.
Published: 8/23/2023
Study Suggests Lorazepam May Increase Odds of Pancreatic Cancer Progression, Death
Patients with pancreatic cancer who took benzodiazepine lorazepam had a shorter progression-free survival than those who took benzodiazepine alprazolam.
Published: 8/23/2023
Case Studies Show IVIG May Improve Neurological Symptoms in Pediatric Multisystem Inflammatory Syndrome
Relapses of MIS-C occurred in 2 patients due to rapid tapering of corticosteroids at 2 weeks instead of the standard protocol of 4 to 6 weeks.
Published: 8/23/2023
As Scientific Evidence Base for Safety, Efficacy of Ayahuasca Use Grows, a DEA Report Asserts a Position Countering the Data
Following an increase in government seizures of ayahuasca, an Indigenous religious organization requested government records that led to these seizures. The DEA responded by sending a single report condemning use of the drug.
Published: 8/22/2023
FDA Approves Vaccine for Pregnant Individuals to Prevent Respiratory Syncytial Virus in Infants
It is the first vaccine of its kind to be FDA approved, and it met multiple safety and efficacy standards through clinical trials.
Published: 8/22/2023
Certain Brain Cells May Help Humans Stay Awake Longer Without Impacting Cognition, Health
Sleep loss is known to impact key processes such as attention, cognition, learning, memory, metabolism, and immune function.
Published: 8/22/2023
Esketamine May Boost Efficacy of Oral Antidepressants in Patients with Fluctuating Response
Researchers sought to find a remedy for the development of treatment-resistant depression in patients whose antidepressant treatment has fluctuated in efficacy.
Published: 8/22/2023
FDA Approves Treatment for CD55-Deficient Protein-Losing Enteropathy
The treatment is the first of its kind to be FDA-approved to treat CHAPLE disease.
Published: 8/21/2023
As The World Enters a "Golden Age" of Medicine, Pharmacy Will Be Hugely Impacted, Suggests NACDS President
“I've never met a pharmacist who didn't want to improve the health of the American people. That's what they're doing and will be doing well in the future,” Steven C. Anderson tells Pharmacy Times at NACDS TSE, August 12 through 14, 2023, San Diego, California.
Published: 8/21/2023
Retatrutide Treatment Results in Reductions in Body Weight Compared to Placebo
Most participants who received retatrutide lost a considerable amount of body weight; however, individual results varied given the diversity of obesity.
Published: 8/21/2023
Pharmacy Focus: Oncology Edition - PARP Inhibitors Are Changing the Game in Prostate Cancer
This month, we spoke with Cassia Griswold, PharmD, a clinical oncology pharmacist at Mayo Clinic Arizona.
Published: 8/21/2023
New Model Can Effectively Predict Intravenous Immunoglobulin Resistance in Patients With Kawasaki Disease
The model was the first to incorporate C-reactive protein/albumin ratio and apply LASSO regression analysis to a predictive model for children with Kawasaki disease.
Published: 8/21/2023
Child Tax Credit Payments Corresponded With Increase in Odds of Low Birth Weight
The results differ from previous studies and the predictions of the researchers that the Child Tax Credit would reduce the prevalence of low birth weight among pregnant women across the country.
Published: 8/21/2023
How Pharmacists Can Help Protect Patients’ Skin From Sunburn, Skin Cancer
Pharmacists can offer valuable information about sunburn, sunscreen, and skin cancer screening and provide OTC recommendations on sunburn treatment and prevention.
Published: 8/18/2023
Precision Medicine Has Broadened the Application of Gene Therapy Testing, Further Specialization May Be Needed to Interpret Results
Opportunities for an additional specialization in molecular pathology may be helpful to train professionals in the real-time interpretation of gene therapy test results.
Published: 8/18/2023
Data Show Durable Efficacy With Repotrectinib for Locally Advanced or Metastatic ROS1-Positive NSCLC
Based on results from a trial of repotrectinib in patients with ROS1-positive locally advanced or metastatic non-small cell lung cancer, the FDA accepted the New Drug Application and set a Prescription Drug User Fee Act goal date of November 27, 2023.
Published: 8/18/2023
New Method Enables Assessment of Immunological Reaction to mRNA SARS-CoV-2 Vaccine
The approach allows investigators to assess post-vaccine response in immunocompromised patients who have received antibody prophylaxis.
Published: 8/18/2023
Case Study: Positive HIV-1 Status Should Not Preclude Heart Transplant
Previous studies have shown promising results with liver or kidney transplants in patients with HIV, but there was a lack of literature regarding heart transplants specifically.
Published: 8/18/2023
Use of First-Line Treatment for Insomnia Low Among Adults With Mental Health Conditions
Although the rate of people with probable insomnia who discussed their sleep habits with a physician was relatively high, the number of people who went on to seek actual treatment was low.
Published: 8/18/2023
Conversations That Cross the Invisible Divide Between Oncology Practice, Industry May Help to Solve Challenges Facing Both
Annual NCODA Oncology Institute brings together leaders in industry to speak with leaders in clinical practice to discuss some of the commonalities and areas of opportunity to address challenges facing oncology professionals.
Published: 8/17/2023
After Adjusting for Social Determinants of Health, Cardiovascular Disease Mortality Differences Disappear Between Black, White Populations
Adjustments for social determinants of health in the US population had a significant impact on cardiovascular disease mortality data between Black and White populations.
Published: 8/17/2023
Study: Healthy, Born-at-Term Infants With Respiratory Syncytial Virus Lower Respiratory Tract Infections Need Intensive Care
The findings of the study demonstrate the need for preventive interventions for all infants in order to reduce the burden of severe illness from respiratory syncytial virus lower respiratory tract infections.
Published: 8/17/2023
Receiving SARS-CoV-2 Booster During Pregnancy May Improve Newborn’s Immune Responses to Virus
A COVID-19 booster dose increased both maternal and cord blood binding and neutralizing antibody levels against virus strains, including Omicron BA.1.
Published: 8/17/2023
Biosimilar Aflibercept Shows Positive Efficacy and Safety Results in Confirmatory Study
The Mylight phase 3 trial confirmed that there was no clinically meaningful differences between aflibercept and its reference biologic, Eylea, for patients with wet macular degeneration.
Published: 8/17/2023
Tucatinib Plus Ado-Trastuzumab Meets Progression-Free Survival Endpoint in Patients With HER2-Positive Breast Cancer
The combination regimen showed positive progression-free survival results among patients with HER2-positive breast cancer in the phase 3 HER2CLIMB-02 trial, but overall survival data have yet to mature.
Published: 8/17/2023
New Telepharmacy Openings Associated With Reduction of Pharmacy Deserts
Researchers recommended less restrictive policy regarding telepharmacies to improve access to medications and pharmacists, while ultimately improving outcomes and adherence to treatment regimens.
Published: 8/17/2023
FDA Approves Hepzato Kit for Liver-Directed Treatment of Metastatic Uveal Melanoma
Melphalan/hepatic delivery system (Hepzato Kit; Delcath Systems Inc) is currently the only liver-directed therapy approved by the FDA for the treatment of netastatic uveal melanoma and percutaneous hepatic perfusion.
Published: 8/16/2023
HIV Experts Discuss Conditions, Functionalities for Patient Use of COMTRAC-HIV App
Topics discussed include care workflow, app functionalities, problems and disadvantages, and benefits for HIV experts.
Published: 8/16/2023
Study Indicates Take-at-Home, Oral Ketamine is an Effective Option for Treatment-Resistant Depression
The daily oral formulation of ketamine, KET01, has the potential to greatly improve the standard treatment practices for treatment-resistant depression, according to investigators.
Published: 8/16/2023
NACDS Leadership Explains Their Role in Healthcare
Session at NACDS Total Store Expo leadership discusses NACDS initiatives and world events.
Published: 8/16/2023
Alcohol Consumption, Risky Drinking Habits Common Among Cancer Survivors, Those Receiving Treatment
Unexpectedly, a study found that more than 70% of cancer survivors were current drinkers, indicating the need for intervention and strategies to reduce harmful drinking habits.
Published: 8/16/2023
Case Study: Intravenous Immunoglobulin Can Treat Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis in Pediatric Population
Intravenous immunoglobulin was found to be the most effective immunotherapy in preventing relapses after treatment with steroids in pediatric patients.
Published: 8/16/2023
Potential Associations Found Between Microbiome, Early Cognitive Development in Infants
Key study finding shows associations between the beat frequency in the rhythmic stimulus in the frontal left sites of infant brains and pathways related to brain modulation and nucleotide levels.
Published: 8/16/2023
Early Intervention With Nutrient Supplementation May Be Beneficial to Patients with Alzheimer Disease
Through previous literature, investigators found that intervention with nutritional supplements may help to improve cognitive performance and reduce the severity of memory impairment in adults with Alzheimer disease.
Published: 8/15/2023
Biologic, Biosimilar Spending Expected to Grow in the Next Decade
The launch of adalimumab biosimilars are expected to affect spending in the immunology space.
Published: 8/15/2023
Common Cold Virus Associated With Rare Blood Clotting Disorder
Prior to this study, anti-platelet factor 4 disorder was thought to be caused by exposure to heparin or autoimmune conditions.
Published: 8/15/2023
AI’s Shot in the Arm of Science and the Concerns We Need to Address
Stakeholders need to convene honest, actionable discussions about the challenges and the safeguards needed to address appropriate use of artificial intelligence in health care.
Published: 8/15/2023
Perioperative Gabapentinoids May Alleviate Pain, Reduce Opioid Use in Patients Undergoing Spine Surgery
A dose of 900 mg per day of gabapentin prior to spine surgery was associated with the lowest pain score among all studied dosages.
Published: 8/15/2023
Individuals With Sustained or Increasing Opioid Use Were Older, Had More Comorbidities, Higher Use of Other Drugs
Study investigators suggest that there is a higher prevalence of pain and treatment needs in this small population.
Published: 8/15/2023
Pharmacy Can Help Drive Adoption of Rheumatoid Arthritis Biosimilars
Pharmacists will have the opportunity to use their knowledge of biosimilars to reinforce their benefits, safety, and efficacy.
Published: 8/15/2023
Case Study: Respiratory Syncytial Virus May Cause Complications in Pregnant Patients
Although not a traditional at-risk group for severe respiratory syncytial virus complications, pregnant patients should be aware of the possibility of infection and be educated on proper prevention procedures.
Published: 8/15/2023
Experts Create Guidelines for Management of Acetaminophen Poisoning
A panel released recommendations in accordance with decades of a changing landscape in acetaminophen poisoning and due to an absence of agreed upon guidelines in the space.
Published: 8/15/2023
Expert Panel Discusses Community Solutions to Advance Food is Medicine Programs
Session at NACDS Total Store Expo discusses how pharmacies can leverage their accessibility to decrease diet-related diseases through health and wellness.
Published: 8/14/2023
FDA Grants Accelerated Approval to Elranatamab-bcmm for Relapsed or Refractory Multiple Myeloma
Elranatamab-bcmm (Elrexfio; Pfizer) is a BCMA-CD3-targeted bispecific antibody approved for adults with relapsed or refractory multiple myeloma who were previously administered at least 4 lines of therapy that included a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.
Published: 8/14/2023
Weight Loss, Alzheimer Drugs Are Top of Mind for the 2023/24 Market
Expert weighs in on the growth of specialty drug spending, particularly with drugs in immunology, neurology, and weight loss.
Published: 8/14/2023
Simulation Demonstrates Potential Effectiveness of Model-Informed Precision Dosing for Heparin
The growing awareness in health care of the challenges associated with proper dosing of anticoagulants such as heparin has inspired the emerging field of anticoagulation stewardship.
Published: 8/14/2023
No Association Found Between COVID-19 Pandemic and Incidence of Health Care-Associated C. Difficile Infections
Prior studies had produced conflicting results on whether the pandemic positively or negatively impacted health care-associated C. difficile infections, yet the results of this current study indicate the pandemic played a limited role.
Published: 8/14/2023
Study Finds Sugar-Sweetened, Artificially Sweetened Beverages Associated With Risk of Liver Cancer, Chronic Liver Disease Mortality
Study authors note that additional research is necessary to confirm findings and identify biological pathways of associations between sweetened beverages and diseases of the liver.
Published: 8/14/2023
Study Finds Myasthenia Gravis Not Caused by Vitamin D Deficiency, Counter to Prior Research
Previous studies were not able to establish whether the risk of developing myasthenia gravis was caused by or led to vitamin D deficiency.
Published: 8/14/2023
Study Shows Drop in Premature Deaths Due to Particulate Matter Pollution, Rise in Years of Cardiovascular Disability
Research shows a substantial difference between overall deaths of men and women at 43% and 28.2%, respectively, from cardiovascular disease associated with particulate matter.
Published: 8/14/2023
FDA Approves New Combination Therapy for BRCA-Positive Metastatic Castration-Resistant Prostate Cancer
Niraparib and abiraterone acetate (Akeega; Janssen Pharmaceutical Companies of Johnson & Johnson) is the first-and-only dual action tablet that combines a PARP inhibitor with abiraterone acetate administered with prednisone.
Published: 8/14/2023
Expert Panel Examines Gap in Health and Wellness for Women
Session at NACDS Total Store Expo discusses how to address shortcomings in women’s health areas in the health and wellness industry.
Published: 8/14/2023
There is Significant Potential for the Pharmacist in a Food as Medicine Prescription System
Pharmacists can improve patient access to both healthful foods and necessary medicines as a continuum of care in underserved communities.
Published: 8/13/2023
Expert Panel Explains How Generative AI Could Impact Retail, Health Care
Session at NACDS Total Store Expo discusses minor changes that retail companies can make to mesh artificial intelligence into their work to increase sales, improve margins, and lower costs.
Published: 8/13/2023
Consumerization of Diagnostic Tools Can Close the Gap Between Delivery, Pharmacy Solution
Entrepreneurs and healthcare retailers can support pharmacists by digitizing the recommendation model and closing the diagnostic gap.
Published: 8/13/2023
Partnerships Can Strengthen Community Pharmacy, Advocacy to Promote Better Health Care Outcomes
Educator and pharmacy advocate encourages pharmacists to work together to improve the scope of the profession and patient access to services.
Published: 8/12/2023
Amyloid-Targeting Class of Alzheimer Disease Drugs Show Potential, Raise Concerns of Accessibility for Diverse Patients
Advancements in the development of amyloid-targeting monoclonal antibodies show promise for treating Alzheimer disease, but there have been concerns around cost, adverse reactions, and inequity of care for marginalized patients.
Published: 8/11/2023
Significant Increase in Hospital Delirium, New Antipsychotic and Benzodiazepine Prescriptions Associated With COVID-19 Pandemic
Unexpectedly, the highest increases in delirium compared to projections were in the 66 to 74 years of age group, which could have important personal and societal repercussions, such as earlier development of dementia.
Published: 8/11/2023
Driving Patient Safety With New Pharmacy HIT Standards
New standards from the National Council for Prescription Drug Programs could drive changes that improve patient safety by optimizing drug therapy to reduce the risk of harm and improve health and well-being before a medication is dispensed.
Published: 8/11/2023
Ambulatory Care Pharmacist-Administered Depression Screenings Can Close Gaps in Care
The study implemented a novel workflow for ambulatory care pharmacists to execute pharmacist-administered depression screenings.
Published: 8/11/2023
Encorafenib, Binimetinib Combination Improves Progression-Free Survival for Patients With BRAF-Mutant Melanoma
In the COLUMBUS study, the FDA requested that the investigators evaluate the contribution of binimetinib while maintaining the same dosage of encorafenib at 300 mg to confirm the benefits of the combination.
Published: 8/11/2023
Humira Biosimilar Effective in Treating Moderate to Severe Chronic Plaque Psoriasis
Although SB5 is an effective treatment for plaque psoriasis, it is recommended that patients consider the potential risks and adverse effects.
Published: 8/11/2023
Low Probability of 5% Weight Loss in Adults With Overweight or Obesity
Despite the low uptake of healthy lifestyle behaviors to achieve 5% weight loss or greater, the probability of weight loss increased among individuals with higher initial BMI.
Published: 8/11/2023
Expert Discusses Current Recommendations for Respiratory Syncytial Virus, Influenza, COVID-19 Vaccination
Gretchen Garofoli, PharmD, an associate professor at the West Virginia School of Pharmacy, discusses the current recommendations for COVID-19, respiratory syncytial virus (RSV), and influenza vaccines and vaccine hesitancy.
Published: 8/11/2023
Study Results Suggest Electrical Communication Between Skin Cells May Initiate Melanoma
Findings may have therapeutic implications because of the potential to target neurotransmitters to treat or prevent melanoma.
Published: 8/10/2023
Remibrutinib Shows Rapid Symptom Control in Chronic Spontaneous Urticaria
Results of phase 3 trials could lead to the approval of remibrutinib to provide more effective and controlled treatment of chronic spontaneous urticaria than H1-antihistamines.
Published: 8/10/2023
Study: Communicating FDA Approval Process Increases Likelihood of Recommendations for Respiratory Syncytial Virus Vaccines
Approximately 57% of individuals who were shown a flowchart of the FDA vaccine approval process were very or somewhat likely to recommend a respiratory syncytial virus vaccine to a pregnant family member or friend compared to only 40% of those who were not shown the process.
Published: 8/10/2023
Disparities in Antiviral Treatment for HCV Lead to Prolonged Infection
Policy efforts must be put in place to support HCV treatment for all individuals to reduce the disparities in direct-acting antiviral treatment.
Published: 8/10/2023
Study Finds Lengthy Wait Time Until Medicare Coverage for New FDA-Approved Technologies
There was no association between the amount of evidence behind a product and the time until Medicare coverage, suggesting issues within the coverage determination process itself.
Published: 8/10/2023
Case Study: Intravenous Immunoglobulin Infusion Effectively Treats Parvovirus B19 Infection
After repeated treatment with packed red blood cell transfusions, treatment with intravenous immunoglobulin in a child with parvovirus B19 infection successfully resolved the infection and negated the need for further transfusions.
Published: 8/10/2023
FDA Grants Accelerated Approval to Talquetamab-tgvs for Patients With Heavily Pretreated Multiple Myeloma
Talquetamab-tgvs (Talvey) is a first-in-class bispecific antibody that binds to GPRC5D and CD3 to induce T cell-mediated killing of GPRC5D-expressing multiple myeloma cells.
Published: 8/10/2023
Study Suggests Naloxone Trainings Should Not Be Limited, Despite Concerns of Increased Drug Use
No major changes were found in overdose behaviors among individuals who received take-home naloxone.
Published: 8/10/2023
Microbiology Quality Control Helps the Cell and Gene Therapy Segment Cure the Incurable
With the continued advancement and approval of cell and gene therapies, the need for trustworthy microbiology quality control solutions is at an all-time high.
Published: 8/9/2023
Dental Disease, Oral Hygiene Important Determinants of Heart Failure in Patients With Type 2 Diabetes
Study shows that as patients with type 2 diabetes lost more teeth, their risk of heart failure grew.
Published: 8/9/2023
Pre-Exposure Prophylaxis Continues to be Effective in Preventing HIV, Certain Populations Face Barriers
Lack of information and access to health care, stigma, discrimination, criminalization, and privacy concerns are among the barriers some groups face when trying to obtain preventative HIV medications.
Published: 8/9/2023
Chronic Immune-Related Adverse Effects Common in Patients With Resected Melanoma Treated With Anti-PD-1 Therapy
Researchers found an increase in patients with melanoma who experience chronic immune-related adverse effects at 18 months compared to a previous study with a follow-up point of 6 months.
Published: 8/9/2023
Long-Term Intake of Probiotics Could Help to Improve Constipation, Increasing Positive Microbiome in Intestines
The effects of probiotic strains on both constipation and cognition among all individuals involved in a meta-analysis remains difficult to determine.
Published: 8/9/2023
Predictive Model for Cervical Cancer Improved With Inclusion of Human Papillomavirus Genotypes
Adding human papillomavirus genotypes to the predictive model had a significantly higher effect in improving accuracy compared to adding epidemiological factors and pelvic examination.
Published: 8/9/2023
Higher Count of Mitochondrial DNA Fraction With Breaks Associated With Increased Future Risk of Non-Hodgkin Lymphoma
Although additional studies are needed, findings indicate that mtDNAfb may be a useful biomarker for future risk of non-Hodgkin lymphoma.
Published: 8/8/2023
Study: School Districts With Greater Social Vulnerability Show Higher Rates of SARS-CoV-2
The findings suggest that varying precautions and factors affected the transmission rates in schools in different periods of the pandemic.
Published: 8/8/2023
Depression, Anxiety Linked to Increased Risk of Developing Lung, Smoking-Related Cancers
Though an association was found between depression and anxiety and lung cancers, there were no connections found to overall, breast, prostate, colorectal, and alcohol-related cancers.
Published: 8/8/2023
Lisaftoclax Granted FDA Clearance for Phase 3 Trial in Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Lisaftoclax is a novel, oral, small-molecule, BCL-2 selective inhibitor being evaluated for treatment of relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.
Published: 8/8/2023
Burden of Aging-Related Comorbidities Higher in Women, Those with HIV
The burden of aging-related comorbidities was higher across every age category in women compared to men, and increased with age.
Published: 8/8/2023
Proposed FDA Rule on Patient Medication Information Seeks to Address Prescription Misuse, Nonadherence
Improved prescription information could help consumers make better health care decisions and result in cost savings.
Published: 8/8/2023
Nose Picking Among Health Care Workers Associated With Increased Risk of SARS-CoV-2
Study results showed no significant association between those who bite their nails and SARS-CoV-2 infection, in addition to a lower rate of infection for those who wear glasses compared to those who don’t wear glasses.
Published: 8/8/2023
Structured Surveillance Rarely Used for Patients with Subsegmental Pulmonary Embolism Despite Recommendations
In addition to the low use of structured surveillance overall, modified CHEST criteria only identified a small portion of patients with subsegmental pulmonary embolism eligible to receive structural surveillance.
Published: 8/8/2023
Inappropriate Medication Use Among Older Adults On-The-Rise in Outpatient Setting
Adults aged 80 years and older and those living in areas with worse economic conditions are more likely to receive potentially inappropriate medications in the outpatient setting, which may be associated with cognitive impairment.
Published: 8/8/2023
Oncological Biosimilars Shown to Be as Safe as Their Reference Products
Study finds patients with cancer feel reassured that biosimilars provide a safe, adequate, and cost-effective alternative to the pricier reference drug.
Published: 8/7/2023
Significant Association Found Between Vitamin D, Improved Insulin Resistance
Researchers say vitamin D supplementation could be a low-cost and effective avenue for the reduction of insulin resistance and better outcomes in preventing and treating diabetes.
Published: 8/7/2023
Research Shows Lack of Resources for Youth at Risk for Heart Disease
Updated guidelines, comprehensive review, and an investment of resources into pediatric preventive cardiology programs could help provide successful care.
Published: 8/7/2023
Pembrolizumab Produces a Sustained Response in Patients With Relapsed/Refractory Primary Mediastinal Large B-Cell Lymphoma
At a median follow-up of 48.7 months, pembrolizumab monotherapy produced an investigator-assessed objective response rate of 41.5% and a 20.8% complete response rate in patients with relapsed/refractory primary mediastinal large B-cell lymphoma.
Published: 8/7/2023
Electrical Stimulation May Improve Sleep Apnea, Daytime Sleepiness Better Than CPAP
More than 1 billion people suffer from sleep apnea, a condition often associated with snoring.
Published: 8/7/2023
African Genomes Could Aid HIV Infections
The findings suggest that CHD1L’s could provide treatment opportunities for individuals infected with HIV-1.
Published: 8/7/2023
Study Finds Low Rate of Asymptomatic C Difficile Carriage in Hospitals
CDI is difficult to contain in health care settings because some patients are unknowing carriers of the toxigenic strains of the infection.
Published: 8/7/2023
Diabetes Independently Associated With Increased Pulmonary Pressure, Decreased Right Ventricle Load Stress
Notably, obesity was not independently associated with pulmonary pressure or decreased right ventricle load stress despite being a condition related to diabetes.
Published: 8/7/2023
FDA Approves First Oral Treatment for Postpartum Depression
However, the FDA said an application for zuranolone to treat major depressive disorder did not provide substantial evidence of efficacy.
Published: 8/7/2023
mRNA-1273 Vaccine Associated With Lower Risk of Adverse Events, Likelihood of COVID-19 Diagnosis
Compared to the BNT162b2 vaccine, the mRNA-1273 vaccine was associated with a lower risk of adverse events, which investigators speculate was due to interrelated safety and efficacy.
Published: 8/4/2023
Unbalanced Sleep Patterns Could Impact Gut Bacteria
Social jet lag could create adverse health impacts that a 90-minute difference in the mid-point of sleep can improve.
Published: 8/4/2023
Research Shows Smoking Status Is a Risk Factor for Hematoma Expansion
The findings suggest that cigarette smoking is an independent predictor for the expansion of hematoma, although smoking status does not cause a difference in mortality.
Published: 8/4/2023
CDC Advisory Committee on Immunization Practices Recommends Nirsevimab-alip to Prevent RSV in Infants
CDC Advisory Committee on Immunization Practices voted 10 to 0 to recommend the routine use of nirsevimab-alip (Beyfortus; Sanofi and AstraZeneca) for the prevention of respiratory syncytial virus lower respiratory tract disease in newborns and infants.
Published: 8/4/2023
What to Know About the Approval of Lecanemab-irmb
Nikhil Palekar discusses the FDA approval of lecanemab-irmb (Leqembi, Eisai) and what this means for those who have Alzheimer Disease.
Published: 8/4/2023
The Role of Specialty Pharmacists in Overcoming Barriers Associated With PCSK9 Inhibitors
Specialty pharmacists play an important role in dispensing PCSK9 inhibitors and serve as a valuable source of assistance and education for patients.
Published: 8/4/2023
Aggressive Medical Management Can Reduce Risk of Stroke Recurrence in Black Adults
Black adults, who have a higher likelihood of suffering from stroke at a young age, benefitted from blood pressure control and increased physical activity.
Published: 8/4/2023
As Fewer Hospitals Report Cases of COVID-19, Wastewater Surveillance Could Be a Better Means of Estimating Countywide Infection Rates
Wastewater surveillance could be the most consistent way to measure COVID-19 across US counties, a recent study indicates.
Published: 8/4/2023
Patients With Transthyretin Cardiac Amyloidosis, Heart Failure With Preserved Ejection Fraction Have Similar All-Cause Death Rates
Notably, patients with transthyretin cardiac amyloidosis had higher rates of heart failure hospitalizations, including patients treated with tafamidis.
Published: 8/4/2023
Exercise Can Improve Chemotherapy-Induced Peripheral Neuropathy in Patients With Ovarian Cancer
The affect of an aerobic exercise program was more prevalent in patients with ovarian cancer who had at least 1 symptom of chemotherapy-induced peripheral neuropathy at the beginning of the trial.
Published: 8/4/2023
Effect of Pharmacist Recommendation on Antibiotic Duration Prescribing at Hospital Discharge
Antibiotic prescribing at hospital discharge is a component of pharmacist-led antimicrobial stewardship programs that is often overlooked.
Published: 8/3/2023
Research Indicates Decline in Hearing by Age 71
Of the individuals that participated in the study, 65.3% reported hearing loss at 71 years and 96.2% reported hearing loss by 90 years.
Published: 8/3/2023
Trastuzumab Deruxtecan Shows Clinically Meaningful Survival Benefits for Patients With Previously Treated HER2-Expressing Tumors
There are currently no HER2-directed therapies for many HER2-expressing solid tumors that are refractory.
Published: 8/3/2023
WikiGuidelines Group Creates Guidelines for Diagnosis, Management of Infective Endocarditis in Adults
Guidelines provide clear recommendation that oral transitional therapy is at least as effective as intravenous-only therapy for the treatment of infective endocarditis.
Published: 8/3/2023
Clostridioides Difficile Infection Associated With Increased Risk of All-Cause Mortality
Clostridioides difficile infection was found to increase the risk of all-cause and cause-specific mortality in a recent study.
Published: 8/3/2023
Military-Related Traumatic Brain Injury a Risk Factor for New-Onset Mental Health Conditions
The risk of death by suicide in soldiers was both directly and indirectly related to traumatic brain injury through confounding mental health diagnoses.
Published: 8/3/2023
Once-Weekly Injections of Icodec Insulin Improves Glycemic Control in Type 2 Diabetes Compared to Once-Daily Alternative
Not only was the glycemic control improved, but those who received once-weekly injections of icodec insulin had spent more time in the target glycemic range compared those who received once-daily injections.
Published: 8/3/2023
FDA Approves Expanded Indication of Ebola Zaire Vaccine for Individuals 12 Years of Age and Older
Ervebo was found to be 100% effective after vaccination in preventing the onset of Ebola virus symptoms after more than 10 days.
Published: 8/3/2023
Daily Low-Dose Aspirin Does Not Significantly Reduce Risk of Stroke, Can Cause Intracranial Bleeding
Study findings contrast with previously reported research linking aspirin to the secondary prevention of stroke, and are especially notable for older adults who may be more susceptible to bleeding-inducing events.
Published: 8/2/2023
Calcitonin Gene-Related Peptide Monoclonal Antibodies Not Associated With COVID-19 Risk, Can Treat Migraine Disorder
Study investigators observed no significant differences in oxygen supplementation, hospitalization, or COVID-19 related death between initiators and non-initiators, though they cautioned more research was needed.
Published: 8/2/2023
Case Study: New Treatment Options for Patients With Chronic Lymphocytic Leukemia
With a better understanding of the underlying pathophysiology of chronic lymphocytic leukemia and the introduction of novel targeted agents, such as Bruton kinase Inhibitors, the prognosis of high-risk patients has changed dramatically.
Published: 8/2/2023
Systematic Review Will Evaluate Effects of Cognitive Interventions for Patients With Chronic Respiratory Diseases
The study authors said that, to their knowledge, this will be the first systematic review focusing on the effects of cognitive interventions for those with chronic respiratory diseases.
Published: 8/2/2023
Disease Severity and Age, Not Inhibitors Alone, Influence Quality of Life in Patients with Hemophilia
Reduced quality of life was observed in patients with hemophilia who were unemployed, had blood-borne illnesses, or had a high annual bleeding rate.
Published: 8/2/2023
MicroRNA Can Assist with Diagnosis, Classification, Prognosis of Diffuse Large B-Cell Lymphoma
microRNAs have shown potential to be used as biomarkers for diagnosing and treating different types of cancers, though their application in doing so had yet to be determined.
Published: 8/2/2023
IVIG-Based Treatment Increased Survival Rates of Renal Transplantation, Stabilizing Graft Function
With an intravenous immunoglobulin-based treatment protocol, individuals who underwent renal transplantation and who were presensitized achieved intermediate-term graft and recipient survival results at 98%.
Published: 8/2/2023
FDA Gives 510(k) Clearance to Respiratory Viral Panel Test for Rapid RSV, COVID-19 Detection
The approved assay can differentiate between infection of COVID-19, influenza, or respiratory syncytial virus, minimizing the need for multiple tests or physician visits.
Published: 8/2/2023
Trial Results Show Oral Orexin Receptor 2 -Selective Agonist Is Effective Over Placebo in Improving Wakefulness, Cataplexy in Patients With Narcolepsy Type 1
Despite the improvements in the patients' symptoms, minor adverse effects including urinary urgency and liver-related issues were reported.
Published: 8/1/2023
Janssen Seeks to Expand Indication for Rilpivirine to Include Children Weighing 10 Kg or More With HIV-1
Rilpivirine is part of the first ever long-acting injectable HIV-1 treatment option for children aged 12 years and older.
Published: 8/1/2023
Metformin Could Aid Hyperglycemia Among Those Infected with SARS-CoV-2
The common diabetes drug could mediate hyperglycemia, which is caused when SARS-CoV-2 infects hepatocytes.
Published: 8/1/2023
Vestibular Rehabilitation Shows Promise in Improving Quality of Life for Those With Chronic Bilateral Vestibular Hypofunction
The authors of the study said there is limited research investigating the impact of vestibular rehabilitation for individuals with bilateral vestibular hypofunction.
Published: 8/1/2023
Drinking Alcohol Daily Could Raise Blood Pressure Despite Lack of Previous Hypertension
The findings suggest that individuals who consume alcohol will have high blood pressure over time compared to non-drinkers.
Published: 8/1/2023
SARS-CoV-2 RNAemia Shown to be Risk Factor for Disease Severity, Mortality
Investigators found that age and the presence of RNAemia in blood were predictors of mortality in patients with severe COVID-19.
Published: 8/1/2023
Group B Streptococcus Vaccine Shows Promise in Phase 2 Study
Study shows maternal vaccination with Pfizer’s hexavalent capsular polysaccharide conjugate vaccine may protect infants against Group B Streptococcus.
Published: 8/1/2023
PrEP Services in Pharmacies Across Southeastern US Would Increase Treatment Capacity for HIV
A new study revealed multiple locations across the southeast, including Georgia, Kentucky, and Florida, with areas that had high HIV risk but little-to-no preexposure prophylaxis services in the area.
Published: 8/1/2023
FDA Approves Dostarlimab Combination for Primary Advanced or Recurrent Endometrial Cancer
Dostarlimab-gxly (Jemperli) approved in combination with carboplatin and paclitaxel for the treatment of adults with primary advanced or recurrent endometrial cancer that is mismatch repair deficient.
Published: 8/1/2023
With Summer Winding Down, Impactful Meetings in Oncology Pharmacy Remain on the Horizon
Published: 8/1/2023
Approval of First OTC Contraception Extends Pharmacists’ Reach in Comprehensive Care
Although the price and availability timeline of norgestrel have yet to be determined, experts already agree that it is an important step toward increased access to contraception.
Published: 8/1/2023
An OTC Oral Contraceptive Is Approved. Will It Be a Trendsetter or a Unique Case?
Reproductive health is top of mind for many patients, public health experts, and policy makers, but will there be effects on the pharmacy industry more broadly?
Published: 8/1/2023
Pharmacists Play a Critical Role in Protecting Patients From Illegal Online Drug Sellers
Although approximately 95% of online drug sellers operate illegally, many consumers may never know the medications they receive are not what they claim to be.
Published: 8/1/2023
Progress Is Being Made in the Optimization of Tolerability, Safety, Efficacy of Oncologic Therapies
There is much to be learned and progress to be made in all these efforts toward the optimization of tolerability, safety, and efficacy of oncologic therapies.
Published: 8/1/2023
The Not So New Role of Pharmacists: No Longer an Overlooked Health Care Provider
Pharmacists are critically important in care delivery in their ability to influence patient success, patient-reported outcomes, and quality of life while reducing the burden on physicians and their clinical support teams.
Published: 7/31/2023
A Dab of MAB: Lecanemab, Aducanumab vs Standard of Care Treatment for Alzheimer Disease
Pharmacists play a key role in the management of modern monoclonal antibody treatments for Alzheimer disease.
Published: 7/31/2023
Patients With High-Risk Disease Have Lower Chances of Survival From Mantle Cell Lymphoma
Investigators identified a specific subgroup of patients with mantle cell lymphoma who were at higher risk by defining a combination of MIPI, Ki-67, and p53/TP53 alternations.
Published: 7/31/2023
Patients With HIV Have Low Risk of End-Stage Renal Disease After Donating Kidney
Patients with HIV can donate a kidney to others with HIV who have a low risk of developing end-stage renal disease or other kidney problems for 2 to 4 years following donation.
Published: 7/31/2023
Pembrolizumab Plus Chemotherapy Led to Pathological Complete Response in Patients with Breast Cancer
The trial was recommended to continue to analyze event-free survival rates, but current results are encouraging for treating estrogen receptor-positive, human epidermal growth factor receptor 2-negative breast cancer.
Published: 7/31/2023
Sleep Disturbance Possible Adverse Effect of Cardiac Disease, New Study Finds
The lowering melatonin levels in patients with heart disease is one example of how heart conditions can influence systems throughout the body.
Published: 7/31/2023
Merck Announces Positive Results From Phase 3 Pneumococcal Vaccine Trials
If approved, the V116 vaccine would be the first pneumococcal conjugate vaccine specifically designed for adults.
Published: 7/31/2023
Complete Revascularization in Patients with Acute Coronary Syndrome, Multivessel Disease Reduced Risk of Heart Failure
The risk of death from both overall and cardiovascular causes was also reduced in patients who underwent complete revascularization.
Published: 7/31/2023
Restricted Eating Shows Similar Improvements in Blood Sugar as Reducing Calories for Type 2 Diabetes
Individuals who restrict their eating to between 12 pm and 8 pm daily lost more weight than those who reduced overall calorie intake for type 2 diabetes.
Published: 7/31/2023
Second OTC Opioid Overdose Reversal Medication Approved by FDA
The approval of RiVive naloxone hydrochloride nasal spray for nonprescription use provides another tool to help quickly reverse the effects of opioid overdose.
Published: 7/28/2023
Community Pharmacists and Technicians: Impacting Public Health One Service at a Time
Community-based pharmacy services are reaching new heights as pharmacists and pharmacy technicians are able to have a larger impact on patient care than ever before.
Published: 7/28/2023
Intravenous Immunoglobulin Effective Controlling Neuromuscular Disease in Patients with Cancer Treated with Immune Checkpoint Inhibitors
It was previously undetermined whether the combination of IVIG and ICI would lead to patient complications or reduced efficacy of the cancer treatment, but 2 successful case reports dispel that belief.
Published: 7/28/2023
Cap on Out-of-Pocket Insulin Costs in Inflation Reduction Act Increased Prescription Fills
Thousands more people filled their insulin prescriptions following the introduction of the cap in January 2023, especially compared to those who were not enrolled in Medicare, a new study finds.
Published: 7/28/2023
Navigating Adverse Events and Maximizing MM Treatment Adherence
The medical experts discuss strategies to achieve treatment adherence.
Published: 7/28/2023
Tirzepatide Demonstrates Significant Weight Loss Compared to Placebo
A new study indicates that adults with obesity or who are overweight with weight-related comorbidities can help manage their weight with lifestyle changes in conjunction with specified treatment.
Published: 7/28/2023
Social Determinants of Health Impacting RRMM Treatment Landscape
Social determinants of health inhibit optimal impact of MM treatment.
Published: 7/28/2023
Barriers to Optimal RSV Vaccination Rates
Financial, clinical, and social barriers to adult RSV vaccination are explored.
Published: 7/28/2023
Analysis of Milk Alternatives Finds Cow’s Milk Contains Higher Levels of Key Nutrients
Study notes that consumers should look for plant-based milk alternative products that list calcium and vitamin D as ingredients.
Published: 7/28/2023
Vaccination Amid Limited RSV Therapy Options for Adults
Medical experts discuss the lack of RSV treatment leading to the importance of immunization.
Published: 7/28/2023
Imaged-Guided Adaptive Radiation Treatments May Reduce Short-Term Adverse Effects in Patients With Prostate Cancer Compared to Non-Adaptive Treatments
Risks of genitourinary and gastrointestinal toxicity were reduced significantly, but longer follow-up is necessary to examine potential future issues.
Published: 7/28/2023
Risankizumab Significantly Reduces Severity of Plaque Psoriasis Compared to Apremilast
Patients on risankizumab also reported greater satisfaction with treatment for moderate plaque psoriasis.
Published: 7/28/2023
Biosimilars Require Standardization of Knowledge in the Field
A panel of experts discuss the state of biosimilars today and the importance of standardizing knowledge of the field.
Published: 7/28/2023
Menstrual Migraines: Overview, Treatment, and Prevention
Pharmacists play a key role in migraine management, therefore, awareness of menstrual migraine-specific prophylaxis is important.
Published: 7/28/2023
Study Indicates Increased Risks of Fatal Heart Attack Due to Combination of Heat Waves, High Fine Particulate Pollution Days
The risk could double if the conditions are met, with deaths more common in women and those aged 80 and older.
Published: 7/27/2023
Vegetarian Diet May Significantly Improve Cardiometabolic Outcomes in Those with High Cardiovascular Risk
Consuming a vegetarian diet lowered LDL-C, HbA1C, and body weight when compared to a usual diet, but did not significantly affect systolic blood pressure levels.
Published: 7/27/2023
Study Confirms Association Between Soft Drink Consumption, Weight Gain in Adolescents
Researchers recommend reducing soft drink consumption and increasing physical activity to begin minimizing this widespread issue.
Published: 7/27/2023
Patients With Cancer Currently Have Lowest Risk of Severe COVID-19 Outcomes Since Start of the Pandemic
Rates of hospitalizations and mortality from COVID-19 were more than 4 times lower in 2022 compared to 2021, as the virus become less severe with new mutations, a recent study found.
Published: 7/27/2023
Mortality Rate of Individuals With Alzheimer Disease, Dementias Increased During COVID-19 Pandemic
The research narrows the most at-risk populations and how to mitigate the impacts on adults with ADRD.
Published: 7/21/2023
Study Shows Combining Telehealth With In-Office Visits for Prenatal Care Performs Adequately Compared With In-Office Only
Not only is a combination of in-office visits and telemedicine an effective model of prenatal care, but it can be an alternative to those who face access barriers.
Published: 7/20/2023
Rural Populations Have More No-Shows for Telehealth Behavioral Health Services
Many living in lower-income rural populations face significant unmet social needs that can bar access to important mental health services.
Published: 7/20/2023
Study Confirms Race, Exposure Risk Play Significant Roles in Who Contracts COVID-19
The findings could help in future vaccine prioritization strategies and therapeutic allocation policies for other pandemic.
Published: 7/19/2023
Double-Blind Trial Shows Low-Cost Subcutaneous Version of Ketamine Is Effective Over Placebo in Treating Treatment-Resistant Depression
Generic ketamine could cost as little as $5, which is significantly lower than the $800 per dose for the currently available S-ketamine nasal spray.
Published: 7/19/2023
FDA Approves Nirsevimab-alip to Prevent RSV in Infants, Toddlers
The approval marks the first monoclonal antibody approved to protect all infants through their first respiratory syncytial virus season.
Published: 7/17/2023
Inflation Reduction Act, EOM, PBM Reform Remain Hot Topics on Capitol Hill
Effective implementation of the Inflation Reduction Act may allow legislators to shift their focus toward controversial pharmacy benefit manager practices, according to a panel discussion during the ATOPP Summit.
Published: 7/17/2023
FDA, USP Advance Standardization, Regulation of Cannabis Nationally
Quality standards and national regulation help to establish its role as medicine.
Published: 7/14/2023
FDA Approves Remdesivir for COVID-19 in Patients With Severe Renal Impairment
The approval makes remdesivir the first and only approved antiviral treatment for patients across all stages of renal disease.
Published: 7/14/2023
Blood Plasma Proteins Could Aid Long Covid
A potential new drug therapy found from blood proteins could improve outcomes for individuals diagnosed with long COVID.
Published: 7/13/2023
FDA Approves First Nonprescription Daily Birth Control Pill
The approval of norgestrel tablets (Opill) could open the door to other prescription-to-OTC contraceptive switches, although that remains to be seen as other pharmaceutical companies weigh their options.
Published: 7/13/2023
Nonhallucinogenic Psychedelics Can Help Manage Mental Health
Further research and regulatory changes are needed, but psychedelic medicines may be able to treat or even cure mental illness in the future.
Published: 7/12/2023
Artificial Intelligence Could Accelerate Access to COVID-19 Treatment
Using artificial intelligence to sort and respond to patient queries could streamline processes and alleviate provider burnout.
Published: 7/12/2023
Study Finds Psilocybin Reduces Alcohol Cravings, Diminishes Shame-Based Thought Patterns in AUD
The use of psilocybin and psychedelic therapy can be a helpful tool for individuals with AUD and could have a positive outcome that can result in self compassion.
Published: 7/11/2023
Monoclonal Antibodies as Pre-exposure Prophylaxis May Be Cost-Effective Approach to Reduce Severe Outcomes in COVID-19
Pre-exposure prophylaxis of neutralizing SARS-CoV-2 monoclonal antibodies may be preventative against SARS-CoV-2 transmission, decreasing frequency of new infections and number of hospitalized patients who need antiviral therapies, thus lowering costs.
Published: 7/10/2023
Study Finds Comorbidities, Pre-Existing Disease Have Significant Impact On COVID-19 Outcomes
The study also found significant evidence of outcomes disparities between minority populations and White populations.
Published: 7/3/2023
Mifepristone Has its Day in Court
As the battle over abortion rages, mifepristone has become the new center of the legal fight between anti-abortion advocates and the FDA.
Published: 6/28/2023
AmerisourceBergen Corporate Partnerships Team Aims to Support, Guide Pharmacy Customers
Claire Biermaas, president of Corporate Partnerships at AmerisourceBergen, discussed the Corporate Partnerships Team, which works closely with pharmacy customers to guide their processes and help execute their vision.
Published: 6/16/2023
In-Person Visits for Patients With Hematologic Neoplasms Decreased During Early Stages of COVID-19 Pandemic
In-person visits to receive oral therapy, outpatient infusions, and inpatient infusion for the treatment of hematologic neoplasms declined in the early months of the COVID-19 pandemic, while telemedicine use increased slightly in the same period but remained low overall.
Published: 6/14/2023
Psychedelic Therapy Can Advance the Scope of Oncology Care
Providing this treatment for patients with cancer may be a smoother transition for oncology professionals than they might expect.
Published: 6/13/2023
FDA Approves MDMA for Clinical Trial Use Investigating Schizophrenia
The study will assess the use of the drug to treat impaired social motivation, or asociality, which is a difficult-to-treat symptom of schizophrenia that can cause significant functional impairment.
Published: 6/9/2023
COVID-19 Infection Prior to Omicron Variant Linked to Higher Risk of Developing Long COVID
There may be more than 200 symptoms associated with long COVID-19.
Published: 6/7/2023
COVID-19 Infection Could Be Detected in Lungs, Heart, Causing Inflammatory Damage
Investigators found thinner ventricular walls, disorganized and ruptured myocardial fiber, mild inflammatory infiltration, and mild epicardia or interstitial fibrosis in the hearts of mice infected with COVID-19.
Published: 6/2/2023
The Latest in the Role of Pharmacogenomics in Mental Health Treatment
Pharmacogenomic testing in combination with therapeutic drug monitoring can be a cost effective and efficient way to advance psychiatric drug therapy.
Published: 6/1/2023
OTC Oral Contraceptive May Break More Precedent Than Expected
As patient access, public health advocates flex their muscles to reduce barriers to care, products, will that continue to translate in marketplace?
Published: 6/1/2023
How the Decentralization of Clinical Trials Can Transform Health Care
Decentralization has already been shown to streamline clinical trials, but it also has the potential to improve the broader health care ecosystem.
Published: 5/26/2023
Five Trends Transforming Pharmacies into Wellness Centers of the Future
With so many radical developments in medicine and technology unfolding at once, the role and potential of the pharmacy as we know it is evolving at breakneck speed.
Published: 5/26/2023
FDA Approves Pfizer’s Paxlovid for Treatment of COVID-19 in Adults
This marks the fourth drug, and first oral antiviral pill, approved by the FDA to treat adults with mild-to-moderate COVID-19.
Published: 5/25/2023
BONUS: American Association of Pharmacy Technicians Convention 2023
Pharmacy Times spoke with 2 presenters at the American Association of Pharmacy Technicians Convention 2023, which covered Wellbutrin and opioid use disorder medication.
Published: 5/24/2023
Research Suggests Risk of Long COVID is Higher for Individuals in Underserved Areas
The risk of long COVID-19 in females in the least deprived areas was comparable to the risk of males in the most deprived areas.
Published: 5/23/2023
Health Equity and Accountability Act of 2022 Aims to Combat Disparities
Federal legislation addresses variety of issues and seeks to build on gains made under the Affordable Care Act.
Published: 5/17/2023
Monoclonal Antibody Combination Found Safe, But Shows Limited Efficacy Treating COVID-19 Symptoms
Study evaluates the effect of long-acting monoclonal antibodies tixagevimab and cilgavimab treating COVID-19 symptoms and viral shedding.
Published: 5/16/2023
Supporting Technicians Increases Resiliency
Routinely celebrating their work contributions and dedication adds value to your organization.
Published: 5/15/2023
Expert: Potential OTC Birth Control Pill Could Open the Door for Other Rx-to-OTC Contraceptive Switches
Although this should be a relatively routine process, the national conversations around abortion and contraception have brought more attention to the decision.
Published: 5/12/2023
Research May Improve Treatment of Fatigue Associated with Long COVID-19
Study shows that the nervous system of individuals experiencing post-COVID-19 fatigue is underactive in 3 key areas.
Published: 5/12/2023
FDA Panel Votes Unanimously in Favor of First OTC Birth Control Medication
An FDA committee voted 17-0 to make the once-daily birth control medication Opill available OTC after deciding the benefits outweigh any potential harms.
Published: 5/10/2023
Latest Mifepristone Legal Debates Raise More Questions, Confusion for Health Care Professionals
Following 2 opposing decisions from judges in Texas and Washington State, Lanton said the issue is back in the Supreme Court.
Published: 5/8/2023
The Impact of a Clinical Pharmacist on Immunosuppressive Medication Adherence in Kidney Transplant Patients
Studies show that patients who had pharmacists as part of their transplant-related care had a significant improvement in clinical outcomes.
Published: 5/3/2023
Monoclonal Antibody Therapy Effective at Reducing Risk of Death From COVID-19 in Unvaccinated, Vaccinated Patients
Neutralizing monoclonal antibody therapies found to improve outcomes for unvaccinated and nonhospital patients at high risk of poor outcome for SARS-CoV-2.
Published: 5/3/2023
Monoclonal Antibody Combination Treatment Not Considered Significantly Effective Against COVID-19
Study shows intramuscular injection may improve treatment success by increasing the speed of drug absorption.
Published: 5/1/2023
FDA Grants Fast Track Designation to Bemnifosbuvir for COVID-19
The SUNRISE-3 trial is investigating its use in high-risk patients regardless of COVID-19 vaccination status.
Published: 4/25/2023
Limitations on Reproductive Rights Makes Agonizing Decisions Even Harder for Pregnant Women With Cancer
Even before the Dobbs ruling overturned country-wide reproductive rights, the oncology field was already facing a dearth of maternal care access challenges.
Published: 4/25/2023
Expert: Reproductive Rights Legislation Impacts Women’s Medical Options When Diagnosed With Cancer While Pregnant
Limitations on a woman’s options when pregnant and diagnosed with cancer can directly impact her ability to save her own life and preserve her fertility for future pregnancies.
Published: 4/25/2023
Pharmacists Will Have a Very Important Role in Psychedelic Medicine for Patients With Cancer
As psychedelic medicine comes further into cancer care, pharmacists will be an important part of the interdisciplinary team in screening and evaluating patients for suitability for psychedelic medicine.
Published: 4/21/2023
Research Suggests Dexamethasone Could Benefit Patients Hospitalized with COVID-19
All-cause inpatient mortality or discharge to hospice was lower for patients who received dexamethasone within 48 hours of either admission or escalation in oxygen support.
Published: 4/21/2023
Study: Link Seen Between Children Exposed to Opioids During Pregnancy, Chronic Diseases
Analysis shows that babies of mothers who used drugs while pregnant were shorter at birth and weighed less during the breastfeeding stage compared with non-drug-exposed infants.
Published: 4/19/2023
Psychedelic-assisted Therapy Is More Analogous to Oncology Care Than Traditional Mental Health Care
The Aquilino Cancer Center established the Bill Richards Center for Healing inside the same building, so patients with cancer can receive psychedelic-assisted therapy in the same location as their cancer care.
Published: 4/14/2023
During Early Pandemic, Pregnant Patients With COVID-19 Infection at Delivery Had Increased Risk of Death
Emerging evidence suggests that the risk of maternal mortality was more than 10-times greater among those with COVID-19 infection.
Published: 4/14/2023
Anakinra Found No Worse Than Standard of Care for Mortality Outcomes Among Patients with COVID-19 Pneumonia
Patients administered anakinra did not meet a study’s primary endpoint of proportion of patients who did not need mechanical ventilation 15 days after starting treatment for severe COVID-19 pneumonia.
Published: 4/13/2023
Real-World Efficacy, Safety of Tixagevimab/Cilgavimab in Patients With Cancer After EUA Revision
The role of monoclonal antibodies in minimizing COVID-19–related complications remains important to assess.
Published: 4/12/2023
Study: Cognitive Impairment in Patients with HIV Not Exacerbated by COVID-19 in Vaccinated Individuals
Among those without HIV, the analyses found that respondents with a history of COVID-19 performed worse on processing speed than those who had never had COVID-19.
Published: 4/6/2023
Long COVID Symptoms for Individuals 12 to 25 May Not Meet WHO’s Definition
The disease is the continuation of new symptoms 3 months after the initial SARS-CoV-2 infection and at least lasting 2 months after infection, according to the health organization.
Published: 4/6/2023
FDA Grants EUA for Vilobelimab for Treatment of Critically Ill Patients With COVID-19
This drug is the first to control complement factor C5a, which is a protein that plays a significant but potentially harmful role in the body's immune response.
Published: 4/4/2023
FDA Grants Accelerated Approval to Enfortumab Vedotin-ejfv Plus Pembrolizumab for Urothelial Carcinoma
Enfortumab vedotin-ejfv (Padcev, Astellas Pharma and Seagen Inc) with pembrolizumab (Keytruda, Merck) approved for the treatment of patients with locally advanced or metastatic urothelial carcinoma who are ineligible for cisplatin-containing chemotherapy.
Published: 4/4/2023
State Abortion Regulations Create a Conundrum for Practicing Pharmacists
Legal expert breaks down the history of power between federal v. state law and why Dobbs v. Jackson has caused such a stir for the pharmaceutical community.
Published: 3/31/2023
Patients Sue Pharmacies for Refusing Hydroxychloroquine, Ivermectin Prescriptions
Pharmacists on duty decline to dispense the medication to manage COVID-19, raising question about self-determination.
Published: 3/27/2023
Pharmacists are Essential in Curbing the Opioid Crisis in Older People
As the risk of respiratory depression is elevated with opioid use, the risk of complications from COVID-19 is increased in patients with opioid use disorder.
Published: 3/24/2023
Study Finds Pandemic Did Not Largely Impact General Population’s Mental Health
The COVID-19 pandemic marginally affected the negative mental health of women more than men, according to a new study.
Published: 3/21/2023
Data Suggest AT-527 May Improve Treatment of Patients with COVID-19, Hepatitis C
Atea’s drug candidate is considered safe and effective against the viruses that cause COVID-19 and hepatitis C, according to new data presented at ICAR 2023.
Published: 3/21/2023
Women Pregnant During the Pandemic Had Increased Prenatal Stress, Not Significantly Linked to Adverse Birth Outcomes
Emotional support greatly improved symptoms of psychological distress from the pandemic among pregnant women.
Published: 3/20/2023
Omicron Less Likely Than Early Variants to Cause Symptoms of Long COVID-19
The risk of long COVID-19 was no worse for patients who had Omicron after the wild-type virus than those just diagnosed with the wild-type.
Published: 3/17/2023
Lawsuit Challenges States’ Ability to Bar Access to Mifepristone
Without a constitutional right to abortion, mail order pharmacy providers need to consider both the federal requirements and various state laws in how they approach the dispensing of mifepristone across state lines.
Published: 3/16/2023
Nasal Foralumab Shows Promise in Regulating Inflammatory Response of COVID-19
Study includes healthy individuals and those who had progressive multiple sclerosis with the nasally administered treatment.
Published: 3/15/2023
Nightlife Setting Found to Propel the Spread of COVID-19
Nightlife transmission of COVID-19 affected a larger number of younger individuals but caused fewer household outbreaks in 2020.
Published: 3/8/2023
USP, FDA Propose Quality Standards for Cannabis, Highlighting its Role as Medicine
This action is of considerable significance as it supports the regulation of cannabis and cannabis-derived products as medicine under the Federal Food, Drug and Cosmetic Act.
Published: 3/3/2023
Study: COVID-19 Vaccination During Pregnancy Protects Infants Against Infection, Hospital Admission
The effectiveness of 2 doses against Omicron infection was highest when the second dose was given in the third trimester of pregnancy compared with the first or second trimesters.
Published: 3/1/2023
Study: Half of Cancer Patients May Develop Long COVID
Patients who had relapsed or treatment-resistant cancer at baseline, or those who had more severe acute COVID-19 infections, were less likely to develop long COVID-19.
Published: 2/27/2023
Data Show Melanoma Site to Be Independent High-Risk Factor for Recurrence, Poor Outcomes
High-risk areas for disease progression include genitalia and the scalp.
Published: 2/24/2023
Study: High Dose Ivermectin Not Effective for Outpatients With COVID-19
Results of the ACTIV-6 study showed that high dose ivermectin use did not demonstrate a clinical benefit for mild to moderate COVID-19.
Published: 2/23/2023
Remdesivir May Lower Mortality in Patients Hospitalized With COVID-19, Not on Oxygen Therapy
In a subgroup analysis, patients with COVID-19 who received conventional oxygen support also benefitted, having 20 fewer deaths per 1000 patients when given remdesivir.
Published: 2/22/2023
Faulty Genes May Cause Multisystem Inflammatory Syndrome in Children
The findings are the first to explain the mechanisms of any Kawasaki disease, a rare childhood inflammatory condition that is triggered by different viruses.
Published: 2/20/2023
Female Patients Hospitalized With COVID-19 Are Less Likely to Have Cardiovascular Complications
Arrhythmia was found to be the most common cardiovascular complication of COVID-19.
Published: 2/17/2023
Study: Restricted Access To Abortion May Trigger Psychiatric Illness in Pregnant Individuals
Those seeking abortion were found to have triple the risk of a psychiatric disorder compared to the general population.
Published: 2/15/2023
Convenience, Effectiveness Prove Significant Attributes in Vaccine Uptake Decisions
US adults have a slightly stronger preference for fewer adverse events in relation to pediatric COVID-19 vaccination, study results show.
Published: 2/14/2023
Nirmatrelvir–Ritonavir Decreased Risk of Death in Patients at Risk of Severe Illness from COVID-19
Relative efficacy of nirmatrelvir–ritonavir appears similar across risk groups, but older adults at risk of severe COVID-19 may benefit more.
Published: 2/14/2023
Fertility Treatment Not Found to Adversely Affect Cardiovascular Health of Offspring
Study shows no robust differences in blood pressure, heart rate, lipids, and glucose measurements in children conceived using assisted reproductive technologies.
Published: 2/13/2023
Long COVID Symptoms May Be Different Than Symptoms of Common Viral Respiratory Infections
Long COVID can impact quality of life, with some symptoms lasting for 1 year before the patient recovers to baseline.
Published: 2/9/2023
FDA Grants EUA to Combination Test for COVID-19, RSV, Influenza
Single nasal swab test can determine whether a patient has COVID-19, influenza, respiratory syncytial virus, or a combination of these viruses in as little as 2 hours.
Published: 2/8/2023
Attorneys General Tell CVS, Walgreens Mail-Order Distribution of Abortion Pills is Illegal
CVS and Walgreens have both recently announced that they are seeking FDA certification to use the mail to distribute mifepristone, the first pill used in a 2-drug abortion.
Published: 2/2/2023
States With Legal Medical, Recreational Cannabis Policies Do Not Have Significantly Higher Rate of Psychosis-Related Outcomes
This is the largest known study to consider medical and recreational cannabis policies with US psychosis-related health care claims.
Published: 2/2/2023
New COVID-19 PCR Test Launched to Detect XBB.1.5 Omicron Sub-Variant
The test, called VirSNiP SARS-CoV-2 Spike F486P, is for research use only and specifically targets the unique mutation F486P found within the XBB.1.5 Omicron sub-variant.
Published: 1/31/2023
Focus Shifts Away from COVID-19 Prevention Toward Preventing Severe Cases in Some Regions
Increasing efforts have focused on treating COVID-19 among patients in rural areas, who can take advantage of traditional medicines.
Published: 1/30/2023
Mortality, Adverse Medication Events, Length of Hospital Stay Rises as More Organ Systems are Impacted by MIS-C Post-COVID-19
Multisystem inflammatory syndrome typically presents approximately 1 month after a COVID infection, occasionally resulting in cardiac complications in previously healthy children.
Published: 1/26/2023
COVID-19 Convalescent Plasma Transfusion Shows Decreased Mortality for Immunocompromised Patients With COVID-19
The therapeutic option is demonstrating favorable results for patients, despite the evolving nature of the SARS-CoV-2 virus.
Published: 1/25/2023
2023 Forecasts for Pharmacy Services, Medication Costs During the Rise of Personalized Medicine
Data from a recent survey reflect a resounding shift toward the role of pharmacies becoming sites for primary care.
Published: 1/25/2023
Study Results Show IVIG May be Effective Therapy for Severe COVID-19
Analysis indicates 4 peptides had significant or nearly significant seropositivity, all of which were associated with membrane and spike proteins of SARS-COVID-2.
Published: 1/18/2023
Clinical Decision-Making, Rapid Follow-Up Lead to Lower Risk of Death From Heart Failure
Study results shows that the use of a point-of-care tool and timely after care were essential to lowering the risk of hospitalization from cardiovascular disease within 30 days after acute HF.
Published: 1/18/2023
Study: Most Long COVID-19 Symptoms Resolve Within a Year After Mild Infection
COVID-19 infection was significantly associated with increased risks of several conditions, including loss of smell and taste, concentration, and memory impairment.
Published: 1/17/2023
HSV Offers Promising Target for Preventive, Therapeutic Vaccines
Vaccination provides an opportunity to prevent and treat herpes simplex virus infection.
Published: 1/17/2023
Fourteen Percent of Those Who Contracted COVID-19 Face Long-Term Challenges
Providers use "Kitchen Sink Approach" because cure proves elusive, symptomatic treatment is sketchy.
Published: 1/16/2023
FDA REMS Change for Abortion Pill Creates Opportunities, Questions for Pharmacists
Although the FDA has now allowed retail pharmacies to dispense mifepristone, a drug used for medicated abortions, questions still remain about the requirements for pharmacies and the availability of the drug.
Published: 1/12/2023
Study Finds New Insights in Young Adults Who Develop Myocarditis After COVID-19 Vaccination
The risk of severe COVID-19 continues to outweigh the rare risk of post-vaccination myocarditis.
Published: 1/12/2023
Treating COVID-19 in the Pediatric Population
An overview of current theses and research surrounding the pathogenesis, presentation, and treatment of COVID-19 in children.
Published: 1/5/2023
FDA Regulatory Change Allows Retail Pharmacies to Dispense Abortion Pills
The changes will almost certainly widen access for patients seeking medicated abortions in states without legal obstacles.
Published: 1/4/2023
Speech Therapy May Effectively Address Long COVID Communication Issues
In addition to the physical symptoms of long COVID, patients have reported vocal, verbal, and cognitive issues that disrupt their ability to communicate.
Published: 1/3/2023
How the Pandemic Changed Pharmacies
Pharmacists have been increasingly recognized as key partners in the clinical services needed to manage the pandemic.
Published: 12/20/2022
It Is a Common Cold, Not COVID-19
Similar symptoms often make it difficult for patients to tell the contagious respiratory conditions apart.
Published: 12/19/2022
Keytruda, mRNA Combination Cancer Vaccine Meets Primary Endpoint in Phase 2 Trial
Merck and Moderna’s adjuvant melanoma treatment shows reduced risk of recurrence or death by 44% compared with pembrolizumab alone.
Published: 12/16/2022
A New Aura of Relief: Emerging Treatments for Migraines
Pharmacological options for those who experience migraines come in the form of abortive or preventative therapies.
Published: 12/16/2022
Pharmacies Poised to Capture At-Home Diagnostics Category
By leveraging do-it-yourself testing momentum, community-based and retail pharmacies can solidify their position as health care hubs with a category management approach that enhances the consumer experience and boosts store relevance and revenue.
Published: 12/15/2022
Patient-Controlled Analgesia: Pharmacy Haven or Nursing Nightmare?
Patient-controlled analgesia typically consists of opioids or local anesthetics, but it may also include non-opioid analgesics or other medications.
Published: 12/13/2022
Novel Compounds Show Potential for Treating Anxiety Disorders With Fewer Adverse Effects
Lead compounds may lower the risk of abuse and other adverse effects compared with other drugs currently being evaluated for mental health disorders, such as MDMA.
Published: 12/12/2022
Case Study: Pharmacist-Driven Allocation of COVID-19 Treatments Allows for Equitable, Efficient Processes
Pharmacists concluded that the workflow could be implemented for any drugs that are in short supply.
Published: 12/5/2022
COVID-19 Found to Elevate Risk of Seizures More Than Influenza
Individuals who had COVID-19 were 55% more likely to develop epilepsy or seizures over the following 6 months than those who had influenza.
Published: 12/1/2022
Study Suggests Long COVID-19 Is Prevalent, Risk Varies Among Populations
Findings support the potential protective association of vaccination in reducing long COVID, although it does not appear to eliminate the risk.
Published: 11/22/2022
Post-COVID-19 Symptoms Not Worse Among Hospitalized Patients Compared to Non-hospitalized Patients
Approximately 2 years after patients were infected with COVID-19, non-hospitalized patients suffered from post-COVID-19 symptoms nearly 8% more than hospitalized patients.
Published: 11/21/2022
Study: Significant New Onset Morbidity Observed in Children, Adolescents, Adults Following COVID-19 Infection
Although long-term health issues from COVID-19 are a major public health concern, evidence on post-acute COVID-19 syndrome, or post-COVID-19, is still limited, specifically among children and adolescents.
Published: 11/21/2022
Multiple SARS-CoV-2 Infections May Elevate Risk of Organ Failure, Death
Individuals with COVID-19 reinfections were twice as likely to die and three times more likely to be hospitalized than those who did not have COVID-19 multiple times.
Published: 11/21/2022
Three Strategies for Pharmacists to Maximize Their Potential as Caregivers Beyond the Bench
In recent years, pharmacist roles have evolved as critically important caregivers who increasingly provide essential health care services far beyond medication dispensing.
Published: 11/15/2022
Fauci Warns About BQ.1 and BQ.1.1 COVID-19 Variants – What to Know and How to Stay Safe
New COVID-19 variants are always cause for concern but are not a cause for panic.
Published: 11/14/2022
Expert: Long-term Care Industry Needs Help of Pharmacists to Improve Infection Prevention, Control
A session presenter at the ASCP 2022 Annual Meeting explained how the COVID-19 pandemic significantly magnified the importance of infection prevention and control practices in long-term care.
Published: 11/7/2022
Expert Panel Urges Clinicians to Get Involved With Public Health Issues
In addition to the ongoing COVID-19 pandemic, significant public health concerns include opioid overdoses, maternal mortality disparities, and climate change.
Published: 11/5/2022
COVID-19 Changes Pharmacy Practice Forever
Pharmacy leaders and academics have been begging the profession to evolve for decades. It took a pandemic to make it happen.
Published: 11/2/2022
Emerging From a Pandemic: Decision-Making Remains Challenging
Double-digit inflation, low reimbursement rates, and staffing shortages present obstacles.
Published: 11/2/2022
If You Want to Know Where Pharmacists' Roles Are Heading, Follow Patients
Last year in particular, pharmacists played a greater role in patient care with an increased workload as they connected patients, providers, and payers.
Published: 10/31/2022
Study Results Show Olfactory Dysfunction Due to COVID-19 May Last for More Than a Year
Highest prevalence is seen among adults, outpatients, and women and can cause persistent severe anosmia or hyposmia, findings indicate.
Published: 10/26/2022
Bacterium in the Gut Could be a Biomarker to Predict the Severity of COVID-19 Symptoms
A researcher suggests that the levels of certain gut bacteria can predict the severity of symptoms that someone can experience when infected with COVID-19.
Published: 10/24/2022
Previous Non-Omicron SARS-CoV-2 Infection May Protect Against Infection of Omicron
Prior infection with SARS-CoV-2 decreased the risk of being reinfected with Omicron among unvaccinated and vaccinated individuals.
Published: 10/24/2022
Risk of Developing Severe Breakthrough Infection From COVID-19 May Increase Over 50 Years of Age
The risk of severe COVID-19 breakthrough infection was stronger with age and some comorbidities—the findings can inform antiviral distribution to prevent death or respiratory failure.
Published: 10/21/2022
Study Finds Lack of Honesty About Following COVID-19 Public Health Measures During the Pandemic
Many people wanted life to feel normal during the COVID-19 pandemic; however, this reason, among many, resulted in people not adhering to public health measures in the United States.
Published: 10/18/2022
The PREP Act Declaration and How the COVID-19 Pandemic Changed the Perception and Role of Pharmacy Technicians
Because we need to be prepared and respond to future crises, making these changes permanent is a top priority for the profession of pharmacy.
Published: 10/17/2022
Know the COVID-19 Vaccine, Treatment Options
Latest Information is key to helping patients stay healthy amid continuously changing landscape.
Published: 10/14/2022
COVID-19 Infection Increases Risk of Diabetes Diagnosis in Pediatric Patients
At month 6 post-COVID-19 infection, 123 patients received a diagnosis of type 1 diabetes (T1D) and only 72 were diagnosed with T1D at 6 months post-non-COVID-19 respiratory infection.
Published: 10/14/2022
NCPA Appoints a New Director to the NCPA Innovation Center Board of Directors
Jeanine Singer, senior vice president of Field Sales and Operations at McKesson, discusses being appointed to the NCPA Innovation Center Board of Directors.
Published: 10/10/2022
Pharmacists Are Empowered Yet Again
FDA revises emergency use authorization to grant prescribing authority for Pfizer’s Paxlovid antiviral treatment for COVID-19.
Published: 9/29/2022
Mitigate Risk for Errors Involving Paxlovid
Take steps to safeguard prescribing, dispensing, and patient use of the COVID-19 antiviral medication.
Published: 9/26/2022
Study Results Show Link Between Excess Weight and Risk of COVID-19, Lasting Disease
Analyses of more than 30,000 adults in the United Kingdom from 9 prospective cohort studies finds a high pre-pandemic BMI was associated with the infection.
Published: 9/23/2022
Study: Children With Primary Immunodeficiency Disease May Have Higher Mortality from COVID-19
In a recent study, researchers observed that more than one-third of children with a primary immunodeficiency disease died from COVID-19.
Published: 9/22/2022
Low Testosterone in Men May be a Risk Factor for Hospitalization from COVID-19
Men with chronically low testosterone levels are more likely to be hospitalized from COVID-19 than those with normal levels, but testosterone therapy could decrease this risk.
Published: 9/16/2022
Antigen Biomarkers Could Predict Disease Progression of Hospitalized COVID-19 Patients
Viral antigen levels in blood plasma can provide clinically important patient outcomes among hospitalized patients with COVID-19.
Published: 9/9/2022
Study: Young Children Previously Infected With COVID-19 May Have Long-term Immune Response
Children younger than age 6 years might be protected from other COVID-19 variants for up to a year after infection.
Published: 9/8/2022
Expert Discusses Findings of PTCB 2022 Workforce Survey
Bill Schimmel, CEO and executive director of the Pharmacy Technician Certification Board (PTCB), discusses why pharmacy technicians are leaving the profession and why they are staying.
Published: 9/5/2022
Expert Discusses Certification for Pharmacy Technicians, Moving Up Career Ladder
Bill Schimmel, CEO and executive director of the Pharmacy Technician Certification Board (PTCB), discusses how pharmacists and pharmacy technicians can advocate for the certification of pharmacy technicians.
Published: 9/2/2022
Expert Discusses Pharmacy Technician Training, Essential for Catching Burnout-Related Mistakes
Bill Schimmel, CEO and executive director of the Pharmacy Technician Certification Board (PTCB), discusses how pharmacy technicians can face burnout and advocate for themselves.
Published: 9/1/2022
Study: Myocarditis Risk Is Significantly Higher After COVID-19 Infection Vs After Vaccine
Analysis includes nearly 43 million individuals aged 13 year and older who received at least 1 dose in England between December 1, 2020, and December 15, 2021.
Published: 8/24/2022
Lack of Awareness of Omicron Variant Infectious Status in More than Half of Adults Contributes to High Transmission Rates
Overall low awareness of the Omicron variant infection contributed to high transmission rates and rapid spread of SARS-CoV-2 in communities.
Published: 8/22/2022
Trial Results Suggest Metformin Is Effective at Reducing Odds of Serious COVID-19 Outcomes
University of Minnesota Medical School Analysis shows comparison with fluvoxamine and ivermectin in a double-blinded, placebo-controlled, randomized study.
Published: 8/22/2022
Prevent Drug Interactions With Paxlovid
Resources for health care professionals include FDA’s patient eligibility screening checklist tool for prescribers.
Published: 8/19/2022
Study: Children Infected With Mild COVID-19 May Still Develop Long Symptoms
Investigators from University of Texas Health Science Center at Houston analyze data from individuals aged 5 to 18 years enrolled in the Texas CARES survey.
Published: 8/17/2022
Study Results Show Leisure Activities May Help Lower Dementia Risk by up to 23%
The meta-analysis reviews 38 available studies on the effects of cognitive, physical, and social activities on brain function.
Published: 8/17/2022
Study: Eczema Drug May Lower Risk of Death From COVID-19
Researchers discovered that a common anti-inflammatory drug could lower the number of patients on ventilators from COVID-19, increasing the likelihood of survival by more than 50%.
Published: 8/16/2022
Historical Mistrust Contributes to Covid-19 Vaccine Hesitancy Among Black Individuals
University of Missouri analyzes social, structural determinants of health that worsen health disparities.
Published: 8/16/2022
Millions of Patients Still Lack Smell, Taste After Recovering from COVID-19
Hearing and vision may not be considered hierarchically superior senses anymore, as a new study sheds light on the importance of taste and smell for quality of life.
Published: 8/12/2022
HHS Guidance for Pharmacists Following Supreme Court Abortion Decision Creates Confusion
Although the guidance has created some confusion around pharmacists’ responsibilities on the federal and state levels, Lanton said it will take time to find cohesive solutions.
Published: 8/10/2022
Expert: Pharmacists’ Paxlovid Authorization is a “Significant Step” Toward Provider Status
In addition to expanding patient access to Paxlovid, the recent authorization of pharmacists to prescribe the drug marks a step toward provider status.
Published: 8/8/2022
Pharmacy Focus: Move the Needle Monday- COVID-19 Extended as Public Health Emergency
With limited supply to immunization options for monkeypox, polio, and influenza, the future of vaccine distribution will have to change.
Published: 8/8/2022
Response to Psychedelic Drugs May Be Determined by Genetic Variations in Serotonin Receptor
Genetic variations in the 5-hydroxytryptamine serotonin receptor uniquely impacted the receptor’s response to psychedelic drugs, including LSD and psilocin, possibly explaining why patients have varied success with psychedelic treatment for psychiatric conditions.
Published: 8/8/2022
Abortion Ban Could Be Life-Threatening for Women With Neurological Conditions
Researchers highlight how a lack of access to medications used to treat multiple sclerosis, migraines, and epilepsy, but not proven safe for pregnancy, threatens child-bearing aged women who live with these conditions.
Published: 7/28/2022
COVID-19 Infection in Children Associated with Post-COVID Conditions, Including Fatigue, Weakness
SARS-CoV-2 infection was associated with post-COVID-19 conditions for children, with associated risk factors including length of hospitalization, number of acute symptoms, and older age.
Published: 7/27/2022
Summertime Medication Sun Safety Tips
With the vast number of drugs that can induce photosensitivity, patients taking any of these medications should receive safety counseling, especially during the summer months.
Published: 7/27/2022
Assessing the Shift in Global Health Care Equity Following the Peaks in the Devastation From COVID-19
Daniel Gagnon, VP of Global UPS Healthcare, discusses vaccine equity panel discussion at the UPS Impact Summit in Atlanta, which was held at the National Center for Civil and Human Rights.
Published: 7/26/2022
Study: Pregnant African Women With COVID-19 Have Double Risk of ICU Admission
Results of analysis also show they have a much higher incidence of dying in the hospital than those without the virus.
Published: 7/26/2022
USP <800> Will Become Enforceable for Facilities Once Revisions of <795>, <797> Approved
Kevin Straughn, PharmD, clinical pharmacist at Duke Regional Hospital, said once the 2 compounding chapters, <797> and <795> become enforceable, there will be a 6-month grace period before USP <800> becomes enforceable.
Published: 7/25/2022
The Best Time to Show the Impact of Pharmacists on Healthcare During COVID-19
It's really important that we capitalize on this time and the impact that pharmacists had to make some of this reform permanent.
Published: 7/18/2022
Increased Responsibilities for Pharmacy Technicians Helps Role of Pharmacist
Ryan Burke, PharmD, director of professional affairs at Pharmacy Technician Certification Board, discusses how the changing role of pharmacy technicians has also helped the role of the pharmacist.
Published: 7/18/2022
Expert: Independent Pharmacies “Layered On” New Patient Services During the Pandemic
Debbie Weitzman of Cardinal Health, discussed how independent retail pharmacies quickly adjusted during the pandemic.
Published: 7/15/2022
Expert Discusses Advanced Roles for Pharmacy Technicians
Ryan Burke, PharmD, director of professional affairs at Pharmacy Technician Certification Board, discusses more advanced roles for pharmacy technicians and how they can continue to grow beyond their current roles.
Published: 7/15/2022
Study: Intermittent Fasting Associated with Less Severe COVID-19 Complications
People who regularly fasted for decades had lower risk of hospitalization or death from COVID-19, adding to the potential health benefits of intermittent fasting.
Published: 7/15/2022
Role of Pharmacy Technicians Continues to Grow in Post-COVID-19 Era
Donald Klepser, PhD, MBA, professor and dean of academic affairs at the College of Pharmacy in the University of Nebraska Medical Center, discusses how the COVID-19 pandemic has changed the role of pharmacy technicians and what is expected as we move forward.
Published: 7/14/2022
Following Supreme Court Reversal of Roe v. Wade, Some Patients Fear Limited Access to Methotrexate
Some anti-abortion laws may lead to legal action against health care providers who prescribe or provide medications that can be used to induce abortions.
Published: 7/13/2022
Expert: FDA Announcement of Pharmacists’ Prescribing Authority for COVID-19 Antiviral Paxlovid ‘Is Pharmacy’s Moment’ to Seize the Path to Provider Status
David Pope, PharmD, CDE, the EVP of Innovation and Industry Relations at OmniSYS, discusses the FDA’s announcement updating pharmacists’ prescriptive authority for the COVID-19 antiviral Paxlovid.
Published: 7/8/2022
FDA Revises Paxlovid EUA to Allow State-Licensed Pharmacists to Prescribe Drug Under Certain Conditions
Paxlovid treats COVID-19 in adults and children [12 years of age and older weighing at least 88 pounds (40 kg)] with positive results of direct SARS-CoV-2 viral testing, and who are at high risk for progression to severe COVID-19, including hospitalization or death.
Published: 7/7/2022
Addressing the Mystery of Long Hauler COVID: The Time is Now
As we learn more about inflammatory syndromes, we may get better at using laboratory tests to identify and isolate the actual cellular and chemical processes that drive them.
Published: 6/30/2022
Examining the Partnership Between Pharmacy and Public Health During the COVID-19 Pandemic
Pharmacy and public health have a long history of collaboration during an emergency.
Published: 6/24/2022
Study: Evusheld Offers Significant Prevention Against Severe COVID-19 Disease, Death
Analysis shows that individuals who received treatment within 3 days of symptom onset with tixagevimab and cilgavimab reduced their risk by 88% compared with the placebo.
Published: 6/23/2022
Merck, Ridgeback Release Data Evaluating Lagevrio for Treatment of COVID-19
Study results showed that a lower proportion of participants treated with LAGEVRIO had an acute care visit compared with those who received the placebo.
Published: 6/22/2022
Expert: Patients With COVID-19 May Have Loss of Taste, Smell for Years After Infection, But Remain Unaware
Kai Zhao, PhD, director of the Nasal Physiology and Therapeutic Center in the Department of Otolaryngology at Ohio State University College of Medicine, discusses how patients who have experienced a loss of taste and smell following COVID-19 infection may be impacted by this symptom for years without realizing it.
Published: 6/22/2022
Clinical Overview: Paxlovid for COVID-19
Paxlovid treats COVID-19 in adults who do not require supplemental oxygen and who are at an increased risk of progression to severe disease.
Published: 6/16/2022
Expert Discusses What Pharmacists Need to Know About Encorafeni, Binimetinib
Brooke Looney, PharmD, certified specialty pharmacist in the Oncology Clinic at Vanderbilt Specialty Pharmacy, discusses medication changes and adverse events for patients starting encorafenib and binimetinib.
Published: 6/14/2022
Expert Discusses New Specialty Drugs That are in the Pipeline
Aimee Banks, PharmD, BCPS, MSCS, clinical pharmacist in the Multiple Sclerosis Clinic at Vanderbilt University Medical Center, discusses new hematology, oncology, and autoimmune therapies in the pipeline that pharmacists should be aware of.
Published: 6/12/2022
PBMs, Lack of Transparency Spur New Models for Specialty Pharmacy Benefit Management
Prescription medications are vital to optimal patient outcomes, but they are also becoming increasingly expensive.
Published: 5/4/2022
Walgreens Launches Fertility Awareness Campaign in Support of National Infertility Awareness Week
Laly Havern, PharmD, MS, BCACP, director in specialty health solutions leading in oncology and fertility at Walgreens, discusses the company's Fertility Awareness Campaign that is being launched as part of National Infertility Awareness Week.
Published: 4/22/2022
California Requires State Universities to Offer Access to Medication Abortion on Campus
32 public colleges with combined enrollment of more than 700,000 students must comply with law by January 2023.
Published: 4/22/2022
Assessing the Efficacy of Rucaparib for Treatment of Patients with Ovarian Cancer
Thomasina Morris, RPh, MHA, BCOP, pharmacist at Moffitt Cancer Center, discusses the efficacy of rucaparib for approved indications based on clinical trial results.
Published: 3/1/2022
Bluebonnet’s Intimate Essentials For Her & Him Fertility Support Multivitamin Formula
Published: 3/1/2022
Overview of Rucaparib’s Use in Patients with Ovarian Cancer
Thomasina Morris, RPh, MHA, BCOP, pharmacist at Moffitt Cancer Center, discusses how rucaparib is currently used when treating patients with ovarian cancer.
Published: 2/25/2022
Understanding the Mechanism of Action of Rucaparib in Cancer Treatment
Thomasina Morris, RPh, MHA, BCOP, pharmacist at Moffitt Cancer Center, discusses the mechanism of action of rucaparib in recurrent and second line ovarian cancer, fallopian tube cancer, and peritoneal cancer.
Published: 2/24/2022
COVID-19 Infection May Have Short-Term Impact on Male Fertility
But vaccines do not cause infertility or harm pregnancy chances, Boston University School of Public Health research results show.
Published: 1/31/2022
The Impact of the COVID-19 Pandemic on Pharmacy Learners’ Academic Health
The unique challenges that pharmacy learners encountered during the COVID-19 pandemic reinforce their importance in the professional pharmacy setting.
Published: 12/15/2021
Legislative, Regulatory Changes Are Occurring Rapidly
Several states lead charge to update immunization protocols, allowing vaccine administration.
Published: 11/18/2021
How Health Systems Can Address the National Blood Shortage, Increase Blood Donations
Jennifer Andrews, MD, pediatric hematologist-oncologist at Vanderbilt University Medical Center and medical director of Vanderbilt University Medical Center’s blood bank, discusses what health systems can do to address the national blood shortage and increase blood donations.
Published: 11/8/2021
How the National Blood Shortage May Impact Patient Care, Outcomes
Jennifer Andrews, MD, pediatric hematologist-oncologist at Vanderbilt University Medical Center and medical director of Vanderbilt University Medical Center’s blood bank, discusses how a national blood shortage could affect patient care and outcomes.
Published: 10/21/2021
Expert: The National Blood Shortage Is Forcing Hospitals to Make Difficult Decisions Regarding Which Patients Get Blood
Jennifer Andrews, MD, pediatric hematologist-oncologist at Vanderbilt University Medical Center and medical director of Vanderbilt University Medical Center’s blood bank, discusses what the national blood shortage may mean for health systems.
Published: 10/19/2021
Oncology Overview: Enfortumab vedotin-ejfv for Advanced or Metastatic Urothelial Cancer
Enfortumab vedotin-ejfv (Seagen; Padcev) is a first-in-class antibody-drug conjugate approved for patients with previously treated locally advanced or metastatic urothelial cancer.
Published: 9/24/2021
Establishing Workflow for In-clinic, Home Administration of Cabotegravir-rilpivirine Injections for HIV-1
Workflow in the clinic and the pharmacy are critical for the implementation of a new and novel medication therapy, such as cabotegravir-rilpivirine.
Published: 7/29/2021
Pharmacy Fact: Clinical Research into Psychedelic Medicine Flourished for Decades Before Criminalization
Trials assessing psychedelic medicine were conducted in the United States for several decades before they were criminalized in 1968, with government and military funding provided for research in the field.
Published: 7/23/2021
Integrated Health-System Specialty Pharmacy Care Model Associated With Lower Oncology Medical Expenses
Research presented at the 2021 American Society of Health-System Pharmacists (ASHP) Specialty Pharmacy Conference suggests overall medical expenses for oncology patients were significantly improved by using an integrated health-system specialty pharmacy (HSSP) care model.
Published: 7/16/2021
Implementing Ambulatory Workload Metrics into Workspace Brings Benefits to Pharmacists, Technicians
The objective of the study was to design and implement a useful tool to record ambulatory metrics that is reportable and can be easily integrated into the clinical workflow.
Published: 7/15/2021
ASHP Survey of Specialty Pharmacies Highlights Concerns Over Access to Payer Networks, Interest in Serving New Populations
The American Society of Health-System Pharmacists’ (ASHP) first annual survey of health-system specialty pharmacies (HSSPs) offered insights into the concerns of specialty pharmacists and provided an opportunity for professionals in the field to outline a potential future for specialty pharmacy.
Published: 7/15/2021
Adoption of Biosimilars in Health Systems Faces Challenges and a Promising Future
The pipeline for biosimilar products in the United States includes at least 26 candidates in phase 3 trials for 13 reference therapies.
Published: 7/15/2021
Communicating With Care and Compassion: A Key to Unlocking Health Care Disparity
White continued to discuss how being self-aware, using the right language, modeling behaviors that support belonging, and fostering an environment with psychological safety is the goal as a a health care provider.
Published: 7/15/2021
Health System Pharmacy Services Are Positioned to Drive Access, Care for Patients Seeking HIV Post-Exposure Prophylaxis
In one program, hospital pharmacists received alerts whenever an antiretroviral was prescribed in the emergency department, enabling prompt action.
Published: 7/15/2021
Specialty Pharmacists Are Essential Patient Advocates
Specialty pharmacists have the expertise and respect necessary to change the health care system while listening to patients’ needs and guiding them through difficult experiences.
Published: 7/14/2021
The Importance of the Assessment of Lutetium Lu 177 Dotatate for Advanced Midgut Neuroendocrine Tumors to the Field
Jonathan Strosberg, MD, section head of the Neuroendocrine Tumor Program and vice president of Medical Oncology at the Moffitt Cancer Center, discusses the overall impact of the research assessing lutetium Lu 177 dotatate for midgut neuroendocrine tumors.
Published: 6/6/2021
An Overview of Patients’ Quality of Life on Lutetium Lu 177 Dotatate for Advanced Midgut Neuroendocrine Tumors
Jonathan Strosberg, MD, section head of the Neuroendocrine Tumor Program and vice president of Medical Oncology at the Moffitt Cancer Center, discusses patients reports of their quality of life while being treated with lutetium Lu 177 dotatate for midgut neuroendocrine tumors.
Published: 6/6/2021
Assessing the Adverse Events From Lutetium Lu 177 Dotatate for Advanced Midgut Neuroendocrine Tumors
Jonathan Strosberg, MD, section head of the Neuroendocrine Tumor Program and vice president of Medical Oncology at the Moffitt Cancer Center, discusses some of the adverse events patients experienced during the phase 3 trial assessing lutetium Lu 177 dotatate for midgut neuroendocrine tumors.
Published: 6/5/2021
Phase 3 Trial Methods in the Assessment of Lutetium Lu 177 Dotatate for Advanced Midgut Neuroendocrine Tumors
Jonathan Strosberg, MD, section head of the Neuroendocrine Tumor Program and vice president of Medical Oncology at the Moffitt Cancer Center, discusses the methods used during the phase 3 trial to assess lutetium Lu 177 dotatate for midgut neuroendocrine tumors.
Published: 6/5/2021
Expert: Pharmacists Are ‘The Heroes of 2021,’ Leading the Charge on Helping to Heal Our Nation
The efforts of pharmacists to keep their doors open during the pandemic, build COVID-19 testing sites, and prepare for and administer COVID-19 vaccinations took extraordinary investment and determination.
Published: 4/29/2021
NACDS, Health Care Providers Thanked by White House Senior Advisor For Their Hard Work in the Pandemic
Cedric Richmond, senior advisor to President Biden and director of the White House Office of Public Engagement, thanked the NACDS and other health care providers for their hard work during a session at the 2021 NACDS Annual Meeting.
Published: 4/28/2021
Johnson & Johnson Commits to Helping Eradicate Racial, Social Injustice in Health Care
According to Michael Sneed, executive vice president of global corporate affairs and chief communication officer for Johnson & Johnson, the health care system has chronically left people of color behind, and the inequities seen throughout the COVID-19 pandemic are only the latest examples.
Published: 4/27/2021
Tips to Finding Balance: Being a Well-Rounded Student Pharmacist
From countless hours of studying to participating in pharmacy organizations to volunteering in the community, it’s no surprise that student pharmacists often struggle to find balance as a well-rounded student.
Published: 4/13/2021
Present and Future Pharmacist Roles in Medication Abortion Care
Educational programming for pharmacy students and practicing pharmacists on medication abortion is limited.
Published: 3/8/2021
Illinois Working on Expanding Access to Contraception for Women
The Illinois legislature is considering pending legislation that would allow pharmacists to provide contraception directly to women.
Published: 3/8/2021
The Next Steps for Amyloid Light Chain Amyloidosis Treatment
Pharmacy Times interviewed Jason Valent, MD, of the Cleveland Clinic the next steps for his CAEL-101 findings, a treatment for patients living with amyloid light chain amyloidosis.
Published: 2/10/2021
New Treatment Can Help Patients Living with Amyloid Light Chain Amyloidosis
Pharmacy Times interviewed Jason Valent, MD, of the Cleveland Clinic his recent CAEL-101 findings, and how it can help shape treatment for patients living with amyloid light chain amyloidosis.
Published: 2/9/2021
CAEL-101 is Effective and Safe for the Treatment of Amyloid Light Chain Amyloidosis
Pharmacy Times interviewed Jason Valent, MD, of the Cleveland Clinic about what CAEL-101 is, how it works, and how it is used to treat patients with amyloid light chain amyloidosis.
Published: 2/7/2021
Researchers Say CAEL-101 is an Effective Amyloid Light Chain Amyloidosis Treatment
Pharmacy Times interviewed Jason Valent, MD, of the Cleveland Clinic about his new research surrounding CAEL-101, a treatment for patients living with amyloid light chain amyloidosis.
Published: 2/6/2021
Treatment Considerations for Managing a Patient With Congenital Plasminogen Deficiency Who Becomes Pregnant
Per Morten Sandset, MD, of the University of Oslo and Oslo University Hospital, discusses the treatment considerations necessary to properly manage a patient with congenital plasminogen deficiency after she became pregnant.
Published: 1/8/2021
A Case of Pregnancy Despite Infertility From Congenital Plasminogen Deficiency
Per Morten Sandset, MD, of the University of Oslo and Oslo University Hospital, discusses the details of a patient who had a successful pregnancy despite documented infertility due to congenital plasminogen deficiency.
Published: 1/6/2021
The Impact of Congenital Plasminogen Deficiency on the Gynecologic System
Per Morten Sandset, MD, of the University of Oslo and Oslo University Hospital, discusses the disease impact on the gynecologic system and how often patients become infertile due to this impact.
Published: 1/4/2021
Treatment Options for Patients With Congenital Plasminogen Deficiency
Per Morten Sandset, MD, of the University of Oslo and Oslo University Hospital, details the treatment options available for patients with congenital plasminogen deficiency.
Published: 1/1/2021
Common Manifestations of Congenital Plasminogen Deficiency and Their Impact on Patient Outcomes
Per Morten Sandset, MD, of the University of Oslo and Oslo University Hospital, describes common manifestations of congenital plasminogen deficiency and their impact on patient outcomes.
Published: 12/24/2020
The Causes and Characteristics of Congenital Plasminogen Deficiency
Per Morten Sandset, MD, of the University of Oslo and Oslo University Hospital, discusses why congenital plasminogen deficiency is often underdiagnosed and describes the causes and characteristics of the disorder.
Published: 12/24/2020
Investigating Second-Line Treatment Options for Myelofibrosis
Rami Komrokji, MD, discusses what the MOST study's results mean for investigating second-line treatment options in myelofibrosis.
Published: 12/16/2020
ALLO-715 Found to Be Effective Against Multiple Myeloma
CAR T-cell therapy associated with greater anti-cancer activity in treating multiple myeloma.
Published: 12/16/2020
Collecting Real-World Data from Patients With Myelofibrosis Is Essential
Rami Komrokji, MD, discusses whether the majority of patients in the MOST study were being treated at the time of enrollment, and why real-world data is so essential.
Published: 12/15/2020
Common Prior Treatments of Participants in the MOST Study
Rami Komrokji, MD, discusses common prior treatments of low-risk and intermediate-1 risk patients in the MOST study.
Published: 12/14/2020
Obtaining Real-World Disease, Demographic Data on Myelofibrosis
Rami Komrokji, MD, clinical director of malignant hematology and department lead clinical investigator at the H. Lee Moffitt Cancer Center and Research Institute speaks about why data are limited in myelofibrosis.
Published: 12/11/2020
The Future of Sickle Cell Disease and Vaso-Occlusive Crisis
In an interview with Pharmacy Times, Helen Thackray, MD, Thackray describes what she hopes to see for future trials involving sickle cell disease and rivipansel for acute vaso-occlusive crisis.
Published: 12/11/2020
Updated Phase 1 Results of Treatment With Teclistamab for Patients With Relapsed/Refractory Multiple Myeloma
For patients with relapsed/refractory multiple myeloma (RRMM), teclistamab was found to have a manageable safety profile, according to data presented at the virtual American Society of Hematology conference.
Published: 12/11/2020
New Data Reinforce Long-Term Benefit of Emicizumab for Patients With Hemophilia A
The data presented at ASH 2020 build on results previously observed in the pivotal HAVEN clinical trial among adults, adolescents, and children with hemophilia A, with and without factor VIII inhibitors.
Published: 12/11/2020
The Importance of Administering Rivipansel Early in VOC for Adults and Children with Sickle Cell Disease
In an interview with Pharmacy Times, Helen Thackray, MD, Thackray emphasizes the importance of administering rivipansel early in vaso-occlusive crisis and how it is meaningful for both adults and children with sickle cell disease.
Published: 12/10/2020
Making Treatment Decisions for Patients with Myelofibrosis
Rami Komrokji, MD, clinical director of malignant hematology and department lead clinical investigator at the H. Lee Moffitt Cancer Center and Research Institute speaks about factors in treatment decisions for patients with myelofibrosis.
Published: 12/10/2020
Preliminary Results of Ciltacabtagene Autoleucel in Treating Relapsed/Refractory Multiple Myeloma
Data from a preliminary phase 1b/2 study demonstrated a single low-dose infusion of ciltacabtagene autoleucel resulted in early, deep, and durable responses in heavily pretreated patients with multiple myeloma.
Published: 12/10/2020
The Clinical Efficacy of MEDI2228 in Treating Relapsed/Refractory Multiple Myeloma
MEDI2228, an ADC that targets the extracellular domain of human BCMA, demonstrated clinical efficacy at all dose levels in treating patients with relapsed/refractory multiple myeloma.
Published: 12/10/2020
New Data Reinforce the Long-Term Benefit of Venetoclax-Based Combination for People With Relapsed/Refractory CLL
Trials confirm patients with chronic lymphocytic leukemia treated with venetoclax-based regimens achieve higher rates of undetectable minimal residual disease, which may be associated with a lower risk of future disease progression or death.
Published: 12/10/2020
The Most Interesting Results from the RESET Clinical Trial
In an interview with Pharmacy Times, Helen Thackray, MD, reveals what finding she believes was the most interesting after analyzing the results of the RESET clinical trial, which covers the early initiation with rivipansel for acute vaso-occulusive crisis in sickle cell disease.
Published: 12/9/2020
Treatment of Acquired Hemophilia A with Rituximab and Emicizumab
Acquired hemophilia A is a rare bleeding disorder caused by autoantibodies that inhibit coagulation factor VIII (FVIII), and the disorder is understudied given its rarity and the lack of randomized prospective trials to guide therapy.
Published: 12/9/2020
Future Treatment Options for Patients With Relapsed/Refractory Multiple Myeloma
Suzanne Trudel, MD, MSC, FRCPC, of the University of Toronto and the Princess Margaret Cancer Centre in Toronto, discusses closing thoughts on the results of the study and its implications for future treatment options for patients with relapsed/refractory multiple myeloma.
Published: 12/9/2020
The Implications of the High Rate of Dose Holds in a Dose Finding Study of Belantamab Mafodotin in Combination with Pomalidomide and Dexamethasone
Suzanne Trudel, MD, MSC, FRCPC, of the University of Toronto and the Princess Margaret Cancer Centre in Toronto, discusses what the implications of the high rate of dose holds that occurred in the study were, and whether there any plans to address this concern in the future.
Published: 12/9/2020
Future Plans for the Evaluation of Ponatinib During the Ongoing OPTIC Trial
Hagop Kantarjian, MD, of the University of Texas MD Anderson Cancer Center, discusses what his team’s plans are for the evaluation of ponatinib during the remaining portion of the OPTIC trial, which is currently ongoing.
Published: 12/9/2020
The Consistency of Treatment Emergent AEs With the Known Safety Profiles for Belantamab Mafodotin and Pomalidomide
Suzanne Trudel, MD, MSC, FRCPC, of the University of Toronto and the Princess Margaret Cancer Centre in Toronto, discusses whether the treatment emergent adverse events (AEs) were consistent with the known safety profiles for belantamab mafodotin and pomalidomide.
Published: 12/9/2020
Common AEs Following Treatment With Belantamab Mafodotin in Combination With Pomalidomide and Dexamethasone
Suzanne Trudel, MD, MSC, FRCPC, of the University of Toronto and the Princess Margaret Cancer Centre in Toronto, discusses common adverse events (AEs) observed in patients with relapsed/refractory multiple myeloma following treatment with belantamab mafodotin in combination with pomalidomide and dexamethasone.
Published: 12/9/2020
The Safety and Arterial Occlusive Events Profiles Observed With Response-based Ponatinib Dosing Regimens
Hagop Kantarjian, MD, of the University of Texas MD Anderson Cancer Center, discusses what the interim analysis of the OPTIC trial demonstrated in terms of the safety and arterial occlusive events profiles with response-based ponatinib dosing regimens.
Published: 12/9/2020
Common Prior Therapies for Patients With Relapsed/Refractory Multiple Myeloma
Suzanne Trudel, MD, MSC, FRCPC, of the University of Toronto and the Princess Margaret Cancer Centre in Toronto, discusses the common prior therapies for patients with relapsed/refractory multiple myeloma who were enrolled in the ALGONQUIN trial.
Published: 12/9/2020
Observed Response to Ponatinib Among Patients With Resistant and Intolerant Chronic-phase CML With Substantial Prior Second-generation Treatment
Hagop Kantarjian, MD, of the University of Texas MD Anderson Cancer Center, discusses what the PACE trial was able to demonstrate in regard to patient response to ponatinib for patients with resistant and intolerant chronic-phase CML with substantial prior second-generation treatment.
Published: 12/9/2020
Dose Limiting Toxicities Following Treatment With Belantamab Mafodotin in Combination With Pomalidomide and Dexamethasone
Suzanne Trudel, MD, MSC, FRCPC, of the University of Toronto and the Princess Margaret Cancer Centre in Toronto, discusses the dose limiting toxicities observed among patients with relapsed/refractory multiple myeloma following treatment with belantamab mafodotin in combination with pomalidomide and dexamethasone.
Published: 12/9/2020
Using Belantamab Mafodotin and Pomalidomide in the Treatment of Relapsed/Refractory Multiple Myeloma
Suzanne Trudel, MD, MSC, FRCPC, of the University of Toronto and the Princess Margaret Cancer Centre in Toronto, discusses what belantamab mafodotin and pomalidomide are, and how they work together to treat relapsed/refractory multiple myeloma.
Published: 12/9/2020
Understanding the Use of Second-generation Tyrosine Kinase Inhibitors in Patients With Chronic-phase CML
Hagop Kantarjian, MD, of the University of Texas MD Anderson Cancer Center, discusses the reasons that the use of second-generation tyrosine kinase inhibitors in patients with chronic-phase CML who have failed one or more second-generation tyrosine kinase inhibitors needed further investigation.
Published: 12/9/2020
Updated Giroctocogene Fitelparvovec Study for Patients with Severe Hemophilia A
The update outlines that all 5 patients in the high dose 3 x 1013 vg/kg cohort have had at least 1 year of follow-up and showed sustained factor VIII (FVIII) activity levels, with a group median FVIII activity of 56.9% and a group geometric mean FVIII activity of 70.4% via chromogenic assay from week 9 to 52.
Published: 12/8/2020
Study Underway to Investigate Efficacy, Safety of New Hemophilia A Treatment
BIVV001 is currently being studied as a recombinant factor VIII treatment for hemophilia A.
Published: 12/8/2020
Study Confirms Benefits of Damoctocog Alfa Pegol in Severe Hemophilia A
A single infusion of damoctocog alfa pegol resulted in 25% higher area under the curve and 20% lower clearance in patients with severe hemophilia A.
Published: 12/8/2020
Study Finds Hematological Changes Common in Patients with COVID-19
The early stage of COVID-19 is typically characterized by lymphocytopenia and thrombocytopenia, whereas the late stage may be characterized by more severe lymphocytopenia and other changes.
Published: 12/8/2020
Further Testing Rivipansel and Its Implications Through the RESET Clinical Trial
Helen Thackray, MD, dives deeper into how the researchers tested rivipansel on the study participants and the implications compared to previous trials.
Published: 12/8/2020
Upcoming Trial to Investigate Belantamab Mafodotin in Patients With Relapsed, Refractory Multiple Myeloma
Belantamab mafodotin is a B-cell maturation antigen-targeting antibody-drug conjugate being investigated in the treatment of multiple myeloma.
Published: 12/8/2020
Rates of Thrombosis Not Significantly Higher in COVID-19 Patients
Study supports a more individualized approach to pharmacological thromboprophylaxis over a universal one in patients with COVID-19.
Published: 12/8/2020
Use of IVIG Therapy Reduces Progression to Mechanical Ventilation in COVID‑19 Patients With Moderate to Severe Hypoxia
Intravenous immunoglobulin administered to hypoxic non-ventilated COVID-19 patients with an A-a gradient of more than 200 mg Hg significantly decreases the rates of progression to mechanical ventilation.
Published: 12/8/2020
Overview and Highlights of the RESET Clinical Trial
Helen Thackray, MD, provides a brief overview and highlights of the RESET clinical trial.
Published: 12/8/2020
Simoctocoga Alfa Effective Treatment for Hemophilia A
The study found that the infusion helped to prevent spontaneous bleeding in patients with hemophilia A.
Published: 12/7/2020
Study: Emicizumab Demonstrates Long-Term Benefit for Patients with Hemophilia A
The proportion of patients with hemophilia A receiving Hemlibra who experienced zero treated bleeds increased with each consecutive 24-week period.
Published: 12/7/2020
Combination Therapy Reduced Risk of Disease Progression or Death by 37% in Relapsed/Refractory Multiple Myeloma
Eligible patients in the APOLLO study had RRMM and received more than or equal to 1 prior line of therapy including lenalidomide and a proteasome inhibitor (PI) and had responded to prior treatment and progressed on or after their last regimen.
Published: 12/7/2020
Closing Thoughts on Research into the Induction of Fetal Hemoglobin by FTX6058
Pharmacy Times® interviewed Christopher Moxham of Fulcrum Therapeutics, on his closing thoughts on the research he conducted into the induction of fetal hemoglobin by FTX6058.
Published: 12/7/2020
The Significance of 3 New Patient Cases in Understanding Congenital Plasminogen Deficiency
Pharmacy Times® interviewed Charles Nakar, MD and Amy Shapiro, MD, of the Indiana Hemophilia & Thrombosis Center, on 3 new patient cases from their presentation and the significance of these cases to their research.
Published: 12/7/2020
Patient Response to Treatment With FTX-6058
Pharmacy Times® interviewed Christopher Moxham of Fulcrum Therapeutics, on the results observed in his research when treating donors who were healthy or had sickle cell disease with FTX-6058.
Published: 12/7/2020
The Diagnosis Process for Patients With Congenital Plasminogen Deficiency
Pharmacy Times® interviewed Charles Nakar, MD and Amy Shapiro, MD, of the Indiana Hemophilia & Thrombosis Center, on the process for the diagnosis of patients with congenital plasminogen deficiency.
Published: 12/7/2020
Understanding Parallel Target Identification Efforts in the Induction of Fetal Hemoglobin
Pharmacy Times® interviewed Christopher Moxham of Fulcrum Therapeutics, on what their parallel target identification efforts were able to identify, and how this identification was important in his research.
Published: 12/7/2020
Response Rates and Survival Outcomes for Ponatinib Among Patients Who Failed Second-generation Tyrosine Kinase Inhibitors
Hagop Kantarjian, MD, of the University of Texas MD Anderson Cancer Center, discusses what the response rates and survival outcomes were for ponatinib among patients who failed second-generation tyrosine kinase inhibitors in the OPTIC trial.
Published: 12/7/2020
AMG 701 Demonstrates Manageable Safety, Favorable Pharmacokinetic Profile in Patients with Relapsed, Refractory Multiple Myeloma
AMG 701 is a bi-specific T-cell engager molecule being investigated for relapsed or refractory heavily pre-treated multiple myeloma.
Published: 12/7/2020
Understanding Further Treatment Opportunities for Patients With Polycythemia Vera
Pharmacy Times® interviewed Brady Stein, MD, MHSc, of the Feinberg School of Medicine at Northwestern University, on the implications of the results of his research on further investigation and treatment opportunities for patients with polycythemia vera.
Published: 12/7/2020
Melflufen Plus Dexamethasone as a Triple Regimen with Bortezomib, Daratumumab in Heavily Pretreated Relapsed/Refractory Multiple Myeloma Well-Tolerated
Melflufen plus dexamethasone as a triple regimen with bortezomib and daratumumab in patients with heavily pretreated relapsed or refractory multiple myeloma with poor prognostic factors was well-tolerated.
Published: 12/7/2020
Understanding Causes of Death of Patients With Polycythemia Vera
Pharmacy Times® interviewed Brady Stein, MD, MHSc, of the Feinberg School of Medicine at Northwestern University, on the noteworthy results observed in the study in relation to cause of death among patients with polycythemia vera.
Published: 12/7/2020
First-in-Class Multiple Myeloma Drug Shows Encouraging Clinical Activity, Manageable Safety
Talquetamab is a bispecific antibody that binds to GPRC5D and CD3 to induce T cell-mediated killing of GPRC5D-expressing multiple myeloma cells.
Published: 12/7/2020
New Bispecific Monoclonal Antibody Shows Deep, Durable Responses in Relapsed, Refractory Multiple Myeloma
Multiple myeloma is characterized by expression of the cell surface BCMA, making this a target for therapeutic intervention with REGN5458.
Published: 12/7/2020
Investigating Prior Data on the Causes of Death for Patients With Polycythemia Vera
Pharmacy Times® interviewed Brady Stein, MD, MHSc, of the Feinberg School of Medicine at Northwestern University, on the issues existing around prior data on the causes of death for patients with polycythemia vera (PV) and why it was important to have greater clarity in this area.
Published: 12/7/2020
IberDd, IberVd Combinations Show Favorable Tolerability in Heavily Pretreated Relapsed/Refractory Multiple Myeloma
The combinations also demonstrated promising clinical activity, even among patients refractory to the last prior regimen and previously exposed to IMiD agents, proteasome inhibitors (PIs), and CD38 antibodies.
Published: 12/7/2020
How Airway Obstruction and Respiratory Distress Can Impact Pediatric Patients Versus Adult Patients With Congenital Plasminogen Deficiency
Pharmacy Times® interviewed Charles Nakar, MD and Amy Shapiro, MD, of the Indiana Hemophilia & Thrombosis Center, on how airway obstruction and respiratory distress can impact pediatric patients versus adult patients.
Published: 12/6/2020
Treatment for Patients With Congenital Plasminogen Deficiency With Airway Obstruction and Respiratory Distress
Pharmacy Times® interviewed Charles Nakar, MD and Amy Shapiro, MD, of the Indiana Hemophilia & Thrombosis Center, on what the treatment options are for patients with congenital plasminogen deficiency with airway obstruction and respiratory distress.
Published: 12/6/2020
The Development and Treatment Potential of FTX-6058
Pharmacy Times® interviewed Christopher Moxham of Fulcrum Therapeutics, on what FTX-6058 is, how it was developed, and what it is able to treat.
Published: 12/6/2020
The Benefit of Maintaining the Expression of the Anti-sickling Damma Ortholog in Patients With Sickle Cell Disease and Beta-thalassemias
Pharmacy Times® interviewed Christopher Moxham of Fulcrum Therapeutics, on how maintaining expression of the anti-sickling gamma ortholog could be beneficial for children and adults with sickle cell disease, and why this is important to investigate.
Published: 12/6/2020
Common Manifestations of Congenital Plasminogen Deficiency
Pharmacy Times® interviewed Charles Nakar, MD and Amy Shapiro, MD, of the Indiana Hemophilia & Thrombosis Center, on the common manifestations of congenital plasminogen deficiency, and whether it is life threatening for patients.
Published: 12/6/2020
Common Treatments for Patients With Polycythemia Vera
Pharmacy Times® interviewed Brady Stein, MD, MHSc, of the Feinberg School of Medicine at Northwestern University, on the common treatments for patients with polycythemia vera.
Published: 12/6/2020
Survival Estimates and Mortality Rates Among Patients With Polycythemia Vera
Pharmacy Times® interviewed Brady Stein, MD, MHSc, of the Feinberg School of Medicine at Northwestern University, on the survival estimates for patients with polycythemia vera in the past and the mortality rates among these patients.
Published: 12/6/2020
Mortality and Causes of Death in Patients With Polycythemia Vera
Pharmacy Times® interviewed Brady Stein, MD, MHSc, of the Feinberg School of Medicine at Northwestern University, on what polycythemia vera (PV) is and why it was important to understand mortality and causes of death among patients with PV.
Published: 12/6/2020
The Causes of Sickle Cell Disease and Beta-thalassemias
Pharmacy Times® interviewed Christopher Moxham of Fulcrum Therapeutics, on what sickle cell disease and beta-thalassemias are caused by, and how hemoglobin gamma can prevent or reduce disease-related pathophysiology in these disorders.
Published: 12/5/2020
New Data on Gilteritinib in AML Presented at 2020 American Society of Hematology Annual Meeting
Five oral presentations will include data on the use of gilteritinib, either as monotherapy or in combination, across the spectrum of patients with acute myeloid leukemia with a positive FLT3 mutation.
Published: 12/4/2020
FDA Expands Indication of Antiviral Therapy to Include Post-Exposure Influenza Prevention
Originally approved in 2018, baloxavir marboxil is indicated for patients aged 12 years and older.
Published: 11/24/2020
Rite Aid Announces Plan to Acquire Bartell Drugs
Under the $95 million deal, Bartell Drugs’ stores will join 69 existing Rite Aid locations in the Seattle area and will continue to operate under the Bartell Drugs name.
Published: 10/7/2020
Kickbacks in the Pharmacy Arena: Lessons to be Learned
An overview of arrangements that pharmacies enter into that violate the federal anti-kickback statute.
Published: 10/6/2020
The Effect of Biosimilars on Cancer Institutions During COVID-19
Cancer care providers have increasingly been using biosimilars on a case-by-case basis with patients.
Published: 8/7/2020
How Specialty Pharmacies Can Improve Transitional Care Amid COVID-19
As clinicians, we must first understand the unique challenges that a patient is facing and then tailor our support to address their specific needs.
Published: 7/29/2020
Ensuring Patient Access to Oncology Care During the COVID-19 Pandemic
Although the treatment of cancer is facing many challenges, the pandemic is also creating massive amounts of new data with which to educate patients, conduct new research, and make more informed clinical decisions.
Published: 7/27/2020
FDA Approves New Nonopioid Pain Medication
The medication is indicated for the relief of mild to moderate pain caused by acute musculoskeletal disorders.
Published: 7/16/2020
Study: Health Care Professionals Vary in Their Beliefs About Medicinal Cannabis Use
The study concluded that pharmacists reportedly scored higher on the knowledge test than neurologists and nurse practitioners.
Published: 7/13/2020
Hypothyroidism Is Associated With Lower Risk in Breast Cancer
One in 8 women will develop breast cancer within their lifetime, making it the most commonly diagnosed cancer among women.
Published: 6/29/2020
Hitting HIV Hard in America: New Steps in Prevention
Access and adherence to pre-exposure prophylaxis is vital in eradicating the HIV epidemic in the United States.
Published: 6/15/2020
New York COVID-19 Testing Pilot Program Includes Independent Community Pharmacies
New York Governor Andrew Cuomo announced last week that New York will launch a COVID-19 testing pilot program with a goal of conducting 7000 tests per week.
Published: 5/27/2020
The Path Ahead in Reopening Community Pharmacies
As states begin to consider reopening businesses around the country, questions remain for pharmacies regarding appropriate strategies to protect the communities they serve from COVID-19.
Published: 5/20/2020
Navigating the Patient Journey in Specialty Pharmacy
Autumn Zuckerman, director of specialty pharmacy at Vanderbilt University Medical Center, and JoAnn Stubbings, a professor at the University of Illinois at Chicago College of Pharmacy, discuss the role of specialty pharmacists in guiding patients throughout their journey.
Published: 5/19/2020
Pharmacy Hero: Pharmacist Takes Time to Educate Patients During COVID-19
Today, we’re thanking Shady Zarnegin, PharmD, lead pharmacist at a Rite Aid in Los Angeles, California.
Published: 5/1/2020
Pharmacy Hero: Pharmacist Cares for Patients, Inspires Daughter to Become a Pharmacist
Today we’re celebrating Lendi Muehlbauer, RPh, who works at a Rite Aid in New Jersey.
Published: 4/9/2020
Advanced Techs Elevate Medication Safety and Patient Care
New PTCB credentials help strengthen the team and free up time for pharmacists.
Published: 1/20/2020
Updates on NMDA Contaminations in Medications
NDMA contamination in medications has caused concern among consumers, and health care professionals after WHO recalled 1159 lots of ARBs including valsartan, losartan, and irbesartan.
Published: 1/16/2020
Pharmacy Technician Certification Board Launches New Requirements and Exam
Starting January 2020, aspiring certified pharmacy technicians must complete a Pharmacy Technician Certification Exam-recognized education or training program, or have equivalent work experience before taking the exam.
Published: 1/16/2020
CDC Report on Antibiotic Resistance Threats Shows Higher Death Toll
Centers for Disease Control and Prevention warns the time for action is now in the "post-antibiotic era."
Published: 11/15/2019
Teva to Resume Production of Vincristine After Widespread Shortages
With vincristine in short supply, Teva will resume production of the chemotherapy agent following its previous decision to remove the product from the market.
Published: 11/14/2019
Vincristine Drug Shortage Stirs Concern for Impact on Pediatric Patients with Cancer
Limited supply of chemotherapy agent that treats several pediatric cancers may lead to rationing of doses.
Published: 10/21/2019
FDA OKs Baloxavir Marboxil for Patients at High Risk of Flu Complications
Baloxavir marboxil (Xofluza, Genentech) is the first antiviral medication indicated for patients at high risk of developing influenza-related complications.
Published: 10/17/2019
PTCB Announces New Certificate Programs
The Pharmacy Technician Certification Board (PTCB) has launched 2 specialty areas of Assessment-Based Certificate Programs: Technician Product Verification (TPV) and Medication History.
Published: 10/16/2019
Influenza Vaccine Recommendations for the 2019-2020 Flu Season
With flu season just around the corner, it is important for pharmacists to be up-to-date on the latest recommendations.
Published: 8/26/2019
Naloxone Dispensing Found Higher at Facilities with Opioid Workflow
A retrospective study by Intermountain Healthcare Research found statistical significance between the rate of patients receiving naloxone with opioid prescriptions at health system pharmacies when compared to non-health system pharmacies. .
Published: 7/8/2019
July 5 Pharmacy Week in Review: Vitamin D Deficiency Linked to Elevated Blood Pressure in Children, Chronic Pain is the Most Common Long-Term Effect of Cancer Treatment
This weekly video program provides our readers with an in-depth review of the latest news, product approvals, FDA rulings, and more. Our Week in Review is a can't miss for the busy pharmacy professional.
Published: 7/5/2019
Senate Bill Proposes Expansion of PrEP Access
Introduced by U.S. Senator Kamala D. Harris (D-CA), the bill requires all insurance plans to cover HIV prevention medications and services without out-of-pocket costs. The bill also facilitates access to PrEP for uninsured individuals.
Published: 6/21/2019
FDA OKs OnabotulinumtoxinA for Upper Limb Spasticity in Children
Officials with the FDA have approved Allergan’s supplemental biologics application (sBLA) for onabotulinumtoxinA (Botox) for the treatment of children, ages 2 to 17 years, with upper limb spasticity.
Published: 6/21/2019
Certified Techs and Pharmacists Make a Great Team
PTCB expands credentialing programs as technicians assume more responsibility and new roles.
Published: 6/20/2019
Liraglutide Approved for Pediatric Patients with Type 2 Diabetes
Officials with the FDA today approved liraglutide (Victoza, Novo Nordisk) injection for treatment of pediatric patients age 10 years or older with type 2 diabetes (T2D).
Published: 6/17/2019
FDA Approves Cariprazine for Treatment of Depressive Episodes
The new indication makes cariprazine the first and only dopamine and serotonin partial agonist to treat the full spectrum of bipolar I symptoms in manic, mixed, and depressive episodes.
Published: 5/28/2019
FDA OKs Dalteparin Sodium for Children with Potentially Life-Threatening Blood Clots
Dalteparin sodium is the first anticoagulant indicated for pediatric patients approved by the agency.
Published: 5/16/2019
Promacta Recalled Due to Potential Peanut Contamination
Promacta (eltrombopag, Novartis) 12.5 mg for oral suspension was distributed nationwide through specialty pharmacies.
Published: 5/13/2019
FDA OKs Combo Treatment for Type 2 Diabetes
Officials with the FDA have approved AstraZeneca’s dapagliflozin, saxagliptin and metformin hydrochloride (Qternmet XR) extended release tablets for adults with type 2 diabetes.
Published: 5/3/2019
First Vaccine for Dengue Disease Prevention Receives FDA Approval
The drug application was granted the FDA’s Priority Review designation, as well as a Tropical Disease Priority Review Voucher under a program intended to encourage development of new drugs and biologics for the prevention and treatment of certain tropical diseases.
Published: 5/2/2019
ASHP Match Ends with Over 5000 Placements in Pharmacy Residency Programs
Across the United States, 5090 individuals were matched to approximately 2500 pharmacy residency programs.
Published: 4/11/2019
Trial Demonstrates Safety and Efficacy of HIV Combination Therapy
The 4-drug combination tablet (Symtuza) was approved by the FDA in July 2018 for infection of HIV type 1 (HIV-1) in treatment-naïve and certain virologically suppressed adults.
Published: 4/11/2019
Clinical Trial Evaluating Novel HIV Vaccine Candidate
The IAVI WOO1 study is one of the first clinical trials of a native-like Env trimer and the first time that this particular trimer is being evaluated in humans
Published: 4/1/2019
FDA OKs First Treatment for Postpartum Depression
Officials with the FDA have approved brexanolone (Zulresso, Sage Therapeutics) injection for intravenous use for the treatment of postpartum depression in adult women.
Published: 3/21/2019
Liraglutide Patent Litigation Case Settled
As a result of the agreement, Teva is licensed to launch a generic version of liraglutide (Victoza, Novo Nordisk) as of December 22, 2023.
Published: 3/18/2019
Match Day Pairs Thousands of Pharmacy Students With Residency Programs
Over the last 5 years, post-graduate year-1 (PGY1) residency positions have grown by 34% and post-graduate year-2 (PGY2) positions by 64%.
Published: 3/16/2019
PrEP Inserts Containing Combo Therapy May Protect Women Against HIV
Vaginal inserts containing tenofovir alafenamide fumarate in combination with elvitegravir were shown to be highly effective in preventing simian/HIV infection in a macaque model.
Published: 3/15/2019
FDA Recognizes Fresenius Kabi with Drug Shortage Assistance Award
The FDA recognized the role Fresenius Kabi played in helping mitigate a shortage of IV saline, specifically sodium chloride injection USP, 0.9% in bags.
Published: 3/12/2019
Esketamine Nasal Spray Receives FDA Approval for Treatment-Resistant Depression
Officials with the FDA have approved esketamine CIII nasal spray (Spravato, Janssen Pharmaceutical Companies of Johnson & Johnson) for use in conjunction with an oral antidepressant in adults with treatment-resistant depression.
Published: 3/6/2019
PTCB Certification Eligibility Requirements To Change Next Year
Students who complete a PTCB-recognized education/training program will be eligible to apply for, and earn, their CPhT credential starting in 2020.
Published: 3/5/2019
Analysis: Dupilumab Improves Quality of Life for Patients With Atopic Dermatitis
Analysis of care in a routine clinical practice setting show that 40-week treatment of biologic dupilumab (Dupixent, Sanofi-Regeneron) plus noncosmetic topical moisturizer (emollient) is associated with significantly improved symptoms and health-related quality of life (HRQoL) in particular patients with atopic dermatitis (AD).
Published: 3/2/2019
Extended-Release Injectable Suspension for Schizophrenia is Launched
Indivior’s once-monthly schizophrenia treatment risperidone (Perseris) extended-release injectable suspension has launched in the United States.
Published: 3/1/2019
Ohio Updates Its Technician Regulations
For techs already employed, required registration with the state board of pharmacy by April 2018, either as a certified or registered tech.
Published: 2/23/2019
Detection of Impurity Prompts Company to Recall 1 Lot of Combination Tablets
Macleods Pharmaceuticals Limited has voluntarily recalled 1 lot of Losartan Potassium/Hydrochlorothiazide combination tablets 100mg/25mg to the consumer level, due to the detection of trace amounts of an unexpected impurity found in the product that is above the acceptable daily intake levels released by the FDA.
Published: 2/23/2019
Influenza Vaccines Prevented Thousands of Deaths in the Previous Flu Season
The flu vaccine prevented 7.1 million illnesses, according to the analysis, along with 109,000 hospitalizations, and 8000 deaths, during the 2017-2018 influenza season.
Published: 2/14/2019
Unvaccinated Teens Doing Research, Getting Immunized
Amid a global measles outbreak, some teenagers are questioning their anti-vaxxer parents about not vaccinating them against many dangerous and deadly diseases.
Published: 2/13/2019
Generic Version of Advair Diskus Launched at Discounted List Price
The FDA announced approval of Wixela Inhub on January 30, 2019.
Published: 2/13/2019
Seasonal Influenza Activity Increases in the United States
Throughout the country, 47 states and Puerto Rico experienced this in the week ended February 2.
Published: 2/9/2019
Recognizing and Avoiding Fraud Landmines, Part 2
The risks are too high for the pharmacy to be cavalier regarding compliance with antifraud laws.
Published: 2/8/2019
Home-Based Monitoring Tests May Boost PrEP Adherence
To reduce the likelihood of people giving up on PrEP because of difficulty committing to multiple annual visits, a team of investigators created PrEP@Home, a home-based monitoring system that will allow people on the PrEP regimen to meet with their health care providers just once a year, its creators say.
Published: 2/8/2019
Study Predicts Virtual Care to Expand in Upcoming Year
A recent study analyzed how health systems utilize and integrate virtual care into their daily practice.
Published: 2/7/2019
FDA OKs First Generic Version of Advair Diskus
The generic drug (Wixela Inhub, Mylan) is indicated to treat patients with asthma and chronic obstructive pulmonary disease, including bronchitis and emphysema.
Published: 1/30/2019
FDA Analysis Addresses ARB Impurity Risk to Patients
Conducted by the FDA, an analysis follows a series of recalls for some generic versions of the angiotensin II receptor blocker (ARB) medicines containing nitrosamine impurities that do not meet the agency’s safety standards.
Published: 1/25/2019
Six Additional Lots of Losartan Tablets Recalled
Torrent Pharmaceuticals Limited has expanded its voluntary recall of Losartan potassium tablets USP to include 6 lots of Losartan potassium and hydrochlorothiazide tablets, USP.
Published: 1/23/2019
Insulin Costs Double in Recent Years
The report authors noted that people with type 1 diabetes spent $5,705 on insulin in 2016, up from $2,864 in 2012.
Published: 1/23/2019
House Committee Investigating Prescription Drug Pricing Practices
The committee is seeking detailed information and documents about some pharmaceutical companies' prescription drug pricing practices.
Published: 1/16/2019
Recall Expanded for Losartan Potassium Tablets
A recall of Torrent Pharmaceuticals Limited’s Losartan Potassium Tablets USP has been expanded to include 8 additional lots. A total of 10 lots are now being recalled at the consumer level, including 2 recalled lots initially announced December 20, 2018.
Published: 1/4/2019
Valsartan Recall: FDA Issues Warning to API Manufacturer
The manufacturer of the active pharmaceutical ingredient found in the medication has received a letter from the agency.
Published: 12/12/2018
New Recall Announced for Products Containing Valsartan
Teva Pharmaceuticals has initiated a voluntary recall in the United States, to the patient level, of all lots of Amlodipine/Valsartan combination tablets and Amlodipine Valsartan/Hydrochlorothiazide combination tablets, due to an impurity detected above specification limits in an active pharmaceutical ingredient (API) manufactured by Mylan India.
Published: 11/28/2018
New Autoinjector Formulation for Tocilizumab Granted FDA Approval
The single-dose, prefilled autoinjector for tocilizumab (Actemra) offers an additional option for patients with rheumatoid arthritis, giant cell arteritis, and 2 forms of juvenile arthritis.
Published: 11/26/2018
Joint Clinical Consensus Statement Addresses Gout Treatment
The statement is intended to serve as a discussion guide for the risk factors, diagnosis, treatment and prevention of the disease.
Published: 11/16/2018
FDA Grants Priority Review for Dupilumab as Potential Treatment for Atopic Dermatitis in Adolescents
The FDA has accepted for Priority Review the supplemental Biologics License Application (sBLA) for Dupixent® (dupilumab) in adolescent patients aged 12 to 17 years with moderate-to-severe atopic dermatitis.
Published: 11/6/2018
FDA OKs Sublingual Opioid Dsuvia
Officials with the FDA have approved a new opioid, (Dsuvia, AcelRx Pharmaceuticals), sparking some controversy in the media that the opioid has potential for abuse.
Published: 11/6/2018
Study: Influenza Vaccine Effectiveness Higher in Children With Prior-Season Vaccination
Findings showed that LAIV was more effective in those vaccinated in both the enrollment season and the prior season than in those vaccinated only in the enrollment season.
Published: 11/6/2018
FDA Approves Sublingual Opioid Sufentanil
Officials with the FDA have approved a new opioid, (Dsuvia, AcelRx Pharmaceuticals), sparking some controversy in the media that the opioid has potential for abuse.
Published: 11/5/2018
Studies Demonstrate the Power of PrEP
Several large investigations have demonstrated the considerable efficacy of TDF/FTC taken daily or intermittently, reducing the risk of HIV acquisition by more than 95% in high-risk individuals.
Published: 11/5/2018
Higher HPV Vaccination Rate Needed to Combat Cancer
Although HPV vaccination rates have steadily increased in recent years, more work is needed in this area to effectively reduce HPV-associated cancer, according to a new report release by the President’s Cancer Panel.
Published: 11/3/2018
FDA Approves Canagliflozin for Type 2 Diabetes Patients with Cardiovascular Disease
Officials with the US FDA have approved canagliflozin (Invokana, Janssen) to reduce the risk of major adverse cardiovascular (CV) events, including heart attack, stroke or death due to a cardiovascular cause in adults with type 2 diabetes (T2D) who have established CV disease.
Published: 10/31/2018
Combination Hormone Therapy for Menopause Gets FDA Approval
Bijuva (estradiol and progesterone) is the first and only FDA-approved bio-identical hormone therapy combination of estradiol and progesterone in a single, oral capsule for the treatment of moderate to severe vasomotor symptoms due to menopause in women with a uterus.
Published: 10/30/2018
October 26 Pharmacy Week in Review: FDA Addressing Accessibility of Naloxone, Therapy Shows Potential for Treating Pancreatic Cancer
This weekly video program provides our readers with an in-depth review of the latest news, product approvals, FDA rulings, and more. Our Week in Review is a can't miss for the busy pharmacy professional.
Published: 10/26/2018
New Antiviral Could Be a Game Changer for Flu Season
A antiviral has been FDA-approved, just in time for flu season.
Published: 10/26/2018
Tapering Biologic RA Treatment Successful, Cost-Effective in Certain Patients
Patients with rheumatoid arthritis who achieve low disease activity or remission may successfully taper their biologic disease-modifying antirheumatic drugs, saving costs as a result.
Published: 10/25/2018
FDA Approves New Influenza Treatment
The approval marks the first new antiviral flu treatment with a novel mechanism of action backed by the agency in nearly 20 years.
Published: 10/24/2018
First New Antiviral for Influenza in 2 Decades Approved by FDA
Officials with the FDA have approved baloxavir marboxil (Xofluza, Shionogi) for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours.
Published: 10/24/2018
A New Safe Medication Disposal Option is Coming to Walgreens Pharmacies
Beginning in spring 2019, all Walgreens pharmacies that do not offer a safe medication disposal kiosk will stock a take home safe medication disposal kit in the pharmacy that will be available at no cost upon patient request.
Published: 10/24/2018
FDA OKs Dupixent for Certain Patients with Asthma
The FDA has approved dupilumab (Dupixent, Regeneron and Sanofi) in patients with moderate-to-severe asthma aged 12 years and older
Published: 10/23/2018
FDA Approves Asthma Indication for Dupixent
The FDA has approved dupilumab (Dupixent, Regeneron and Sanofi) in patients with moderate-to-severe asthma aged 12 years and older.
Published: 10/22/2018
FDA Approves Dupilumab as Additional Maintenance Therapy in Certain Children with Asthma
The FDA has approved dupilumab (Dupixent®, Regeneron and Sanofi) as an add-on maintenance therapy in patients with moderate-to-severe asthma aged 12 years and older with an eosinophilic phenotype or with oral corticosteroid-dependent asthma.
Published: 10/22/2018
Pharmacy Week in Review: Plan Proposed to Require Drug Prices in TV Ads, Study Links Obesity to Colon Cancer in Women
A look at last week's top stories in the world of pharmacy.
Published: 10/19/2018
CMS Officials Announce Plan to Require Price Transparency in Prescription Drug TV Ads
Officials with the Centers for Medicare & Medicaid Services this week proposed requiring drug manufacturers to include prices in direct-to-consumer television advertisements for prescription drugs.
Published: 10/17/2018
The Pharmacist's Role in the Fight Against Influenza
Pharmacists have traditionally played a role in the frontline fight against influenza, but in recent years, that role has become even more important.
Published: 10/11/2018
HPV Vaccine Use Expanded to Include Individuals Up to Age 45 Years
Officials with the FDA have approved a supplemental application for Merck's Gardasil 9 that expands the approved use of the HPV vaccine to include women and men aged 27 to 45 years
Published: 10/7/2018
In Utero Antiretroviral Exposure Potentially Linked to Neurological Abnormalities
Efavirenz exposure (EVF) in utero is being linked to higher risk of neurologic abnormalities in infants and children.
Published: 10/5/2018
Study: In Utero Antiretroviral Exposure Possibly Linked to Neurologic Outcomes
Efavirenz exposure (EVF) in utero is being linked to higher risk of neurologic abnormalities in infants and children.
Published: 10/5/2018
FDA OKs Treatment for Community-Acquired Bacterial Pneumonia and Skin Infections
FDA officials have approved omadacycline (Nuzyra, Paratek), a modernized tetracycline, to treat adults with acute skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP).
Published: 10/4/2018
Survey: Vaccination in Pregnant Women Increases with Access and Education from Providers
The CDC suggests that providers can better inform women about the recommended maternal vaccines.
Published: 10/3/2018
The Evolution of Pharmacy Technicians: Traditional and Emerging Advancement Opportunities
The growth of pharmacists’ roles across health care settings has led to the need for a comparable evolution in the responsibilities and roles of pharmacy technicians.
Published: 9/28/2018
Gilead to Launch Authorized Generic Versions of Hepatitis C Treatments
Officials with Gilead Sciences, Inc. plan to launch authorized generic versions of Epclusa and Harvoni.
Published: 9/26/2018
Pharmacists Play a Key Role in Counseling Patients About Probiotics
Patients have probably heard about probiotics and their role in maintaining digestive health, but they may be unaware of how to use them.
Published: 9/24/2018
New 340B Stewardship Principles Aim to Increase Transparency, Strengthen Program
The American Hospital Association (AHA) and individual hospitals have initiated new principles for ensuring good stewardship of the 340B drug program.
Published: 9/24/2018
Summit on Drug Shortages Explores Disaster Impacts on Supply Chain
A coalition of health care industry leaders hosted a meeting Thursday in Washington, DC, to examine how to address this problem.
Published: 9/22/2018
Why Vaccines Work
Edward Jenner created the first vaccine to protect against smallpox in the 1790s.1 Since then, the pathway to effective and safe vaccines has not been direct or easy, yet millions of lives have been saved, proving that vaccines, in general, are powerful medical interventions.1
Published: 9/20/2018
How Does Continuing Education Benefit Patients?
Brandon Newman, PharmD, CSP, Program Director, Vanderbilt Specialty Pharmacy, talks about why pharmacists should pursue continuing education to benefit their patients.
Published: 9/17/2018
September 14 Pharmacy Week in Review: FDA Ensuring Compounding Quality, New Drug Therapy for Treating Asthma
This weekly video program provides our readers with an in-depth review of the latest news, product approvals, FDA rulings, and more. Our Week in Review is a can't miss for the busy pharmacy professional.
Published: 9/14/2018
FDA Revises Compounding Policy Priorities Plan
The FDA is taking new steps to better ensure the quality of compounded drugs, while also preserving patient access to these medications.
Published: 9/11/2018
Statins Offer Little Benefit to Healthy Older Adults
Although statins have been linked to benefits among older patients with cardiovascular disease, the results of a recent study indicate that there is insufficient evidence to recommend the drug class’ widespread use in healthy adults over the age of 75.
Published: 9/7/2018
CDC: More Adolescents Receiving HPV Vaccination, But Improvement Needed
Recent data show that more adolescents are starting and completing the series of HPV vaccinations meant to prevent cervical cancer. Despite the incease in immunizations, some forms of cancers caused by HPV are rising.
Published: 8/29/2018
Study: Daily Aspirin Did Not Reduce Risk of First Heart Attack, Stroke
Daily aspirin did not reduce the occurrence of major cardiovascular events a study of more than 12,500 participants considered to be at risk.
Published: 8/27/2018
PTCB Sees Success in Advanced Technician Certification Program
In a sign of the profession’s evolution, more than 300 pharmacy technicians have now been certified as Compounded Sterile Preparation Technicians, according to the Pharmacy Technician Certification Board.
Published: 8/22/2018
Expert Panel Recommends Limiting Opioid Prescribing Based on Type of Operation
An expert panel of health care providers and patients are recommending that opioid prescribing limits should be based on the operation performed rather than a blanket approach.
Published: 8/21/2018
FDA OKs First Medical Mobile App for Contraceptive Use
The FDA permitted marketing of the first mobile medical app that can be used as a method of contraception to prevent pregnancy.
Published: 8/13/2018
FDA Expands Valsartan Products Recall
The agency has amended its list of drugs that contain the ingredient, which is used to treat high blood pressure and heart failure.
Published: 8/8/2018
Utilizing Information Technology to Address Oral Chemotherapy Challenges
Howard Cohen, RPh, MS, FASHP, from Smilow Cancer Hospital at Yale-New Haven Health, explains how health systems can utilize information technology as a tool to address the challenges of oral chemotherapies.
Published: 8/5/2018
How Can Pharmacists Help Patients Improve Medication Adherence to Oncolytics?
Ali McBride, PharmD, MS, BCPS, BCOP, explains what strategies can help ensure patients are adherent to oral chemotherapy regimens.
Published: 8/4/2018
Pharmacists Play Key Role in Oncology Care
Nancy Egerton, PharmD, BCOP, discusses the pharmacist's role in oncology care.
Published: 8/3/2018
Alembic: Valsartan Products Not Subject to Recall
Earlier in the month, FDA officials announced that several, but not all, drug products containing the active ingredient valsartan, were recalled due to an impurity, N-nitrosodimethylamine (NDMA), which was found in the recalled products.
Published: 7/31/2018
Pharmacy Week in Review: FDA OKs Drug for Endometriosis Pain, Diabetes Boosts Cancer Risk for Women
A look at last week's top stories in the world of pharmacy.
Published: 7/27/2018
July 27 Pharmacy Week in Review: Drug Approved for Endometriosis Pain, Diabetes Increases Cancer Risk
This weekly video program provides our readers with an in-depth review of the latest news, product approvals, FDA rulings, and more. Our Week in Review is a can't miss for the busy pharmacy professional.
Published: 7/27/2018
FDA Approves Orilissa for Treatment of Endometriosis Pain
Officials with the FDA have approved elagolix (Orilissa, AbbVie), a product specifically developed for women with moderate to severe endometriosis pain.
Published: 7/25/2018
FDA OKs New Drug for Endometriosis Pain Management
Officials with the FDA have approved elagolix (Orilissa, AbbVie), a product specifically developed for women with moderate to severe endometriosis pain.
Published: 7/24/2018
Point-of-Care Testing: Train, Practice, Prepare
Point-of-care testing can help patients determine whether or not they need to see a prescriber for an antibiotic or for other types of treatment, and it can address the growing primary care provider shortage.
Published: 7/12/2018
Neurosyphilis Occurence in Individuals with HIV
The American Journal of Medicine has published a new article that describes the reemergence of neurosyphilis and identifies HIV coinfection in individuals in Western countries as a key risk factor.
Published: 7/10/2018
Enzyme Mutation May Trigger Certain Psychiatric Diseases
New research suggests psychiatric diseases that affect a patient’s ability to appropriately respond to stimuli may be triggered by the misplacement of an enzyme in the pathway within neurons.
Published: 7/6/2018
Pharmacy Week in Review: FDA Approvals for Schizophrenia, Severe Emphysema
A look at last week's top stories in the world of pharmacy.
Published: 7/6/2018
Tobacco Use Associated with Disease Progression in Youth Living with HIV
Between 33% and 38% of youth living with HIV use tobacco.
Published: 7/3/2018
FDA Approves New Treatment Regimen for Schizophrenia
Officials with the FDA have approved Alkermes' aripiprazole lauroxil (Aristada Initio) extended-release product for the treatment of schizophrenia in adults.
Published: 7/3/2018
First Continuous Glucose Monitoring System with Fully Implantable Sensor Gains FDA Approval
Senseonics was granted FDA approval for the Eversense Continuous Glucose Monitoring (CGM) system’s use in people 18 years of age and older with diabetes.
Published: 6/22/2018
What Role Does Patient Satisfaction Play in Specialty Pharmacy?
Brandon Newman, PharmD, CSP, Program Director, Vanderbilt Specialty Pharmacy, speaks about how specialty pharmacies have to adjust their operations to meet the needs of their patients.
Published: 4/30/2018
How Can the CSP Strengthen the Specialty Pharmacy Industry?
Brandon Newman, PharmD, CSP, Program Director, Vanderbilt Specialty Pharmacy, speaks to the benefits of becoming a certified specialty pharmacist.
Published: 3/7/2018
Why is it Important for Specialty Pharmacists to Become Certified?
Brandon Newman, PharmD, CSP, Program Director, Vanderbilt Specialty Pharmacy, talks about why the Certified Specialty Pharmacist distinction is significant.
Published: 2/5/2018
How Can Specialty Pharmacies Benefit from Clinical Outcomes Data?
Brandon Newman, PharmD, CSP, Program Director, Vanderbilt Specialty Pharmacy, discusses why clinical outcomes data are important for specialty pharmacies.
Published: 1/19/2018
Departing PTCB Director Reflects on Evolving Technician Roles
As the Executive Director and CEO of the Pharmacy Technician Certification Board (PTCB), Everett B. McAllister, RPh, MPA, has both witnessed and shepherded a number of significant changes in the technician profession.
Published: 12/29/2017
What Do Changes in the Population Mean for Pharmacy Care?
It is important to align pharmacy services with changes in the population.
Published: 8/25/2017
Even in a Saturated Market, These Pharmacy Students Are Getting Hired
Check out the video to learn which pharmacy students are getting recruited.
Published: 8/22/2017
How Will Changes in Payment Models for Chronic Illness Care Change Pharmacy?
A growing number of plans have begun adjusting payment to pharmacies according to adherence rates.
Published: 8/22/2017
Shifting Payment Models from Dispensing Model to Patient Care: No Easy Answers
Accepting some risks and investing in time and staffing are needed to build out service models.
Published: 8/22/2017
Pharmacies Can Play Key Role in Diabetes Prevention
There are 30 million Americans living with diabetes, and 84 million Americans have prediabetes.
Published: 8/22/2017
What Should Pharmacists Advise Diabetes Patients About Lifestyle Modifications?
In this clip, Brooke Hudspeth, PharmD, CDE, of the Kroger Co., explains how pharmacists can play a role in reinforcing the importance of lifestyle modifications for the prevention and management of type 2 diabetes.
Published: 8/22/2017
What Role Can Pharmacists Play In Implementing Lifestyle Modifications with Diabetes Patients?
In this clip, Brooke Hudspeth, PharmD, CDE, of the Kroger Co. discusses how pharmacists can educate patients about lifestyle modifications that could impact their diabetes.
Published: 8/21/2017
Interpreta and Higi Partner to Combine and Interpret Clinical and Consumer Health Data from Retail Self-Screening Stations
Published: 8/21/2017
What Treatment Options Are Available for Diabetes Patients?
Brooke Hudspeth, PharmD, CDE, of the Kroger Co., discusses the newest therapies available for type 2 diabetes management.
Published: 8/21/2017
Pharmacy Times and Parata Systems Celebrate 2017 Next-Generation Pharmacist Winners
Pharmacy Times and Parata Systems, founding partners of the Next-Generation Pharmacist awards, congratulate the 2017 winners named at an award gala held August 19 at the San Diego Zoo in San Diego, California.
Published: 8/21/2017
Collaboration Between Community, Hospital Pharmacists Central to Reducing Hospital Readmission Rates
While building the relationships between hospitals and community pharmacists can be difficult, the benefits are far-reaching.
Published: 8/21/2017
Priority One: The Message Is Top Priority!
Priority One™ leverages the power and reach of Pharmacy Times®, the most-trusted pharmacy resource, to deliver messages to a selectively targeted proprietary list of decision-makers.
Published: 8/9/2017
Glimpse into Future of Retail and Health Care at 2017 Total Store Expo
The popular “Vision” pavilion will return to the Exhibit Hall at the 2017 National Association of Chain Drug Stores (NACDS) Total Store Expo, which will be held at the San Diego Convention Center from August 19 – 22.
Published: 8/9/2017
Pharmacy Times Ranks No. 1 Among Pharmacists in Average Page Exposures
Results of 2017 Kantar Media Readership Survey demonstrate publication's ongoing valuable leadership among retail pharmacists.
Published: 7/17/2017
Pharmacy Times and Parata Systems Reveal 2017 Next-Generation Pharmacist Finalists
Pharmacy Times and Parata Systems, founding partners of the Next-Generation Pharmacist awards, have announced this year’s 30 finalists.
Published: 6/21/2017
How Can Pharmacists Maintain Adherence?
Autumn Bagwell, PharmD, BCPS, clinical pharmacist at Vanderbilt Specialty Pharmacy, discusses methods pharmacists can employ to maintain adherence.
Published: 3/17/2017
Pharmacist-Led Clinics May Improve Diabetes Care
A collaborative clinic could save more than $5000 per patient over 3 years.
Published: 3/7/2017
How Collaborative Care Programs Can Benefit Specialty Pharmacy
Autumn Bagwell, PharmD, BCPS, clinical pharmacist at Vanderbilt Specialty Pharmacy, discusses how collaborative care programs among providers can benefit patients undergoing treatment.
Published: 3/1/2017
Parenteral Nutrition Compounding Practices at Work
Health-system pharmacies can regulate cost-effective and efficient operations for parenteral nutrition compounding practices. Laura Mark, MS, PharmD, FASHP, led a tech talk at the Baxter Booth at the ASHP Midyear Clinical Meeting to discuss parenteral nutrition compounding practices.
Published: 12/8/2016
How Pharmacists Can Improve Access to Expensive Specialty Drugs
Autumn Bagwell, PharmD, BCPS, clinical pharmacist at Vanderbilt Specialty Pharmacy, discusses how to address the challenge of access to high cost specialty medications.
Published: 10/17/2016
Optimal Patient Management in Hepatitis C Treatment
Autumn Bagwell, PharmD, BCPS, clinical pharmacist at Vanderbilt Specialty Pharmacy, discusses the components of an effective patient management program to optimize adherence.
Published: 9/13/2016
Priority Review for Ovarian Cancer Drug Highlights Week in Cancer News
Top news of the week in oncology, and cancer drug development.
Published: 9/4/2016
Prescription Drop Boxes a Success on State Level
Drop boxes from a pharmacy chain collected 6400 pounds of unused and expired medications.
Published: 8/30/2016
AMA, Omada Health, Intermountain Healthcare Partner to Reduce Incidence of Type 2 Diabetes
Published: 7/26/2016
Optimizing Collaborative Care in Patient Management
Autumn Bagwell, PharmD, BCPS, clinical pharmacist at Vanderbilt Specialty Pharmacy, discusses the elements of an effective interdisciplinary collaborative patient management program.
Published: 5/26/2016
Our Voice: A Pharmacy Technician Journaling Initiative
As patient-centered care becomes the focus and standard of health care, pharmacy technicians have experienced dramatic increases in their roles and responsibilities.
Published: 3/23/2016
Strategies to Avoid Hypotension During Afib Rate Control
Rapid ventricular response in atrial fibrillation patients is a daily occurrence in the emergency department.
Published: 2/8/2016
Off-Label Uses for NOACs
Katie Greenlee, PharmD, BCPS-AQ Cardiology, of the Cleveland Clinic gives examples of certain off-label uses for NOACs that seem promising.
Published: 12/14/2015
An Overview of the Types of Burns a Patient Can Sustain
Patrick Dougherty, PharmD, BCPS,clinical pharmacist at the Emergency Medicine Peninsula Regional Medical Center, provides an overview of the various types of burns a patient can sustain.
Published: 12/11/2015
Why Should Pharmacists Report to MedWatch?
Teresa Rubio, PharmD, of the FDA Office on Health and Constituents outlines why it is important for pharmacists to report to MedWatch.
Published: 12/10/2015
What Are Currently Some of the Major Trends in Pharmacy?
James Hoffman, PharmD, MS, FASHP of St. Jude Children's Research Hospital, discusses some of the major trends in pharmacy. This video was recorded at the 2015 American Society of Health-System Pharmacists Midyear Meeting.
Published: 12/10/2015
What Pharmacists Should Know about the Duration of DAPT
Christopher Betz, PharmD, BCPS, FKSHP, FASHP, professor in the department of clinical and administrative sciences at Sullivan University College of Pharmacy, discusses what pharmacists should know about the duration of dual antiplatelet therapy.
Published: 12/10/2015
Celebrating 50 Years of ASHP Midyear
The American Society of Health-System Pharmacists has just finished celebrating 50 years of its Midyear Clinical Meeting.
Published: 12/10/2015
How the Type of Antiplatelet Agents Can Impact Patient Outcomes
Christopher Betz, PharmD, BCPS, FKSHP, FASHP, professor in the department of clinical and administrative sciences at Sullivan University College of Pharmacy, discusses how the type of antiplatelet agent chosen can impact patient outcomes.
Published: 12/10/2015
The Role of the Pharmacist in Counseling Patients with ACS
Christopher Betz, PharmD, BCPS, FKSHP, FASHP, professor in the department of clinical and administrative sciences at Sullivan University College of Pharmacy, discusses the importance of counseling patients with acute coronary syndrome.
Published: 12/10/2015
How the Type of Stent Used Impacts the Duration of DAPT
Christopher Betz, PharmD, BCPS, FKSHP, FASHP, professor in the department of clinical and administrative sciences at Sullivan University College of Pharmacy, discusses how the type of stent used impacts the duration of dual antiplatelet therapy.
Published: 12/10/2015
What Pharmacists Need to Know About Post-Stent DAPT
Do you know the current guidelines for using dual antiplatelet therapy after drug-eluting stent implantation?
Published: 12/10/2015
3 Exotic Diseases Pharmacists Should Know
Pharmacists should learn how to properly diagnose foreign-acquired diseases in order to optimize outcomes for infected patients.
Published: 12/10/2015
Concerns with Medication Use Risks Outside of Pharmacy
Matthew C. Grissinger, RPh, FISMP, FASCP, director, of error reporting programs at the Institute for Safe Medication Practices, discusses medication use risk outside the pharmacy.
Published: 12/10/2015
The Role of the Pharmacist in ACS Management with Platelet Aggregation Inhibitors
Christopher Betz, PharmD, BCPS, FKSHP, FASHP, professor in the department of clinical and administrative sciences at Sullivan University College of Pharmacy, discusses what the role of the pharmacist is in acute coronary syndrome management with platelet aggregation inhibitors.
Published: 12/10/2015
Role of Platelet Aggregation Inhibitors in ACS Management
Katie Greenlee, PharmD, BCPS-AQ Cardiology, of the Cleveland Clinic discusses the role of platelet aggregation inhibitors in ACS management.
Published: 12/9/2015
Tips to Spot Medication Errors Outside the Hospital Pharmacy
Identifying medication use risks outside the hospital pharmacy requires something simple: speaking with other members of the health care team.
Published: 12/9/2015
2016 Pharmacy Forecast: More Patient Empowerment
Health-system pharmacists must look beyond immediate operational challenges and consider the larger trends that will ultimately affect their practices.
Published: 12/9/2015
How Patient Empowerment Is Affecting Pharmacy Practice
James Hoffman, PharmD, MS, FASHP of St. Jude Children's Research Hospital, describes how the growing trend of patient empowerment will affect the practice of pharmacy going forward.
Published: 12/9/2015
Using Platelet Aggregation Inhibitors in Different Patient Populations
Katie Greenlee, PharmD, BCPS-AQ Cardiology, of the Cleveland Clinic discusses the different nuances pharmacists have to consider when using platelet aggregation inhibitors in different patient populations.
Published: 12/9/2015
Challenging and Memorable Burn Cases
Patrick Dougherty, PharmD, BCPS, a clinical pharmacist at the Emergency Medicine Peninsula Regional Medical Center, talks about some memorable experiences he has had with burn patients.
Published: 12/8/2015
What Pharmacists Should Report to FDA MedWatch
Pharmacists should take advantage of the FDA's adverse drug event reporting system to promote patient safety.
Published: 12/8/2015
Role of the Pharmacist in ACS Management with Platelet Aggregation Inhibitors
Andrew North, PharmD, BCPS, a specialty practice pharmacist in emergency medicine at the Ohio State University Wexner Medical Center, discusses the pharmacist's role in acute coronary syndrome management with platelet aggregation inhibitors.
Published: 12/8/2015
Health-System Pharmacists: What's in Your Crash Cart?
Certain items are must-haves in any crash cart during a hospital code.
Published: 12/8/2015
Internal and External Factors That Can Affect Pharmacists' Reliability
Natasha Nicol, Pharm D, FASHP, director of Global Patient Safety Affairs at Cardinal Health, discusses internal and external factors that could affect pharmacists' reliability.
Published: 12/7/2015
How Pharmacists Can Provide Help in Cardiopulmonary Resuscitation Efforts
Andrew North, PharmD, BCPS, a specialty practice pharmacist in emergency medicine at the Ohio State University Wexner Medical Center, discusses some ways pharmacists can help in cardiopulmonary resuscitation efforts.
Published: 12/7/2015
Typical Medications in a Crash Cart
Andrew North, PharmD, BCPS, a specialty practice pharmacist in emergency medicine at the Ohio State University Wexner Medical Center, talks about what is inside a crash cart.
Published: 12/7/2015
Documentation and Communication Pharmacists Can Provide in Emergency Situations
Andrew North, PharmD, BCPS, a specialty practice pharmacist in emergency medicine at the Ohio State University Wexner Medical Center, discusses the role pharmacists can play in emergency situations.
Published: 12/7/2015
What a Crash Cart Contains Besides Medication
Andrew North, PharmD, BCPS, a specialty practice pharmacist in emergency medicine at the Ohio State University Wexner Medical Center, discusses what is in a crash cart beyond medications.
Published: 12/7/2015
Acute Treatment of Minor Burns
Patrick Dougherty, PharmD, BCPS, a clinical pharmacist at the Emergency Medicine Peninsula Regional Medical Center, gives some examples of treatment for minor burns.
Published: 12/7/2015
Pharmacist Role in ACS Management with Platelet Aggregation Inhibitors
Katie Greenlee, PharmD, BCPS-AQ Cardiology, of the Cleveland Clinic discusses the role of the pharmacist in ACS management with platelet aggregation inhibitors.
Published: 12/7/2015
The Pharmacist's Role in Burn Management
Patrick Dougherty, PharmD, BCPS, a clinical pharmacist at the Emergency Medicine Peninsula Regional Medical Center, discusses how pharmacists can help burn patients.
Published: 12/7/2015
Pharmacists Can Reduce Medication Errors During Emergency Codes
Health-system pharmacists can help save lives by reducing the risk of medication errors before, during, and after hospital emergency codes.
Published: 12/7/2015
4 Things Pharmacists Should Know About Medical Marijuana
Should hospitals open their own medical marijuana dispensaries?
Published: 12/7/2015
The Pharmacist's Role in Managing the Medication Process Outside the Pharmacy
Matthew C. Grissinger, RPh, FISMP, FASCP, director, of error reporting programs at the Institute for Safe Medication Practices, discusses what the pharmacist's role is in managing the medication process outside the pharmacy.
Published: 12/7/2015
Heroin-Related Deaths on the Rise
Heroin's popularity is starting to creep into demographic groups that historically had lower rates of use and related deaths.
Published: 7/9/2015
Pharmacists Make Progress Toward Attaining Provider Status
Speakers at the ASHP Midyear Clinical Meeting ranging from ASHP President Gerald Meyer, PharmD, to Michael Lee, PharmD, of the Indian Health Service, argued that pharmacists are closer than ever before to achieving their goal of attaining provider status.
Published: 12/12/2013
Considerations for Constructing a Specialty Pharmacy Service Business Plan
Specialty pharmacy presents itself as both a challenging business model and a significant financial opportunity under the right circumstances, especially for health systems. Kevin Colgan, MA, FASHP, of Rush University Medical Center and Kyle Skiermont, PharmD, of Fairview Pharmacy Services provided an overview of specialty pharmacies and presented strategies for building a successful specialty pharmacy business.
Published: 12/11/2013
Health Care Quality Measurement and Reporting: Experiences from the NQF
Quality and performance measurement has become an integral part of the health care system. As pharmacists continue to increase their role and exposure as health care providers, they are well positioned to assist in identifying ways to improve the quality of care delivered and to play an integral role in the development of quality measures, according to Curtis Collins, PharmD, MS, BCPS (AQ-ID), FASHP, who spoke at the ASHP Midyear Meeting.
Published: 12/11/2013
Controlling the Obesity Epidemic: Where Does Pharmacy Weigh In?
As the prevalence of obesity continues to increase and treatment strategies evolve, pharmacists are not only in a position to advise on appropriate use of pharmacotherapy for obesity, but also to assist in improving outcomes from gastric bypass surgery.
Published: 12/11/2013
The Clinical Impact of Next-Generation Sequencing (NGS) on Pharmacy Practice
Genomic sequencing is rapidly increasing its value as a clinical tool in the diagnosis and treatment of many diseases, including cancer. In his presentation, Justin M. Balko, PharmD, PhD, from Vanderbilt University, provided a background on the current state of next-generation genomic sequencing (NGS), and the potential role that pharmacists play as this science continues to evolve.
Published: 12/10/2013
Colin Powell Addresses Health-System Pharmacists
Retired general and former secretary of state Colin Powell discussed his thoughts on the US health care system and the role pharmacists play within it during his keynote address at the ASHP Midyear Clinical Meeting.
Published: 12/10/2013
Integration of Advanced Clinical Pharmacy Services in an Accountable Care Organization
In this session, a sustainable business model for pharmacists practicing in an accountable care organization environment was described by Kelly Boesen, PharmD, BCPS, and Sandra Leal, PharmD, MPH, CDE, FAPhA, of the El Rio Health Center in Tucson, Arizona.
Published: 12/10/2013
The Ideal Clinical Practice: Myth or Reality
New and experienced pharmacists are always on the lookout for ways to improve their careers. This presentation focuses on some key strategies for identifying new opportunities that allow new and experienced pharmacists to develop and apply their clinical skills.
Published: 12/9/2013
Newest Drugs of Abuse: Spice, Bath Salts, Salvia, and Beyond
Illicit drug use continues to be a prevalent and growing problem in the United States, and the use of newer substances is on the rise. Because of the increasing prevalence and "tweaking" of compounds to avoid detection, the identification of drug abuse by practitioners often relies on signs and symptoms. In this session, presenters reviewed some of these agents, including their history and their impact on those abusing them.
Published: 12/9/2013
Making the Most of the ASHP Midyear
The editor of the Pharmacy Times Health-System Edition offers pointers on getting as much as you can out of the 2013 ASHP Midyear Clinical Meeting.
Published: 12/9/2013
Coming Soon
Published: 11/6/2013
Vanderbilt University and Bristol-Myers Squibb Sign Collaboration Agreement to Develop Novel Treatments for Parkinson's Disease
Vanderbilt University and Bristol-Myers Squibb Company announced that they have signed a collaboration agreement for the discovery, development and commercialization of novel therapies acting on the mGluR4 glutamate receptor, known as positive allosteric modulators or PAMs, for the treatment of Parkinson's disease.
Published: 9/25/2012
Errors Lurk in Switch to E-Prescribing
Transitioning to more advanced e-prescribing systems could lead to a rise in drug errors that threaten patient safety.
Published: 6/2/2011
Treatment of Comorbid Diabetes and Dyslipidemia: A Novel Role for Colesevelam
Published: 8/6/2010
Rx Product News: March 2009
Published: 3/1/2009
February Health Systems Product News
Published: 2/1/2009
Health System Product News
Published: 1/1/2009
Rx Product News: January 2009
Published: 1/1/2009
December Product News
Published: 12/1/2008
Rx Product News: December 2008
Published: 12/1/2008
Rx Product News: November 2008
Published: 11/1/2008
November Product News
Published: 11/1/2008
Rx Product News: September 2008
Published: 9/1/2008
September Product News
Published: 9/1/2008
News CAPSULES: August 2008
Published: 8/1/2008
Top 200 Prescription Drugs of 2007
With expansion in the generics market and fewer FDA drug approvals, growth in dollar sales for drugs was down in 2007, though the number of prescriptions dispensed increased slightly.
Published: 5/1/2008
Pediatric Asthma Deserves Special Considerations
Appropriate treatment, monitoring, and patient education can control asthma and its symptoms and allow patients to live fully active lives.
Published: 4/1/2008
April Product News
Published: 4/1/2008
National Panel Updates Its Asthma Guideline
The National Asthma Education and Prevention Program's Expert Panel has issued revised guidelines for treating asthma in children and adults.
Published: 4/1/2008
Patent Expirations Could Mean Biologics Competition
As patent expirations creep closer, blockbuster drugs face increasing competition, and the FDA faces increasing pressure.
Published: 3/1/2008